How to achieve sustained and complete protein release from PLGA-based microparticles?

International Journal of Pharmaceutics

Volumn 350, Issue 1-2, 2008, Pages 14-26

  Giteau, A ^a,b   Venier Julienne, M C ^a,b   Aubert Pouessel A ^c   Benoit, J P ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ D'ANGERS   (France)

^c CNRS   (France)

Author keywords

In vitro release; Microspheres; Poly(lactic co glycolic acid) (PLGA); Protein; Release mechanism; Sustained release

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CHYMOTRYPSIN A; ERYTHROPOIETIN; GAMMA INTERFERON; INSULIN; INTERLEUKIN 18; LYSOZYME; MICROSPHERE; POLYGLACTIN; POLYMER; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; SOMATOMEDIN C; TETANUS TOXOID;

DRUG DELIVERY SYSTEM; DRUG FORMULATION; HYDROPHILICITY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN SECRETION; PROTEIN STABILITY; REVIEW; SUSTAINED DRUG RELEASE;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; POROSITY; PROTEIN FOLDING; PROTEINS; SOLUBILITY; VISCOSITY;

EID: 38549156628     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.11.012     Document Type: Review

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