Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3- aminomethylquinolines: Reducing human ether-a-go-go-related gene (hERG) associated liabilities

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4336-4351

  Kasai, Shizuo ^a   Kamata, Makoto ^a   Masada, Shinichi ^a   Kunitomo, Jun ^a   Kamaura, Masahiro ^a   Okawa, Tomohiro ^a   Takami, Kazuaki ^a   Ogino, Hitomi ^a   Nakano, Yoshihide ^a   Ashina, Shuntarou ^a   Watanabe, Kaoru ^a   Kaisho, Tomoko ^a   Imai, Yumi N ^a   Ryu, Sunghi ^a   Nakayama, Masaharu ^a   Nagisa, Yasutaka ^a   Takekawa, Shiro ^a   Kato, Koki ^a   Murata, Toshiki ^a   Suzuki, Nobuhiro ^a   Ishihara, Yuji ^a   more..

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXY 2 METHYLPROPYLAMINE; 3 (1 CHLOROETHYL) 8 METHYLQUINOLIN 7 AMINE DIHYDROCHLORIDE; 3 AMINOMETHYLQUINOLINE; 3[1 [(2 (ACETYLAMINO)ETHYL)AMINO)ETHYL] 8 METHYLQUINOLIN 7 YL] 4 (CYCLOPROPYLMETHOXY)BENZAMIDE; 4 (2 CYCLOPROPYLETHOXY) N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL]BENZAMIDE; 4 (2 METHYLPROPOXYL) N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL]BENZAMIDE; 4 (CYCLOPROPYLMETHOXY) N 8 METHYL 3 1PYRROLIDIN 1; 4 (CYCLOPROPYLMETHOXY) N [8 METHYL 3 (1 PYRROLIDIN 1YLETHYL)QUINOLIN 7 YL]BENZAMIDE; 4 (CYCLOPROPYLMETHOXY) N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL]BENZAMIDE; 4 (CYCLOPROPYLMETHOXY) N [8 METHYL 3 [(2 METHYLPYRROLIDIN 1 YL)METHYL]QUINOLIN 7 YL]BENZAMIDE; 4 BUTOXY [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL]BENZAMIDE; 4 BUTYLSULFONYL N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL) QUINOLIN 7 YL]BENZAMIDE; 4 FLUOROPHENYL GROUP; 4 HEXANOYL N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL]BENZAMIDE; 5 (4 FLUOROPHENYL) N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL) QUINOLIN 7 YL]PENTANAMIDE; 5 (4 FLUOROPHENYL) N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL] 5 OXOPENTANAMIDE; 7 AMINO 8 METHYLQUINOLINE 3 CARBOXALDEHYDE; 8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 AMINE; 8 METHYL 3 [(2 METHYLPYRROLIDIN 1 YL)METHYL]QUINOLIN 7 AMINE; BENZILIC ACID; CARBON; CYCLOPROPYLMETHOXYL GROUP; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; METHYL GROUP; N [3 (1 CHLOROETHYL) 8 METHYLQUINOLIN 7 YL] 4 (CYCLOPROPYLMETHOXY)BENZAMIDE; N [8 METHYL 3 (PYRROLIDIN 1 YLMETHYL)QUINOLIN 7 YL] 4 (PENTANOYLAMINO)BENZAMIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; FOOD INTAKE; MOLECULAR DOCKING; NONHUMAN; PATCH CLAMP; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-OBESITY AGENTS; BENZAMIDES; CHO CELLS; CRICETINAE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; OBESITY; QUINOLINES; RATS; RATS, INBRED F344; RECEPTORS, PITUITARY HORMONE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861033306     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300167z     Document Type: Article

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