메뉴 건너뛰기




Volumn 17, Issue 19-20, 2011, Pages 2389-2397

Discontinuous release of bone morphogenetic protein-2 loaded within interconnected pores of honeycomb-like polycaprolactone scaffold promotes bone healing in a large bone defect of rabbit ulna

Author keywords

[No Author keywords available]

Indexed keywords

BONE; COMPUTERIZED TOMOGRAPHY; DEFECTS; HONEYCOMB STRUCTURES; POLYCAPROLACTONE; PROTEINS; RADIOLOGY;

EID: 80053093007     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2011.0032     Document Type: Article
Times cited : (34)

References (50)
  • 2
    • 42649095181 scopus 로고    scopus 로고
    • A review of materials, fabrication methods, and strategies used to enhance bone regeneration in engineered bone tissues
    • Stevens, B., Yang, Y., Mohandas, A., Stucker, B., and Nguyen, K.T. A review of materials, fabrication methods, and strategies used to enhance bone regeneration in engineered bone tissues. J Biomed Mater Res B Appl Biomater 85, 573, 2008.
    • (2008) J Biomed Mater Res B Appl Biomater , vol.85 , pp. 573
    • Stevens, B.1    Yang, Y.2    Mohandas, A.3    Stucker, B.4    Nguyen, K.T.5
  • 3
    • 33644789527 scopus 로고    scopus 로고
    • Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics
    • Mastrogiacomo, M., Scaglione, S., Martinetti, R., Dolcini, L., Beltrame, F., Cancedda, R., et al. Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics. Biomaterials 27, 3230, 2006.
    • (2006) Biomaterials , vol.27 , pp. 3230
    • Mastrogiacomo, M.1    Scaglione, S.2    Martinetti, R.3    Dolcini, L.4    Beltrame, F.5    Cancedda, R.6
  • 4
    • 3042778829 scopus 로고    scopus 로고
    • Engineering principles of clinical cell-based tissue engineering
    • Muschler, G.F., Nakamoto, C., and Griffith, L.G. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 86-A, 1541, 2004.
    • (2004) J Bone Joint Surg Am , vol.86 A , pp. 1541
    • Muschler, G.F.1    Nakamoto, C.2    Griffith, L.G.3
  • 5
    • 0003145938 scopus 로고
    • Lineage of osteogenic cells and their relationship to the stromal system
    • Bilezikian, J.P., Raisz, L.G., and Rodan, G.A, eds CA: Academic Press
    • Owen, M., and Peck, W. Lineage of osteogenic cells and their relationship to the stromal system. In: Bilezikian, J.P., Raisz, L.G., and Rodan, G.A, eds. Principles of Bone Biology, Volume Irvine, CA: Academic Press, 1985, pp. 1-25.
    • (1985) Principles of Bone Biology Irvine , pp. 1-25
    • Owen, M.1    Peck, W.2
  • 6
    • 0024521423 scopus 로고
    • Osteogenic stem cells and the stromal system of bone and marrow
    • Beresford, J.N. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop Relat Res 270, 1989.
    • (1989) Clin Orthop Relat Res , vol.270
    • Beresford, J.N.1
  • 7
    • 0017103248 scopus 로고
    • Precursor cells of mechanocytes
    • Friedenstein, A.J. Precursor cells of mechanocytes. Int Rev Cytol 47, 327, 1976.
    • (1976) Int Rev Cytol , vol.47 , pp. 327
    • Friedenstein, A.J.1
  • 9
    • 13744256148 scopus 로고    scopus 로고
    • Delivery of growth factors using gene therapy to enhance bone healing
    • Southwood, L.L., Frisbie, D.D., Kawcak, C.E., and McIlwraith, C.W. Delivery of growth factors using gene therapy to enhance bone healing. Vet Surg 33, 565, 2004.
    • (2004) Vet Surg , vol.33 , pp. 565
    • Southwood, L.L.1    Frisbie, D.D.2    Kawcak, C.E.3    McIlwraith, C.W.4
  • 10
    • 8544278195 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells
    • Karageorgiou, V., Meinel, L., Hofmann, S., Malhotra, A., Volloch, V., Kaplan, D., et al. Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells. J Biomed Mater Res A 71, 528, 2004.
    • (2004) J Biomed Mater Res A , vol.71 , pp. 528
    • Karageorgiou, V.1    Meinel, L.2    Hofmann, S.3    Malhotra, A.4    Volloch, V.5    Kaplan, D.6
  • 11
    • 0027769670 scopus 로고
    • Initiation and promotion of bone differentiation by bone morphogenetic proteins
    • Reddi, A.H., and Cunningham, N.S. Initiation and promotion of bone differentiation by bone morphogenetic proteins. J Bone Miner Res 8 Suppl 2, S499, 1993.
    • (1993) J Bone Miner Res , vol.8 , Issue.SUPPL. 2
    • Reddi, A.H.1    Cunningham, N.S.2
  • 12
    • 0019500534 scopus 로고
    • Cell biology and biochemistry of endochondral bone development
    • Reddi, A.H. Cell biology and biochemistry of endochondral bone development. Coll Relat Res 1, 209, 1981.
    • (1981) Coll Relat Res , vol.1 , pp. 209
    • Reddi, A.H.1
  • 13
    • 85119303864 scopus 로고    scopus 로고
    • Bone: Formation by autoinduction. 1965
    • Urist, M.R. Bone: formation by autoinduction. 1965. Clin Orthop Relat Res 4, 2002.
    • Clin Orthop Relat Res , vol.4 , pp. 2002
    • Urist, M.R.1
  • 14
    • 0001449699 scopus 로고
    • Solubilized and insolubilized bone morphogenetic protein
    • Urist, M.R., Mikulski, A., and Lietze, A. Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA 76, 1828, 1979.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 1828
    • Urist, M.R.1    Mikulski, A.2    Lietze, A.3
  • 18
    • 0028271621 scopus 로고
    • Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model
    • Cook, S.D., Baffes, G.C., Wolfe, M.W., Sampath, T.K., and Rueger, D.C. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop Relat Res 302, 1994.
    • (1994) Clin Orthop Relat Res , vol.302
    • Cook, S.D.1    Baffes, G.C.2    Wolfe, M.W.3    Sampath, T.K.4    Rueger, D.C.5
  • 20
    • 49349090133 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: The road from laboratory to clinic, part II (BMP delivery)
    • Bessa, P.C., Casal, M., and Reis, R.L. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen Med 2, 81, 2008.
    • (2008) J Tissue Eng Regen Med , vol.2 , pp. 81
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 21
    • 0036899744 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients
    • Govender, S., Csimma, C., Genant, H.K., Valentin-Opran, A., Amit, Y., Arbel, R., et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 84-A, 2123, 2002.
    • (2002) J Bone Joint Surg Am , vol.84 A , pp. 2123
    • Govender, S.1    Csimma, C.2    Genant, H.K.3    Valentin-Opran, A.4    Amit, Y.5    Arbel, R.6
  • 22
  • 23
    • 0037082740 scopus 로고    scopus 로고
    • Fused deposition modeling of novel scaffold architectures for tissue engineering applications
    • Zein, I., Hutmacher, D.W., Tan, K.C., and Teoh, S.H. Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 23, 1169, 2002.
    • (2002) Biomaterials , vol.23 , pp. 1169
    • Zein, I.1    Hutmacher, D.W.2    Tan, K.C.3    Teoh, S.H.4
  • 24
    • 64549145109 scopus 로고    scopus 로고
    • Mandibular defect reconstruction using three-dimensional polycaprolactone scaffold in combination with platelet-rich plasma and recombinant human bone morphogenetic protein-2: De novo synthesis of bone in a single case
    • Schuckert, K.H., Jopp, S., and Teoh, S.H. Mandibular defect reconstruction using three-dimensional polycaprolactone scaffold in combination with platelet-rich plasma and recombinant human bone morphogenetic protein-2: de novo synthesis of bone in a single case. Tissue Eng Part A 15, 493, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 493
    • Schuckert, K.H.1    Jopp, S.2    Teoh, S.H.3
  • 25
    • 33644612205 scopus 로고    scopus 로고
    • Cranioplasty after trephination using a novel biodegradable burr hole cover: Technical case report
    • Schantz, J.T., Lim, T.C., Ning, C., Teoh, S.H., Tan, K.C., Wang, S.C., et al. Cranioplasty after trephination using a novel biodegradable burr hole cover: technical case report. Neurosurgery 58, ONS, 2006.
    • (2006) Neurosurgery , vol.58
    • Schantz, J.T.1    Lim, T.C.2    Ning, C.3    Teoh, S.H.4    Tan, K.C.5    Wang, S.C.6
  • 26
    • 0042861475 scopus 로고    scopus 로고
    • Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices
    • Endres, M., Hutmacher, D.W., Salgado, A.J., Kaps, C., Ringe, J., Reis, R.L., et al. Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices. Tissue Eng 9, 689, 2003.
    • (2003) Tissue Eng , vol.9 , pp. 689
    • Endres, M.1    Hutmacher, D.W.2    Salgado, A.J.3    Kaps, C.4    Ringe, J.5    Reis, R.L.6
  • 27
    • 0035094757 scopus 로고    scopus 로고
    • Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling
    • Hutmacher, D.W., Schantz, T., Zein, I., Ng, K.W., Teoh, S.H., Tan, K.C., et al. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 55, 203, 2001.
    • (2001) J Biomed Mater Res , vol.55 , pp. 203
    • Hutmacher, D.W.1    Schantz, T.2    Zein, I.3    Ng, K.W.4    Teoh, S.H.5    Tan, K.C.6
  • 28
    • 33644945469 scopus 로고    scopus 로고
    • Poly(epsilon-caprolactone)
    • Mark, J.E., ed. New York, NY: Oxford University Press Inc.
    • Iroh, J., and Mark, J. Poly(epsilon-caprolactone). In: Mark, J.E., ed. Polymer Data Handbook. New York, NY: Oxford University Press Inc., 1999, pp. 361-362.
    • (1999) Polymer Data Handbook , pp. 361-362
    • Iroh, J.1    Mark, J.2
  • 29
    • 0034672872 scopus 로고    scopus 로고
    • Scaffolds in tissue engineering bone and cartilage
    • Hutmacher, D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 21, 2529, 2000.
    • (2000) Biomaterials , vol.21 , pp. 2529
    • Hutmacher, D.W.1
  • 30
    • 11144279123 scopus 로고    scopus 로고
    • Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2
    • Rai, B., Teoh, S.H., Hutmacher, D.W., Cao, T., and Ho, K.H. Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2. Biomaterials 26, 3739, 2005.
    • (2005) Biomaterials , vol.26 , pp. 3739
    • Rai, B.1    Teoh, S.H.2    Hutmacher, D.W.3    Cao, T.4    Ho, K.H.5
  • 31
    • 0037657946 scopus 로고    scopus 로고
    • Engineering what comes naturally
    • Wozney, J.M., and Li, R.H. Engineering what comes naturally. Nat Biotechnol 21, 506, 2003.
    • (2003) Nat Biotechnol , vol.21 , pp. 506
    • Wozney, J.M.1    Li, R.H.2
  • 32
    • 39149143035 scopus 로고    scopus 로고
    • Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
    • Ai-Aql, Z.S., Alagl, A.S., Graves, D.T., Gerstenfeld, L.C., and Einhorn, T.A. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 87, 107, 2008.
    • (2008) J Dent Res , vol.87 , pp. 107
    • Ai-Aql, Z.S.1    Alagl, A.S.2    Graves, D.T.3    Gerstenfeld, L.C.4    Einhorn, T.A.5
  • 33
    • 61549132911 scopus 로고    scopus 로고
    • Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration
    • Kempen, D.H.R., Lu, L., Heijink, A., Hefferan, T.E., Creemers, L.B., Maran, A., et al. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 30, 2816, 2009.
    • (2009) Biomaterials , vol.30 , pp. 2816
    • Kempen, D.H.R.1    Lu, L.2    Heijink, A.3    Hefferan, T.E.4    Creemers, L.B.5    Maran, A.6
  • 34
    • 0041559960 scopus 로고    scopus 로고
    • Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein
    • Yamamoto, M., Takahashi, Y., and Tabata, Y. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 24, 4375, 2003.
    • (2003) Biomaterials , vol.24 , pp. 4375
    • Yamamoto, M.1    Takahashi, Y.2    Tabata, Y.3
  • 35
    • 0032992531 scopus 로고    scopus 로고
    • Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
    • Uludag, H., D'Augusta, D., Palmer, R., Timony, G., and Wozney, J. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J Biomed Mater Res 46, 193, 1999.
    • (1999) J Biomed Mater Res , vol.46 , pp. 193
    • Uludag, H.1    D'Augusta, D.2    Palmer, R.3    Timony, G.4    Wozney, J.5
  • 36
    • 0032773857 scopus 로고    scopus 로고
    • Rhbmp-collagen sponges as osteoinductive devices: Effects of in vitro sponge characteristics and protein pI on in vivo rhBMP pharmacokinetics
    • Uludag, H., Friess, W., Williams, D., Porter, T., Timony, G., D'Augusta, D., et al. rhBMP-collagen sponges as osteoinductive devices: effects of in vitro sponge characteristics and protein pI on in vivo rhBMP pharmacokinetics. Ann N Y Acad Sci 875, 369, 1999.
    • (1999) Ann N y Acad Sci , vol.875 , pp. 369
    • Uludag, H.1    Friess, W.2    Williams, D.3    Porter, T.4    Timony, G.5    D'Augusta, D.6
  • 37
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee, J., Son, M.J., Woolard, K., Donin, N.M., Li, A., Cheng, C.H., et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 13, 69, 2008.
    • (2008) Cancer Cell , vol.13 , pp. 69
    • Lee, J.1    Son, M.J.2    Woolard, K.3    Donin, N.M.4    Li, A.5    Cheng, C.H.6
  • 38
    • 34249744411 scopus 로고    scopus 로고
    • Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair
    • Rai, B., Oest, M.E., Dupont, K.M., Ho, K.H., Teoh, S.H., Guldberg, R.E., et al. Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. J Biomed Mater Res A 81, 888, 2007.
    • (2007) J Biomed Mater Res A , vol.81 , pp. 888
    • Rai, B.1    Oest, M.E.2    Dupont, K.M.3    Ho, K.H.4    Teoh, S.H.5    Guldberg, R.E.6
  • 39
    • 84885153948 scopus 로고    scopus 로고
    • Dusseldorf Germany: Springer Verlag
    • Narayan, R., ed. Biomedical Materials. Dusseldorf, Germany: Springer Verlag, 2009, 566p.
    • (2009) Biomedical Materials , pp. 566
    • Narayan, R.1
  • 42
    • 0032100625 scopus 로고    scopus 로고
    • Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats
    • Onishi, T., Ishidou, Y., Nagamine, T., Yone, K., Imamura, T., Kato, M., et al. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Bone 22, 605, 1998.
    • (1998) Bone , vol.22 , pp. 605
    • Onishi, T.1    Ishidou, Y.2    Nagamine, T.3    Yone, K.4    Imamura, T.5    Kato, M.6
  • 43
    • 0028787830 scopus 로고
    • Enhanced expression of type i receptors for bone morphogenetic proteins during bone formation
    • Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., et al. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. J Bone Miner Res 10, 1651, 1995.
    • (1995) J Bone Miner Res , vol.10 , pp. 1651
    • Ishidou, Y.1    Kitajima, I.2    Obama, H.3    Maruyama, I.4    Murata, F.5    Imamura, T.6
  • 44
    • 36248966424 scopus 로고    scopus 로고
    • Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells
    • Mehlhorn, A.T., Niemeyer, P., Kaschte, K., Muller, L., Finkenzeller, G., Hartl, D., et al. Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells. Cell Prolif 40, 809, 2007.
    • (2007) Cell Prolif , vol.40 , pp. 809
    • Mehlhorn, A.T.1    Niemeyer, P.2    Kaschte, K.3    Muller, L.4    Finkenzeller, G.5    Hartl, D.6
  • 45
    • 0029018646 scopus 로고
    • Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates
    • Cook, S.D., Wolfe, M.W., Salkeld, S.L., and Rueger, D.C. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg Am 77, 734, 1995.
    • (1995) J Bone Joint Surg Am , vol.77 , pp. 734
    • Cook, S.D.1    Wolfe, M.W.2    Salkeld, S.L.3    Rueger, D.C.4
  • 47
    • 0037162547 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
    • Street, J., Bao, M., deGuzman, L., Bunting, S., Peale, F.V., Ferrara, N., et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99, 9656, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9656
    • Street, J.1    Bao, M.2    Deguzman, L.3    Bunting, S.4    Peale, F.V.5    Ferrara, N.6
  • 48
    • 45549085001 scopus 로고    scopus 로고
    • Osteogenesis and angiogenesis: The potential for engineering bone
    • Kanczler, J.M., and Oreffo, R.O.C. Osteogenesis and angiogenesis: the potential for engineering bone. Eur Cell Mater 15, 100, 2008.
    • (2008) Eur Cell Mater , vol.15 , pp. 100
    • Kanczler, J.M.1    Oreffo, R.O.C.2
  • 49
    • 35348915916 scopus 로고    scopus 로고
    • Polycaprolactone-20% tricalcium phosphate scaffolds in combination with platelet-rich plasma for the treatment of critical-sized defects of the mandible: A pilot study
    • Rai, B., Ho, K.H., Lei, Y., Si-Hoe, K.M., Jeremy Teo, C.M., Yacob, K.B., et al. Polycaprolactone-20% tricalcium phosphate scaffolds in combination with platelet-rich plasma for the treatment of critical-sized defects of the mandible: a pilot study. J Oral Maxillofac Surg 65, 2195, 2007.
    • (2007) J Oral Maxillofac Surg , vol.65 , pp. 2195
    • Rai, B.1    Ho, K.H.2    Lei, Y.3    Si-Hoe, K.M.4    Jeremy Teo, C.M.5    Yacob, K.B.6
  • 50
    • 2342499807 scopus 로고    scopus 로고
    • The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds
    • Rai, B., Teoh, S.H., Ho, K.H., Hutmacher, D.W., Cao, T., Chen, F., et al. The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Biomaterials 25, 5499, 2004.
    • (2004) Biomaterials , vol.25 , pp. 5499
    • Rai, B.1    Teoh, S.H.2    Ho, K.H.3    Hutmacher, D.W.4    Cao, T.5    Chen, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.