The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery

Artificial Organs

Volumn 34, Issue 12, 2010, Pages 1150-1153

  La, Wan Geun ^a   Kang, Sun Woong ^b   Yang, Hee Seok ^b   Bhang, Suk Ho ^a   Lee, Sun Hwa ^c   Park, Jung Ho ^c   Kim, Byung Soo ^a  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

^c Korea University College of Medicine   (South Korea)

Author keywords

BMP 2 delivery; Bone formation; Fibrin gel; Heparin conjugated poly(lactic co glycolic acid) nanosphere

Indexed keywords

BONE; NANOSPHERES; PROTEINS;

BONE FORMATION; BONE MORPHOGENETIC PROTEIN-2; BONE MORPHOGENETIC PROTEIN-2 DELIVERY; BONE REGENERATION; DELIVERY SYSTEMS; FIBRIN GELS; HEPARIN-CONJUGATED POLY(LACTIC-CO-GLYCOLIC ACID) NANOSPHERE; ORTHOTOPIC; POLY LACTIC-CO-GLYCOLIC ACID; POLY(LACTIC-CO-GLYCOLIC ACID);

POLYSACCHARIDES;

BONE MORPHOGENETIC PROTEIN 2; FIBRIN; HEPARIN; NANOSPHERE; POLYGLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; IMPLANTATION; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; OSSIFICATION; PRIORITY JOURNAL;

EID: 78650038240     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2009.00988.x     Document Type: Article

References (17)

1. Derner R, Anderson AC. The bone morphogenic protein. Clin Podiatr Med Surg 2005;22:607-18.
2. Kanakaris NK, Giannoudis PV. Clinical applications of bone morphogenetic proteins: current evidence. J Surg Orthop Adv 2008;17:133-46.
3. Bessa PC, Casal M, Reis RL. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen Med 2008;2:81-96.
4. Issa JP, Bentley MV, Iyomasa MM, Sebald W, Albuquerque RF. Sustained release carriers used to deliver bone morphogenetic proteins in the bone healing process. Anat Histol Embryol 2008;37:181-7.
5. Jovanovic SA, Hunt DR, Bernard GW, et al. Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clin Oral Implants Res 2007;18:224-30.
6. Visser R, Arrabal PM, Becerra J, Rinas U, Cifuentes M. The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo. Biomaterials 2009;30:2032-37.
7. Ristiniemi J, Flinkkilä T, Hyvönen P, et al. RhBMP-7 accelerates the healing in distal tibial fractures treated by external fixation. J Bone Joint Surg Br 2007;89:265-72.
8. Shields LB, Raque GH, Glassman SD, et al. Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 2006;31:542-7.
9. Takahashi Y, Yamamoto M, Tabata Y. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate. Biomaterials 2005;26:4856-65.
10. Jeon O, Song SJ, Kang SW, Putnam AJ, Kim BS. Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(l-lactic-co-glycolic acid) scaffold. Biomaterials 2007;28:2763-71.
11. Jeon O, Song SJ, Yang HS, et al. Long-term delivery enhances in vivo osteogenic efficacy of bone morphogenetic protein-2 compared to short-term delivery. Biochem Biophys Res Commun 2008;369:774-80.
12. Zhao B, Katagiri T, Toyoda H, Takada T, et al. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 2006;281:23246-53.
13. Jeon O, Kang SW, Lim HW, Hyung Chung J, Kim BS. Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(l-lactide-co-glycolide) nanospheres and fibrin gel. Biomaterials 2006;27:1598-607.
14. Zhao J, Shinkai M, Takezawa T, et al. Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2. J Biosci Bioeng 2009;107:318-23.
15. Fu YC, Nie H, Ho ML, Wang CK, Wang CH. Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol Bioeng 2008;99:996-1006.
16. Freilich M, Patel C, Wei M, et al. Growth of new bone guided by implants in a murine calvarial model. Bone 2008;43:781-8.
17. Karageorgiou V, Tomkins M, Fajardo R, et al. Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo. J Biomed Mater Res A 2006;78:324-34.