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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3781-3785

Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition

(13) Mihalic, Jeffrey T a Fan, Pingchen a Chen, Xi a Chen, Xiaoqi a Fu, Ying a Motani, Alykhan b Liang, Lingming b Lindstrom, Michelle b Tang, Liang b Chen, Jin Long b Jaen, Juan a Dai, Kang b Li, Leping a

a AMGEN INC (United States)

b NONE (United States)

Author keywords

MCHR1; Melanin concentrating hormone; Reducing hERG inhibition

Indexed keywords

AMG 076; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; POTASSIUM CHANNEL HERG; SIBUTRAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CLINICAL EVALUATION; CLINICAL EXAMINATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; QT PROLONGATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BODY WEIGHT; BRAIN; CARBAZOLES; CYCLOHEXANECARBOXYLIC ACIDS; DIET, HIGH-FAT; DOGS; DRUG EVALUATION, PRECLINICAL; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RECEPTORS, PITUITARY HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861189511 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.04.006 Document Type: Article

Times cited : (19)

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