The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries

European Journal of Pharmacology

Volumn 602, Issue 2-3, 2009, Pages 194-202

  Nagasaki, Hiroshi ^a   Chung, Shinjae ^b   Dooley, Colette T ^c   Wang, Zhiwei ^b   Li, Chunying ^b   Saito, Yumiko ^d   Clark, Stewart D ^b   Houghten, Richard A ^c   Civelli, Olivier ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Antagonist; Combinatorial libraries; G protein coupled receptors; MCH1 receptor; TPI 1361 17

Indexed keywords

APPETITE STIMULANT; DRUG VEHICLE; G PROTEIN COUPLED RECEPTOR; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N [3 [ 1 ( 2 (BENZYLAMINO) 1 METHYLETHYL]]3 [[[2 (3 FLUOROPHENYL)ETHYL] 2 THIOXOMIDAZOLIDIN 4 YL] PROPYL]GUANIDINE; TPI 1361 17; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CHEMICAL MODIFICATION; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG RESEARCH; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOSKELETAL PROTEINS; DRUG EVALUATION, PRECLINICAL; EATING; ETHYLENETHIOUREA; GUANIDINES; HUMANS; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; TASTE; THIOUREA;

EID: 58149175660     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.068     Document Type: Article

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