Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5443-5448

  Sasmal, Pradip K ^a   Sasmal, Sanjita ^a   Rao, P Tirumala ^a   Venkatesham, B ^a   Roshaiah, M ^a   Abbineni, Chandrasekhar ^a   Khanna, Ish ^a,c   Jadhav, Vikram P ^a   Suresh, J ^a   Talwar, Rashmi ^a   Muzeeb, Syed ^a   Receveur, Jean Marie ^b   Frimurer, Thomas M ^b   Rist, Øystein ^b   Elster, Lisbeth ^b   Högberg, Thomas ^b,d  

^a DR REDDY'S LABORATORIES LTD   (India)

^b 7TM Pharma A S   (Denmark)

^c Kareus Therapeutics   (United States)

^d LEO PHARMA A S   (Denmark)

Author keywords

Benzimidazoles; MCHR1 antagonists; Melanin concentrating hormone (MCH); Obesity

Indexed keywords

AMG 076; BENZIMIDAZOLE DERIVATIVE; GW 856464; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; NGD 4715; SNAP 7941; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; DEPRESSION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENERGY METABOLISM; HOMEOSTASIS; IN VIVO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; OBESITY; STRESS; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; BENZIMIDAZOLES; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; OBESITY; PROTEIN BINDING; RECEPTORS, SOMATOSTATIN; WEIGHT LOSS;

EID: 77956176750     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.086     Document Type: Article

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