Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway

Stem Cells and Development

Volumn 19, Issue 4, 2010, Pages 557-568

  Lee, Kyu Won ^a   Yook, Jin Yong ^a   Son, Mi Young ^a   Kim, Min Jeong ^a,b   Koo, Deog Bon ^c   Han, Yong Mahn ^d   Cho, Yee Sook ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Daegu University   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALIZARIN RED S; ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OCTAMER TRANSCRIPTION FACTOR 4; OSTEOCALCIN; OSTEONECTIN; OSTEOPROTEGERIN; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; SIALOPROTEIN; SMAD PROTEIN; TACROLIMUS; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; HUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN RECEPTORS; CELL DIFFERENTIATION; CELL LINE; CHROMONES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MORPHOLINES; OCTAMER TRANSCRIPTION FACTOR-3; OSTEOBLASTS; OSTEOGENESIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIROLIMUS; SMAD PROTEINS; TACROLIMUS;

EID: 77950603770     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2009.0147     Document Type: Article

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