Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans

Journal of Periodontology

Volumn 71, Issue 8, 2000, Pages 1241-1257

  Cochran, David L ^a   Jones, Archie A ^a   Lilly, Leslie Clark ^b   Fiorellini, Joseph P ^c   Howell, Howard ^c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b PFIZER INC   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Clinical trials; Dental implants, endosseous; Follow up studies; Growth factors; Protein, bone morphogenetic; Protein, differentiation; Protein, recombinant; Tooth extraction

Indexed keywords

BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; GELATIN SPONGE; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BIOPSY; BONE DENSITY; BONE DEVELOPMENT; BONE TRANSPLANTATION; CLINICAL TRIAL; DRUG EFFECT; FOLLOW UP; HUMAN; JAW; LONGITUDINAL STUDY; ORAL SURGERY; PATHOLOGY; PILOT STUDY; PROSPECTIVE STUDY; RADIOGRAPHY; SAFETY; TOOTH EXTRACTION; TOOTH IMPLANTATION; TOOTH RADIOGRAPHY; TOOTH SOCKET;

ALVEOLAR PROCESS; ALVEOLAR RIDGE AUGMENTATION; BIOPSY; BONE DENSITY; BONE MORPHOGENETIC PROTEINS; BONE TRANSPLANTATION; DENTAL IMPLANTATION, ENDOSSEOUS; DENTAL IMPLANTS; FOLLOW-UP STUDIES; GELATIN SPONGE, ABSORBABLE; HUMANS; LONGITUDINAL STUDIES; OSTEOGENESIS; PILOT PROJECTS; PROSPECTIVE STUDIES; RADIOGRAPHY, BITEWING; RECOMBINANT PROTEINS; SAFETY; TOOTH EXTRACTION; TOOTH SOCKET; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034242765     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2000.71.8.1241     Document Type: Article

References (28)

1. Cochran DL. Implant therapy. Ann Periodontol 1996; 1:707-790.
2. Nemcovsky CE, Serfaty V. Alveolar ridge preservation following tooth extraction of maxillary anterior teeth. Report on 23 consecutive cases. J Periodontol 1996;67: 390-395.
3. Boyne PJ, Mikels TE. Restoration of alveolar ridge by inframandibular transposition osseous grafting. J Oral Surg 1968;26:569-576.
4. Lekovic V, Kenney EB, Weinlaender M, et al. A bone regeneration approach to alveolar ridge maintenance following tooth extraction. J Periodontol 1997;68:563-570.
5. Lekovic V, Camargo PM, Klokkevold P, et al. Preservation of alveolar bone in extraction sockets using bioabsorable membranes. J Periodontol 1998;69:1044-1049.
6. Nyman S, Lang NP, Buser D, Bragger U. Bone regeneration adjacent to titanium dental implants using guided tissue regeneration: A report of two cases. Int J Oral Maxillofac Implants 1990;5:9-14.
7. Seibert J, Nyman S. Localized ridge augmentation in dogs: A pilot study using membrane and hydroxyapatite. J Periodontol 1990;61:157-165.
8. Simion M, Trisi P, Piattelli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodontics Restorative Dent 1994;14:497-511.
9. Buser, D, Dula K, Belser UC, Hirt H-P, Berthold H. Localized ridge augmentation using guided bone regeneration. Surgical procedure in the mandible. Int J Periodontics Restorative Dent 1995;15:11-29.
10. Simion M, Jovanovic SA, Trisi P, Scarano A, Piattelli A. Vertical ridge augmentation around dental implants using a membrane technique and autogenous bone or allografts in humans. Int J Periodontics Restorative Dent 1998;18:9-23.
11. Caffesse R, Nasjletti C, Morrison E, Sanchez R. Guided tissue regeneration: Comparison of bioabsorable and non-bioabsorable membranes. Histologic and histometric study in dogs. J Periodontol 1994;65:583-591.
12. Mellonig J, Nevins M, Sanchez R. Evaluation of a bioabsorable physical barrier for guided bone regeneration. Part II. Material and a bone replacement graft. Int J Periodontics Restorative Dent 1998;18:138-149.
13. Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-1534.
14. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000 1999;19:40-58.
15. Toriumi DM, Kotler HS, Luxenberg DP, Holtrop ME, Wang EA. Mandibular reconstruction with a recombinant bone-inducing factor. Arch Otolaryngol Head Neck Surg 1991; 117:1101-1112.
16. Cochran DL, Schenk R, Buser D, Wozney JM, Jones AA. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. J Periodontol 1999;70:139-150.
17. Hanisch O, Tatakis DN, Boskovic MM, Rohrer MD, Wikesjö UME. Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2. Int J Oral Maxillofac Implants 1997;12: 604-610.
18. Hanisch O, Tatakis DN, Rohrer MD, Wöhrle PS, Wozney JM, Wikesjö UME. Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. Int J Oral Maxillofac Implants 1997;12:785-792.
19. Nevins M, Kirker-Head C, Wozney JM, Palmer R, Graham D. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int J Periodontics Restorative Dent 1996;16:9-19.
20. Sigurdsson TJ, Fu E, Tatakis DN, Rohrer MD, Wikesjö UME. Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clin Oral Implants Res 1997;8:367-374.
21. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 1997;17:11-25.
22. Ishikawa I, Kinoshsita A, Oda S, Roongruanphol T. Regenerative therapy in periodontal diseases. Histological observations after implantation of rhBMP-2 in the surgically created periodontal defects in dogs. Dent Jpn 1994;31:141-146.
23. King GN, King N, Cruchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997;76:1460-1470.
24. Kinoshita A, Oda S, Takahashi K, Yokota S, Ishikawa I. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. J Periodontol 1997;68:103-109.
25. Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjö UME. Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 1995; 66:131-138.
26. Howell TH, Fiorellini J, Jones A, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int J Periodontics Restorative Dent 1997;17:124-139.
27. Jaffin RA, Berman CL. The excessive bone loss of Brånemark fixtures in type IV bone. A 5-year analysis. J Periodontol 1991:62:2-4.
28. Cochran DL, Jones A, De La Fontaine J, et al. Periodontal regeneration and localized osseous regeneration in the oral cavity. In: Lynch SE, Genco RJ, Marx RE, eds. Tissue Engineering, Applications in Maxillofacial Surgery and Periodontics. Chicago: Quintessence Publishing Co., Inc.; 1999:245-257.