Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: Orally efficacious antiobesity therapeutics

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2274-2277

  McBriar, Mark D ^a   Guzik, Henry ^a   Xu, Ruo ^a   Paruchova, Jaroslava ^a   Li, Shengjian ^a,b   Palani, Anandan ^a   Clader, John W ^a   Greenlee, William J ^a   Hawes, Brian E ^a   Kowalski, Timothy J ^a   O'Neill, Kim ^a   Spar, Brian ^a   Weig, Blair ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; ATC 0175; BICYCLO COMPOUND; GW 803430; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; SIBUTRAMINE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; ENERGY; FOOD INTAKE; HUMAN; NONHUMAN; OBESITY; SIDE EFFECT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-OBESITY AGENTS; BICYCLO COMPOUNDS; BIOLOGICAL AVAILABILITY; BRAIN; CYCLOHEPTANES; CYCLOHEXANES; EATING; MICE; OBESITY; RATS; RECEPTORS, PITUITARY HORMONE; RECEPTORS, SOMATOSTATIN; UREA;

EID: 20244363643     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049035q     Document Type: Article

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