Health economics: A cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7

Injury

Volumn 38, Issue 3, 2007, Pages 371-377

  Dahabreh, Ziad ^a   Dimitriou, Rozalia ^a   Giannoudis, Peter V ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Bone morphogenetic protein 7 (BMP 7); Cost analysis; Fracture non union; Health economics

Indexed keywords

OSTEOGENIC PROTEIN 1;

ADULT; AGED; ARTICLE; BONE TRANSPLANTATION; CLINICAL ARTICLE; CONTROLLED STUDY; COST BENEFIT ANALYSIS; FEMALE; FOLLOW UP; FRACTURE; HEALTH ECONOMICS; HOSPITAL COST; HOSPITALIZATION; HUMAN; MALE; MONOTHERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SURGICAL TECHNIQUE;

ADOLESCENT; ADULT; AGED; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE TRANSPLANTATION; COSTS AND COST ANALYSIS; DRUG COSTS; FEMALE; FRACTURE HEALING; FRACTURES, BONE; FRACTURES, UNUNITED; GREAT BRITAIN; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; REOPERATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33847303506     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injury.2006.08.055     Document Type: Article

References (34)

1. Ackerman S.J., Mafilios M.S., and Polly Jr. D.W. Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: an evidence-based modeling approach. Spine 27 (2002) 94-99
2. Arrington E.D., Smith W.J., Chambers H.G., et al. Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res 329 (1996) 300-309
3. Beaver R., Brinker M.R., and Barrack R.L. An analysis of the actual cost of tibial nonunions. J LA State Med Soc 149 (1997) 200-206
4. Braddock M., Houston P., Campbell C., et al. Born again bone: tissue engineering for bone repair. News Physiol Sci 16 (2001) 208-213
5. Brighton C.T., Friedenberg Z.B., Zemsky L.M., et al. Direct-current stimulation of non-union and congenital pseudarthrosis. Exploration of its clinical application. J Bone Joint Surg Am 57 (1975) 368-377
6. Brinker M.R. Nonunions: evaluation and treatment. In: Browner B.D., Jupiter J.B., Levine A.M., and Trafton P.G. (Eds). Skeletal trauma basic science management and reconstruction. 3rd ed. vol. I (2003), Saunders, Philadelphia, PA 507-604
7. Chapman M.W., Bucholz R., and Cornell C. Treatment of acute fractures with a collagen-calcium phosphate graft material. A randomized clinical trial. J Bone Joint Surg Am 79 (1997) 495-502
8. Connolly J. Symposium. Clinical application of bioelectric effects. Clin Orthop Relat Res 161 (1981) 2-162
9. Connolly J.F., Guse R., Tiedeman J., et al. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop Relat Res 266 (1991) 259-270
10. Cook S.D., Baffes G.C., Wolfe M.W., et al. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop Relat Res 301 (1994) 302-312
11. Cook S.D., Baffes G.C., Wolfe M.W., et al. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Joint Surg Am 76 (1994) 827-838
12. Cook S.D., Dalton J.E., Tan E.H., et al. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 19 (1994) 1655-1663
13. Cook S.D., and Rueger D.C. Osteogenic protein-1: biology and applications. Clin Orthop Relat Res 324 (1996) 29-38
14. Cook S.D., Wolfe M.W., Salkeld S.L., et al. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg Am 77 (1995) 734-750
15. Darder A., and Gomar F. A series of tibial fractures treated conservatively. Injury 6 (1975) 225-235
16. Fernyhough J.C., Schimandle J.J., Weigel M.C., et al. Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion. Spine 17 (1992) 1474-1480
17. Friedlaender G.E., Perry C.R., Cole J.D., et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 83 (2001) 151-158
18. Geesink R.G., Hoefnagels N.H., and Bulstra S.K. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J Bone Joint Surg Br 81 (1999) 710-718
19. Gustilo R.B., Mendoza R.M., and Williams D.N. Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma 24 (1984) 742-746
20. Heckman J.D., Ryaby J.P., McCabe J., et al. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am 76 (1994) 26-34
21. Heckman J.D., and Sarasohn-Kahn J. The economics of treating tibia fractures. The cost of delayed unions. Bull Hosp Joint Dis 56 (1997) 63-72
22. Jones A., Swiontkowski M., Polly D., et al. Use of rhBMP-2 in the treatment of open tibial shaft fractures: do improved outcomes outweigh the additional expense of rhBMP-2?. Proceedings of the 20th orthopaedic trauma association meeting (2004)
23. Khan S.N., Cammisa Jr. F.P., Sandhu H.S., et al. The biology of bone grafting. J Am Acad Orthop Surg 13 (2005) 77-86
24. Lieberman J.R., Daluiski A., and Einhorn T.A. The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am 84 (2002) 1032-1044
25. Netten A., Rees T., and Harrison G. Unit costs of health and social care 2001 (2001), Personal Social Services Research Unit, University of Kent
26. ®; 2001-2004.
27. Orthopaedic products price list & loaner reference guide, 2001-2004. Smith & Nephew; 2004.
28. Pharmacy cost references. Leeds, UK: St. James's University Hospital; 2004.
29. Polly Jr. D.W., Ackerman S.J., Shaffrey C.I., et al. A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion. Orthopedics 26 (2003) 1027-1037
30. Provider-Provider Tariff, 2004-2005. Service Agreement Department. Leeds, UK: Leeds Teaching Hospital NHS Trust; 2004.
31. Puno R.M., Teynor J.T., Nagano J., et al. Critical analysis of results of treatment of 201 tibial shaft fractures. Clin Orthop Relat Res 212 (1986) 113-121
32. St John T.A., Vaccaro A.R., Sah A.P., et al. Physical and monetary costs associated with autogenous bone graft harvesting. Am J Orthop 32 (2003) 18-23
33. ® (osteogenic protein 1) in the treatment of tibial nonunions in the UK and Germany. Poster, Sixth EFFORT congress; 2003.
34. Wiss D.A., and Stetson W.B. Tibial nonunion: treatment alternatives. J Am Acad Orthop Surg 4 (1996) 249-257