Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells

Biochemical and Biophysical Research Communications

Volumn 280, Issue 3, 2001, Pages 874-877

  Maeda, T ^a   Matsunuma, A ^a   Kawane, T ^a   Horiuchi, N ^a  

^a OHU UNIVERSITY   (Japan)

Author keywords

Alkaline phosphatase; Bone morphogenetic protein 2; Collagenase 1; Mineralization; Osteoblast; Simvastatin

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT;

EID: 0034805319     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4232     Document Type: Article

References (16)

1. The prevention and treatment of osteoporosis
2. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton
3. Bone formation: Osteoblast lineage cells, growth factors, matrix proteins, and the mineralization process
4. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells
5. Hydrophilicity/lipophilicity: Relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors
6. Stimulation of bone formation in vitro and in rodents by statins
7. Insulin-like growth factor I suppresses parathyroid hormone (PTH)/PTH-related protein receptor expression via a mitogen-activated protein kinase pathway in UMR-106 osteoblast-like cells
8. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats
9. Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-101 BSP)
10. Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures
11. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts
12. Protein prenylation: Molecular mechanisms and functional consequences
13. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normo- cholesterolemic animals
14. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
15. Effects of basic fibroblast growth factor on bone formation in vitro
16. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability