Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3163-3167

  Sasmal, Sanjita ^a   Balasubrahmanyam, D ^a   Kanna Reddy, Hariprasada R ^a   Balaji, Gade ^a   Srinivas, Gujjary ^a   Cheera, Srisailam ^a   Abbineni, Chandrasekhar ^a   Sasmal, Pradip K ^a   Khanna, Ish ^a   Sebastian, V J ^a   Jadhav, Vikram P ^a   Singh, Manvendra P ^a   Talwar, Rashmi ^a   Suresh, J ^a   Shashikumar, Dhanya ^a   Harinder Reddy, K ^a   Sihorkar, V ^a   Frimurer, Thomas M ^b   Rist, Øystein ^b   Elster, Lisbeth ^b   Högberg, Thomas ^b,c   more..

^a DR REDDY'S LABORATORIES LTD   (India)

^b 7TM Pharma A S   (Denmark)

^c LEO PHARMA A S   (Denmark)

Author keywords

hERG; MCHR1 antagonists; Melanin concentrating hormone (MCH); Obesity; Quinazolines

Indexed keywords

MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; QUINAZOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; EXPERIMENTAL DOG; MICROSOME; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

CARDIOVASCULAR DISEASES; DRUG DESIGN; HUMANS; QUINAZOLINES; RECEPTORS, PITUITARY HORMONE; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859838181     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.049     Document Type: Article

References (23)

1. J.L. Nahon Biology 329 2006 623
2. G. Hervieu Expert Opin. Ther. Targets 10 2006 211
3. T. Shimazaki, T. Yoshimizu, and S. Chaki CNS Drugs 20 2006 801
4. G. Rivera, V. Bocanegra-Garcia, S. Galiano, N. Cirauqui, J. Ceras, S. Perez, I. Aldana, and A. Monge Curr. Med. Chem. 1025 2008 15
5. T.J. Kowalski, and T. Sasikumar BioDrugs 21 2007 311
6. D.S. Ludwig, N.A. Tritos, J.W. Mastaitis, R. Kulkarni, E. Kokkotou, J. Elmquist, B. Lowell, J.S. Flier, and E. Maratos-Flier J. Clin. Invest. 107 2001 379
7. M. Shimada, N.A. Tritos, B.B. Lowell, J.S. Flier, and E. Maratos-Flier Nature 396 1998 670
8. Y. Chen, C. Hu, C.-K. Hsu, Q. Zhang, C. Bi, M. Asnicar, H.M. Hsiung, N. Fox, L.J. Slieker, D.D. Yang, M.L. Heiman, and Y. Shi Endocrinology 143 2002 2469
9. D.J. Marsh, D.T. Weingarth, D.E. Novi, H.Y. Chen, M.E. Trumbauer, A.S. Chen, X.-M. Guan, M.M. Jiang, Y. Feng, R.E. Camacho, Z. Shen, E.G. Frazier, H. Yu, J.M. Metzger, S.J. Kuca, L.P. Shearman, S. Gopal-Truter, D.J. MacNeil, A.M. Strack, D.E. MacIntyre, L.H.T. Van der Ploeg, and S. Qian Proc. Natl. Acad. Sci. U.S.A. 99 2002 3240
10. G. Hervieu Expert Opin. Ther. Targets 7 2003 495
11. S. Chaki, T. Funakoshi, S. Hirota-Okuno, M. Nishiguchi, T. Shimazaki, M. Iijima, A.J. Grottick, K. Kanuma, K. Omodera, Y. Sekiguchi, S. Okuyama, T.A. Tran, G. Semple, and W. Thomsen J. Pharmacol. Exp. Ther. 313 2005 831
12. Sasmal, S.; Balaji, G.; Kanna Reddy, H. R.; Balasubrahmanyam, D.; Srinivas, G.; Kyasa, S.; Sasmal, P. K.; Khanna, I.; Talwar, R.; Suresh, J.; Jadhav, V. P.; Muzeeb, S.; Shashikumar, D.; Reddy, K. H.; Sebastian, V. J.; Frimurer, T. M.; Rist, Ø.; Elster, L.; Högberg, T. Bioorg. Med. Chem. Lett. 2012, 22. http://dx.doi.org/10.1016/j.bmcl.2012.03.050.
13. For recent reviews on hERG, see: I. Staudacher, P.A. Schweizer, H.A. Katus, and D. Thomas Curr. Opin. Drug. Discov. Devel. 13 2010 23
14. H. Wulff, N.A. Castle, and L.A. Pardo Nat. Rev. Drug Disc. 8 2009 982
15. C.E. Pollard, J.P. Valentin, and T.G. Hammond Br. J. Pharmacol. 154 2008 1538
16. K. Finlayson, H.J. Witchel, J. McCulloch, and J. Sharkey Eur. J. Pharmacol. 500 2004 129
17. W.G. Verschueren, I. Dierynck, K.I.E. Amssoms, L. Hu, P.M.J.G. Boonants, G.M.E. Pille, F.F.D. Daeyaert, K. Hertogs, D.L.N.G. Surleraux, and P.B.T.P. Wigerinck J. Med. Chem. 2005 1930 48
18. PCT WO2005113504.
19. K.C. Nicolaou, S.A. Snyder, D.A. Longbottom, A.Z. Nalbandian, and X. Huang Chem. Eur. J. 10 2004 5581
20. T. Ulven, T.M. Frimurer, J.-M. Receveur, P.B. Little, Ø. Rist, P. Nørregaard, and T. Högberg J. Med. Chem. 48 2005 5684
21. For other quinazoline derivatives as MCHR1 antagonists, see: K. Kanuma, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, Y. Nagase, I. Iida, J.-I. Yamaguchi, G. Semple, T.-A. Tran, and Y. Sekiguchi Bioorg. Med. Chem. 14 2006 3307
22. K. Kanuma, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, G. Semple, T.-A. Tran, B. Kramer, D. Hsu, M. Casper, B. Thomsen, N. Beeley, and Y. Sekiguchi Bioorg. Med. Chem. Lett. 15 2005 3853
23. K. Kanuma, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, G. Semple, T.-A. Tran, B. Kramer, D. Hsu, M. Casper, B. Thomsen, N. Beeley, and Y. Sekiguchi Bioorg. Med. Chem. Lett. 15 2005 2565