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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2309-2312

Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists

(7) Lim, Chae Jo a Kim, Nakjeong a Lee, Eun Kyoung a,b Lee, Byung Ho a Oh, Kwang Seok a Yoo, Sung Eun a Yi, Kyu Yang a,b

a Korea Research Institute of Chemical Technology (South Korea)

b University of Science and Technology (UST) (South Korea)

Author keywords

2 Arylbenzimidazole; MCH R1 antagonists; Melanin concentrating hormone (MCH); Obesity

Indexed keywords

ACETANILIDE; AROMATIC HYDROCARBON; BENZIMIDAZOLE DERIVATIVE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETANILIDES; ADMINISTRATION, ORAL; ANIMALS; BENZIMIDAZOLES; BRAIN; HUMANS; RATS; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953286032 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2011.02.099 Document Type: Article

Times cited : (17)

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