A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein-2: A potential treatment for infected bone defects

Journal of Orthopaedic Research

Volumn 24, Issue 3, 2006, Pages 327-332

  Suzuki, Akinobu ^a   Terai, Hidetomi ^a   Toyoda, Hiromitsu ^a   Namikawa, Takashi ^a   Yokota, Yoshiko ^b   Tsunoda, Takanori ^b   Takaoka, Kunio ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Antibiotics; Biodegradable delivery system; Bone defects; Human bone protein

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CEFAZOLIN; COPOLYMER; DIBEKACIN; MACROGOL; MINOCYCLINE; PHOSPHATE BUFFERED SALINE; POLYDIOXANONE; POLYGLUTAMIC ACID; POLYMER; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TEICOPLANIN; VANCOMYCIN; ANTIINFECTIVE AGENT; BONE MORPHOGENETIC PROTEIN; DRUG CARRIER; POLYGLACTIN; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; AUDITORY OSSICLE; BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; BIOLOGICAL ACTIVITY; BONE INFECTION; BONE REMODELING; CALVARIA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELUTION; FOLLOW UP; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; RAT STRAIN; SKULL DEFECT; SKULL RADIOGRAPHY; TREATMENT OUTCOME; ANIMAL; BONE REGENERATION; DISEASE MODEL; DRUG EFFECT; IMPLANT; INJURY; MICROBIOLOGICAL EXAMINATION; PATHOLOGY; SKULL; WISTAR RAT; WOUND HEALING;

ABSORBABLE IMPLANTS; ANIMALS; ANTI-BACTERIAL AGENTS; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; IMPLANTS, EXPERIMENTAL; MALE; MICROBIAL SENSITIVITY TESTS; OSSEOINTEGRATION; POLYGLACTIN 910; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SKULL; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 33645750961     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20049     Document Type: Article

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