Enhancement of in vivo bone regeneration efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells

Journal of Biomedical Materials Research - Part A

Volumn 93, Issue 2, 2010, Pages 666-672

  Kang, Jin Muk ^a   Kang, Sun Woong ^a   La, Wan Geun ^a   Yang, Yoon Sun ^b   Kim, Byung Soo ^a  

^a Hanyang University   (South Korea)

^b MEDIPOST Co Ltd   (South Korea)

Author keywords

BMP 2; Bone regeneration; Human cord blood mesenchymal stem cells; Osteogenic differentiation; Scaffold; Tissue engineering

Indexed keywords

ATHYMIC MICE; BONE FORMATION; BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; CORD BLOOD; GROUP 4; HISTOLOGICAL ANALYSIS; HOST CELLS; IN-VITRO; IN-VIVO; MESENCHYMAL STEM CELL; MRNA EXPRESSION; OSTEOCALCIN; OSTEOGENIC DIFFERENTIATION; PLGA/HA; POLY(LACTIC-CO-GLYCOLIC ACID); RT-PCR ANALYSIS;

BLOOD; BONE; CELL CULTURE; HYDROXYAPATITE; STEM CELLS; TISSUE ENGINEERING;

SCAFFOLDS;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; HYDROXYAPATITE; OSTEOCALCIN; POLYGLACTIN; TISSUE SCAFFOLD;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; CELL DIFFERENTIATION; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; GENE EXPRESSION; HISTOLOGY; HOST CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOGENICALLY UNDIFFERENTIATED HUMAN CORD BLOOD MESENCHYMAL STEM CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS TISSUE; UMBILICAL CORD BLOOD;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL MARKERS; BONE REGENERATION; CELL DIFFERENTIATION; CELLS, CULTURED; DURAPATITE; FEMALE; FETAL BLOOD; HUMANS; IMPLANTS, EXPERIMENTAL; LACTIC ACID; MATERIALS TESTING; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; OSTEOBLASTS; OSTEOGENESIS; POLYGLYCOLIC ACID; RNA, MESSENGER; SURFACE PROPERTIES; TISSUE SCAFFOLDS;

EID: 77950278578     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32282     Document Type: Article

References (34)

1. Bieback K, Kern S, Kluter H, Eichler H. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells 2004;22:625-634.
2. Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000;109:235-242.
3. Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA. Multilineage differentiation activity by cells isolated from umbilical cord blood: Expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 2001;7:581-588.
4. Kogler G, Sensken S, Airey JA, Trapp T, Muschen M, Feldhahn N, Liedtke S, Sorg RV, Fischer J, Rosenbaum C, Greschat S, Knipper A, Bender J, Degistirici O, Gao J, Caplan AI, Colletti EJ, Almeida-Porada G, Muller HW, Zanjani E, Wernet P. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004;200:123-135.
5. Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004;103:1669-1675.
6. Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE. Stored placental blood for unrelated bone marrow reconstitution. Blood 1993;81:1679-1690.
7. Mayani H, Lansdorp PM. Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Blood 1994;83:2410-2417.
8. Bradstock KF, Hertzberg MS, Kerridge IH, Svennilson J, McGurgan M, Huang G, Antonenas V, Gottlieb DJ. Unrelated umbilical cord blood transplantation for adults with haematological malignancies: Results from a single Australian centre. Intern Med J 2006;36:355-361.
9. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294-1301.
10. Kogler G, Sensken S, Wernet P. Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood. Exp Hematol 2006;34:1589-1595.
11. Yang SE, Ha CW, Jung M, Jin HJ, Lee M, Song H, Choi S, Oh W, Yang YS. Mesenchymal stem/progenitor cells developed in cultures from UC blood. Cytotherapy 2004;6:476-486.
12. Jager M, Degistirici O, Knipper A, Fischer J, Sager M, Krauspe R. Bone healing and migration of cord blood-derived stem cells into a critical size femoral defect after xenotransplantation. J Bone Miner Res 2007;22:1224-1233.
13. Ito C, Evans WE, McNinch L, Coustan-Smith E, Mahmoud H, Pui CH, Campana D. Comparative cytotoxicity of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. J Clin Oncol 1996;14:2370-2376.
14. Rauch F, Lauzier D, Croteau S, Travers R, Glorieux FH, Hamdy R. Temporal and spatial expression of bone morphogenetic protein-2, -4, and -7 during distraction osteogenesis in rabbits. Bone 2000;27:453-459.
15. Katagiri T, Yamaguchi A, Ikeda T, Yoshiki S, Wozney JM, Rosen V, Wang EA, Tanaka H, Omura S, Suda T. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 1990;172:295-299.
16. Wang EA, Israel DI, Kelly S, Luxenberg DP. Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 1993;9:57-71.
17. Puleo DA. Dependence of mesenchymal cell responses on duration of exposure to bone morphogenetic protein-2 in vitro. J Cell Physiol 1997;173:93-101.
18. Gerhart TN, Kirker-Head CA, Kriz MJ, Holtrop ME, Hennig GE, Hipp J, Schelling SH, Wang E. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop Relat Res 1993;293:317-326.
19. Muschler GF, Hyodo A, Manning T, Kambic H, Easley K. Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin Orthop Relat Res 1994;308:229-240.
20. Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg Am 1992;74:659-670.
21. Kim SS, Ahn KM, Park MS, Lee JH, Choi CY, Kim BS. A poly(lactide-co- glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity. J Biomed Mater Res A 2007;80:206-215.
22. Kim SS, Sun Park M, Jeon O, Yong Choi C, Kim BS. Poly (lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials 2006;27:1399-1409.
23. Liu TY, Chen SY, Liu DM, Liou SC. On the study of BSAloaded calcium-deficient hydroxyapatite nano-carriers for controlled drug delivery. J Control Release 2005;107:112-121.
24. Matsumoto T, Okazaki M, Inoue M, Yamaguchi S, Kusunose T, Toyonaga T, Hamada Y, Takahashi J. Hydroxyapatite particles as a controlled release carrier of protein. Biomaterials 2004;25:3807-3812.
25. Mizushima Y, Ikoma T, Tanaka J, Hoshi K, Ishihara T, Ogawa Y, Ueno A. Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs. J Control Release 2006;110:260-265.
26. Kim SS, Park MS, Gwak SJ, Choi CY, Kim BS. Accelerated bonelike apatite growth on porous polymer/ceramic composite scaffolds in vitro. Tissue Eng 2006;12:2997-3006.
27. Jeon O, Rhie JW, Kwon IK, Kim JH, Chung HM, Kim BS, Lee SH. In vivo bone formation following transplantation of human adipose-derived stromal cells that are not differentiated osteogenically. Tissue Eng 2008;14:1285-1294.
28. Kim SS, Gwak SJ, Kim BS. Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/ hydroxyapatite composite particulates and bone morphogenetic protein-2. J Biomed Mater Res A 2008;87:245-253.
29. Sun JS, Chang WH, Chen LT, Huang YC, Juang LW, Lin FH. The influence on gene-expression profiling of osteoblasts behavior following treatment with the ionic products of sintered beta-dicalcium pyrophosphate dissolution. Biomaterials 2004;25:607-616.
30. Malaval L, Modrowski D, Gupta AK, Aubin JE. Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures. J Cell Physiol 1994;158:555-572.
31. Conejero JA, Lee JA, Parrett BM, Terry M, Wear-Maggitti K, Grant RT, Breitbart AS. Repair of palatal bone defects using osteogenically differentiated fat-derived stem cells. Plast Reconstr Surg 2006;117:857-863.
32. Yoon E, Dhar S, Chun DE, Gharibjanian NA, Evans GR. In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model. Tissue Eng 2007;13:619-627.
33. Flautre B, Anselme K, Delecourt C, Lu J, Hardouin P, Descamps M. Histological aspects in bone regeneration of an association with porous hydroxyapatite and bone marrow cells. J Mater Sci Mater Med 1999;10:811-814.
34. Yoshikawa T, Ohgushi H, Akahane M, Tamai S, Ichijima K. Analysis of gene expression in osteogenic cultured marrow/hydroxyapatite construct implanted at ectopic sites: A comparison with the osteogenic ability of cancellous bone. J Biomed Mater Res 1998;41:568-573.