RhBMP-7 accelerates the healing in distal tibial fractures treated by external fixation

Journal of Bone and Joint Surgery - Series B

Volumn 89, Issue 2, 2007, Pages 265-272

  Ristiniemi, Jukka ^a   Flinkkila T ^a   Hyvonen P ^a   Lakovaara, M ^a   Pakarinen, H ^a   Jalovaara, P ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; RECOMBINANT OSTEOGENIC PROTEIN 1;

ABSENTEEISM; ADULT; AGED; ARTICLE; BONE DEFECT; CLINICAL ARTICLE; CONTROLLED STUDY; COW; DRUG DELIVERY SYSTEM; EXTERNAL FIXATOR; FOLLOW UP; FRACTURE EXTERNAL FIXATION; FRACTURE HEALING; HUMAN; ILIZAROV TECHNIQUE; MALE; MALLEOLUS FRACTURE; PRIORITY JOURNAL; RADIODIAGNOSIS; TIBIA FRACTURE; TREATMENT RESPONSE;

ADULT; AGED; BONE MORPHOGENETIC PROTEINS; COMBINED MODALITY THERAPY; EXTERNAL FIXATORS; FEMALE; FOLLOW-UP STUDIES; FRACTURE FIXATION; FRACTURE HEALING; FRACTURES, UNUNITED; HUMANS; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; REOPERATION; TIBIAL FRACTURES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 33947229511     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.89B2.18230     Document Type: Article

References (44)

1. McFerran MA, Smith SW, Boulas HJ, Schwartz HS. Complications encountered in the treatment of pilon fractures. J Orthop Trauma 1992;6:195-200.
2. Wyrsch B, McFerran MA, McAndrew M, et al. Operative treatment of fractures of the tibial plafond: a randomized, prospective study. J Bone Joint Surg [Am] 1996;78-A:1646-57.
3. Anglen JO. Early outcome of hybrid external fixation for fracture of the distal tibia. J Orthop Trauma 1999;13:92-7.
4. Pugh KJ, Wolinsky PR, McAndrew MP, Johnson KD. Tibial pilon fractures: a comparison of treatment methods. J Trauma 1999;47:937-41.
5. Cook SD, Rueger DC. Osteagenic protein-1: biology and applications. Clin Orthop 1996;324:29-38.
6. Matthews SJ. Biological activity of bone morphogenetic proteins (BMPs). Injury 2005;3(Suppl 3):34-7.
7. Einhorn TA. Clinical applications of recombinant human BMPs: early experience and future development. J Bone Joint Surg [Am] 2003;85-A(Suppl 3):82-8.
8. Termaat MF, Be Boer FC, Bakker FC, Patka P, Haarman HJ. Bone morphogenetic proteins: development and clinical efficacy in the treatment of fractures and bone defects. J Bone Joint Surg [Am] 2005;87-A:1367-78.
9. Cook SD, Patron LP, Salkeld SL, Rueger DC. Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs. J Bone Joint Surg [Am] 2003,85-A(Suppl 3):116-23.
10. Cook SD, Salkeld SL, Patron LP, Sargent MC, Rueger DC. Healing course of primate ulna segmental defects treated with osteogenic protein-1. J Invest Surg 2002;15:69-79.
11. Hyun SJ, Han DK, Choi SH, et al. Effect of recombinant human bone morphogenetic protein-2, -4, and -7 on bone formation in rat calvarial defects. J Periodontol 2005;76:1667-74.
12. Welch RD, Jones AL, Bucholz RW, et al. Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model. J Bone Miner Res 1998;13:1483-90.
13. de Boer FC, Bremer JA, Blokhuis TJ, et al. Effect of recombinant human osteogenic protein-1 on the healing of a freshly closed diaphyseal fracture. Bone 2002;31:158-64.
14. Grauer JN, Vaccaro AR, Kato M, et al. Development of a New Zealand white rabbit model of spinal pseudarthrosis repair and evaluation of the potential role of OP-1 to overcome pseudarthrosis. Spine 2004;29:1405-12.
15. Johnsson R, Stromqvist B, Aspenberg P. Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion. Spine 2002;27:2654-61.
16. Vaccaro AR, Anderson DG, Patel T, et al. Comparison of OP-1 Putty (rhBMP-7) to iliac crest autograft for posterolateral lumbar arthrodesis: a minimum 2-year follow-up pilot study. Spine 2005;30:2709-16.
17. Friedlander GE, Perry CR, Cole JD, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg [Am] 2001;83-A(Suppl 1):151-8.
18. Geesink RG, Hoefnagels NH, Bullstra SK. Osteogenic activity of OP-1 bone morphogenetic protein(BMP-7) in a human fibular defect. J Bone Joint Surg [Br] 1999;81-A:710-18.
19. Patel TC, Erulkar JS, Gruaer JN, et al. Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion. Spine 2001;26:1656-61.
20. McKee MD, Schemitsch EH, Waddell JR, et al. The effect of human recombinant bone morphogenetic protein (rhBMP-7) on the healing of open tibial shaft fractures: results of a multi-center, prospective, randomized clinical trial. Procs Annual Meeting American Academy of Orthopaedic Surgeons, 2003.
21. Müller ME, Nazarian S, Koch P, Schatzker J. The comprehensive classification of fractures of long bones. New York: Springer, 1990.
22. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg [Am] 1976,58-A:453-8.
23. Tornetta P 3rd, Weiner L, Bergman M, et al. Pilon fractures: treatment with combined internal and external fixation. J Orthop Trauma 1993;17:489-96.
24. Robinson CM, McLaughland G, Christie J, McQueen MM, Court-Brown CM. Tibial fractures with bone loss treated by primary reamed intramedullary nailing. J Bone Joint Surg [Br] 1995;77-B:906-13.
25. Green SA, Gibbs P. The relationship of angulation to translation in fracture deformities. J Bone Joint Surg [Am] 1994;76-A:390-7.
26. Lindsjo U, Danckwardt-Lilliestrom G, Sahlstedt B. Measurement of the motion range in the loaded ankle. Clin Orthop 1985; 199:68-71.
27. Paley D. Normal lower limb alignment and joint orientation. In: Paley D, ed. Principles of deformity correction. Berlin: Springer-Verlag, 2002:8-9.
28. Merchant TC, Dietz FR. Long-term follow-up after fractures of the tibial and fibular shafts. J Bone Joint Surg [Am] 1989;71-A:599-606.
29. Govender S, Csimma C, Genant HK. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of our hundred and fifty patients. J Bone Joint Surg [Am] 2002;84-A:2123-34.
30. Miniscalco P, Gambera D, Bertone C, et al. Healing of fresh tibial fractures with OP-1: a preliminary report. Acta Biomed Parmense 2002;73:27-33.
31. Teeny SM, Wiss DA. Open reduction and internal fixation of tibial plafond fractures: variables contributing to poor results and complications. Clin Orthop 1993;292:108-17.
32. Bone L, Stegemann P, McNamara K, Seibel R. External fixation of severely comminuted and open tibial pilon fractures. Clin Orthop 1993;292:101-7.
33. Marsh JL, Bonar S, Nopola JV, Decoster TA, Hurwitz SR. Use of an articulated external fixator for fractures of the tibial plafond. J Bone Joint Surg [Am] 1995;77-A:1498-509.
34. Court-Brown CM. Fractures of the tibia and fibula. In: Buckholz HW, Heckman JD, eds. Rockwood and Green's fractures in adults Fifth ed. Philadelphia: JB Lippincott Company, 2001:1939-2000.
35. Ristiniemi J, Flinkkilä T, Hyvönen P, et al. Two ring hybrid external fixation of distal tibial fractures: a review of 47 cases. J Trauma 2007;62:174-83.
36. Ramoshebi LN, Ripamonti U. Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick choriollantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-beta 1. Anat Rec 2000;259:97-107.
37. Cho TJ, Gersterdeld LC, Einhorn TA. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 2002;17:513-20.
38. Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg [Am] 2003;85-A:1544-52.
39. Watson JT, Kanges DE, Cramer KE, Moed BR. Analysis of failure of hybrid external fixation techniques for the treatment of distal tibial pilon fractures. Procs OTA meeting, 2000.
40. Worlock P, Slack R, Harvey L, Mawhinney R. The prevention of infection in open fractures: an experimental study of the effect of fracture stability. Injury 1994;25:31-8.
41. Watson JT, Anders M, Moed BR. Management strategies for bone loss in tibial shaft fractures. Clin Orthop 1995;315:138-52.
42. Whelan DB, Bhandari M, McKee MD, et al. Interobserver and intraobserver variation in the assessment of the healing of tibial fractures after intramedullary fixation. J Bone Joint Surg [Am] 2002;84-A:15-18.
43. Marsh JL, Weigel OP, Dirschl DR. Tibial plafond fractures: how do these ankles function over time? J Bone Joint Surg [Am]2003;85-A:287-95.
44. Vuoriainen T, Helenius M, Heikkila J, Olkkonen S. Falling accidents of pedestrians and cyclists in Espoo, Helsinki, Jyäaskylä and Oulu (Finnish National Road Administration Series 48/2000). http://alkotiehallininfo.fi/kulkaisot/pdf/3200634.pdf (Date last accessed March 27th 2001).