Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system

Journal of Controlled Release

Volumn 147, Issue 2, 2010, Pages 193-201

  Choi, Dong Hoon ^a,b   Park, Chul Ho ^a   Kim, Ik Hwan ^b   Chun, Heung Jae ^c   Park, Kwideok ^a   Han, Dong Keun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

Alginate; Coaxial system; Core shell microcapsule; Dual growth factor delivery; PLGA; Stem cells

Indexed keywords

COAXIAL SYSTEMS; CORE-SHELL; GROWTH FACTOR DELIVERY; PLGA; STEM CELL;

ALGINATE; BIOMOLECULES; BONE; ENCAPSULATION; FEEDING; GENE EXPRESSION; HYDROGELS; NOZZLES; ORGANIC POLYMERS; PEPTIDES; POLYMER BLENDS; SHELLS (STRUCTURES);

STEM CELLS;

ALGINIC ACID; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; DEXAMETHASONE; OSTEOCALCIN; OSTEOPONTIN; POLYGLACTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HYDROGEL; MALE; MICROCAPSULE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; UPREGULATION; VOLUMETRY;

ALGINATES; ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; CAPSULES; CELL DIFFERENTIATION; CELL SURVIVAL; DEXAMETHASONE; DRUG CARRIERS; DRUG COMBINATIONS; DRUG COMPOUNDING; GENE EXPRESSION; GLUCURONIC ACID; HEXURONIC ACIDS; LACTIC ACID; MALE; MICROSCOPY, ELECTRON, SCANNING; OSTEOGENESIS; PARTICLE SIZE; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; STROMAL CELLS;

EID: 77957018566     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.07.103     Document Type: Article

References (27)

1. Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
2. Karsenty G. The complexities of skeletal biology. Nature 2003, 423:316-318.
3. Crotts G., Park T.G. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues. J. Microencapsul. 1998, 15:699-713.
4. Bae S.E., Choi D.H., Han D.K., Park K. Effect of temporally controlled release of dexamethasone on in vivo chondrogenic differentiation of mesenchymal stromal cells. J. Control. Rel. 2010, 143:23-30.
5. Solorio L.D., Fu A.S., Hernandez-Irizarry R., Alsberg E. Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-beta1 from incorporated polymer microspheres. J. Biomed. Mater. Res: Part A 2010, 92:1139-1144.
6. Chen R.R., Mooney D.J. Polymeric growth factor delivery strategies for tissue engineering. Pharm. Res. 2003, 20:1103-1112.
7. Richardson T.P., Peters M.C., Ennett A.B., Mooney D.J. Polymeric system for dual growth factor delivery. Nat. Biotech. 2001, 19:1029-1034.
8. Loscertales I.G., Barrero A., Guerrero I., Cortijo R., Marquez M., Ganan-Calvo A.M. Micro/nano encapsulation via electrified coaxial liquid jets. Science 2002, 295:1695-1698.
9. Hwang Y.K., Jeong U., Cho E.C. Production of uniform-sized polymer core-shell microcapsules by coaxial electrospraying. Langmuir 2008, 24:2446-2451.
10. Berkland C., Pollauf E., Pack D.W., Kim K. Uniform double-walled polymer microspheres of controllable shell thickness. J. Control. Rel. 2004, 96:101-111.
11. Kim B.S., Oh J.M., Kim K.S., Seo K.S., Cho J.S., Khang G.K., Lee H.B., Park K., Kim M.S. BSA-FITC-loaded microcapsule for in vivo delivery. Biomaterials 2009, 30:902-909.
12. Yeo Y., Park K.N. A new microencapsulation method using an ultrasonic atomizer based on interfacial solvent exchange. J. Control. Rel. 2004, 100:379-388.
13. Sun Z., Zussman E., Yarin A.L., Wendorff J.H. Compound core-shell polymer nanofibers by co-electrospinning. Adv. Mater. 2003, 1929-1932.
14. Xu J., Wang W., Ludeman M., Cheng K., Hayami T., Lotz J.C., Kapila S. Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels. Tissue Eng: Part A 2008, 14:667-680.
15. Ueng S.W.N., Lee M.S., Lin S., Chan E., Liu S. Development of a biodegradable alginate carrier system for antibiotics and bone cells. J. Ortho. Res. 2007, 25:62-72.
16. J. Li, R. Tao, W. Wu, H. Cao, J. Xin, J. Li, J. Guo, L. Jiang, C. Gao, A.A. Demetriou, D.L. Farkas, L. Li, 3D PLGA scaffolds improve differentiation and function of bone marrow mesenchymal stem cell-derived hepatocytes, Stem Cells Dev. 2010, doi:10.1089/scd.2009.0415.
17. Bae S.E., Son J.S., Park K., Han D.K. Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery. J. Control. Rel. 2009, 133:37-43.
18. Yuan Y., Chesnutt B.M., Utturkar G., Haggard W.O., Yang Y., Ong J.L., Bumgardner J.D. The effect of cross-linking of chitosan microspheres with genipin on protein release. Carbohydr. Polym. 2007, 68:561-567.
19. Chen H., Ouyang W., Lawuyi B., Prakash S. Genipin cross-linked alginate-chitosan microcapsules: membrane characterization and optimization of cross-linking reaction. Biomacromolecules 2006, 7:2091-2098.
20. Jay S.M., Saltzman W.M. Controlled delivery of VEGF via modulation of alginae microparticle ionic crosslinking. J. Control. Rel. 2009, 134:26-34.
21. Holland T.A., Tabata Y., Mikos A.G. Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J. Control. Rel. 2005, 101:111-125.
22. Jaklenec A., Hinckfuss A., Bilgen B., Ciombor D.M., Aaron R., Mathiowitz E. Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microsphere-based scaffolds. Biomaterials 2008, 29:1518-1525.
23. Kempen D.H.R., Lu L., Heijink A., Hefferan T.E., Creemers L.B., Maran A., Yaszemski M.J., Dhert W.J.A. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 2009, 30:2816-2825.
24. Discher D.E., Mooney D.J., Zandstra P.W. Growth factors, matrices, and forces combine and control stem cells. Science 2009, 324:1673-1677.
25. Willerth S.M., Faxel T.E., Gottlieb D.I., Sakiyama-Elbert S.E. The effects of soluble growth factors on embryonic stem cell differentiation inside of fibrin scaffolds. Stem Cells 2007, 25:2235-2244.
26. Young S., Patel Z.S., Kretlow J.D., Murphy M.B., Mountziaris P.M., Baggett L.S., Ueda H., Tabata Y., Jansen J.A., Wong M., Mikos A.G. Dose effect of dual delivery of vascular endothelial growth factor and bone morphogenetic protein-2 on bone regeneration in a rat critical-size defect model. Tissue Eng: Part A 2009, 15:2347-2362.
27. Solorio L.D., Fu A.S., Hernandez-Irizarry R., Alsberg E. Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-1 from incorporated polymer microspheres. J. Biomed. Mater. Res. 2010, 92A:1139-1144.