Icariin: A potential osteoinductive compound for bone tissue engineering

Tissue Engineering - Part A

Volumn 16, Issue 1, 2010, Pages 233-243

  Zhao, Jiyuan ^a   Ohba, Shinsuke ^b   Komiyama, Yusuke ^b   Shinkai, Masashige ^a   Chung, Ung Il ^a,b   Nagamune, Teruyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; BONE; CALCIUM; CALCIUM ALLOYS; CALCIUM PHOSPHATE; CELL CULTURE; CEMENTS; CORROSION PREVENTION; PROTEINS; SOLAR CONCENTRATORS; TISSUE ENGINEERING;

ACTIVE COMPOUNDS; BONE DISEASE; BONE FORMATION; BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; BONE TISSUE ENGINEERING; CALCIUM PHOSPHATE CEMENT; CALVARIAL DEFECTS; EPIMEDIUM; FIBROBLASTIC CELLS; ICARIIN; IN-VIVO; MC3T3-E1 CELL; NEW BONE THICKNESS; OSTEOGENIC; OSTEOGENIC DIFFERENTIATION; OSTEOGENIC EFFECTS; PREOSTEOBLASTIC CELLS; PUBESCENS; REGENERATIVE MEDICINE;

BONE CEMENT;

EPIMEDIUM; EPIMEDIUM PUBESCENS; MUS;

BMP2 PROTEIN, MOUSE; BONE CEMENT; BONE MORPHOGENETIC PROTEIN 2; FLAVONOID; HELIOXANTHIN; ICARIIN; LIGNAN;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE MINERALIZATION; BONE REGENERATION; CELL STRAIN 3T3; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; EPIMEDIUM; MALE; METABOLISM; MOUSE; PATHOLOGY; SKULL FRACTURE; TIME;

ANIMALS; BONE CEMENTS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CALCIFICATION, PHYSIOLOGIC; DRUG SYNERGISM; EPIMEDIUM; FLAVONOIDS; LIGNANS; MALE; MICE; NIH 3T3 CELLS; SKULL FRACTURES; TIME FACTORS;

EID: 77049109253     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0165     Document Type: Article

References (34)

1. Otto, W.R., and Rao, J. Tomorrow's skeleton staff: mesen-chymal stem cells and the repair of bone and cartilage. Cell Prolif 37, 97, 2004.
2. Li, W.J., Tuli, R., Huang, X., Laquerriere, P., and Tuan R.S. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomater-ials 26, 5158, 2005.
3. Cowan, C.M., Shi, Y.Y., Aalami, O.O., Chou, Y.F., Mari, C., Thomas, R., Quarto, N., Contag, C.H., Wu, B., and Long-aker, M.T. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol 22, 560, 2004.
4. Datta, N., Pham, Q.P., Sharma, U., Sikavitsas, V.I., Jansen, J.A., and Mikos, A.G. In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. PNAS 103, 2488, 2006.
5. Liu, X., and Ma, P.X. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 32, 477, 2004.
6. Knabe, C., Driessens, F.C., Planell, J.A., Gildenhaar, R., Berger, G., Reif, D., Fitzner, R., Radlanski, R.J., and Gross, U. Evaluation of calcium phosphates and experimental calcium phosphate bone cements using osteogenic cultures. J Biomed Mater Res 52, 498, 2000.
7. Vehof, J.W., van den Dolder, J., de Ruijter, J.E., Spauwen, P.H., and Jansen, J.A. Bone formation in CaP-coated and noncoated titanium fiber mesh. J Biomed Mater Res A 64, 417, 2003.
8. Franceschi, R.T., Yang, S., Rutherford, R.B., Krebsbach, P.H., Zhao, M., and Wang, D. Gene therapy approaches for bone regeneration. Cells Tissues Organs 176, 95, 2004.
9. Byers, B.A., Guldberg, R.E., and Garcia, A.J. Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Tissue Eng 10, 1757, 2004.
10. Yamamoto, M., Tabata, Y., Hong, L., Miyamoto, S., Hashimoto, N., and Ikada, Y. Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. J Control Release 64, 133, 2000.
11. Lieberman, J.R., Daluiski, A., and Einhorn, T.A. The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am 84, 1032, 2002.
12. Bridwell, K.H., Anderson, P.A., Boden, S.D., Vaccaro, A.R., and Zigler, J.E. What's new in spine surgery. J Bone Joint Surg Am 86, 1587, 2004.
13. Geesink, R.G., Hoefnagels, N.H., and Bulstra, S.K. Osteo-genic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J Bone Joint Surg Br 81, 710, 1999.
14. Zhao, B., Katagiri, T., Toyoda, H., Takada, T., Yanai, T., and Fukuda, T. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 281, 23246, 2006.
15. Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., and Gutierrez, G. Stimulation of bone formation in vitro and in rodents by statins. Science 286, 1946, 1999.
16. Notoya, K., Yoshida, K., Tsukuda, R., and Taketomi, S. Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture. J Bone Miner Res 9, 395, 1994.
17. Civitelli, R. In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics. Calcif Tissue Int 61, S12, 1997.
18. Notoya, K., Nagai, H., Oda, T., Gotoh, M., Hoshino, T., Muranishi, H., Taketomi, S., Sohda, T., and Makino, T. Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. J Pharmacol Exp Ther 290, 1054, 1999.
19. Ohba, S., Nakajima, K., Komiyama, Y., Kugimiya, F., Igawa, K., Itaka, K., Moro, T., Nakamura, K., Kawaguchi, H., Takato, T., and Chung, U.I. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Bio-phys Res Commun 357, 854, 2007.
20. Ma, Z., Wang, R., and Qiu, M. Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariec-tomized rats. Chin J Obstet Gynecol 34, 82, 1999.
21. Wang, B., Quan, J., and Guo, S. Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat. Chin J Obstet Gynecol 35, 724, 2000.
22. Yu, S., Chen, K., Li, S., and Zhang, K. In vitro and in vivo studies of the effect of a Chinese herb medicine on osteo-clastic bone resorption. Chin J Dent Res 2, 7, 1999.
23. Xie, F., Wu, C., Lai, W., Yang, X., Cheung, P., Yao, X., Leung, P., and Wong, M. The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. Evid Based Complement Alternat Med 2, 353, 2005.
24. Qian, G., Zhang, X., Lu, L., Wu, X., Li, S., and Meng, J. Regulation of Cbfa1 expression by total flavonoids of Herba Epimedii. Endocr J 53, 87, 2006.
25. Meng, F., Li, Y., Xiong, Z., Jiang, Z., and Li, F. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine 12, 189, 2005.
26. Xue, Y., Wang, P., Qi, Q., Ni, H., Ma, X., and Guo, S. The experimental study of the effects of icariin on increasing smad4 mRNA level in MC3T3-E1 cell in vitro. Chin J Orthop 25, 119, 2005.
27. Zhao, J., Ohba, S., Shinkai, M., Chung, U.I., and Nagamune, T. Icariin induces osteogenic differentiation in vitro in a BMP-and Runx2-dependent manner. Biochem Biophys Res Com-mun 369, 444, 2008.
28. Kugimiya, F., Kawaguchi, H., Kamekura, S., Chikuda, H., Ohba, S., Yano, F., Ogata, N., Katagiri, T., Harada, Y., Azuma, Y., Nakamura, K., and Chung, U.I. Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem 280, 35704, 2005.
29. Sarkar, B.C.R., and Chauhan, U.P.S. A new method for determining micro quantities of calcium in biological materials. Anal Chem 20, 155, 1967.
30. Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B.D., Nakashima, K., and Takayanagi, H. NFAT and Osterix cooperatively regulate bone formation. Nat Med 11, 880, 2005.
31. Takagishi, Y., Kawakami, T., Hara, Y., Shinkai, M, Takezawa, T., and Nagamune, T. Bone-like tissue formation by three-dimensional culture of MG63 osteosarcoma cells in gelatin hydrogels using calcium-enriched medium. Tissue Eng 12, 927, 2006.
32. Jono, S., Peinado, C., and Giachelli, C.M. Phosphoryla-tion of osteopontin is required for inhibition of vascular smooth muscle cell calcification. J Biol Chem 275, 20197, 2000.
33. Phimphilai, M., Zhao, Z., Boulez, H., Roca, H., and Fran-ceschi, R.T. BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. J Bone Miner Res 21, 637, 2006.
34. Bae, J.S., Gutierrez, S., Marla, R., Prate, J., Decades, R., van Wine, A.J., Stein, J.L., Stein, G.S., Lian, J.B., and Javed, A. Re-constitution of Runx2=Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. J Cell Biochem 100, 434, 2007.