Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions

Journal of Spinal Disorders and Techniques

Volumn 21, Issue 8, 2008, Pages 557-562

  Vaidya, Rahul ^a   Sethi, Anil ^a   Bartol, Stephen ^b   Jacobson, Mark ^b   Coe, Chad ^b   Craig, Joseph G ^b  

^a DETROIT RECEIVING HOSPITAL   (United States)

^b HENRY FORD HOSPITAL   (United States)

Author keywords

cage migration; PEEK cage; rhBMP 2; spinal fusion; subsidence

Indexed keywords

BONE MORPHOGENETIC PROTEIN; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ARTICLE; BONE PLATE; CLINICAL TRIAL; FEMALE; HUMAN; INSTRUMENTATION; JOINT INSTABILITY; MALE; MIDDLE AGED; PROSTHESIS FAILURE; RISK ASSESSMENT; SPINE FUSION;

ADULT; AGED; BONE MORPHOGENETIC PROTEINS; BONE PLATES; CHEMOTHERAPY, ADJUVANT; FEMALE; HUMANS; JOINT INSTABILITY; MALE; MIDDLE AGED; PROSTHESIS FAILURE; RECOMBINANT PROTEINS; RISK ASSESSMENT; SPINAL FUSION; TRANSFORMING GROWTH FACTOR BETA;

EID: 60849124256     PISSN: 15360652     EISSN: None     Source Type: Journal    
DOI: 10.1097/BSD.0b013e31815ea897     Document Type: Article

References (23)

1. Matge G. Cervical cage fusion with 5 different implants: 250 cases. Acta Neurochir. 2002;144:539-550.
2. Brantigan JW, Steffee AD. A carbon fiber implant to aid interbody lumbar fusion. Two year clinical results in the first 26 patients. Spine. 1993;18:2106-2117.
3. Cho DY, Lee WY, Sheu PC. Treatment of multilevel cervical fusion with cages. Surg Neurol. 2004;62:378-386.
4. Boakye M, Mummaneni PV, Garrett M, et al. Anterior cervical discectomy and fusion involving a polyetheretherketone spacer and bone morphogenetic protein. J Neurosurg Spine. 2005;2:521-525.
5. Toth JM, Wang M, Estes BT, et al. Polyetheretherketone as a biomaterial for spinal applications. Biomaterials. 2006;27:324-334.
6. Desogus N, Ennas F, Leuze R, et al. Posterior lumbar interbody fusion with PEEK cages: personal experience with 20 patients. J Neurosurg Sci. 2005;49:137-141.
7. Spruit M, Falk RG, Beckmann L, et al. The in vitro stabilizing effect of polyetheretherketone cages versus titanium cage of similar design for anterior lumbar interbody fusion. Eur Spine J. 2005;14:752-758.
8. Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg. 2003;85A:1544-1552.
9. Mummaneni PV, Pan J, Haid RW, et al. Contribution of recombinant human bone morphogenetic protein-2 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report. J Neurosurg (Spine 1). 2004;1:19-23.
10. Lane JM. Bone morphogenic protein science and studies. J Orthop Trauma. 2005;19(suppl):S17-S22.
11. Knippenberg M, Helder MN, Doulabi BZ, et al. Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells. Biochem Biophys Res Commun. 2006;342:902-908.
12. Otsuka E, Notoya M, Hagiwara H. Treatment of myoblastic C2C12 cells with BMP-2 stimulates vitamin D-induced formation of osteoclasts. Calcific Tissue Int. 2003;739:72-77.
13. Baskin DS, Ryan P, Sonntag V, et al. A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine. 2003;28:1219-1224.
14. Burkus JK, Transfeldt EE, Kitchel SH, et al. Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine. 2002;27:2396-2408.
15. Burkus JK, Sandhu HS, Gornet MF, et al. Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg. 2005;87-A:1205-1212.
16. Janssen ME, Lam C, Beckham R. Outcomes of allogenic cages in anterior and posterior lumbar interbody fusion. Eur Spine J. 2001;10(suppl 2):S158-S168.
17. Burkus JK. Bone morphogenetic proteins in anterior lumbar interbody fusion: old techniques and new technologies. J Neurosurg (Spine 1). 2004;3:254-260.
18. Sandhu HS. Bone morphogenetic proteins and spinal surgery. Spine. 2003;28(15S):S64-S73.
19. Kleeman TJ, Michael Ahn U, Talbot-Kleeman A. Laproscopic anterior lumbar interbody fusion with rhBMP-2: a prospective study of clinical and radiographic outcomes. Spine. 2001;26:2751-2756.
20. Pradhan BB, Bae HW, Dawson EG, et al. Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2. Spine. 2006;31:E277-E284.
21. Vaidya R, Carp J, Sethi A, et al. Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J. 2007;16:1257-1265.
22. Cho DY, Liau WR, Lee WY, et al. Preliminary experience using a Polyetheretherketone (PEEK) cage in the treatment of cervical disc disease. Neurosurgery. 2002;51:1343-1350.
23. Vaidya R, Weir R, Sethi A, et al. Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence. J Bone Joint Surg (Br). 2007;89-B:342-345.