Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2460-2467

  Fox, Brian M ^a   Natero, Reina ^a   Richard, Kevin ^a   Connors, Richard ^a   Roveto, Philip M ^a   Beckmann, Holger ^b   Haller, Katrin ^b   Golde, Justin ^a   Xiao, Shou Hua ^a   Kayser, Frank ^a  

^a AMGEN INC   (United States)

^b Amgen Research GmbH   (Germany)

Author keywords

MCHR1 antagonist; Melanin concentrating hormone receptor 1; Pyrrolidine; Reducing hERG inhibition

Indexed keywords

ANILIDE; BENZAMIDE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; POTASSIUM CHANNEL HERG; PYRROLIDINE DERIVATIVE;

ARTICLE; DRUG INHIBITION; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; PYRROLIDINES; RECEPTORS, SOMATOSTATIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953271288     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.046     Document Type: Article

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