메뉴 건너뛰기




Volumn 64, Issue 12, 2012, Pages 1277-1291

Studies of bone morphogenetic protein-based surgical repair

Author keywords

Bone fracture; Bone tissue engineering; Drug delivery; Oral surgery; Regenerative medicine; RhBMPs; Spinal surgery

Indexed keywords

BONE FRACTURE; BONE TISSUE ENGINEERING; REGENERATIVE MEDICINE; RHBMPS; SPINAL SURGERY;

EID: 84865291114     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.03.014     Document Type: Review
Times cited : (221)

References (267)
  • 1
    • 84872879971 scopus 로고    scopus 로고
    • Medtech INsight, Life Science Intelligence, Inc, Hungtington Beach, CA,
    • U.S. Market for Fracture Fixation Products, 2011 Analysis 14 September 2011, Medtech INsight, Life Science Intelligence, Inc, Hungtington Beach, CA, http://www.lifescienceintelligence.com/market-reports-page.php?id=A326.
    • (2011) U.S. Market for Fracture Fixation Products, 2011 Analysis
  • 3
    • 0024362147 scopus 로고
    • Donor site pain from the ilium. A complication of lumbar spine fusion
    • Summers B.N., Eisenstein S.M. Donor site pain from the ilium. A complication of lumbar spine fusion. J. Bone Joint Surg. Br. 1989, 71:677-680.
    • (1989) J. Bone Joint Surg. Br. , vol.71 , pp. 677-680
    • Summers, B.N.1    Eisenstein, S.M.2
  • 5
    • 45449119098 scopus 로고    scopus 로고
    • Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques
    • Pollock R., Alcelik I., Bhatia C., Chuter G., Lingutla K., Budithi C., Krishna M. Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques. Eur. Spine J. 2008, 17:845-852.
    • (2008) Eur. Spine J. , vol.17 , pp. 845-852
    • Pollock, R.1    Alcelik, I.2    Bhatia, C.3    Chuter, G.4    Lingutla, K.5    Budithi, C.6    Krishna, M.7
  • 6
    • 70449480749 scopus 로고    scopus 로고
    • Autograft and nonunions: morbidity with intramedullary bone graft versus iliac crest bone graft
    • (table of contents)
    • Conway J.D. Autograft and nonunions: morbidity with intramedullary bone graft versus iliac crest bone graft. Orthop. Clin. North Am. 2010, 41:75-84. (table of contents).
    • (2010) Orthop. Clin. North Am. , vol.41 , pp. 75-84
    • Conway, J.D.1
  • 7
    • 0029411574 scopus 로고
    • Induction of bone by a demineralized bone matrix gel: a study in a rat femoral defect model
    • Feighan J.E., Davy D., Prewett A.B., Stevenson S. Induction of bone by a demineralized bone matrix gel: a study in a rat femoral defect model. J. Orthop. Res. 1995, 13:881-891.
    • (1995) J. Orthop. Res. , vol.13 , pp. 881-891
    • Feighan, J.E.1    Davy, D.2    Prewett, A.B.3    Stevenson, S.4
  • 8
    • 22544464414 scopus 로고    scopus 로고
    • Use of bone graft substitutes and bioactive materials in treatment of distal radius fractures
    • Hartigan B.J., Cohen M.S. Use of bone graft substitutes and bioactive materials in treatment of distal radius fractures. Hand Clin. 2005, 21:449-454.
    • (2005) Hand Clin. , vol.21 , pp. 449-454
    • Hartigan, B.J.1    Cohen, M.S.2
  • 9
    • 26444463135 scopus 로고    scopus 로고
    • Demineralized bone matrix: basic science and clinical applications
    • (vii)
    • Pacaccio D.J., Stern S.F. Demineralized bone matrix: basic science and clinical applications. Clin. Podiatr. Med. Surg. 2005, 22:599-606. (vii).
    • (2005) Clin. Podiatr. Med. Surg. , vol.22 , pp. 599-606
    • Pacaccio, D.J.1    Stern, S.F.2
  • 11
    • 0020640796 scopus 로고
    • Immune responses to osteochondral allografts. Current knowledge and future directions
    • Friedlaender G.E. Immune responses to osteochondral allografts. Current knowledge and future directions. Clin. Orthop. Relat. Res. 1983, 58-68.
    • (1983) Clin. Orthop. Relat. Res. , pp. 58-68
    • Friedlaender, G.E.1
  • 12
    • 0033961003 scopus 로고    scopus 로고
    • Bone graft materials. An overview of the basic science
    • Bawer T.W., Muschler G.F. Bone graft materials. An overview of the basic science. Clin. Orthop. Relat. Res. 2000, 371:10-27.
    • (2000) Clin. Orthop. Relat. Res. , vol.371 , pp. 10-27
    • Bawer, T.W.1    Muschler, G.F.2
  • 13
    • 0030055972 scopus 로고    scopus 로고
    • Tissue engineered bone-regeneration using degradable polymers: the formation of mineralized matrices
    • Laurencin C.T., Attawia M.A., Elgendy H.E., Herbert K.M. Tissue engineered bone-regeneration using degradable polymers: the formation of mineralized matrices. Bone 1996, 19:93S-99S.
    • (1996) Bone , vol.19
    • Laurencin, C.T.1    Attawia, M.A.2    Elgendy, H.E.3    Herbert, K.M.4
  • 15
    • 0037290212 scopus 로고    scopus 로고
    • Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair
    • Borden M., El-Amin S.F., Attawia M., Laurencin C.T. Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials 2003, 24:597-609.
    • (2003) Biomaterials , vol.24 , pp. 597-609
    • Borden, M.1    El-Amin, S.F.2    Attawia, M.3    Laurencin, C.T.4
  • 17
  • 19
    • 0032736866 scopus 로고    scopus 로고
    • Bioactive factors for bone tissue engineering
    • Boden S.D. Bioactive factors for bone tissue engineering. Clin. Orthop. Relat. Res. 1999, S84-S94.
    • (1999) Clin. Orthop. Relat. Res.
    • Boden, S.D.1
  • 20
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin C.H., Miyazono K., ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 21
    • 0036599845 scopus 로고    scopus 로고
    • The role of growth factors in the repair of bone. Biology and clinical applications
    • Lieberman J.R., Daluiski A., Einhorn T.A. The role of growth factors in the repair of bone. Biology and clinical applications. J. Bone Joint Surg. Am. 2002, 84-A:1032-1044.
    • (2002) J. Bone Joint Surg. Am. , pp. 1032-1044
    • Lieberman, J.R.1    Daluiski, A.2    Einhorn, T.A.3
  • 22
    • 43949090746 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)
    • Bessa P.C., Casal M., Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). J. Tissue Eng. Regen. Med. 2008, 2:1-13.
    • (2008) J. Tissue Eng. Regen. Med. , vol.2 , pp. 1-13
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 23
    • 33646573974 scopus 로고    scopus 로고
    • A prospective randomized study of posterolateral lumbar fusion using osteogenic protein-1 (OP-1) versus local autograft with ceramic bone substitute: emphasis of surgical exploration and histologic assessment
    • Kanayama M., Hashimoto T., Shigenobu K., Yamane S., Bauer T.W., Togawa D. A prospective randomized study of posterolateral lumbar fusion using osteogenic protein-1 (OP-1) versus local autograft with ceramic bone substitute: emphasis of surgical exploration and histologic assessment. Spine (Phila Pa 1976) 2006, 31:1067-1074.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 1067-1074
    • Kanayama, M.1    Hashimoto, T.2    Shigenobu, K.3    Yamane, S.4    Bauer, T.W.5    Togawa, D.6
  • 24
    • 38549128632 scopus 로고    scopus 로고
    • Use of bone morphogenetic proteins for treatment of non-unions and future perspectives
    • Schmidmaier G., Schwabe P., Wildemann B., Haas N.P. Use of bone morphogenetic proteins for treatment of non-unions and future perspectives. Injury 2007, 38:S35-S41.
    • (2007) Injury , vol.38
    • Schmidmaier, G.1    Schwabe, P.2    Wildemann, B.3    Haas, N.P.4
  • 25
    • 85045483986 scopus 로고    scopus 로고
    • Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review
    • (iii-iv)
    • Garrison K.R., Donell S., Ryder J., Shemilt I., Mugford M., Harvey I., Song F. Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. Health Technol. Assess. 2007, 11:1-150. (iii-iv).
    • (2007) Health Technol. Assess. , vol.11 , pp. 1-150
    • Garrison, K.R.1    Donell, S.2    Ryder, J.3    Shemilt, I.4    Mugford, M.5    Harvey, I.6    Song, F.7
  • 26
    • 22844432930 scopus 로고    scopus 로고
    • Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects
    • Termaat M.F., Den Boer F.C., Bakker F.C., Patka P., Haarman H.J. Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects. J. Bone Joint Surg. Am. 2005, 87:1367-1378.
    • (2005) J. Bone Joint Surg. Am. , vol.87 , pp. 1367-1378
    • Termaat, M.F.1    Den Boer, F.C.2    Bakker, F.C.3    Patka, P.4    Haarman, H.J.5
  • 27
    • 63849258968 scopus 로고    scopus 로고
    • Role of bone morphogenetic proteins and their antagonists in healing of bone fracture
    • Dean D.B., Watson J.T., Moed B.R., Zhang Z. Role of bone morphogenetic proteins and their antagonists in healing of bone fracture. Front. Biosci. 2009, 1:2878-2888.
    • (2009) Front. Biosci. , vol.1 , pp. 2878-2888
    • Dean, D.B.1    Watson, J.T.2    Moed, B.R.3    Zhang, Z.4
  • 28
    • 51649100793 scopus 로고    scopus 로고
    • Application of BMP-7 to tibial non-unions: a 3-year multicenter experience
    • Kanakaris N.K., et al. Application of BMP-7 to tibial non-unions: a 3-year multicenter experience. Injury 2008, 39(Suppl. 2):S83-S90.
    • (2008) Injury , vol.39 , Issue.SUPPL. 2
    • Kanakaris, N.K.1
  • 29
    • 70349673922 scopus 로고    scopus 로고
    • Use of bone morphogenetic proteins in sinus augmentation procedure
    • Park J.B. Use of bone morphogenetic proteins in sinus augmentation procedure. J. Craniofac. Surg. 2009, 20:1501-1503.
    • (2009) J. Craniofac. Surg. , vol.20 , pp. 1501-1503
    • Park, J.B.1
  • 32
    • 80053052616 scopus 로고    scopus 로고
    • The use of bone morphogenetic protein 7 in fracture non-unions
    • O'hEireamhoin S., Quinlan J.F., Rourke K.O. The use of bone morphogenetic protein 7 in fracture non-unions. Orthop. Surg. 2011, 3:40-44.
    • (2011) Orthop. Surg. , vol.3 , pp. 40-44
    • O'hEireamhoin, S.1    Quinlan, J.F.2    Rourke, K.O.3
  • 34
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • Urist M.R. Bone: formation by autoinduction. Science 1965, 150:893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 35
    • 33744772589 scopus 로고    scopus 로고
    • Function of BMPs and BMP antagonists in adult bone
    • Abe E. Function of BMPs and BMP antagonists in adult bone. Ann. N. Y. Acad. Sci. 2006, 1068:41-53.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1068 , pp. 41-53
    • Abe, E.1
  • 36
    • 78149403368 scopus 로고    scopus 로고
    • The indications and use of bone morphogenetic proteins in foot, ankle, and tibia surgery
    • El-Amin S.F., Hogan M.V., Allen A.A., Hinds J., Laurencin C.T. The indications and use of bone morphogenetic proteins in foot, ankle, and tibia surgery. Foot Ankle Clin. 2010, 15:543-551.
    • (2010) Foot Ankle Clin. , vol.15 , pp. 543-551
    • El-Amin, S.F.1    Hogan, M.V.2    Allen, A.A.3    Hinds, J.4    Laurencin, C.T.5
  • 38
    • 0025216220 scopus 로고
    • Recombinant human bone morphogenetic protein induces bone formation
    • Wang E.A., et al. Recombinant human bone morphogenetic protein induces bone formation. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:2220-2224.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 2220-2224
    • Wang, E.A.1
  • 39
    • 0026739256 scopus 로고
    • Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro
    • Sampath T.K., et al. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J. Biol. Chem. 1992, 267:20352-20362.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20352-20362
    • Sampath, T.K.1
  • 40
    • 0026640324 scopus 로고
    • Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells
    • Israel D.I., Nove J., Kerns K.M., Moutsatsos I.K., Kaufman R.J. Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells. Growth Factors 1992, 7:139-150.
    • (1992) Growth Factors , vol.7 , pp. 139-150
    • Israel, D.I.1    Nove, J.2    Kerns, K.M.3    Moutsatsos, I.K.4    Kaufman, R.J.5
  • 41
    • 17644407766 scopus 로고    scopus 로고
    • Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor
    • Hillger F., Herr G., Rudolph R., Schwarz E. Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor. J. Biol. Chem. 2005, 280:14974-14980.
    • (2005) J. Biol. Chem. , vol.280 , pp. 14974-14980
    • Hillger, F.1    Herr, G.2    Rudolph, R.3    Schwarz, E.4
  • 42
    • 0031733643 scopus 로고    scopus 로고
    • Potential role of bone morphogenetic proteins in fracture healing
    • Bostrom M.P., Camacho N.P. Potential role of bone morphogenetic proteins in fracture healing. Clin. Orthop. Relat. Res. 1998, S274-S282.
    • (1998) Clin. Orthop. Relat. Res.
    • Bostrom, M.P.1    Camacho, N.P.2
  • 43
    • 0035371958 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: a regional gene therapy approach to bone regeneration
    • Laurencin C.T., Attawia M.A., Lu L.Q., Borden M.D., Lu H.H., Gorum W.J., Lieberman J.R. Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: a regional gene therapy approach to bone regeneration. Biomaterials 2001, 22:1271-1277.
    • (2001) Biomaterials , vol.22 , pp. 1271-1277
    • Laurencin, C.T.1    Attawia, M.A.2    Lu, L.Q.3    Borden, M.D.4    Lu, H.H.5    Gorum, W.J.6    Lieberman, J.R.7
  • 44
    • 0031909665 scopus 로고    scopus 로고
    • Role of morphogenetic proteins in skeletal tissue engineering and regeneration
    • Reddi A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat. Biotechnol. 1998, 16:247-252.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 247-252
    • Reddi, A.H.1
  • 46
    • 0037102257 scopus 로고    scopus 로고
    • Safety profile for the clinical use of bone morphogenetic proteins in the spine
    • Poynton A.R., Lane J.M. Safety profile for the clinical use of bone morphogenetic proteins in the spine. Spine 2002, 27:S40-S48.
    • (2002) Spine , vol.27
    • Poynton, A.R.1    Lane, J.M.2
  • 47
    • 4544353771 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model
    • Seeherman H.J., Bouxsein M., Kim H., Li R., Li X.J., Aiolova M., Wozney J.M. Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model. J. Bone Joint Surg. Am. 2004, 86-A:1961-1972.
    • (2004) J. Bone Joint Surg. Am. , pp. 1961-1972
    • Seeherman, H.J.1    Bouxsein, M.2    Kim, H.3    Li, R.4    Li, X.J.5    Aiolova, M.6    Wozney, J.M.7
  • 48
    • 21344473040 scopus 로고    scopus 로고
    • Delivery of bone morphogenetic proteins for orthopedic tissue regeneration
    • Seeherman H., Wozney J.M. Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine Growth Factor Rev. 2005, 16:329-345.
    • (2005) Cytokine Growth Factor Rev. , vol.16 , pp. 329-345
    • Seeherman, H.1    Wozney, J.M.2
  • 49
    • 0042360393 scopus 로고    scopus 로고
    • The application of bone morphogenetic proteins to dental tissue engineering
    • Nakashima M., Reddi A.H. The application of bone morphogenetic proteins to dental tissue engineering. Nat. Biotechnol. 2003, 21:1025-1032.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 1025-1032
    • Nakashima, M.1    Reddi, A.H.2
  • 51
    • 36348967117 scopus 로고    scopus 로고
    • A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft)
    • McKay W.F., Peckham S.M., Badura J.M. A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft). Int. Orthop. 2007, 31:729-734.
    • (2007) Int. Orthop. , vol.31 , pp. 729-734
    • McKay, W.F.1    Peckham, S.M.2    Badura, J.M.3
  • 54
    • 33847180890 scopus 로고    scopus 로고
    • The influence of recombinant human BMP-2 on bone-implant osseointegration: biomechanical testing and histomorphometric analysis
    • Lan J., Wang Z.F., Shi B., Xia H.B., Cheng X.R. The influence of recombinant human BMP-2 on bone-implant osseointegration: biomechanical testing and histomorphometric analysis. Int. J. Oral Maxillofac. Surg. 2007, 36:345-349.
    • (2007) Int. J. Oral Maxillofac. Surg. , vol.36 , pp. 345-349
    • Lan, J.1    Wang, Z.F.2    Shi, B.3    Xia, H.B.4    Cheng, X.R.5
  • 55
    • 84863256645 scopus 로고    scopus 로고
    • Enhanced bone regeneration around dental implant with bone morphogenetic protein 2 gene and vascular endothelial growth factor protein delivery
    • Luo T., Zhang W., Shi B., Cheng X., Zhang Y. Enhanced bone regeneration around dental implant with bone morphogenetic protein 2 gene and vascular endothelial growth factor protein delivery. Clin. Oral Implants Res. 2012, 23:467-473.
    • (2012) Clin. Oral Implants Res. , vol.23 , pp. 467-473
    • Luo, T.1    Zhang, W.2    Shi, B.3    Cheng, X.4    Zhang, Y.5
  • 57
    • 0036899744 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients
    • Govender S., et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J. Bone Joint Surg. Am. 2002, 84-A:2123-2134.
    • (2002) J. Bone Joint Surg. Am. , pp. 2123-2134
    • Govender, S.1
  • 58
    • 33744815209 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies
    • Swiontkowski M.F., et al. Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies. J. Bone Joint Surg. Am. 2006, 88:1258-1265.
    • (2006) J. Bone Joint Surg. Am. , vol.88 , pp. 1258-1265
    • Swiontkowski, M.F.1
  • 59
    • 84872882028 scopus 로고    scopus 로고
    • (April 30,). United States Food and Drug Administration, Department of Health and Human Services, Center for Devices and Radiological Health. INFUSE Bone Graft - P000054.
    • (April 30, 2004). United States Food and Drug Administration, Department of Health and Human Services, Center for Devices and Radiological Health. INFUSE Bone Graft - P000054. http://www.accessdata.fda.gov/cdrh_docs/pdf/P000054a.pdf.
    • (2004)
  • 60
    • 70449700270 scopus 로고    scopus 로고
    • A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France
    • Alt V., Donell S.T., Chhabra A., Bentley A., Eicher A., Schnettler R. A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France. Injury 2009, 40:1269-1275.
    • (2009) Injury , vol.40 , pp. 1269-1275
    • Alt, V.1    Donell, S.T.2    Chhabra, A.3    Bentley, A.4    Eicher, A.5    Schnettler, R.6
  • 61
    • 79959579500 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation
    • Aro H.T., et al. Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation. J. Bone Joint Surg. Am. 2011, 93:801-808.
    • (2011) J. Bone Joint Surg. Am. , vol.93 , pp. 801-808
    • Aro, H.T.1
  • 62
    • 84872891693 scopus 로고    scopus 로고
    • A Randomized Controlled Cost Study of Infuse BMP 2 vs Iliac Crest Autograft for Non Union of Long Bone Fractures
    • Capital District Health Authority, Canada
    • A Randomized Controlled Cost Study of Infuse BMP 2 vs Iliac Crest Autograft for Non Union of Long Bone Fractures. ClinicalTrials.gov, Bethesda, MD 15 September 2011, Capital District Health Authority, Canada, http://www.clinicaltrials.gov/ct2/show/NCT00856479.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 63
    • 84872886909 scopus 로고    scopus 로고
    • Tibial Delayed Healing Pivotal Clinical Trial, Medtronic Spinal and Biologicals
    • Tibial Delayed Healing Pivotal Clinical Trial, Medtronic Spinal and Biologicals. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT01016067.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 64
    • 84872887948 scopus 로고    scopus 로고
    • RhBMP-2 Versus Autograft in Critical Size Tibial Defects, Major Extremity Trauma Research Consortia
    • rhBMP-2 Versus Autograft in Critical Size Tibial Defects, Major Extremity Trauma Research Consortia. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT00853489.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 65
    • 84872881170 scopus 로고    scopus 로고
    • Study Evaluating rhBMP-2/CPM in Closed Distal Radius Fractures, Wyeth-a Wholly Owned Subsidiary of Pfizer
    • Study Evaluating rhBMP-2/CPM in Closed Distal Radius Fractures, Wyeth-a Wholly Owned Subsidiary of Pfizer. ClinicalTrials.gov, Bethesda, MD, 15 September 2011 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT00161629.
    • (2011) ClinicalTrials.gov, Bethesda, MD, 15 September 2011
  • 66
    • 84872885009 scopus 로고    scopus 로고
    • A Study of rhBMP-2/CPM in Closed Fractures of the Humerus, Wyeth-a Wholly Owned Subsidiary of Pfizer
    • A Study of rhBMP-2/CPM in Closed Fractures of the Humerus, Wyeth-a Wholly Owned Subsidiary of Pfizer. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT00384852.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 67
    • 84872883238 scopus 로고    scopus 로고
    • Feasibility and Safety Study of rhBMP-2/CPM for Hip Fractures, Wyeth-a Wholly Owned Subsidiary of Pfizer
    • Feasibility and Safety Study of rhBMP-2/CPM for Hip Fractures, Wyeth-a Wholly Owned Subsidiary of Pfizer. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT00384358.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 68
    • 84872884200 scopus 로고    scopus 로고
    • A Phase 2/3 Multicenter, Controlled Trial of rhBMP-2/CPM in Tibial Fractures, Pfizer Subsidiary-Wyeth
    • A Phase 2/3 Multicenter, Controlled Trial of rhBMP-2/CPM in Tibial Fractures, Pfizer Subsidiary-Wyeth. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT00387686.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 69
    • 84872886334 scopus 로고    scopus 로고
    • A Phase 2, Multicenter, Double-blind, Randomized, Stratified, Controlled, Efficacy, Safety and Feasibility Study of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)/Calcium Phosphate Matrix (CPM) as an Adjuvant Therapy in Closed Fractures of the Humerus, Pfizer, Inc
    • A Phase 2, Multicenter, Double-blind, Randomized, Stratified, Controlled, Efficacy, Safety and Feasibility Study of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)/Calcium Phosphate Matrix (CPM) as an Adjuvant Therapy in Closed Fractures of the Humerus, Pfizer, Inc. ClinicalStudyResults.org 15 September 2011, http://www.clinicalstudyresults.org/documents/company-study_11378_0.pdf.
    • (2011) ClinicalStudyResults.org
  • 70
    • 84872891612 scopus 로고    scopus 로고
    • 15. A Phase 2, Multicenter, Singleblind, Randomized, Stratified, Standard-or-Care Controlled, Feasibility and Safety Study of rhBMP-2/CPM as an Adjuvant Therapy for Fractures of the Proximal Femur, Pfizer, Inc
    • 15. A Phase 2, Multicenter, Singleblind, Randomized, Stratified, Standard-or-Care Controlled, Feasibility and Safety Study of rhBMP-2/CPM as an Adjuvant Therapy for Fractures of the Proximal Femur, Pfizer, Inc. ClinicalStudyResults.org 15 September 2011, http://www.clinicalstudyresults.org/documents/company-study_11402_0.pdf.
    • (2011) ClinicalStudyResults.org
  • 71
    • 0035222452 scopus 로고    scopus 로고
    • Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions
    • Friedlaender G.E., et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J. Bone Joint Surg. Am. 2001, 83-A(Suppl. 1):S151-S158.
    • (2001) J. Bone Joint Surg. Am. , Issue.SUPPL. 1
    • Friedlaender, G.E.1
  • 72
    • 0032728667 scopus 로고    scopus 로고
    • Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect
    • Geesink R.G., Hoefnagels N.H., Bulstra S.K. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J. Bone Joint Surg. Br. 1999, 81:710-718.
    • (1999) J. Bone Joint Surg. Br. , vol.81 , pp. 710-718
    • Geesink, R.G.1    Hoefnagels, N.H.2    Bulstra, S.K.3
  • 73
    • 24144476275 scopus 로고    scopus 로고
    • Osteogenic protein-1 (bone morphogenic protein-7) combined with various adjuncts in the treatment of humeral diaphyseal nonunions
    • Bong M.R., Capla E.L., Egol K.A., Sorkin A.T., Distefano M., Buckle R., Chandler R.W., Koval K.J. Osteogenic protein-1 (bone morphogenic protein-7) combined with various adjuncts in the treatment of humeral diaphyseal nonunions. Bull. Hosp. Jt. Dis. 2005, 63:20-23.
    • (2005) Bull. Hosp. Jt. Dis. , vol.63 , pp. 20-23
    • Bong, M.R.1    Capla, E.L.2    Egol, K.A.3    Sorkin, A.T.4    Distefano, M.5    Buckle, R.6    Chandler, R.W.7    Koval, K.J.8
  • 75
    • 57049122787 scopus 로고    scopus 로고
    • Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients
    • Calori G.M., Tagliabue L., Gala L., d'Imporzano M., Peretti G., Albisetti W. Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients. Injury 2008, 39:1391-1402.
    • (2008) Injury , vol.39 , pp. 1391-1402
    • Calori, G.M.1    Tagliabue, L.2    Gala, L.3    d'Imporzano, M.4    Peretti, G.5    Albisetti, W.6
  • 76
    • 70349784094 scopus 로고    scopus 로고
    • A cost analysis of treatment of tibial fracture nonunion by bone grafting or bone morphogenetic protein-7
    • Dahabreh Z., Calori G.M., Kanakaris N.K., Nikolaou V.S., Giannoudis P.V. A cost analysis of treatment of tibial fracture nonunion by bone grafting or bone morphogenetic protein-7. Int. Orthop. 2009, 33:1407-1414.
    • (2009) Int. Orthop. , vol.33 , pp. 1407-1414
    • Dahabreh, Z.1    Calori, G.M.2    Kanakaris, N.K.3    Nikolaou, V.S.4    Giannoudis, P.V.5
  • 77
    • 84872891941 scopus 로고    scopus 로고
    • OP Device vs. Bone Autograft for the Treatment of Tibial Nonunions, Olympus Biotech Corporation
    • OP Device vs. Bone Autograft for the Treatment of Tibial Nonunions, Olympus Biotech Corporation. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00679328.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 78
    • 84872891673 scopus 로고    scopus 로고
    • A Prospective Randomized Controlled Trial on the Use of Bone Morphogenetic 7 (BMP-7) (OP-1) and Demineralized Bone Matrix in Tibial Non-Union, University Hospital, Ghent
    • A Prospective Randomized Controlled Trial on the Use of Bone Morphogenetic 7 (BMP-7) (OP-1) and Demineralized Bone Matrix in Tibial Non-Union, University Hospital, Ghent. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00551941.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 79
    • 67651248249 scopus 로고    scopus 로고
    • Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome
    • Schwartz C.E., Martha J.F., Kowalski P., Wang D.A., Bode R., Li L., Kim D.H. Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome. Health Qual. Life Outcomes 2009, 7:49.
    • (2009) Health Qual. Life Outcomes , vol.7 , pp. 49
    • Schwartz, C.E.1    Martha, J.F.2    Kowalski, P.3    Wang, D.A.4    Bode, R.5    Li, L.6    Kim, D.H.7
  • 80
    • 0036843201 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2
    • Burkus J.K., Transfeldt E.E., Kitchel S.H., Watkins R.G., Balderston R.A. Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine (Phila Pa 1976) 2002, 27:2396-2408.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 2396-2408
    • Burkus, J.K.1    Transfeldt, E.E.2    Kitchel, S.H.3    Watkins, R.G.4    Balderston, R.A.5
  • 81
    • 0038384735 scopus 로고    scopus 로고
    • A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate
    • (discussion 1225)
    • Baskin D.S., Ryan P., Sonntag V., Westmark R., Widmayer M.A. A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine (Phila Pa 1976) 2003, 28:1219-1224. (discussion 1225).
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 1219-1224
    • Baskin, D.S.1    Ryan, P.2    Sonntag, V.3    Westmark, R.4    Widmayer, M.A.5
  • 82
    • 19944417622 scopus 로고    scopus 로고
    • Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery
    • Burkus J.K., Sandhu H.S., Gornet M.F., Longley M.C. Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J. Bone Joint Surg. Am. 2005, 87:1205-1212.
    • (2005) J. Bone Joint Surg. Am. , vol.87 , pp. 1205-1212
    • Burkus, J.K.1    Sandhu, H.S.2    Gornet, M.F.3    Longley, M.C.4
  • 84
    • 67650128701 scopus 로고    scopus 로고
    • RhBMP-2 versus iliac crest bone graft for lumbar spine fusion: a randomized, controlled trial in patients over sixty years of age
    • Glassman S.D., Carreon L.Y., Djurasovic M., Campbell M.J., Puno R.M., Johnson J.R., Dimar J.R. RhBMP-2 versus iliac crest bone graft for lumbar spine fusion: a randomized, controlled trial in patients over sixty years of age. Spine (Phila Pa 1976) 2008, 33:2843-2849.
    • (2008) Spine (Phila Pa 1976) , vol.33 , pp. 2843-2849
    • Glassman, S.D.1    Carreon, L.Y.2    Djurasovic, M.3    Campbell, M.J.4    Puno, R.M.5    Johnson, J.R.6    Dimar, J.R.7
  • 86
    • 84872885726 scopus 로고    scopus 로고
    • 32. Spine Fusion Instrumented with BMP-2 vs Uninstrumented with Infuse BMP-2 Alone, Capital District Health Authority, Canada
    • 32. Spine Fusion Instrumented with BMP-2 vs Uninstrumented with Infuse BMP-2 Alone, Capital District Health Authority, Canada. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00405600.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 87
    • 0036894554 scopus 로고    scopus 로고
    • Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies
    • Boden S.D., Kang J., Sandhu H., Heller J.G. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976) 2002, 27:2662-2673.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 2662-2673
    • Boden, S.D.1    Kang, J.2    Sandhu, H.3    Heller, J.G.4
  • 88
    • 23244467021 scopus 로고    scopus 로고
    • Initial fusion rates with recombinant human bone morphogenetic protein-2/compression resistant matrix and a hydroxyapatite and tricalcium phosphate/collagen carrier in posterolateral spinal fusion
    • Glassman S.D., Dimar J.R., Carreon L.Y., Campbell M.J., Puno R.M., Johnson J.R. Initial fusion rates with recombinant human bone morphogenetic protein-2/compression resistant matrix and a hydroxyapatite and tricalcium phosphate/collagen carrier in posterolateral spinal fusion. Spine (Phila Pa 1976) 2005, 30:1694-1698.
    • (2005) Spine (Phila Pa 1976) , vol.30 , pp. 1694-1698
    • Glassman, S.D.1    Dimar, J.R.2    Carreon, L.Y.3    Campbell, M.J.4    Puno, R.M.5    Johnson, J.R.6
  • 89
    • 33750290922 scopus 로고    scopus 로고
    • Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft
    • (discussion 2540)
    • Dimar J.R., Glassman S.D., Burkus K.J., Carreon L.Y. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine (Phila Pa 1976) 2006, 31:2534-2539. (discussion 2540).
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 2534-2539
    • Dimar, J.R.1    Glassman, S.D.2    Burkus, K.J.3    Carreon, L.Y.4
  • 90
    • 55449109599 scopus 로고    scopus 로고
    • Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion
    • Mulconrey D.S., Bridwell K.H., Flynn J., Cronen G.A., Rose P.S. Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion. Spine (Phila Pa 1976) 2008, 33:2153-2159.
    • (2008) Spine (Phila Pa 1976) , vol.33 , pp. 2153-2159
    • Mulconrey, D.S.1    Bridwell, K.H.2    Flynn, J.3    Cronen, G.A.4    Rose, P.S.5
  • 91
    • 67651148520 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge with an osteoconductive bulking agent in posterolateral arthrodesis with instrumentation. A prospective randomized trial
    • Dawson E., Bae H.W., Burkus J.K., Stambough J.L., Glassman S.D. Recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge with an osteoconductive bulking agent in posterolateral arthrodesis with instrumentation. A prospective randomized trial. J. Bone Joint Surg. Am. 2009, 91:1604-1613.
    • (2009) J. Bone Joint Surg. Am. , vol.91 , pp. 1604-1613
    • Dawson, E.1    Bae, H.W.2    Burkus, J.K.3    Stambough, J.L.4    Glassman, S.D.5
  • 92
    • 3042511491 scopus 로고    scopus 로고
    • Lumbar interbody fusion after treatment with recombinant human bone morphogenetic protein-2 added to poly(L-lactide-co-D, L-lactide) bioresorbable implants
    • Lanman T.H., Hopkins T.J. Lumbar interbody fusion after treatment with recombinant human bone morphogenetic protein-2 added to poly(L-lactide-co-D, L-lactide) bioresorbable implants. Neurosurg. Focus. 2004, 16:E9.
    • (2004) Neurosurg. Focus. , vol.16
    • Lanman, T.H.1    Hopkins, T.J.2
  • 93
    • 68349120403 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study
    • Katayama Y., et al. Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study. Int. Orthop. 2009, 33:1061-1067.
    • (2009) Int. Orthop. , vol.33 , pp. 1061-1067
    • Katayama, Y.1
  • 94
    • 20444480616 scopus 로고    scopus 로고
    • Anterior cervical discectomy and fusion involving a polyetheretherketone spacer and bone morphogenetic protein
    • Boakye M., Mummaneni P.V., Garrett M., Rodts G., Haid R. Anterior cervical discectomy and fusion involving a polyetheretherketone spacer and bone morphogenetic protein. J. Neurosurg. Spine 2005, 2:521-525.
    • (2005) J. Neurosurg. Spine , vol.2 , pp. 521-525
    • Boakye, M.1    Mummaneni, P.V.2    Garrett, M.3    Rodts, G.4    Haid, R.5
  • 96
    • 84872885891 scopus 로고    scopus 로고
    • RhBMP-2/CRM/CD HORIZON Spinal System Pivotal Study, Medtronic Spinal and Biologics
    • rhBMP-2/CRM/CD HORIZON Spinal System Pivotal Study, Medtronic Spinal and Biologics. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://clinicaltrials.gov/ct2/show/NCT00707265.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 97
    • 0036897076 scopus 로고    scopus 로고
    • Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies
    • Johnsson R., Stromqvist B., Aspenberg P. Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976) 2002, 27:2654-2661.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 2654-2661
    • Johnsson, R.1    Stromqvist, B.2    Aspenberg, P.3
  • 98
    • 0242404585 scopus 로고    scopus 로고
    • A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions
    • Vaccaro A.R., et al. A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur. Spine J. 2003, 12:495-500.
    • (2003) Eur. Spine J. , vol.12 , pp. 495-500
    • Vaccaro, A.R.1
  • 99
    • 4444296471 scopus 로고    scopus 로고
    • A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis
    • Vaccaro A.R., et al. A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine (Phila Pa 1976) 2004, 29:1885-1892.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 1885-1892
    • Vaccaro, A.R.1
  • 100
    • 26244461248 scopus 로고    scopus 로고
    • A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions
    • Vaccaro A.R., et al. A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur. Spine J. 2005, 14:623-629.
    • (2005) Eur. Spine J. , vol.14 , pp. 623-629
    • Vaccaro, A.R.1
  • 101
    • 29444440588 scopus 로고    scopus 로고
    • Comparison of OP-1 Putty (rhBMP-7) to iliac crest autograft for posterolateral lumbar arthrodesis: a minimum 2-year follow-up pilot study
    • Vaccaro A.R., et al. Comparison of OP-1 Putty (rhBMP-7) to iliac crest autograft for posterolateral lumbar arthrodesis: a minimum 2-year follow-up pilot study. Spine (Phila Pa 1976) 2005, 30:2709-2716.
    • (2005) Spine (Phila Pa 1976) , vol.30 , pp. 2709-2716
    • Vaccaro, A.R.1
  • 102
    • 35948931791 scopus 로고    scopus 로고
    • Use of osteogenic protein-1 in patients at high risk for spinal pseudarthrosis: a prospective cohort study assessing safety, health-related quality of life, and radiographic fusion. Invited submission from the Joint Section on Disorders of the Spine and Peripheral Nerves, March 2007
    • Furlan J.C., Perrin R.G., Govender P.V., Petrenko Y., Massicotte E.M., Rampersaud Y.R., Lewis S., Fehlings M.G. Use of osteogenic protein-1 in patients at high risk for spinal pseudarthrosis: a prospective cohort study assessing safety, health-related quality of life, and radiographic fusion. Invited submission from the Joint Section on Disorders of the Spine and Peripheral Nerves, March 2007. J. Neurosurg. Spine 2007, 7:486-495.
    • (2007) J. Neurosurg. Spine , vol.7 , pp. 486-495
    • Furlan, J.C.1    Perrin, R.G.2    Govender, P.V.3    Petrenko, Y.4    Massicotte, E.M.5    Rampersaud, Y.R.6    Lewis, S.7    Fehlings, M.G.8
  • 103
    • 70449530510 scopus 로고    scopus 로고
    • BMP-7 (OP-1) safety in anterior cervical fusion surgery
    • Leach J., Bittar R.G. BMP-7 (OP-1) safety in anterior cervical fusion surgery. J. Clin. Neurosci. 2009, 16:1417-1420.
    • (2009) J. Clin. Neurosci. , vol.16 , pp. 1417-1420
    • Leach, J.1    Bittar, R.G.2
  • 104
    • 84872877559 scopus 로고    scopus 로고
    • 54. A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions, Olympus Biotech Corporation
    • 54. A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions, Olympus Biotech Corporation. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00679107.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 105
    • 84872881123 scopus 로고    scopus 로고
    • OP-1 Putty for Posterolateral Fusions, Olympus Biotech Corporation
    • OP-1 Putty for Posterolateral Fusions, Olympus Biotech Corporation. ClincalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00677950.
    • (2011) ClincalTrials.gov, Bethesda, MD
  • 106
    • 84872889842 scopus 로고    scopus 로고
    • Study of OP-1 Putty in Uninstrumented Posterolateral Fusions, Olympus Biotech Corporation
    • Study of OP-1 Putty in Uninstrumented Posterolateral Fusions, Olympus Biotech Corporation. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00678353.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 107
    • 84872886035 scopus 로고    scopus 로고
    • A Pilot Study to Evaluate an OP-1 Putty Spinal System and an Autograft Spinal System, Olympus Biotech Corporation
    • A Pilot Study to Evaluate an OP-1 Putty Spinal System and an Autograft Spinal System, Olympus Biotech Corporation. ClinicalTrials.gov, Bethesda, MD 15 September 2011, http://www.clinicaltrials.gov/ct2/show/NCT00678171.
    • (2011) ClinicalTrials.gov, Bethesda, MD
  • 109
    • 33751109482 scopus 로고    scopus 로고
    • Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine
    • Smucker J.D., Rhee J.M., Singh K., Yoon S.T., Heller J.G. Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine (Phila Pa 1976) 2006, 31:2813-2819.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 2813-2819
    • Smucker, J.D.1    Rhee, J.M.2    Singh, K.3    Yoon, S.T.4    Heller, J.G.5
  • 110
    • 67649117871 scopus 로고    scopus 로고
    • Adverse effects of posterior lumbar interbody fusion using rhBMP-2
    • (author reply 924)
    • Smoljanovic T., Bojanic I., Delimar D. Adverse effects of posterior lumbar interbody fusion using rhBMP-2. Eur. Spine J. 2009, 18:920-923. (author reply 924).
    • (2009) Eur. Spine J. , vol.18 , pp. 920-923
    • Smoljanovic, T.1    Bojanic, I.2    Delimar, D.3
  • 111
    • 79959950769 scopus 로고    scopus 로고
    • A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned
    • Carragee E.J., Hurwitz E.L., Weiner B.K. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 2011, 11:471-491.
    • (2011) Spine J. , vol.11 , pp. 471-491
    • Carragee, E.J.1    Hurwitz, E.L.2    Weiner, B.K.3
  • 113
    • 79955661469 scopus 로고    scopus 로고
    • The maxillary sinus: challenges and treatments for implant placement
    • (16, 18-9; quiz 20, 34)
    • Tasoulis G., Yao S.G., Fine J.B. The maxillary sinus: challenges and treatments for implant placement. Compend. Contin. Educ. Dent. 2011, 32:10-14. (16, 18-9; quiz 20, 34).
    • (2011) Compend. Contin. Educ. Dent. , vol.32 , pp. 10-14
    • Tasoulis, G.1    Yao, S.G.2    Fine, J.B.3
  • 115
    • 70350337082 scopus 로고    scopus 로고
    • Bone morphogenetic proteins for periodontal and alveolar indications; biological observations-clinical implications
    • Wikesjo U.M., Qahash M., Huang Y.H., Xiropaidis A., Polimeni G., Susin C. Bone morphogenetic proteins for periodontal and alveolar indications; biological observations-clinical implications. Orthod. Craniofac. Res. 2009, 12:263-270.
    • (2009) Orthod. Craniofac. Res. , vol.12 , pp. 263-270
    • Wikesjo, U.M.1    Qahash, M.2    Huang, Y.H.3    Xiropaidis, A.4    Polimeni, G.5    Susin, C.6
  • 117
    • 77952317665 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) for sinus lift
    • Garg A. Bone morphogenetic protein (BMP) for sinus lift. Dent. Implantol. Update 2010, 21:25-29.
    • (2010) Dent. Implantol. Update , vol.21 , pp. 25-29
    • Garg, A.1
  • 118
    • 68549104163 scopus 로고    scopus 로고
    • Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation
    • Triplett R.G., Nevins M., Marx R.E., Spagnoli D.B., Oates T.W., Moy P.K., Boyne P.J. Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation. J. Oral Maxillofac. Surg. 2009, 67:1947-1960.
    • (2009) J. Oral Maxillofac. Surg. , vol.67 , pp. 1947-1960
    • Triplett, R.G.1    Nevins, M.2    Marx, R.E.3    Spagnoli, D.B.4    Oates, T.W.5    Moy, P.K.6    Boyne, P.J.7
  • 119
    • 0034242765 scopus 로고    scopus 로고
    • Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans
    • Cochran D.L., Jones A.A., Lilly L.C., Fiorellini J.P., Howell H. Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans. J. Periodontol. 2000, 71:1241-1257.
    • (2000) J. Periodontol. , vol.71 , pp. 1241-1257
    • Cochran, D.L.1    Jones, A.A.2    Lilly, L.C.3    Fiorellini, J.P.4    Howell, H.5
  • 121
    • 38549156628 scopus 로고    scopus 로고
    • How to achieve sustained and complete protein release from PLGA-based microparticles?
    • Giteau A., Venier-Julienne M.C., Aubert-Pouëssel A., Benoit J.P. How to achieve sustained and complete protein release from PLGA-based microparticles?. Int. J. Pharm. 2008, 350:14-26.
    • (2008) Int. J. Pharm. , vol.350 , pp. 14-26
    • Giteau, A.1    Venier-Julienne, M.C.2    Aubert-Pouëssel, A.3    Benoit, J.P.4
  • 122
    • 33847303506 scopus 로고    scopus 로고
    • Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7
    • Dahabreh Z., Dimitriou R., Giannoudis P.V. Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7. Injury 2007, 38:371-377.
    • (2007) Injury , vol.38 , pp. 371-377
    • Dahabreh, Z.1    Dimitriou, R.2    Giannoudis, P.V.3
  • 123
    • 14344254895 scopus 로고    scopus 로고
    • Recombinant human bone morphogenic protein-2-enhanced anterior spine fusion without bone encroachment into the spinal canal: a histomorphometric study in a thoracoscopically instrumented porcine model
    • Zhang H., Sucato D.J., Welch R.D. Recombinant human bone morphogenic protein-2-enhanced anterior spine fusion without bone encroachment into the spinal canal: a histomorphometric study in a thoracoscopically instrumented porcine model. Spine (Phila Pa 1976) 2005, 30:512-518.
    • (2005) Spine (Phila Pa 1976) , vol.30 , pp. 512-518
    • Zhang, H.1    Sucato, D.J.2    Welch, R.D.3
  • 124
    • 69249212175 scopus 로고    scopus 로고
    • Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers
    • Lee M., Li W., Siu R.K., Whang J., Zhang X., Soo C., Ting K., Wu B.M. Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers. Biomaterials 2009, 30:6094-6101.
    • (2009) Biomaterials , vol.30 , pp. 6094-6101
    • Lee, M.1    Li, W.2    Siu, R.K.3    Whang, J.4    Zhang, X.5    Soo, C.6    Ting, K.7    Wu, B.M.8
  • 125
    • 0023804185 scopus 로고
    • Cartilaginous transdifferentiation of rat tenosynovial cells under the influence of bone morphogenetic protein in tissue culture
    • Sato K., Miura T., Iwata H. Cartilaginous transdifferentiation of rat tenosynovial cells under the influence of bone morphogenetic protein in tissue culture. Clin. Orthop. Relat. Res. 1988, 233-239.
    • (1988) Clin. Orthop. Relat. Res. , pp. 233-239
    • Sato, K.1    Miura, T.2    Iwata, H.3
  • 127
    • 49349090133 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
    • Bessa P.C., Casal M., Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J. Tissue Eng. Regen. Med. 2008, 2:81-96.
    • (2008) J. Tissue Eng. Regen. Med. , vol.2 , pp. 81-96
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 129
    • 0242659880 scopus 로고    scopus 로고
    • Collagen sponges for bone regeneration with rhBMP-2
    • Geiger M., Li R.H., Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv. Drug Deliv. Rev. 2003, 55:1613-1629.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 1613-1629
    • Geiger, M.1    Li, R.H.2    Friess, W.3
  • 130
    • 0033118704 scopus 로고    scopus 로고
    • The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a human primate anterior interbody fusion model
    • Hecht B.P., Fischgrund J.S., Herkowitz H.N., Penman L., Toth J.M., Shirkhoda A. The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a human primate anterior interbody fusion model. Spine (Phila Pa 1976) 1999, 24:629-636.
    • (1999) Spine (Phila Pa 1976) , vol.24 , pp. 629-636
    • Hecht, B.P.1    Fischgrund, J.S.2    Herkowitz, H.N.3    Penman, L.4    Toth, J.M.5    Shirkhoda, A.6
  • 132
    • 0033215480 scopus 로고    scopus 로고
    • Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers
    • David S.M., Gruber H.E., Meyer R.A., Murakami T., Tabor O.B., Howard B.A., Wozney J.M., Hanley E.N. Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers. Spine (Phila Pa 1976) 1999, 24:1973-1979.
    • (1999) Spine (Phila Pa 1976) , vol.24 , pp. 1973-1979
    • David, S.M.1    Gruber, H.E.2    Meyer, R.A.3    Murakami, T.4    Tabor, O.B.5    Howard, B.A.6    Wozney, J.M.7    Hanley, E.N.8
  • 133
    • 18844362943 scopus 로고    scopus 로고
    • Lower dose of rhBMP-2 achieves spine fusion when combined with an osteoconductive bulking agent in non-human primates
    • Barnes B., Boden S.D., Louis-Ugbo J., Tomak P.R., Park J.S., Park M.S., Minamide A. Lower dose of rhBMP-2 achieves spine fusion when combined with an osteoconductive bulking agent in non-human primates. Spine (Phila Pa 1976) 2005, 30:1127-1133.
    • (2005) Spine (Phila Pa 1976) , vol.30 , pp. 1127-1133
    • Barnes, B.1    Boden, S.D.2    Louis-Ugbo, J.3    Tomak, P.R.4    Park, J.S.5    Park, M.S.6    Minamide, A.7
  • 134
    • 34250355162 scopus 로고    scopus 로고
    • Controlled release of recombinant human bone morphogenetic protein-7 in nanoscaffolds
    • Tan K.J., Liao S., Chan C.K. Controlled release of recombinant human bone morphogenetic protein-7 in nanoscaffolds. Nanomedicine (Lond) 2007, 2:385-390.
    • (2007) Nanomedicine (Lond) , vol.2 , pp. 385-390
    • Tan, K.J.1    Liao, S.2    Chan, C.K.3
  • 135
    • 18344401277 scopus 로고    scopus 로고
    • Biomimetic Coatings vs. Collagen Sponges as a Carrier for BMP-2: A Comparison of the Osteogenic Responses Triggered In Vivo Using an Ectopic Rat Model
    • Liu Y., Hunziker E.B., Van de Vaal C., de Groot K. Biomimetic Coatings vs. Collagen Sponges as a Carrier for BMP-2: A Comparison of the Osteogenic Responses Triggered In Vivo Using an Ectopic Rat Model. Key Eng. Mater. 2004, 254-256:619-622.
    • (2004) Key Eng. Mater. , pp. 619-622
    • Liu, Y.1    Hunziker, E.B.2    Van de Vaal, C.3    de Groot, K.4
  • 136
    • 33745778061 scopus 로고    scopus 로고
    • Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel
    • Yamamoto M., Takahashi Y., Tabata Y. Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Eng. 2006, 12:1305-1311.
    • (2006) Tissue Eng. , vol.12 , pp. 1305-1311
    • Yamamoto, M.1    Takahashi, Y.2    Tabata, Y.3
  • 137
    • 0035018439 scopus 로고    scopus 로고
    • Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study
    • Hunt D.R., Jovanovic S.A., Wikesjö U.M., Wozney J.M., Bernard G.W. Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study. J. Periodontol. 2001, 72:651-658.
    • (2001) J. Periodontol. , vol.72 , pp. 651-658
    • Hunt, D.R.1    Jovanovic, S.A.2    Wikesjö, U.M.3    Wozney, J.M.4    Bernard, G.W.5
  • 138
    • 14744301738 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein 2 enhances bone healing in an experimental model of fractures at risk of non-union
    • Eckardt H., Christensen K.S., Lind M., Hansen E.S., Hall D.W.R., Hvid I. Recombinant human bone morphogenetic protein 2 enhances bone healing in an experimental model of fractures at risk of non-union. Injury 2005, 36:489-494.
    • (2005) Injury , vol.36 , pp. 489-494
    • Eckardt, H.1    Christensen, K.S.2    Lind, M.3    Hansen, E.S.4    Hall, D.W.R.5    Hvid, I.6
  • 139
    • 33846280901 scopus 로고    scopus 로고
    • Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells
    • Kim J., et al. Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 2007, 28:1830-1837.
    • (2007) Biomaterials , vol.28 , pp. 1830-1837
    • Kim, J.1
  • 140
    • 77954383096 scopus 로고    scopus 로고
    • Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration
    • Patterson J., Siew R., Herring S.W., Lin A.S., Guldberg R., Stayton P.S. Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration. Biomaterials 2010, 31:6772-6781.
    • (2010) Biomaterials , vol.31 , pp. 6772-6781
    • Patterson, J.1    Siew, R.2    Herring, S.W.3    Lin, A.S.4    Guldberg, R.5    Stayton, P.S.6
  • 144
    • 3142703230 scopus 로고    scopus 로고
    • Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells
    • Simmons C.A., Alsberg E., Hsiong S., Kim W.J., Mooney D.J. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone 2004, 35:562-569.
    • (2004) Bone , vol.35 , pp. 562-569
    • Simmons, C.A.1    Alsberg, E.2    Hsiong, S.3    Kim, W.J.4    Mooney, D.J.5
  • 145
    • 62249105227 scopus 로고    scopus 로고
    • Enhancement of posterolateral lumbar spine fusion using low-dose rhBMP-2 and cultured marrow stromal cells
    • Fu T.S., Chen W.J., Chen L.H., Lin S.S., Kiu S.J., Ueng S.W. Enhancement of posterolateral lumbar spine fusion using low-dose rhBMP-2 and cultured marrow stromal cells. J. Orthop. Res. 2009, 27:380-384.
    • (2009) J. Orthop. Res. , vol.27 , pp. 380-384
    • Fu, T.S.1    Chen, W.J.2    Chen, L.H.3    Lin, S.S.4    Kiu, S.J.5    Ueng, S.W.6
  • 147
    • 84864312695 scopus 로고    scopus 로고
    • Repair of rat calvarial bone defects by controlled release of rhBMP-2 from an injectable bone regeneration composite
    • Tan R., She Z., Wang M., Yu X., Jin H., Feng Q. Repair of rat calvarial bone defects by controlled release of rhBMP-2 from an injectable bone regeneration composite. J. Tissue Eng. Regen. Med. 2012, 6:614-621.
    • (2012) J. Tissue Eng. Regen. Med. , vol.6 , pp. 614-621
    • Tan, R.1    She, Z.2    Wang, M.3    Yu, X.4    Jin, H.5    Feng, Q.6
  • 150
    • 84855397191 scopus 로고    scopus 로고
    • Enhanced healing of rat calvarial defects with sulfated chitosan coated CDHA/BMP-2 scaffolds
    • Zhao J., et al. Enhanced healing of rat calvarial defects with sulfated chitosan coated CDHA/BMP-2 scaffolds. Tissue Eng. Part A 2012, 18:185-197.
    • (2012) Tissue Eng. Part A , vol.18 , pp. 185-197
    • Zhao, J.1
  • 154
    • 8544278195 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells
    • Karageorgiou V., Meinel L., Hofmann S., Malhotra A., Volloch V., Kaplan D. Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells. J. Biomed. Mater. Res. A 2004, 71:528-537.
    • (2004) J. Biomed. Mater. Res. A , vol.71 , pp. 528-537
    • Karageorgiou, V.1    Meinel, L.2    Hofmann, S.3    Malhotra, A.4    Volloch, V.5    Kaplan, D.6
  • 155
    • 33745944870 scopus 로고    scopus 로고
    • Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo
    • Karageorgiou V., et al. Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo. J. Biomed. Mater. Res. A 2006, 78:324-334.
    • (2006) J. Biomed. Mater. Res. A , vol.78 , pp. 324-334
    • Karageorgiou, V.1
  • 156
    • 77957372082 scopus 로고    scopus 로고
    • Silk fibroin microparticles as carriers for delivery of human recombinant bone morphogenetic protein-2: in vitro and in vivo bioactivity
    • Bessa P.C., et al. Silk fibroin microparticles as carriers for delivery of human recombinant bone morphogenetic protein-2: in vitro and in vivo bioactivity. Tissue Eng. Part C Methods 2010, 16:937-945.
    • (2010) Tissue Eng. Part C Methods , vol.16 , pp. 937-945
    • Bessa, P.C.1
  • 157
    • 80053607677 scopus 로고    scopus 로고
    • The use of injectable sonication-induced silk hydrogel for VEGF(165) and BMP-2 delivery for elevation of the maxillary sinus floor
    • Zhang W., et al. The use of injectable sonication-induced silk hydrogel for VEGF(165) and BMP-2 delivery for elevation of the maxillary sinus floor. Biomaterials 2011, 32:9415-9224.
    • (2011) Biomaterials , vol.32 , pp. 9415-9224
    • Zhang, W.1
  • 158
    • 0032820711 scopus 로고    scopus 로고
    • Proteolysis and cell migration: creating a path?
    • Murphy G., Gavrilovic J. Proteolysis and cell migration: creating a path?. Curr. Opin. Cell Biol. 1999, 11:614-621.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 614-621
    • Murphy, G.1    Gavrilovic, J.2
  • 159
    • 33745656223 scopus 로고    scopus 로고
    • An in vitro and in vivo analysis of fibrin glue use to control bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth
    • (discussion 404)
    • Patel V.V., Zhao L., Wong P., Pradhan B.B., Bae H.W., Kanim L., Delamarter R.B. An in vitro and in vivo analysis of fibrin glue use to control bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth. Spine J. 2006, 6:397-403. (discussion 404).
    • (2006) Spine J. , vol.6 , pp. 397-403
    • Patel, V.V.1    Zhao, L.2    Wong, P.3    Pradhan, B.B.4    Bae, H.W.5    Kanim, L.6    Delamarter, R.B.7
  • 160
    • 34547197434 scopus 로고    scopus 로고
    • Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex
    • Chung Y.I., Ahn K.M., Jeon S.H., Lee S.Y., Lee J.H., Tae G. Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. J. Control. Release 2007, 121:91-99.
    • (2007) J. Control. Release , vol.121 , pp. 91-99
    • Chung, Y.I.1    Ahn, K.M.2    Jeon, S.H.3    Lee, S.Y.4    Lee, J.H.5    Tae, G.6
  • 161
    • 77950846241 scopus 로고    scopus 로고
    • Heparin-conjugated fibrin as an injectable system for sustained delivery of bone morphogenetic protein-2
    • Yang H.S., La W.G., Bhang S.H., Jeon J.Y., Lee J.H., Kim B.S. Heparin-conjugated fibrin as an injectable system for sustained delivery of bone morphogenetic protein-2. Tissue Eng. Part A 2010, 16:1225-1233.
    • (2010) Tissue Eng. Part A , vol.16 , pp. 1225-1233
    • Yang, H.S.1    La, W.G.2    Bhang, S.H.3    Jeon, J.Y.4    Lee, J.H.5    Kim, B.S.6
  • 162
    • 79959991096 scopus 로고    scopus 로고
    • Human adipose derived stem cells reduce callus volume upon BMP-2 administration in bone regeneration
    • Keibl C., Fugl A., Zanoni G., Tangl S., Wolbank S., Redl H., van Griensven M. Human adipose derived stem cells reduce callus volume upon BMP-2 administration in bone regeneration. Injury 2011, 42:814-820.
    • (2011) Injury , vol.42 , pp. 814-820
    • Keibl, C.1    Fugl, A.2    Zanoni, G.3    Tangl, S.4    Wolbank, S.5    Redl, H.6    van Griensven, M.7
  • 163
    • 0032820817 scopus 로고    scopus 로고
    • Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone
    • Tay B.K., Patel V.V., Bradford D.S. Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone. Orthop. Clin. North Am. 1999, 30:615-623.
    • (1999) Orthop. Clin. North Am. , vol.30 , pp. 615-623
    • Tay, B.K.1    Patel, V.V.2    Bradford, D.S.3
  • 164
    • 12344265826 scopus 로고    scopus 로고
    • Bone reconstruction: from bioceramics to tissue engineering
    • El-Ghannam A. Bone reconstruction: from bioceramics to tissue engineering. Expert Rev. Med. Devices 2005, 2:87-101.
    • (2005) Expert Rev. Med. Devices , vol.2 , pp. 87-101
    • El-Ghannam, A.1
  • 165
    • 73249114720 scopus 로고    scopus 로고
    • Bioceramics of calcium orthophosphates
    • Dorozhkin S.V. Bioceramics of calcium orthophosphates. Biomaterials 2010, 31:1465-1485.
    • (2010) Biomaterials , vol.31 , pp. 1465-1485
    • Dorozhkin, S.V.1
  • 166
    • 0034850411 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 potentiates the in vivo osteogenic ability of marrow/hydroxyapatite composites
    • Noshi T., et al. Recombinant human bone morphogenetic protein-2 potentiates the in vivo osteogenic ability of marrow/hydroxyapatite composites. Artif. Organs 2001, 25:201-208.
    • (2001) Artif. Organs , vol.25 , pp. 201-208
    • Noshi, T.1
  • 167
    • 33646769625 scopus 로고    scopus 로고
    • A novel hydroxyapatite fiber mesh as a carrier for recombinant human bone morphogenetic protein-2 enhances bone union in rat posterolateral fusion model
    • Morisue H., et al. A novel hydroxyapatite fiber mesh as a carrier for recombinant human bone morphogenetic protein-2 enhances bone union in rat posterolateral fusion model. Spine (Phila Pa 1976) 2006, 31:1194-1200.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 1194-1200
    • Morisue, H.1
  • 168
    • 77952012517 scopus 로고    scopus 로고
    • Experimental study of nano-hydroxyapatite/recombinant human bone morphogenetic protein-2 composite artificial bone
    • Zhu W., et al. Experimental study of nano-hydroxyapatite/recombinant human bone morphogenetic protein-2 composite artificial bone. Artif. Cells Blood Substit. Immobil. Biotechnol. 2010, 38:150-156.
    • (2010) Artif. Cells Blood Substit. Immobil. Biotechnol. , vol.38 , pp. 150-156
    • Zhu, W.1
  • 169
    • 0036897239 scopus 로고    scopus 로고
    • Successful transpedicular lumbar interbody fusion by means of a composite of osteogenic protein-1 (rhBMP-7) and hydroxyapatite carrier: a comparison with autograft and hydroxyapatite in the sheep spine
    • Blattert T.R., Delling G., Dalal P.S., Toth C.A., Balling H., Weckbach A. Successful transpedicular lumbar interbody fusion by means of a composite of osteogenic protein-1 (rhBMP-7) and hydroxyapatite carrier: a comparison with autograft and hydroxyapatite in the sheep spine. Spine (Phila Pa 1976) 2002, 27:2697-2705.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 2697-2705
    • Blattert, T.R.1    Delling, G.2    Dalal, P.S.3    Toth, C.A.4    Balling, H.5    Weckbach, A.6
  • 170
    • 0035313214 scopus 로고    scopus 로고
    • Induction of bone formation by recombinant human osteogenic protein-1 and sintered porous hydroxyapatite in adult primates
    • Ripamonti U., Crooks J., Rueger D.C. Induction of bone formation by recombinant human osteogenic protein-1 and sintered porous hydroxyapatite in adult primates. Plast. Reconstr. Surg. 2001, 107:977-988.
    • (2001) Plast. Reconstr. Surg. , vol.107 , pp. 977-988
    • Ripamonti, U.1    Crooks, J.2    Rueger, D.C.3
  • 172
    • 0023234146 scopus 로고
    • Hydroxyapatite and tricalcium phosphate bone graft substitutes
    • Bucholz R.W., Carlton A., Holmes R.E. Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop. Clin. North Am. 1987, 18:323-334.
    • (1987) Orthop. Clin. North Am. , vol.18 , pp. 323-334
    • Bucholz, R.W.1    Carlton, A.2    Holmes, R.E.3
  • 173
    • 3042759715 scopus 로고    scopus 로고
    • Beta-tricalcium phosphate combined with recombinant human bone morphogenetic protein-2: a substitute for autograft, used for packing interbody fusion cages in the canine lumbar spine
    • Ohyama T., Kubo Y., Iwata H., Taki W. Beta-tricalcium phosphate combined with recombinant human bone morphogenetic protein-2: a substitute for autograft, used for packing interbody fusion cages in the canine lumbar spine. Neurol. Med. Chir. (Tokyo) 2004, 44:234-240.
    • (2004) Neurol. Med. Chir. (Tokyo) , vol.44 , pp. 234-240
    • Ohyama, T.1    Kubo, Y.2    Iwata, H.3    Taki, W.4
  • 174
  • 175
    • 79952742634 scopus 로고    scopus 로고
    • The effect of BMP-2 on the osteoconductive properties of β-tricalcium phosphate in rat calvaria defects
    • Luvizuto E.R., Tangl S., Zanoni G., Okamoto T., Sonoda C.K., Gruber R., Okamoto R. The effect of BMP-2 on the osteoconductive properties of β-tricalcium phosphate in rat calvaria defects. Biomaterials 2011, 32:3855-3861.
    • (2011) Biomaterials , vol.32 , pp. 3855-3861
    • Luvizuto, E.R.1    Tangl, S.2    Zanoni, G.3    Okamoto, T.4    Sonoda, C.K.5    Gruber, R.6    Okamoto, R.7
  • 176
    • 38349011726 scopus 로고    scopus 로고
    • Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    • Fellah B.H., Gauthier O., Weiss P., Chappard D., Layrolle P. Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model. Biomaterials 2008, 29:1177-1188.
    • (2008) Biomaterials , vol.29 , pp. 1177-1188
    • Fellah, B.H.1    Gauthier, O.2    Weiss, P.3    Chappard, D.4    Layrolle, P.5
  • 177
    • 0035876414 scopus 로고    scopus 로고
    • Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2
    • Alam M.I., Asahina I., Ohmamiuda K., Takahashi K., Yokota S., Enomoto S. Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2. Biomaterials 2001, 22:1643-1651.
    • (2001) Biomaterials , vol.22 , pp. 1643-1651
    • Alam, M.I.1    Asahina, I.2    Ohmamiuda, K.3    Takahashi, K.4    Yokota, S.5    Enomoto, S.6
  • 178
    • 0033564706 scopus 로고    scopus 로고
    • Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate
    • Boden S.D., Martin G.J., Morone M.A., Ugbo J.L., Moskovitz P.A. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate. Spine (Phila Pa 1976) 1999, 24:1179-1185.
    • (1999) Spine (Phila Pa 1976) , vol.24 , pp. 1179-1185
    • Boden, S.D.1    Martin, G.J.2    Morone, M.A.3    Ugbo, J.L.4    Moskovitz, P.A.5
  • 180
    • 79960015095 scopus 로고    scopus 로고
    • Biomimetic calcium phosphate coatings as bone morphogenetic protein delivery systems in spinal fusion
    • Majid K., Tseng M.D., Baker K.C., Reyes-Trocchia A., Herkowitz H.N. Biomimetic calcium phosphate coatings as bone morphogenetic protein delivery systems in spinal fusion. Spine J. 2011, 11:560-567.
    • (2011) Spine J. , vol.11 , pp. 560-567
    • Majid, K.1    Tseng, M.D.2    Baker, K.C.3    Reyes-Trocchia, A.4    Herkowitz, H.N.5
  • 181
    • 0036025219 scopus 로고    scopus 로고
    • Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model
    • Louis-Ugbo J., et al. Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model. J. Orthop. Res. 2002, 20:1050-1059.
    • (2002) J. Orthop. Res. , vol.20 , pp. 1050-1059
    • Louis-Ugbo, J.1
  • 182
    • 0037082557 scopus 로고    scopus 로고
    • Delivery of recombinant human bone morphogenetic protein-2 using a compression-resistant matrix in posterolateral spine fusion in the rabbit and in the non-human primate
    • Suh D.Y., Boden S.D., Louis-Ugbo J., Mayr M., Murakami H., Kim H.S., Minamide A., Hutton W.C. Delivery of recombinant human bone morphogenetic protein-2 using a compression-resistant matrix in posterolateral spine fusion in the rabbit and in the non-human primate. Spine (Phila Pa 1976) 2002, 27:353-360.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 353-360
    • Suh, D.Y.1    Boden, S.D.2    Louis-Ugbo, J.3    Mayr, M.4    Murakami, H.5    Kim, H.S.6    Minamide, A.7    Hutton, W.C.8
  • 183
    • 0037342898 scopus 로고    scopus 로고
    • Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion
    • Akamaru T., Suh D., Boden S.D., Kim H.S., Minamide A., Louis-Ugbo J. Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion. Spine (Phila Pa 1976) 2003, 28:429-434.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 429-434
    • Akamaru, T.1    Suh, D.2    Boden, S.D.3    Kim, H.S.4    Minamide, A.5    Louis-Ugbo, J.6
  • 184
    • 0023755311 scopus 로고
    • Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein
    • Takaoka K., Nakahara H., Yoshikawa H., Masuhara K., Tsuda T., Ono K. Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein. Clin. Orthop. Relat. Res. 1988, 250-254.
    • (1988) Clin. Orthop. Relat. Res. , pp. 250-254
    • Takaoka, K.1    Nakahara, H.2    Yoshikawa, H.3    Masuhara, K.4    Tsuda, T.5    Ono, K.6
  • 185
    • 0035809843 scopus 로고    scopus 로고
    • The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2
    • Itoh S., et al. The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2. J. Biomed. Mater. Res. 2001, 54:445-453.
    • (2001) J. Biomed. Mater. Res. , vol.54 , pp. 445-453
    • Itoh, S.1
  • 186
  • 187
    • 1142311629 scopus 로고    scopus 로고
    • Effect of nano-hydroxyapatite/collagen composite and bone morphogenetic protein-2 on lumbar intertransverse fusion in rabbits
    • Sun T.S., Guan K., Shi S.S., Zhu B., Zheng Y.J., Cui F.Z., Zhang W., Liao S.S. Effect of nano-hydroxyapatite/collagen composite and bone morphogenetic protein-2 on lumbar intertransverse fusion in rabbits. Chin. J. Traumatol. 2004, 7:18-24.
    • (2004) Chin. J. Traumatol. , vol.7 , pp. 18-24
    • Sun, T.S.1    Guan, K.2    Shi, S.S.3    Zhu, B.4    Zheng, Y.J.5    Cui, F.Z.6    Zhang, W.7    Liao, S.S.8
  • 188
    • 70449337340 scopus 로고    scopus 로고
    • Enhanced regeneration of critical bone defects using a biodegradable gelatin sponge and beta-tricalcium phosphate with bone morphogenetic protein-2
    • Matsumoto G., Omi Y., Kubota E., Ozono S., Tsuzuki H., Kinoshita Y., Yamamoto M., Tabata Y. Enhanced regeneration of critical bone defects using a biodegradable gelatin sponge and beta-tricalcium phosphate with bone morphogenetic protein-2. J. Biomater. Appl. 2009, 24:327-342.
    • (2009) J. Biomater. Appl. , vol.24 , pp. 327-342
    • Matsumoto, G.1    Omi, Y.2    Kubota, E.3    Ozono, S.4    Tsuzuki, H.5    Kinoshita, Y.6    Yamamoto, M.7    Tabata, Y.8
  • 189
    • 69649083312 scopus 로고    scopus 로고
    • Segmental bone regeneration using an rhBMP-2-loaded gelatin/nanohydroxyapatite/fibrin scaffold in a rabbit model
    • Liu Y., et al. Segmental bone regeneration using an rhBMP-2-loaded gelatin/nanohydroxyapatite/fibrin scaffold in a rabbit model. Biomaterials 2009, 30:6276-6285.
    • (2009) Biomaterials , vol.30 , pp. 6276-6285
    • Liu, Y.1
  • 190
    • 79953066984 scopus 로고    scopus 로고
    • Evaluation of an injectable silk fibroin enhanced calcium phosphate cement loaded with human recombinant bone morphogenetic protein-2 in ovine lumbar interbody fusion
    • Gu Y., Chen L., Yang H.L., Luo Z.P., Tang T.S. Evaluation of an injectable silk fibroin enhanced calcium phosphate cement loaded with human recombinant bone morphogenetic protein-2 in ovine lumbar interbody fusion. J. Biomed. Mater. Res. A 2011, 97:177-185.
    • (2011) J. Biomed. Mater. Res. A , vol.97 , pp. 177-185
    • Gu, Y.1    Chen, L.2    Yang, H.L.3    Luo, Z.P.4    Tang, T.S.5
  • 191
    • 0037409732 scopus 로고    scopus 로고
    • New synthetic biodegradable polymers as BMP carriers for bone tissue engineering
    • Saito N., Takaoka K. New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials 2003, 24:2287-2293.
    • (2003) Biomaterials , vol.24 , pp. 2287-2293
    • Saito, N.1    Takaoka, K.2
  • 192
    • 18844400299 scopus 로고    scopus 로고
    • Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins
    • Saito N., et al. Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins. Adv. Drug Deliv. Rev. 2005, 57:1037-1048.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1037-1048
    • Saito, N.1
  • 194
    • 0027313504 scopus 로고
    • Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein
    • Miyamoto S., Takaoka K., Okada T., Yoshikawa H., Hashimoto J., Suzuki S., Ono K. Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein. Clin. Orthop. Relat. Res. 1993, 333-343.
    • (1993) Clin. Orthop. Relat. Res. , pp. 333-343
    • Miyamoto, S.1    Takaoka, K.2    Okada, T.3    Yoshikawa, H.4    Hashimoto, J.5    Suzuki, S.6    Ono, K.7
  • 195
    • 0032764225 scopus 로고    scopus 로고
    • New synthetic absorbable polymers as BMP carriers: plastic properties of poly-D, L-lactic acid-polyethylene glycol block copolymers
    • Saito N., Okada T., Toba S., Miyamoto S., Takaoka K. New synthetic absorbable polymers as BMP carriers: plastic properties of poly-D, L-lactic acid-polyethylene glycol block copolymers. J. Biomed. Mater. Res. 1999, 47:104-110.
    • (1999) J. Biomed. Mater. Res. , vol.47 , pp. 104-110
    • Saito, N.1    Okada, T.2    Toba, S.3    Miyamoto, S.4    Takaoka, K.5
  • 196
    • 0007930068 scopus 로고    scopus 로고
    • Biodegradable poly-d,l-lactic acid-polyethylene glycol block copolymers as a BMP delivery system for inducing bone
    • Saito N., et al. Biodegradable poly-d,l-lactic acid-polyethylene glycol block copolymers as a BMP delivery system for inducing bone. J. Bone Joint Surg. Am. 2001, 83-A(Suppl. 1):S92-S98.
    • (2001) J. Bone Joint Surg. Am. , Issue.SUPPL. 1
    • Saito, N.1
  • 197
    • 0035066563 scopus 로고    scopus 로고
    • A biodegradable polymer as a cytokine delivery system for inducing bone formation
    • Saito N., et al. A biodegradable polymer as a cytokine delivery system for inducing bone formation. Nat. Biotechnol. 2001, 19:332-335.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 332-335
    • Saito, N.1
  • 198
    • 33645750961 scopus 로고    scopus 로고
    • A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein-2: a potential treatment for infected bone defects
    • Suzuki A., Terai H., Toyoda H., Namikawa T., Yokota Y., Tsunoda T., Takaoka K. A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein-2: a potential treatment for infected bone defects. J. Orthop. Res. 2006, 24:327-332.
    • (2006) J. Orthop. Res. , vol.24 , pp. 327-332
    • Suzuki, A.1    Terai, H.2    Toyoda, H.3    Namikawa, T.4    Yokota, Y.5    Tsunoda, T.6    Takaoka, K.7
  • 199
    • 0037382964 scopus 로고    scopus 로고
    • Anterior thoracic spinal fusion in dogs by injection of recombinant human bone morphogenetic protein-2 and a synthetic polymer
    • Takahashi J., Saito N., Ebara S., Kinoshita T., Itoh H., Okada T., Nozaki K., Takaoka K. Anterior thoracic spinal fusion in dogs by injection of recombinant human bone morphogenetic protein-2 and a synthetic polymer. J. Spinal Disord. Tech. 2003, 16:137-143.
    • (2003) J. Spinal Disord. Tech. , vol.16 , pp. 137-143
    • Takahashi, J.1    Saito, N.2    Ebara, S.3    Kinoshita, T.4    Itoh, H.5    Okada, T.6    Nozaki, K.7    Takaoka, K.8
  • 201
    • 0036288004 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 application by a poly(D, L-lactide)-coated interbody cage: in vivo results of a new carrier for growth factors
    • Kandziora F., et al. Bone morphogenetic protein-2 application by a poly(D, L-lactide)-coated interbody cage: in vivo results of a new carrier for growth factors. J. Neurosurg. 2002, 97:40-48.
    • (2002) J. Neurosurg. , vol.97 , pp. 40-48
    • Kandziora, F.1
  • 202
    • 15344347281 scopus 로고    scopus 로고
    • Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant
    • Yoneda M., Terai H., Imai Y., Okada T., Nozaki K., Inoue H., Miyamoto S., Takaoka K. Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant. Biomaterials 2005, 26:5145-5152.
    • (2005) Biomaterials , vol.26 , pp. 5145-5152
    • Yoneda, M.1    Terai, H.2    Imai, Y.3    Okada, T.4    Nozaki, K.5    Inoue, H.6    Miyamoto, S.7    Takaoka, K.8
  • 203
    • 0037409988 scopus 로고    scopus 로고
    • Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier
    • Murakami N., et al. Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier. Biomaterials 2003, 24:2153-2159.
    • (2003) Biomaterials , vol.24 , pp. 2153-2159
    • Murakami, N.1
  • 204
    • 0042335648 scopus 로고    scopus 로고
    • Lumbar spinal fusion with a mineralized collagen matrix and rhBMP-2 in a rabbit model
    • Liao S.S., Guan K., Cui F.Z., Shi S.S., Sun T.S. Lumbar spinal fusion with a mineralized collagen matrix and rhBMP-2 in a rabbit model. Spine (Phila Pa 1976) 2003, 28:1954-1960.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 1954-1960
    • Liao, S.S.1    Guan, K.2    Cui, F.Z.3    Shi, S.S.4    Sun, T.S.5
  • 205
    • 23244447834 scopus 로고    scopus 로고
    • Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate in a rabbit model
    • Namikawa T., et al. Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate in a rabbit model. Spine (Phila Pa 1976) 2005, 30:1717-1722.
    • (2005) Spine (Phila Pa 1976) , vol.30 , pp. 1717-1722
    • Namikawa, T.1
  • 207
    • 55349144153 scopus 로고    scopus 로고
    • Improved bone healing by angiogenic factor-enriched platelet-rich plasma and its synergistic enhancement by bone morphogenetic protein-2
    • Park E.J., Kim E.S., Weber H.P., Wright R.F., Mooney D.J. Improved bone healing by angiogenic factor-enriched platelet-rich plasma and its synergistic enhancement by bone morphogenetic protein-2. Int. J. Oral Maxillofac. Implants 2008, 23:818-826.
    • (2008) Int. J. Oral Maxillofac. Implants , vol.23 , pp. 818-826
    • Park, E.J.1    Kim, E.S.2    Weber, H.P.3    Wright, R.F.4    Mooney, D.J.5
  • 210
    • 0035668346 scopus 로고    scopus 로고
    • Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix
    • Woo B.H., et al. Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix. Pharm. Res. 2001, 18:1747-1753.
    • (2001) Pharm. Res. , vol.18 , pp. 1747-1753
    • Woo, B.H.1
  • 211
    • 0036005924 scopus 로고    scopus 로고
    • Slow and continuous application of human recombinant bone morphogenetic protein via biodegradable poly(lactide-co-glycolide) foamspheres
    • Weber F.E., Eyrich G., Gratz K.W., Maly F.E., Sailer H.F. Slow and continuous application of human recombinant bone morphogenetic protein via biodegradable poly(lactide-co-glycolide) foamspheres. Int. J. Oral Maxillofac. Surg. 2002, 31:60-65.
    • (2002) Int. J. Oral Maxillofac. Surg. , vol.31 , pp. 60-65
    • Weber, F.E.1    Eyrich, G.2    Gratz, K.W.3    Maly, F.E.4    Sailer, H.F.5
  • 212
    • 0035998364 scopus 로고    scopus 로고
    • Experimental studies on bone induction using low-molecular-weight poly (dl-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2
    • Bessho K., Carnes D.L., Cavin R., Ong J.L. Experimental studies on bone induction using low-molecular-weight poly (dl-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. 2002, 61:61-65.
    • (2002) J. Biomed. Mater. Res. , vol.61 , pp. 61-65
    • Bessho, K.1    Carnes, D.L.2    Cavin, R.3    Ong, J.L.4
  • 213
    • 39549119382 scopus 로고    scopus 로고
    • Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2
    • Fu Y.C., Nie H., Ho M.L., Wang C.K., Wang C.H. Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol. Bioeng. 2008, 99:996-1006.
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 996-1006
    • Fu, Y.C.1    Nie, H.2    Ho, M.L.3    Wang, C.K.4    Wang, C.H.5
  • 214
    • 77950278578 scopus 로고    scopus 로고
    • Enhancement of in vivo bone regeneration efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells
    • Kang J.M., Kang S.W., La W.G., Yang Y.S., Kim B.S. Enhancement of in vivo bone regeneration efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells. J. Biomed. Mater. Res. A 2010, 93:666-672.
    • (2010) J. Biomed. Mater. Res. A , vol.93 , pp. 666-672
    • Kang, J.M.1    Kang, S.W.2    La, W.G.3    Yang, Y.S.4    Kim, B.S.5
  • 215
    • 33846657400 scopus 로고    scopus 로고
    • The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres
    • Wei G., Jin Q., Giannobile W.V., Ma P.X. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007, 28:2087-2096.
    • (2007) Biomaterials , vol.28 , pp. 2087-2096
    • Wei, G.1    Jin, Q.2    Giannobile, W.V.3    Ma, P.X.4
  • 216
    • 77950681035 scopus 로고    scopus 로고
    • Ceramic/polymer nanocomposites with tunable drug delivery capability at specific disease sites
    • Liu H., Webster T.J. Ceramic/polymer nanocomposites with tunable drug delivery capability at specific disease sites. J. Biomed. Mater. Res. A 2010, 93:1180-1192.
    • (2010) J. Biomed. Mater. Res. A , vol.93 , pp. 1180-1192
    • Liu, H.1    Webster, T.J.2
  • 217
    • 23744517121 scopus 로고    scopus 로고
    • Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo
    • Ruhe P.Q., Boerman O.C., Russel F.G., Spauwen P.H., Mikos A.G., Jansen J.A. Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo. J. Control. Release 2005, 106:162-171.
    • (2005) J. Control. Release , vol.106 , pp. 162-171
    • Ruhe, P.Q.1    Boerman, O.C.2    Russel, F.G.3    Spauwen, P.H.4    Mikos, A.G.5    Jansen, J.A.6
  • 218
    • 51849089563 scopus 로고    scopus 로고
    • Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2
    • Kim S.S., Gwak S.J., Kim B.S. Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2. J. Biomed. Mater. Res. A 2008, 87:245-253.
    • (2008) J. Biomed. Mater. Res. A , vol.87 , pp. 245-253
    • Kim, S.S.1    Gwak, S.J.2    Kim, B.S.3
  • 219
    • 77957018566 scopus 로고    scopus 로고
    • Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system
    • Choi D.H., Park C.H., Kim I.H., Chun H.J., Park K., Han D.K. Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system. J. Control. Release 2010, 147:193-201.
    • (2010) J. Control. Release , vol.147 , pp. 193-201
    • Choi, D.H.1    Park, C.H.2    Kim, I.H.3    Chun, H.J.4    Park, K.5    Han, D.K.6
  • 220
    • 34447253328 scopus 로고    scopus 로고
    • Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects
    • Oest M.E., Dupont K.M., Kong H.J., Mooney D.J., Guldberg R.E. Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects. J. Orthop. Res. 2007, 25:941-950.
    • (2007) J. Orthop. Res. , vol.25 , pp. 941-950
    • Oest, M.E.1    Dupont, K.M.2    Kong, H.J.3    Mooney, D.J.4    Guldberg, R.E.5
  • 221
    • 77952009950 scopus 로고    scopus 로고
    • BMP-2/PLGA delayed-release microspheres composite graft, selection of bone particulate diameters, and prevention of aseptic inflammation for bone tissue engineering
    • Ji Y., Xu G.P., Zhang Z.P., Xia J.J., Yan J.L., Pan S.H. BMP-2/PLGA delayed-release microspheres composite graft, selection of bone particulate diameters, and prevention of aseptic inflammation for bone tissue engineering. Ann. Biomed. Eng. 2010, 38:632-639.
    • (2010) Ann. Biomed. Eng. , vol.38 , pp. 632-639
    • Ji, Y.1    Xu, G.P.2    Zhang, Z.P.3    Xia, J.J.4    Yan, J.L.5    Pan, S.H.6
  • 222
    • 34249894420 scopus 로고    scopus 로고
    • Heterobifunctional poly(ethylene glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cell differentiation and osteogenesis
    • Liu H.W., Chen C.H., Tsai C.L., Lin I.H., Hsiue G.H. Heterobifunctional poly(ethylene glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cell differentiation and osteogenesis. Tissue Eng. 2007, 13:1113-1124.
    • (2007) Tissue Eng. , vol.13 , pp. 1113-1124
    • Liu, H.W.1    Chen, C.H.2    Tsai, C.L.3    Lin, I.H.4    Hsiue, G.H.5
  • 223
    • 64549129642 scopus 로고    scopus 로고
    • Effect of autologous bone marrow stromal cell seeding and bone morphogenetic protein-2 delivery on ectopic bone formation in a microsphere/poly(propylene fumarate) composite
    • Kempen D.H., Kruyt M.C., Lu L., Wilson C.E., Florschutz A.V., Creemers L.B., Yaszemski M.J., Dhert W.J. Effect of autologous bone marrow stromal cell seeding and bone morphogenetic protein-2 delivery on ectopic bone formation in a microsphere/poly(propylene fumarate) composite. Tissue Eng. Part A 2009, 15:587-594.
    • (2009) Tissue Eng. Part A , vol.15 , pp. 587-594
    • Kempen, D.H.1    Kruyt, M.C.2    Lu, L.3    Wilson, C.E.4    Florschutz, A.V.5    Creemers, L.B.6    Yaszemski, M.J.7    Dhert, W.J.8
  • 225
    • 33947178806 scopus 로고    scopus 로고
    • Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(l-lactic-co-glycolic acid) scaffold
    • Jeon O., Song S.J., Kang S.W., Putnam A.J., Kim B.S. Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(l-lactic-co-glycolic acid) scaffold. Biomaterials 2007, 28:2763-2771.
    • (2007) Biomaterials , vol.28 , pp. 2763-2771
    • Jeon, O.1    Song, S.J.2    Kang, S.W.3    Putnam, A.J.4    Kim, B.S.5
  • 226
    • 44949119587 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells
    • Kang S.W., La W.G., Kang J.M., Park J.H., Kim B.S. Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells. Biotechnol. Lett. 2008, 30:1163-1168.
    • (2008) Biotechnol. Lett. , vol.30 , pp. 1163-1168
    • Kang, S.W.1    La, W.G.2    Kang, J.M.3    Park, J.H.4    Kim, B.S.5
  • 227
    • 56349132615 scopus 로고    scopus 로고
    • Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells
    • Kim S.E., Jeon O., Lee J.B., Bae M.S., Chun H.J., Moon S.H., Kwon I.K. Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells. J. Biomed. Sci. 2008, 15:771-777.
    • (2008) J. Biomed. Sci. , vol.15 , pp. 771-777
    • Kim, S.E.1    Jeon, O.2    Lee, J.B.3    Bae, M.S.4    Chun, H.J.5    Moon, S.H.6    Kwon, I.K.7
  • 229
    • 34547585979 scopus 로고    scopus 로고
    • Biodegradable polymers as biomaterials
    • Nair L.S., Laurencin C.T. Biodegradable polymers as biomaterials. Prog. Polym. Sci. 2007, 32:762-798.
    • (2007) Prog. Polym. Sci. , vol.32 , pp. 762-798
    • Nair, L.S.1    Laurencin, C.T.2
  • 231
    • 84860390109 scopus 로고    scopus 로고
    • Functional restoration of critically sized segmental defects with bone morphogenetic protein-2 and heparin treatment
    • Johnson M.R., Boerckel J.D., Dupont K.M., Guldberg R.E. Functional restoration of critically sized segmental defects with bone morphogenetic protein-2 and heparin treatment. Clin. Orthop. Relat. Res. 2011, 469:3111-3117.
    • (2011) Clin. Orthop. Relat. Res. , vol.469 , pp. 3111-3117
    • Johnson, M.R.1    Boerckel, J.D.2    Dupont, K.M.3    Guldberg, R.E.4
  • 232
    • 80053093007 scopus 로고    scopus 로고
    • Discontinuous release of bone morphogenetic protein-2 loaded within interconnected pores of honeycomb-like polycaprolactone scaffold promotes bone healing in a large bone defect of rabbit ulna
    • Bae J.H., Song H.R., Kim H.J., Lim H.C., Park J.H., Liu Y., Teoh S.H. Discontinuous release of bone morphogenetic protein-2 loaded within interconnected pores of honeycomb-like polycaprolactone scaffold promotes bone healing in a large bone defect of rabbit ulna. Tissue Eng. Part A 2011, 17:2389-2397.
    • (2011) Tissue Eng. Part A , vol.17 , pp. 2389-2397
    • Bae, J.H.1    Song, H.R.2    Kim, H.J.3    Lim, H.C.4    Park, J.H.5    Liu, Y.6    Teoh, S.H.7
  • 233
    • 80053363820 scopus 로고    scopus 로고
    • Fusion Performance of Low Dose rhBMP-2 and BMSCs in Biodegradable Scaffolds: A Comparative Study in a Large Animal Model of Anterior Lumbar Interbody Fusion
    • Abbah S.A., Lam C.X., Ramruttun A.K., Goh J.C., Wong H.K. Fusion Performance of Low Dose rhBMP-2 and BMSCs in Biodegradable Scaffolds: A Comparative Study in a Large Animal Model of Anterior Lumbar Interbody Fusion. Spine (Phila Pa 1976) 2011, 36:1752-1759.
    • (2011) Spine (Phila Pa 1976) , vol.36 , pp. 1752-1759
    • Abbah, S.A.1    Lam, C.X.2    Ramruttun, A.K.3    Goh, J.C.4    Wong, H.K.5
  • 235
    • 80053358773 scopus 로고    scopus 로고
    • Expanded indication for recombinant human bone morphogenetic protein 2
    • (author reply 1817-8)
    • Woo E.J. Expanded indication for recombinant human bone morphogenetic protein 2. Spine (Phila Pa 1976) 2011, 36:1817. (author reply 1817-8).
    • (2011) Spine (Phila Pa 1976) , vol.36 , pp. 1817
    • Woo, E.J.1
  • 236
    • 84877137522 scopus 로고    scopus 로고
    • Spine Experts Repudiate Medtronic Studies
    • Meier B., Wilson D. Spine Experts Repudiate Medtronic Studies. The New York Times March 21 2012, http://www.nytimes.com/2011/06/29/business/29spine.html.
    • (2012) The New York Times
    • Meier, B.1    Wilson, D.2
  • 237
  • 240
    • 84872879908 scopus 로고    scopus 로고
    • Senators introduce bi-partisan medical device bill
    • Senators introduce bi-partisan medical device bill. Mass Device 2012, http://www.massdevice.com/news/senators-introduce-bi-partisan-medical-device-bill.
    • (2012) Mass Device
  • 241
    • 2942560777 scopus 로고    scopus 로고
    • Genetic modification of stem cells to enhance bone repair
    • Gamradt S.C., Lieberman J.R. Genetic modification of stem cells to enhance bone repair. Ann. Biomed. Eng. 2004, 32:136-147.
    • (2004) Ann. Biomed. Eng. , vol.32 , pp. 136-147
    • Gamradt, S.C.1    Lieberman, J.R.2
  • 242
    • 77951766763 scopus 로고    scopus 로고
    • Complications related to osteobiologics use in spine surgery: a systematic review
    • Mroz T.E., Wang J.C., Hashimoto R., Norvell D.C. Complications related to osteobiologics use in spine surgery: a systematic review. Spine (Phila Pa 1976) 2010, 35:S86-S104.
    • (2010) Spine (Phila Pa 1976) , vol.35
    • Mroz, T.E.1    Wang, J.C.2    Hashimoto, R.3    Norvell, D.C.4
  • 243
    • 0033521078 scopus 로고    scopus 로고
    • Stimulation of bone formation in vitro and in rodents by statins
    • Mundy G., et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999, 286:1946-1949.
    • (1999) Science , vol.286 , pp. 1946-1949
    • Mundy, G.1
  • 244
    • 0034685669 scopus 로고    scopus 로고
    • Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells
    • Sugiyama M., Kodama T., Konishi K., Abe K., Asami S., Oikawa S. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem. Biophys. Res. Commun. 2000, 271:688-692.
    • (2000) Biochem. Biophys. Res. Commun. , vol.271 , pp. 688-692
    • Sugiyama, M.1    Kodama, T.2    Konishi, K.3    Abe, K.4    Asami, S.5    Oikawa, S.6
  • 245
    • 0001433806 scopus 로고    scopus 로고
    • Dermal application of lovastatin to rats causes greater increases in bone formation and plasma concentrations that when administered by oral gavage
    • Gutierrez G., Garrett I.R., Rossini G.e.a. Dermal application of lovastatin to rats causes greater increases in bone formation and plasma concentrations that when administered by oral gavage. J. Bone Miner. Res. 2000, 15:S427.
    • (2000) J. Bone Miner. Res. , vol.15
    • Gutierrez, G.1    Garrett, I.R.2    Rossini, G.3
  • 247
    • 0034805319 scopus 로고    scopus 로고
    • Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells
    • Maeda T., Matsunuma A., Kawane T., Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem. Biophys. Res. Commun. 2001, 280:874-877.
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , pp. 874-877
    • Maeda, T.1    Matsunuma, A.2    Kawane, T.3    Horiuchi, N.4
  • 250
    • 0036242398 scopus 로고    scopus 로고
    • Statins as modulators of bone formation
    • Edwards C.J., Spector T.D. Statins as modulators of bone formation. Arthritis Res. 2002, 4:151-153.
    • (2002) Arthritis Res. , vol.4 , pp. 151-153
    • Edwards, C.J.1    Spector, T.D.2
  • 251
    • 77952285581 scopus 로고    scopus 로고
    • Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway
    • Chen P.Y., Sun J.S., Tsuang Y.H., Chen M.H., Weng P.W., Lin F.H. Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. Nutr. Res. 2010, 30:191-199.
    • (2010) Nutr. Res. , vol.30 , pp. 191-199
    • Chen, P.Y.1    Sun, J.S.2    Tsuang, Y.H.3    Chen, M.H.4    Weng, P.W.5    Lin, F.H.6
  • 252
    • 34249675109 scopus 로고    scopus 로고
    • The role of statins in primary prevention of cardiovascular disease
    • (author reply 1100-1)
    • Eichler K., Puhan M.A., Bachmann L.M. The role of statins in primary prevention of cardiovascular disease. Arch. Intern. Med. 2007, 167:1100. (author reply 1100-1).
    • (2007) Arch. Intern. Med. , vol.167 , pp. 1100
    • Eichler, K.1    Puhan, M.A.2    Bachmann, L.M.3
  • 253
    • 0036205571 scopus 로고    scopus 로고
    • Potential use of HMG-CoA reductase inhibitors for osteoporosis
    • Cushenberry L., Debittner M.R. Potential use of HMG-CoA reductase inhibitors for osteoporosis. Ann. Pharmacother. 2002, 36:671-678.
    • (2002) Ann. Pharmacother. , vol.36 , pp. 671-678
    • Cushenberry, L.1    Debittner, M.R.2
  • 254
    • 40849100000 scopus 로고    scopus 로고
    • Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner
    • Zhao J., Ohba S., Shinkai M., Chung U.I., Nagamune T. Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem. Biophys. Res. Commun. 2008, 369:444-448.
    • (2008) Biochem. Biophys. Res. Commun. , vol.369 , pp. 444-448
    • Zhao, J.1    Ohba, S.2    Shinkai, M.3    Chung, U.I.4    Nagamune, T.5
  • 257
    • 0034082289 scopus 로고    scopus 로고
    • In vivo osteogeneic capability of cultured allogeneic bone in porous hydroxvapatite: immunosuppressive and osteogeneic potential of FK506 in vivo
    • Yoshikawa T., Nakajima H., Yamada E., Akahane M., Dohi Y., Ohgushi H., Tamai S., Ichijima K. In vivo osteogeneic capability of cultured allogeneic bone in porous hydroxvapatite: immunosuppressive and osteogeneic potential of FK506 in vivo. J. Bone Miner. Res. 2000, 15:1147-1157.
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1147-1157
    • Yoshikawa, T.1    Nakajima, H.2    Yamada, E.3    Akahane, M.4    Dohi, Y.5    Ohgushi, H.6    Tamai, S.7    Ichijima, K.8
  • 263
    • 77950603770 scopus 로고    scopus 로고
    • Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
    • Lee K.W., Yook J.Y., Son M.Y., Kim M.J., Koo D.B., Han Y.M., Cho Y.S. Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev. 2010, 19:557-568.
    • (2010) Stem Cells Dev. , vol.19 , pp. 557-568
    • Lee, K.W.1    Yook, J.Y.2    Son, M.Y.3    Kim, M.J.4    Koo, D.B.5    Han, Y.M.6    Cho, Y.S.7
  • 264
    • 34247884252 scopus 로고    scopus 로고
    • A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner
    • Ohba S., et al. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem. Biophys. Res. Commun. 2007, 357:854-860.
    • (2007) Biochem. Biophys. Res. Commun. , vol.357 , pp. 854-860
    • Ohba, S.1
  • 266
    • 80052708936 scopus 로고    scopus 로고
    • The small molecule PKA-selective cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization
    • Epub a head of print
    • Lo K.W.-H., Kan H.M., Ashe K.M., Laurencin C.T. The small molecule PKA-selective cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J. Tissue Eng. Regen. Med. 2011, Epub a head of print. 10.1002/term.395.
    • (2011) J. Tissue Eng. Regen. Med.
    • Lo, K.W.-H.1    Kan, H.M.2    Ashe, K.M.3    Laurencin, C.T.4
  • 267
    • 77956391258 scopus 로고    scopus 로고
    • Osteoinductive ceramics as a synthetic alternative to autologous bone grafting
    • Yuan H., et al. Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:13614-13619.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 13614-13619
    • Yuan, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.