4-Arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 427-430

  Lim, Chae Jo ^a,b   Kim, Soo Hee ^a,b   Lee, Byung Ho ^a   Oh, Kwang Seok ^a   Yi, Kyu Yang ^a,b  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

4 Arylphthalazin 1(2H) one; MCH R1 antagonists; Melanin concentrating hormone (MCH); Obesity

Indexed keywords

4 (3,4 DIFLUOROPHENYL) DERIVATIVE; 4 ARYLPHTHALAZIN 1(2H) ONE DERIVATIVE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-OBESITY AGENTS; BENZIMIDAZOLES; BODY WEIGHT; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; HOMEOSTASIS; HUMANS; HYDRAZINES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; OBESITY; PHTHALAZINES; PROTEIN BINDING; RECEPTORS, PITUITARY HORMONE;

EID: 84655175128     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.111     Document Type: Article

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