Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 18, 2006, Pages 4872-4878

  Witty, David R ^a   Bateson, John ^a   Hervieu, Guillaume J ^a   Al Barazanji, Kamal ^a   Jeffrey, Phillip ^a   Hamprecht, Dieter ^a   Haynes, Andrea ^a   Johnson, Christopher N ^a   Muir, Alison I ^a   O'Hanlon, Peter J ^a   Stemp, Geoffrey ^a   Stevens, Alex J ^a   Thewlis, Kevin ^a   Winborn, Kim Y ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antagonist; Anxiety; Benzotriazinone; Bicyclic heterocycle; Biphenylcarboxamide; Cyclisation; Feeding; MCH; MCH R1; Melanin concentrating hormone; Obesity; Quinazolinone; Stress; Thienopyrimidinone

Indexed keywords

HORMONE RECEPTOR BLOCKING AGENT; LIGAND; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST; PHTHALIMIDE DERIVATIVE; PYRIMIDINONE DERIVATIVE; QUINAZOLINONE DERIVATIVE; SB 568849; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; RECEPTOR AFFINITY;

AMIDES; ANILIDES; BIPHENYL COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746837233     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.061     Document Type: Article

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