Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent Melanin-Concentrating Hormone Receptor 1 (MCH-R1) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4859-4863

  Berglund, Susanne ^a   Egner, Bryan J ^a   Gradén, Henrik ^a   Gradén, Joakim ^a   Morgan, David G A ^b   Inghardt, Tord ^a   Giordanetto, Fabrizio ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

MCH; MCH R1 antagonists; Melanin Concentrating Hormone; Obesity

Indexed keywords

MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PYRROLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-OBESITY AGENTS; DRUG STABILITY; HUMANS; MICE; PYRROLES; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 50049099395     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.079     Document Type: Article

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