Functional restoration of critically sized segmental defects with bone morphogenetic protein-2 and heparin treatment

Clinical Orthopaedics and Related Research

Volumn 469, Issue 11, 2011, Pages 3111-3117

  Johnson, Mela R ^a   Boerckel, Joel D ^a   Dupont, Kenneth M ^a   Guldberg, Robert E ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; HEPARIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TISSUE SCAFFOLD;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOMECHANICS; BONE DEFECT; BONE GROWTH; BONE RADIOGRAPHY; BONE REGENERATION; BONE STRENGTH; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; FEMALE; FEMUR; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT;

EID: 84860390109     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-011-2012-x     Document Type: Conference Paper

References (26)

1. SD Boden 2005 The ABCs of BMPs Orthop Nurs. 24 49 52 15722975 10.1097/00006416-200501000-00014
2. H Cheng W Jiang FM Phillips RC Haydon Y Peng L Zhou HH Luu N An B Breyer P Vanichakarn JP Szatkowski JY Park TC He 2003 Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs) J Bone Joint Surg Am. 85 1544 1552 12925636
3. TM Chu SJ Warden CH Turner RL Stewart 2007 Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2 Biomaterials. 28 459 467 16996588 10.1016/j.biomaterials.2006.09.004 1:CAS:528:DC%2BD28XhtFeiu7rK
4. W Friess H Uludag S Foskett R Biron C Sargeant 1999 Characterization of absorbable collagen sponges as rhBMP-2 carriers Int J Pharm. 187 91 99 10502616 10.1016/S0378-5173(99)00174-X 1:CAS:528:DyaK1MXmt1SgsLg%3D
5. H Hosseinkhani M Yamamoto Y Inatsugu Y Hiraoka S Inoue H Shimokawa Y Tabata 2006 Enhanced ectopic bone formation using a combination of plasmid DNA impregnation into 3-D scaffold and bioreactor perfusion culture Biomaterials. 27 1387 1398 16139884 10.1016/j.biomaterials.2005.08.017 1:CAS:528: DC%2BD2MXht1Klu7fN
6. O Jeon SJ Song SW Kang AJ Putnam BS Kim 2007 Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold Biomaterials. 28 2763 2771 17350678 10.1016/j.biomaterials.2007.02.023 1:CAS:528:DC%2BD2sXjtVamurk%3D
7. O Jeon SJ Song HS Yang SH Bhang SW Kang MA Sung JH Lee BS Kim 2008 Long-term delivery enhances in vivo osteogenic efficacy of bone morphogenetic protein-2 compared to short-term delivery Biochem Biophys Res Commun. 369 774 780 18313401 10.1016/j.bbrc.2008.02.099 1:CAS:528:DC%2BD1cXjs12nsL4%3D
8. SE Kim O Jeon JB Lee MS Bae H-J Chun S-H Moon IK Kwon 2008 Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells J Biomed Sci. 15 771 777 18773307 10.1007/s11373-008-9277-4 1:CAS:528:DC%2BD1MXjs1Kgsw%3D%3D
9. SJ Lee 2000 Cytokine delivery and tissue engineering Yonsei Med J. 41 704 719 11204822 1:CAS:528:DC%2BD3MXhtVaru7w%3D
10. JR Lieberman A Daluiski TA Einhorn 2002 The role of growth factors in the repair of bone. Biology and clinical applications J Bone Joint Surg Am. 84 1032 1044 12063342
11. H Lin Y Zhao W Sun B Chen J Zhang W Zhao Z Xiao J Dai 2008 The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2 Biomaterials. 29 1189 1197 18083224 10.1016/j.biomaterials.2007.11.032 1:CAS:528: DC%2BD1cXnvVCjuw%3D%3D
12. ME Oest KM Dupont HJ Kong DJ Mooney RE Guldberg 2007 Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects J Orthop Res. 25 941 950 17415756 10.1002/jor.20372 1:CAS:528:DC%2BD2sXotFanur8%3D
13. A Peister ER Deutsch Y Kolambkar DW Hutmacher RE Guldberg 2009 Amniotic fluid stem cells produce robust mineral deposits on biodegradable scaffolds Tissue Eng A. 15 3129 3138 10.1089/ten.tea.2008.0536 1:CAS:528: DC%2BD1MXht1aqs73I
14. BD Porter AS Lin A Peister D Hutmacher RE Guldberg 2007 Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor Biomaterials. 28 2525 2533 17258311 10.1016/j.biomaterials.2007.01.013 1:CAS:528: DC%2BD2sXis1CrsLw%3D
15. B Rai ME Oest KM Dupont KH Ho SH Teoh RE Guldberg 2007 Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair J Biomed Mater Res A. 81 888 899 17236215
16. EH Riley JM Lane MR Urist KM Lyons 1996 Bone morphogenetic protein-2: biology and applications Clin Orthop Relat Res. 324 39 46 8595775 10.1097/00003086-199603000-00006
17. TK Sampath N Muthukumaran AH Reddi 1987 Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography Proc Natl Acad Sci USA. 84 7109 7113 3478684 10.1073/pnas.84.20. 7109 1:CAS:528:DyaL2sXmtlSjurs%3D
18. MF Sciadini KD Johnson 2000 Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model J Orthop Res. 18 289 302 10815831 10.1002/jor.1100180218 1:CAS:528:DC%2BD3cXjslSnur8%3D
19. T Takada T Katagiri M Ifuku N Morimura M Kobayashi K Hasegawa A Ogamo R Kamijo 2003 Sulfated polysaccharides enhance the biological activities of bone morphogenetic proteins J Biol Chem. 278 43229 43235 12912996 10.1074/jbc.M300937200 1:CAS:528:DC%2BD3sXosFSku74%3D
20. H Uludag D DAugusta J Golden J Li G Timony R Riedel JM Wozney 2000 Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: a correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model J Biomed Mater Res. 50 227 238 10679688 10.1002/(SICI)1097-4636(200005)50:2<227::AID-JBM18>3.0.CO;2-2 1:CAS:528:DC%2BD3cXhs1Wrt7o%3D
21. H Uludag T Gao TJ Porter W Friess JM Wozney 2001 Delivery systems for BMPs: factors contributing to protein retention at an application site J Bone Joint Surg Am 83 Suppl 1 S128 S135 11314790
22. M Von Walter C Herren TJ Gensior GC Steffens B Hermanns-Sachweh W Jahnen-Dechent M Rüger HJ Erli 2008 Biomimetic modification of the TiO(2)/glass composite Ecopore with heparinized collagen and the osteoinductive factor BMP-2 Acta Biomater. 4 997 1004 10.1016/j.actbio.2008.01.020
23. DA Wong A Kumar S Jatana G Ghiselli K Wong 2008 Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2) Spine. 8 1011 1018 10.1016/j.spinee.2007.06.014
24. JM Wozney 1989 Bone morphogenetic proteins Prog Growth Factor Res. 1 267 280 2491264 10.1016/0955-2235(89)90015-X 1:CAS:528:DyaK3cXhslGqtLk%3D
25. C Xie D Reynolds H Awad PT Rubery G Pelled D Gazit RE Guldberg EM Schwarz RJ OKeefe X Zhang 2007 Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering Tissue Eng. 13 435 445 17518596 10.1089/ten.2006.0182 1:CAS:528:DC%2BD2sXivVSlt70%3D
26. B Zhao T Katagiri H Toyoda T Takada T Yanai T Fukuda UI Chung T Koike K Takaoka R Kamijo 2006 Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2 J Biol Chem. 281 23246 23253 16754660 10.1074/jbc.M511039200 1:CAS:528:DC%2BD28XnvVWjur4%3D