Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder

Lancet

Volumn 361, Issue 9369, 2003, Pages 1617-1620

  Groet, Jürgen ^a   McElwaine, Suzanne ^a   Spinelli, Monica ^b   Rinaldi, Andrea ^b   Burtscher, Ingo ^a   Mulligan, Claire ^a   Mensah, Afua ^a   Cavani, Simona ^c   Dagna Bricarelli, Franca ^c   Basso, Giuseppe ^b   Cotter, Finbarr E ^a   Nizetic, Dean ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PADOVA   (Italy)

^c GALLIERA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR GATA 1;

ACUTE MEGAKARYOCYTIC LEUKEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; EXON; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LEUKEMIA REMISSION; MALE; MUTATION RATE; MYELOPROLIFERATIVE DISORDER; NEWBORN; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; TISSUE SECTION;

EID: 0037906527     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)13266-7     Document Type: Article

References (5)

1. Gamis A.S., Hilden J.M. Transient myeloproliferative disorder, a disorder with too few data and many unanswered questions: does it contain an important piece of the puzzle to understanding hematopoiesis and acute myelogenous leukemia? J Pediatr Hematol Oncol. 24:2002;2-5.
2. Taub J.W., Ravindranath Y. Down syndrome and the transient myeloproliferative disorder: why is it transient? J Pediatr Hematol Oncol. 24:2002;6-8.
3. Al-Kasim F., Doyle J.J., Massey G.V., Weinstein H.J., Zipursky A. Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome. J Pediatr Hematol Oncol. 24:2002;9-13.
4. Wechsler J., Greene M., McDevitt M.A., et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet. 32:2002;148-152.
5. Orkin S.H. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 1:2000;57-64.