Stimulation of bone formation in vitro and in rodents by statins

Science

Volumn 286, Issue 5446, 1999, Pages 1946-1949

  Mundy, G ^a   Garrett, R ^a   Harris, S ^b   Chan, J ^a   Chen, D ^a   Rossini, G ^a   Boyce, B ^b   Zhao, M ^a   Gutierrez, G ^a  

^a OsteoScreen   (United States)

^b Univ of Texas Health Science Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; BONE MORPHOGENETIC PROTEIN 2; COMPACTIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; MEVINOLIN; PARATHYROID HORMONE[1-34]; RECOMBINANT FIBROBLAST GROWTH FACTOR; SIMVASTATIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION; NONHUMAN; ORAL DRUG ADMINISTRATION; OSSIFICATION; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BONE DENSITY; BONE MORPHOGENETIC PROTEINS; CELL LINE; FEMALE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MALE; MICE; MICE, INBRED ICR; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOPOROSIS; OVARIECTOMY; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT PROTEINS; SIMVASTATIN; SKULL; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033521078     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5446.1946     Document Type: Article

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