Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4274-4279

  Berglund, Susanne ^a   Egner, Bryan J ^a   Gradén, Henrik ^a   Gradén, Joakim ^a   Morgan, David G A ^b   Inghardt, Tord ^a   Giordanetto, Fabrizio ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

MCH; MCH R1 antagonists; Melanin concentrating hormone; Obesity, hERG, hERG inhibitors

Indexed keywords

3 CHLOROPYRIDONE; AMIDE; BENZIMIDAZOLE; IMIDAZOLE DERIVATIVE; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N SULFONYLUREA; PIPERAZINE; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; PYRAZINE; PYRAZOLE; PYRIDONE DERIVATIVE; PYRROLE; SULFONE; SULFONYLUREA; TRIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; OBESITY;

ANIMAL FEED; ANIMALS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ETHER-A-GO-GO POTASSIUM CHANNELS; FEEDING BEHAVIOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; OBESITY; PIPERIDINES; PROTEIN BINDING; RATS; RECEPTORS, PITUITARY HORMONE; UREA;

EID: 67650168965     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.066     Document Type: Article

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