Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2353-2366

  Kamata, Makoto ^a   Yamashita, Toshiro ^a   Imaeda, Toshihiro ^a   Tanaka, Toshio ^a   Masada, Shinichi ^a   Kamaura, Masahiro ^a   Kasai, Shizuo ^a   Hara, Ryoma ^a   Sasaki, Shigekazu ^a   Takekawa, Shiro ^a   Asami, Asano ^a   Kaisho, Tomoko ^a   Suzuki, Nobuhiro ^a   Ashina, Shuntaro ^a   Ogino, Hitomi ^a   Nakano, Yoshihide ^a   Nagisa, Yasutaka ^a   Kato, Koki ^a   Kato, Kaneyoshi ^a   Ishihara, Yuji ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 METHYLQUINOLINE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; QUINOLINE DERIVATIVE; SCAFFOLD PROTEIN; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; CONTROLLED STUDY; DIET; DIET RESTRICTION; FOOD INTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OBESITY; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-OBESITY AGENTS; BENZAMIDES; BIOLOGICAL AVAILABILITY; EATING; HUMANS; MICE; MICE, KNOCKOUT; QUINOLINES; RATS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863229791     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201596h     Document Type: Article

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