Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor

Journal of Biological Chemistry

Volumn 280, Issue 15, 2005, Pages 14974-14980

  Hillger, Frank ^a,c   Herr, Gerhard ^b   Rudolph, Rainer ^a   Schwarz, Elisabeth ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b Advanced Tissue Regeneration GmbH   (Germany)

^c Biochemische Institut   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BONE; CELLS; ESCHERICHIA COLI; MUTAGENESIS; NEUROLOGY; SPECTROSCOPY;

BIOLOGICAL ACTIVITY; BIOPHYSICAL COMPARISON; MATURE GROWTH FACTOR; NERVE GROWTH FACTOR (NGF);

POLYPEPTIDES;

BONE MORPHOGENETIC PROTEIN 2; GROWTH FACTOR; PEPTIDE; TRANSFORMING GROWTH FACTOR BETA;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL; BIOLOGICAL ACTIVITY; BIOPHYSICS; CIRCULAR DICHROISM; COMPARATIVE STUDY; CONTROLLED STUDY; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; MALE; NONHUMAN; OSSIFICATION; OXIDATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN ISOLATION; PURIFICATION; RAT; STRUCTURE ANALYSIS; THERMODYNAMICS;

ANIMALS; BIOPHYSICS; BONE MORPHOGENETIC PROTEINS; CIRCULAR DICHROISM; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GROWTH SUBSTANCES; HYDROGEN-ION CONCENTRATION; MALE; NERVE GROWTH FACTOR; OXYGEN; PEPTIDES; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; TRANSFORMING GROWTH FACTOR BETA; ULTRAVIOLET RAYS;

ESCHERICHIA COLI;

EID: 17644407766     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414413200     Document Type: Article

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