Melanin concentrating hormone receptor 1 (MCHR1) antagonists - Still a viable approach for obesity treatment?

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6039-6047

  Högberg, Thomas ^a   Frimurer, Thomas M ^b   Sasmal, Pradip K ^c  

^a LEO PHARMA A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Chemometric analysis; GPCR structures; hERG; MCHR1 antagonists; Melanin concentrating hormone (MCH); Obesity

Indexed keywords

ALB 127158; AMG 076; BMS 819881; BMS 830216; GW 856464; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; NGD 4715; SNAP 7941; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG PENETRATION; DRUG SELECTIVITY; DRUG STRUCTURE; OBESITY; X RAY;

EID: 84866384546     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.025     Document Type: Review

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