Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant

Biomaterials

Volumn 26, Issue 25, 2005, Pages 5145-5152

  Yoneda, Masahiro ^a   Terai, Hidetomi ^a   Imai, Yuuki ^a   Okada, Takao ^b   Nozaki, Kazutoshi ^c   Inoue, Hikaru ^d   Miyamoto, Shimpei ^a   Takaoka, Kunio ^a  

^a School of Medicine   (Japan)

^b Taki Chemical Co Ltd   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

^d OLYMPUS CORPORATION   (Japan)

Author keywords

Biodegradation; BMP (bone morphogenetic protein); Bone tissue engineering; Calcium phosphate; Drug delivery; Osteoconduction

Indexed keywords

BIODEGRADATION; BIOMECHANICS; BLOCK COPOLYMERS; CARBOXYLIC ACIDS; COMPOSITE MATERIALS; IMPLANTS (SURGICAL); KETONES; POLYETHYLENE GLYCOLS; POROUS MATERIALS; PROTEINS; RADIOGRAPHY;

BONE DEFECTS; OSTEOGENIC BIOMATERIALS; P-DIOXANONE; POLY-D,L-LACTIC ACID;

BONE;

BIOMATERIAL; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE; KETONE DERIVATIVE; MACROGOL; POLYLACTIC ACID; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABLE IMPLANT; BIOMECHANICS; BONE DEFECT; BONE RADIOGRAPHY; BONE REGENERATION; BONE REMODELING; COMPOSITE MATERIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMUR; FRACTURE HEALING; HISTOLOGY; IMPLANTATION; LONG BONE; MECHANICS; NONHUMAN; PRIORITY JOURNAL; RABBIT; THREE DIMENSIONAL IMAGING; TREATMENT OUTCOME;

ABSORBABLE IMPLANTS; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOMECHANICS; BONE MORPHOGENETIC PROTEINS; BONY CALLUS; CALCIUM PHOSPHATES; DENSITOMETRY, X-RAY; FEMORAL FRACTURES; FEMUR; FRACTURE HEALING; GUIDED TISSUE REGENERATION; HUMANS; LACTATES; OSTEOGENESIS; POLYDIOXANONE; POLYETHYLENE GLYCOLS; RABBITS; RECOMBINANT PROTEINS; TOMOGRAPHY, SPIRAL COMPUTED; TRANSFORMING GROWTH FACTOR BETA;

ORYCTOLAGUS CUNICULUS;

EID: 15344347281     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2005.01.054     Document Type: Article

References (27)

1. T.W. Bauer, and G.F. Muschler Bone graft materials An overview of the basic science. Clin Orthop 371 2000 10 27
2. A.S. Greenwald, S.D. Boden, V.M. Goldberg, Y. Khan, C.T. Laurencin, and R.N. Rosier Bone-graft substitutes: fact, fictions & applications J Bone Joint Surg Am 83 Suppl 2 2001 98 103
3. H.A. Hoogendoorn, W. Renooij, L.M.A. Akkermanns, D.D.S. Visser, and P. Wittebol Long-term study of large ceramic implants in dog femora Clin Orthop 187 1984 281 288
4. M. Ozawa Experimental study on bone conductivity and absorbability of the pure β-TCP J Jpn Soc Biomater 13 1995 167 175
5. J.D. Debruijn, Y.P. Bovell, J.E. Davies, and C.A. Vanblitterswijk Osteoclastic resorption of calcium phosphate is potentiated in postosteogenic culture conditions J Biomed Mater Res 28-1 1994 105 112
6. J. Dong, H. Kojima, T. Uemura, M. Kikuchi, T. Tateishi, and J. Tanaka In vivo evaluation of a novel porous hydroxyapatite to sustain osteogenesis of transplanted bone marrow-derived osteoblastic cells J Biomed Mater Res 57-2 2001 208 216
7. J.R. Lieberman, A. Daluiski, and T.A. Einhorn The role of growth factors in the repair of bone. Biology and clinical application J Bone Jt Surg Am 84-A6 2002 1032 1044
8. A.W.A. Baltzer, C. Lattermann, J.D. Whalen, P. Wooley, K. Weiss, M. Grimm, S.C. Ghivizzani, P.D. Robbins, and C.H. Evans Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene Gene Therapy 7-9 2000 734 739
9. E.A. Wang, V. Rosen, J.S. D'Alessandro, M. Bauduy, P. Cordes, T. Harada, and D.I. Israel Recombinant human bone morphogenetic protein induces bone formation Proc Natl Acad Sci USA 87 1990 2220 2224
10. K. Takaoka, H. Nakahara, H. Yoshikawa, K. Masuhara, T. Tsuda, and K. Ono Ectopic Bone Induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein Clin Orthop 234 1988 250 254
11. A.G. Zabka, G.E. Pluhar, R.B. Edwards, P.A. Manley, K. Hayashi, J.P. Heiner, V.L. Kalscheur, H.J. Seeherman, and M.D. Markel Histomorphometric description of allograft bone remodeling and union in a canine segmental femoral defect model: a comparison of rhBMP-2, cancellous bone graft, and absorbable collagen sponge J Orthop Res 19-2 2001 318 327
12. C. Jeppsson, M. Bostrom, and P. Aspenberg Intraosseous BMP implants in rabbits - Inhibitory effect on bone formation Acta Orthop Scad 70-1 1999 77 83
13. N. Saito, T. Okada, S. Toba, S. Miyamoto, and K. Takaoka New synthetic absorbable polymers as BMP carriers: plastic properties of poly-d,l-lactic acid-polyethylene glycol block copolymers J Biomed Mater Res 47-1 1999 104 110
14. N. Saito, T. Okada, H. Horiuchi, N. Murakami, J. Takahashi, M. Nawata, H. Ota, K. Nozaki, and K. Takaoka A biodegradable polymer as a cytokine delivery system for inducing bone formation Nat Biotechnol 19-4 2001 332 335
15. N. Saito, T. Okada, H. Horiuchi, N. Murakami, J. Takahashi, M. Nawata, H. Ota, S. Miyamoto, K. Nozaki, and K. Takaoka Biodegradable poly-d,l-lactic acid-polyethylene glycol block copolymers as a BMP delivery system for inducing bone J Bone Jt Surg Am 83-A Suppl 1-Pt 2 2001 S92 S98
16. N. Saito, T. Okada, H. Horiuchi, H. Ota, J. Takahashi, N. Murakami, M. Nawata, S. Kojima, K. Nozaki, and K. Takaoka Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers Bone 32-4 2003 381 386
17. N. Murakami, N. Saito, H. Horiuchi, T. Okada, K. Nozaki, and K. Takaoka Repair of segmental defects in rabbit humeri with titanium fiber mesh cylinders containing recombinant human bone morphogenetic protein-2 (rhBMP-2) and a synthetic polymer J Biomed Mater Res 62-2 2002 169 174
18. N. Murakami, N. Saito, J. Takahashi, H. Ota, H. Horiuchi, M. Nawata, T. Okada, K. Nozaki, and K. Takaoka Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier Biomaterials 24-13 2003 2153 2159
19. M.H. Crigel, and M. Balligand Critical size defect model on the femur in rabbits Vet Comp Orthop Traumatol 3 2002 158 163
20. N. Matsushita, H. Terai, T. Okada, K. Nozaki, H. Inoue, S. Miyamoto, and K. Takaoka A new bone-inducing biodegradable porous beta-tricalcium phosphate J Biomed Mater Res 70A-3 2004 450 458
21. C.A. Kirkerhead, T.N. Gerhart, S.H. Schelling, G.E. Hennig, E. Wang, and M.E. Holtrop Long-term healing of bone using recombinant human bone morphogenetic protein 2 Clin Orthop 318 1995 222 230
22. M.R. Urist, A. Lietze, and E. Dawson β-tricalcium phosphate delivery system for bone morphogenetic protein Clin Orthop 187 1983 277 280
23. M.R. Urist, O. Nilsson, J. Rasmussen, W. Hirota, T. Lovell, T. Schmalzreid, and G.A. Finerman Bone regeneration under the influence of a bone morphogenetic protein (BMP) beta tricalcium phosphate (TCP) composite in skull trephine defects in dogs Clin Orthop 214 1987 295 304
24. P. Laffargue, H.F. Hildebrand, M. Rtaimate, P. Frayssinet, J.P. Amoureux, and X. Marchandise Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects Bone 25-2 Suppl 1999 55S 58S
25. S. Jingushi, K. Urabe, K. Okazaki, G. Hirata, A. Sakai, T. Ikenoue, and Y. Iwamoto Intramuscular bone induction by human recombinant bone morphogenetic protein-2 with beta-tricalcium phosphate as a carrier: in vivo bone banking for muscle-pedicle autograft J Orthop Sci 7-4 2002 490 494
26. S. Yamada, D. Heymann, J.M. Bouler, and G. Daculsi Osteoclast resorption of calcium phosphate ceramics with different hydroxyapatite/β-tricalcium phosphate ratios Biomaterials 18 1997 1037 1041
27. H. Kaneko, T. Arakawa, H. Mano, T. Kaneda, A. Ogasawara, M. Nakagawa, Y. Toyama, Y. Yabe, M. Kumegawa, and Y. Hakeda Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts Bone 27 2000 479 486