Molecular and Neural Control of Insect Circadian Rhythms

Insect Molecular Biology and Biochemistry

Volumn , Issue , 2012, Pages 513-551

  Zhang, Yong ^a   Emery, Patrick ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84865285750     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-384747-8.10015-7     Document Type: Chapter

References (344)

1. Abraham G., Muraleedharan D. Role of corpus allatum on the modulation of feeding rhythm in the semilooper caterpillar, Achaea janata (L). Chronobiol. Intl. 1990, 7:419-424.
2. Akten B., Jauch E., Genova G.K., Kim E.Y., Edery I., et al. A role for CK2 in the Drosophila circadian oscillator. Nat. Neurosci. 2003, 6:251-257.
3. Akten B., Tangredi M.M., Jauch E., Roberts M.A., Ng F., et al. Ribosomal s6 kinase cooperates with casein kinase 2 to modulate the Drosophila circadian molecular oscillator. J. Neurosci. 2009, 29:466-475.
4. Allada R., White N.E., So W.V., Hall J.C., Rosbash M. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 1998, 93:791-804.
5. Antoch M.P., Song E.-J., Chang A.-M., Vitaterna M.H., Zhao Y., et al. Functional identification of the mouse circadian clock gene by transgenic BAC rescue. Cell 1997, 89:655-667.
6. Bae K., Lee C., Sidote D., Chuang K.Y., Edery I. Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators. Mol. Cell Biol. 1998, 18:6142-6151.
7. Bae K., Jin X., Maywood E.S., Hastings M.H., Reppert S.M., Weaver D.R. Differential functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron 2001, 30:525-536.
8. Baggs J.E., Green C.B. Nocturnin, a deadenylase in Xenopus laevis retina: A mechanism for posttranscriptional control of circadian-related mRNA. Curr. Biol. 2003, 13:189-198.
9. Bargiello T.A., Jackson F.R., Young M.W. Restoration of circadian behavioural rhythms by gene transfer in Drosophila. Nature 1984, 312:752-754.
10. Bartel D.P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
11. Benito J., Zheng H., Hardin P.E. PDP1epsilon functions downstream of the circadian oscillator to mediate behavioral rhythms. J. Neurosci. 2007, 27:2539-2547.
12. Benito J., Houl J.H., Roman G.W., Hardin P.E. The blue-light photoreceptor CRYPTOCHROME is expressed in a subset of circadian oscillator neurons in the Drosophila CNS. J. Biol. Rhythms. 2008, 23:296-307.
13. Benna C., Bonaccorsi S., Wulbeck C., Helfrich-Forster C., Gatti M., et al. Drosophila timeless2 is required for chromosome stability and circadian photoreception. Curr. Biol. 2010, 20:346-352.
14. Blanchardon E., Grima B., Klarsfeld A., Chelot E., Hardin P.E., et al. Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression. Eur. J. Neurosci. 2001, 13:871-888.
15. Blau J., Young M.W. Cycling vrille expression is required for a functional Drosophila clock. Cell 1999, 99:661-671.
16. Bloch G. The social clock of the honeybee. J. Biol. Rhythms 2010, 25:307-317.
17. Boothroyd C.E., Wijnen H., Naef F., Saez L., Young M.W. Integration of light and temperature in the regulation of circadian gene expression in Drosophila. PLoS Genet 2007, 3:e54.
18. Brand A.H., M A.S., Perrimon N. Ectopic expression in Drosophila. Drosophila melanogaster: Practical Uses in Cell and Molecular Biology 1994, 635-654. Academic Press, San Diego, CA. L.S.B. Goldstein, E.A. Fyrberg (Eds.).
19. Brandes C., Plautz J.D., Stanewsky R., Jamison C.F., Straume M., et al. Novel features of Drosophila period transcription revealed by real-time luciferase reporting. Neuron 1996, 16:687-692.
20. Buhr E.D., Yoo S.H., Takahashi J.S. Temperature as a universal resetting cue for mammalian circadian oscillators. Science 2010, 330:379-385.
21. Bunger M.K., Wilsbacher L.D., Moran S.M., Clendenin C., Radcliffe L.A., et al. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 2000, 103:1009-1017.
22. Busza A., Emery-Le M., Rosbash M., Emery P. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 2004, 304:1503-1506.
23. Busza A., Murad A., Emery P. Interactions between circadian neurons control temperature synchronization of Drosophila behavior. J. Neurosci. 2007, 27:10722-10733.
24. Cashmore A.R. Cryptochromes: Enabling plants and animals to determine circadian time. Cell 2003, 114:537-543.
25. Ceriani M.F., Darlington T.K., Staknis D., Mas P., Petti A.A., et al. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science 1999, 285:553-556.
26. Ceriani M.F., Hogenesch J.B., Yanovsky M., Panda S., Straume M., Kay S.A. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J. Neurosci. 2002, 22:9305-9319.
27. Chang D.C., Reppert S.M. A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK: CYCLE-mediated transcription. Curr. Biol. 2003, 13:758-762.
28. Chang D.C., McWatters H.G., Williams J.A., Gotter A.L., Levine J.D., Reppert S.M. Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. J. Biol. Chem. 2003, 278:38149-38158.
29. Chatterjee A., Tanoue S., Houl J.H., Hardin P.E. Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clock. Curr. Biol. 2010, 20:300-309.
30. Cheng Y., Gvakharia B., Hardin P. Two alternatively spliced transcripts from the Drosophila period gene rescue rhythms having different molecular and behavioral characteristics. Mol. Cell Biol. 1998, 18:6505-6514.
31. Chiu J.C., Vanselow J.T., Kramer A., Edery I. The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock. Genes. Dev. 2008, 22:1758-1772.
32. Choi C., Fortin J.P., McCarthy E., Oksman L., Kopin A.S., Nitabach M.N. Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr. Biol. 2009, 19:1167-1175.
33. Claridge-Chang A., Wijnen H., Naef F., Boothroyd C., Rajewsky N., Young M. Circadian regulation of gene expression systems in the Drosophila head. Neuron 2001, 32:657-671.
34. Clark F., Deadman D., Greenwood M., Larsen K.S. A circadian rhythm of locomotor activity in newly emerged Ceratophyllus sciurorum. Med. Vet. Entomol. 1997, 11:213-216.
35. Collins B.H., Rosato E., Kyriacou C.P. Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C. Proc. Natl. Acad. Sci. USA 2004, 101:1945-1950.
36. Collins B., Mazzoni E.O., Stanewsky R., Blau J. Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr. Biol. 2006, 16:441-449.
37. Cope G.A., Deshaies R.J. COP9 signalosome: A multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 2003, 114:663-671.
38. Currie J., Goda T., Wijnen H. Selective entrainment of the Drosophila circadian clock to daily gradients in environmental temperature. BMC Biol. 2009, 7:49.
39. Curtin K., Huang Z.J., Rosbash M. Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron 1995, 14:365-372.
40. Cusumano P., Klarsfeld A., Chelot E., Picot M., Richier B., Rouyer F. PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila. Nat. Neurosci. 2009, 12:1431-1437.
41. Cymborowski B., Muszynska-Pytel M., Porcheron P., Cassier P. Hemo-lymph ecdysteroid titers controlled by a circadian clock mechanism in larvae of the wax moth, Galleria mellonella. J. Insect. Physiol 1991, 37:35-40.
42. Cymborowski B., Hong S.F., McWatters H.G., Saunders D.S. S-antigen antibody partially blocks entrainment and the effects of constant light on the circadian rhythm of locomotor activity in the adult blow fly, Calliphora vicina. J. Biol. Rhythms. 1996, 11:68-74.
43. Cyran S.A., Buchsbaum A.M., Reddy K.L., Lin M.C., Glossop N.R., et al. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 2003, 112:329-341.
44. Cyran S.A., Yiannoulos G., Buchsbaum A.M., Saez L., Young M.W., Blau J. The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J. Neurosci. 2005, 25:5430-5437.
45. Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes. Dev. 2000, 14:2950-2961.
46. Danbara Y., Sakamoto T., Uryu O., Tomioka K. RNA interference of timeless gene does not disrupt circadian locomotor rhythms in the cricket Gryllus bimaculatus. J. Insect. Physiol. 2010, 1738-1745.
47. Darlington T.K., Wager-Smith K., Ceriani M.F., Staknis D., Gekakis N., et al. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 1998, 280:1599-1603.
48. Das S., Dimopoulos G. Molecular analysis of photic inhibition of blood-feeding in Anopheles gambiae. BMC Physiol. 2008, 8:23.
49. DeBruyne J.P., Weaver D.R., Reppert S.M. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 2007, 10:543-545.
50. Dibner C., Sage D., Unser M., Bauer C., d'Eysmond T., et al. Circadian gene expression is resilient to large fluctuations in overall transcription rates. EMBO J. 2009, 28:123-134.
51. Dissel S., Codd V., Fedic R., Garner K.J., Costa R., et al. A constitutively active cryptochrome in Drosophila melanogaster. Nat. Neurosci. 2004, 7:834-840.
52. Dolezelova E., Dolezel D., Hall J.C. Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene. Genetics 2007, 177:329-345.
53. Dubruille R., Emery P. A plastic clock: How circadian rhythms respond to environmental cues in Drosophila. Mol. Neurobiol. 2008, 38:129-145.
54. Dubruille R., Murad A., Rosbash M., Emery P. A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet 2009, 5. e1000787.
55. Dunlap J.C. Molecular bases for circadian clocks. Cell 1999, 96:271-290.
56. Edery I., Zwiebel L.J., Dembinska M.E., Rosbash M. Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. USA 1994, 91(6):2260-2264.
57. Edery I., Rutila J.E., Rosbash M. Phase shifting of the circadian clock by induction of the Drosophila period protein. Science 1994, 263:237-240.
58. Egan E.S., Franklin T.M., Hilderbrand-Chae M.J., McNeil G.P., Roberts M.A., et al. An extraretinally expressed insect cryptochrome with similarity to the bluelight photoreceptors of mammals and plants. J. Neurosci. 1999, 19:3665-3673.
59. Emerson K.J., Bradshaw W.E., Holzapfel C.M. Complications of complexity: Integrating environmental, genetic and hormonal control of insect diapause. Trends Genet 2009, 25:217-225.
60. Emery I.F., Noveral J.M., Jamison C.F., Siwicki K.K. Rhythms of Drosophila period gene expression in culture. Proc. Natl. Acad. Sci. USA 1997, 94:4092-4096.
61. Emery P., So W.V., Kaneko M., Hall J.C., Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell 1998, 95:669-679.
62. Emery P., Stanewsky R., Hall J.C., Rosbash M. A unique circadian-rhythm photoreceptor. Nature 2000, 404:456-457.
63. Emery P., Stanewsky R., Helfrich-Forster C., Emery-Le M., Hall J.C., Rosbash M. Drosophila CRY is a deep-brain circadian photoreceptor. Neuron 2000, 26:493-504.
64. Etchegaray J.P., Machida K.K., Noton E., Constance C.M., Dallmann R., et al. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol. Cell. Biol. 2009, 29:3853-3866.
65. Ewer J., Frisch B., Hamblen-Coyle M.J., Rosbash M., Hall J.C. Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J.Neurosci. 1992, 12:3321-3349.
66. Fang Y., Sathyanarayanan S., Sehgal A. Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). Genes Dev. 2007, 21:1506-1518.
67. Fleury F., Allemand R., Fouillet P., Bouletreau M. Genetic variation in locomotor activity rhythm among populations of Leptopilina heterotoma (Hymenoptera: Eucoilidae), a larval parasitoid of Drosophila species. Behav. Genet 1995, 25:81-89.
68. Frank K.D., Zimmerman W.F. Action spectra for phase shifts of a circadian rhythm in Drosophila. Science 1969, 163:688-689.
69. Frisch B., Hardin P.E., Hamblen-Coyle M.J., Rosbash M., Hall J.C. A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron 1994, 12:555-570.
70. Froy O., Chang D., Reppert S. Redox potential differential roles in dCRY and mCRY1 functions. Curr. Biol. 2002, 12:147-152.
71. Froy O., Gotter A.L., Casselman A.L., Reppert S.M. Illuminating the circadian clock in monarch butterfly migration. Science 2003, 300:1303-1305.
72. Fujii S., Amrein H. Ventral lateral and DN1 clock neurons mediate distinct properties of male sex drive rhythm in Drosophila. Proc. Natl. Acad. Sci. USA 2010, 107:10590-10595.
73. Fujii S., Krishnan P., Hardin P., Amrein H. Nocturnal male sex drive in Drosophila. Curr. Biol. 2007, 17:244-251.
74. Gegear R.J., Casselman A., Waddell S., Reppert S.M. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature 2008, 454:1014-1018.
75. Gegear R.J., Foley L.E., Casselman A., Reppert S.M. Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature 2010, 463:804-807.
76. Gekakis N., Saez L., Delahaye-Brown A.-M., Myers M.P., Sehgal A., et al. Isolation of timeless by PER protein interactions: Defective interaction between timeless protein and long-period mutant PERL. Science 1995, 270:811-815.
77. Giebultowicz J.M., Hege D.M. Circadian clock in malphigian tubules. Nature 1997, 386:664.
78. Glaser F.T., Stanewsky R. Temperature synchronization of the Drosophila circadian clock. Curr. Biol. 2005, 15:1352-1356.
79. Glossop N.R., Lyons L.C., Hardin P.E. Interlocked feedback loops within the Drosophila circadian pacemaker. Science 1999, 286:766-768.
80. Glossop N.R., Houl J.H., Zheng H., Ng F.S., Dudek S.M., Hardin P.E. VRILLE feeds back to control circadian transcription of clock in the Drosophila circadian oscillator. Neuron 2003, 37:249-261.
81. Gotter A.L., Manganaro T., Weaver D.R., Kolakowski L.F., Possidente B., Sriram S., et al. A timeless function for mouse timeless. Nat. Neurosci. 2000, 3:755-756.
82. Griffin E.A.J., Staknis D., Weitz C.J. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 1999, 286:768-771.
83. Grima B., Lamouroux A., Chelot E., Papin C., Limbourg-Bouchon B., Rouyer F. The F-box protein slimb controls the levels of clock proteins period and timeless. Nature 2002, 420:178-182.
84. Grima B., Chelot E., Xia R., Rouyer F. Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature 2004, 431:869-873.
85. Haddow A.J. Rhythmic biting activity of certain East African mosquitoes. Nature 1956, 177:531-532.
86. Hall J.C., Chang D.C., Dolezelova E. Principles and problems revolving around rhythm-related genetic variants. Cold Spring Harb Symp. Quant. Biol. 2007, 72:215-232.
87. Hamasaka Y., Nassel D.R. Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila. J. Comp. Neurol. 2006, 494:314-330.
88. Hamasaka Y., Wegener C., Nassel D.R. GABA modulates Drosophila circadian clock neurons via GABAB receptors and decreases in calcium. J. Neurobiol. 2005, 65:225-240.
89. Hamasaka Y., Rieger D., Parmentier M.L., Grau Y., Helfrich-Forster C., Nassel D.R. Glutamate and its metabotropic receptor in Drosophila clock neuron circuits. J. Comp. Neurol. 2007, 505:32-45.
90. Hao H., Allen D.L., Hardin P.E. A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Mol. Cell Biol. 1997, 17:3687-3693.
91. Hardin P.E., Hall J.C., Rosbash M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 1990, 343:536-540.
92. Hardin P.E., Hall J.C., Rosbash M. Circadian oscillations in period gene mRNA levels are transcriptionally regulated. Proc. Natl. Acad. Sci. USA 1992, 89:11711-11715.
93. Hattar S., Lucas R.J., Mrosovsky N., Thompson S., Douglas R.H., et al. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 2003, 424:76-81.
94. He Q., Cheng P., Liu Y. The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex. Genes. Dev. 2005, 19:1518-1531.
95. Helfrich-Forster C. The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 1995, 92:612-616.
96. Helfrich-Forster C. Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster - sex-specific differences suggest a different quality of activity. J. Biol. Rhythms 2000, 15:135-154.
97. Helfrich-Forster C. Neurobiology of the fruit fly's circadian clock. Genes Brain Behav. 2005, 4:65-76.
98. Helfrich-Forster C., Winter C., Hofbauer A., Hall J.C., Stanewsky R. The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron 2001, 30:249-261.
99. Helfrich-Forster C., Shafer O.T., Wulbeck C., Grieshaber E., Rieger D., Taghert P. Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster. J. Comp. Neurol. 2007, 500:47-70.
100. Helfrich-Forster C., Yoshii T., Wulbeck C., Grieshaber E., Rieger D., et al. The lateral and dorsal neurons of Drosophila melanogaster: New insights about their morphology and function. Cold Spring Harb. Symp. Quant. Biol. 2007, 72:517-525.
101. Hoang N., Schleicher E., Kacprzak S., Bouly J.P., Picot M., et al. Human and Drosophila cryptochromes are light activated by flavin photoreduction in living cells. PLoS Biol. 2008, 6:e160.
102. Hooven L.A., Sherman K.A., Butcher S., Giebultowicz J.M. Does the clock make the poison? Circadian variation in response to pesticides. PLoS One 2009, 4:e6469.
103. Howlader G., Sharma V.K. Circadian regulation of egg-laying behavior in fruit flies Drosophila melanogaster. J. Insect Physiol. 2006, 52:779-785.
104. Howlader G., Paranjpe D.A., Sharma V.K. Non-ventral lateral neuron-based, non-PDF-mediated clocks control circadian egg-laying rhythm in Drosophila melanogaster. J. Biol. Rhythms 2006, 21:13-20.
105. Huang Z.J., Edery I., Rosbash M. PAS is a dimerization domain common to Drosophila Period and several transcription factors. Nature 1993, 364:259-262.
106. Hunter-Ensor M., Ousley A., Sehgal A. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 1996, 84:677-685.
107. Hyun S., Lee Y., Hong S.T., Bang S., Paik D., et al. Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Neuron 2005, 48:267-278.
108. Im S.H., Taghert P.H. PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila. J. Comp. Neurol. 2010, 518:1925-1945.
109. Ito C., Goto S.G., Shiga S., Tomioka K., Numata H. Peripheral circadian clock for the cuticle deposition rhythm in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 2008, 105:8446-8451.
110. Ivanchenko M., Stanewsky R., Giebultowicz J.M. Circadian photoreception in Drosophila: Functions of cryptochrome in peripheral and central clocks. J. Biol. Rhythms 2001, 16:205-215.
111. Johard H.A., Yoishii T., Dircksen H., Cusumano P., Rouyer F., et al. Peptidergic clock neurons in Drosophila: Ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons. J. Comp. Neurol. 2009, 516:59-73.
112. Kadener S., Stoleru D., McDonald M., Nawathean P., Rosbash M. Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes. Dev. 2007, 21:1675-1686.
113. Kadener S., Menet J.S., Schoer R., Rosbash M. Circadian transcription contributes to core period determination in Drosophila. PLoS Biol. 2008, 6:e119.
114. Kadener S., Menet J.S., Sugino K., Horwich M.D., Weissbein U., et al. A role for microRNAs in the Drosophila circadian clock. Genes. Dev. 2009, 23:2179-2191.
115. Kanai S., Kikuno R., Toh H., Ryo H., Todo T. Molecular evolution of the photolyase-blue-light photoreceptor family. J. Mol. Evol. 1997, 45:535-548.
116. Kaneko M., Hall J.C. Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J. Comp. Neurol. 2000, 422:66-94.
117. Kaneko M., Helfrich-Forster C., Hall J.C. Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: Newly identified pacemakers candidates and novel features of clock gene product cycling. J. Neurosci. 1997, 17:6745-6760.
118. Kaushik R., Nawathean P., Busza A., Murad A., Emery P., Rosbash M. PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. PLoS Biol. 2007, 5:e146.
119. Keegan K.P., Pradhan S., Wang J.P., Allada R. Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genes. PLoS Comput. Biol. 2007, 3:e208.
120. Kenny N.A., Saunders D.S. Adult locomotor rhythmicity as "hands" of the maternal photoperiodic clock regulating larval diapause in the blowfly, Calliphora vicina. J. Biol. Rhythms 1991, 6:217-233.
121. Khan S.A., Narain K., Dutta O., Handique R., Srivastava V.K., Mahanta J. Biting behaviour and biting rhythm of potential Japanese encephalitis vectors in Assam. J. Commun. Dis. 1997, 29:109-120.
122. Kim E.Y., Edery I. Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc. Natl. Acad. Sci. USA 2006, 103:6178-6183.
123. Kim E.Y., Bae K., Ng F.S., Glossop N.R., Hardin P.E., Edery I. Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity. Neuron 2002, 34:69-81.
124. Kim E.Y., Ko H.W., Yu W., Hardin P.E., Edery I. A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function. Mol. Cell Biol. 2007, 27:5014-5028.
125. Kivimae S., Saez L., Young M.W. Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol. 2008, 6:e183.
126. Klarsfeld A., Malpel S., Michard-Vanhee C., Picot M., Chelot E., Rouyer F. Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J. Neurosci. 2004, 24:1468-1477.
127. Klemm E., Ninnemann H. Detailed action spectrum for the daily shift in pupal emergence of Drosophila pseudoobscura. Photochem. Photobiol. 1976, 24:371.
128. Kloss B., Price J.L., Saez L., Blau J., Rothenfluh-Hilfiker A., et al. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iε. Cell 1998, 94:97-107.
129. Kloss B., Rothenfluh A., Young M.W., Saez L. Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron 2001, 30:699-706.
130. Knowles A., Koh K., Wu J.T., Chien C.T., Chamovitz D.A., Blau J. The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J. Neurosci. 2009, 29:1152-1162.
131. Ko H.W., Jiang J., Edery I. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 2002, 420:673-678.
132. Ko H.W., Kim E.Y., Chiu J., Vanselow J.T., Kramer A., Edery I. A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks. J. Neurosci. 2010, 30:12664-12675.
133. Koh K., Zheng X., Sehgal A. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 2006, 312:1809-1812.
134. Konopka R.J., Benzer S. Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 1971, 68:2112-2116.
135. Krishnan B., Dryer S.E., Hardin P.E. Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature 1999, 400:375-378.
136. Krishnan B., Levine J.D., Lynch M.K., Dowse H.B., Funes P., et al. A new role for cryptochrome in a Drosophila circadian oscillator. Nature 2001, 411:313-317.
137. Krishnan P., Chatterjee A., Tanoue S., Hardin P.E. Spike amplitude of single unit responses in antennal sensillae is controlled by the Drosophila circadian clock. Curr. Biol. 2008, 803-807.
138. Krupp J.J., Kent C., Billeter J.C., Azanchi R., So A.K., et al. Social experience modifies pheromone expression and mating behavior in male Drosophila melanogaster. Curr. Biol. 2008, 18:1373-1383.
139. Kula E., Levitan E.S., Pyza E., Rosbash M. PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function. J. Biol. Rhythms 2006, 21:104-117.
140. Kula-Eversole E., Nagoshi E., Shang Y., Rodriguez J., Allada R., Rosbash M. Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc. Natl. Acad. Sci. USA 2010, 107:13497-13502.
141. Kume K., Zylka M.J., Sriram S., Shearman L.P., Weaver D.R., et al. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 1999, 98:193-205.
142. Kusk M., Ahmed R., Thomsen B., Bendixen C., Issinger O.G., Boldyreff B. Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. Mol. Cell Biochem. 1999, 191:51-58.
143. Kwon Y., Shen W.L., Shim H.S., Montell C. Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J. Neurosci. 2010, 30:10465-10471.
144. Landskron J., Chen K.F., Wolf E., Stanewsky R. A role for the PERIOD: PERIOD homodimer in the Drosophila circadian clock. PLoS Biol. 2009, 7:e3.
145. Lazzari C.R. Circadian rhythm of egg hatching in Triatoma infestans (Hemiptera: Reduviidae). J. Med. Entomol. 1991, 28:740-741.
146. Lear B.C., Merrill C.E., Lin J.M., Schroeder A., Zhang L., Allada R. A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior. Neuron 2005, 48:221-227.
147. Lear B.C., Lin J.M., Keath J.R., McGill J.J., Raman I.M., Allada R. The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker. Neuron 2005, 48:965-976.
148. Lear B.C., Zhang L., Allada R. The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior. PLoS Biol. 2009, 7. e1000154.
149. Lee C., Parikh V., Itsukaichi T., Bae K., Edery I. Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science 1996, 271:1740-1744.
150. Lee C., Bae K., Edery I. The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation and interactions with the PER-TIM complex. Neuron 1998, 4:857-867.
151. Lee C., Bae K., Edery I. PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription. Mol. Cell Biol. 1999, 19:5316-5325.
152. Lee G., Bahn J.H., Park J.H. Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila. Proc. Natl. Acad. Sci. USA 2006, 103:12580-12585.
153. Lee J.E., Edery I. Circadian regulation in the ability of Drosophila to combat pathogenic infections. Curr. Biol. 2008, 18:195-199.
154. Lee T., Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 1999, 22:451-461.
155. Levine J.D., Casey C.I., Kalderon D.D., Jackson F.R. Altered circadian pacemaker functions and cyclic AMP rhythms in the Drosophila learning mutant dunce. Neuron 1994, 13:967-974.
156. Levine J.D., Funes P., Dowse H.B., Hall J.C. Advanced analysis of a cryptochrome mutation's effects on the robustness and phase of molecular cycles in isolated peripheral tissues of Drosophila. BMC Neurosci. 2002, 3.
157. Levine J.D., Funes P., Dowse H.B., Hall J.C. Resetting the circadian clock by social experience in Drosophila melanogaster. Science 2002, 298:2010-2012.
158. Lim C., Chung B.Y., Pitman J.L., McGill J.J., Pradhan S., et al. Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr. Biol. 2007, 17:1082-1089.
159. Lin F.J., Song W., Meyer-Bernstein E., Naidoo N., Sehgal A. Photic signaling by cryptochrome in the Drosophila circadian system. Mol. Cell Biol. 2001, 21:7287-7294.
160. Lin J.M., Kilman V.L., Keegan K., Paddock B., Emery-Le M., et al. A role for casein kinase 2alpha in the Drosophila circadian clock. Nature 2002, 420:816-820.
161. Lin J.M., Schroeder A., Allada R. In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J. Neurosci. 2005, 25:11175-11183.
162. Lin Y., Han M., Shimada B., Wang L., Gibler T.M., et al. Influence of the period-dependent circadian clock on diurnal, circadian, aperiodic gene expression in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 2002, 99:9562-9567.
163. Lin Y., Stormo G.D., Taghert P.H. The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J. Neurosci. 2004, 24:7951-7957.
164. Lindauer M. Dauertaenze im Bienenstock und ihre Beziehung zur Sonnenbahn. Natwissen 1954, 41:506-507.
165. Lindauer M. Time-compensated sun orientation in bees. Cold Spring Harb. Symp. Quant. Biol. 1960, 25:371-377.
166. Low K.H., Lim C., Ko H.W., Edery I. Natural variation in the splice site strength of a clock gene and species-specific thermal adaptation. Neuron 2008, 60:1054-1067.
167. Lowrey P.L., Shimomura K., Antoch M.P., Yamazaki S., Zemenides P.D., et al. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 2000, 288:483-492.
168. Maier B., Wendt S., Vanselow J.T., Wallach T., Reischl S., et al. A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes. Dev 2009, 23:708-718.
169. Majercak J., Sidote D., Hardin P.E., Edery I. How a circadian clock adapts to seasonal decreases in temperature and day length. Neuron 1999, 24:219-230.
170. Majercak J., Chen W.F., Edery I. Splicing of the period gene 3'-terminal intron is regulated by light, circadian clock factors, and phospholipase C. Mol. Cell Biol. 2004, 24:3359-3372.
171. Martinek S., Inonog S., Manoukian A.S., Young M.W. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 2001, 105:769-779.
172. Matsumoto A., Ukai-Tadenuma M., Yamada R.G., Houl J., Uno K.D., et al. A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes. Dev. 2007, 21:1687-1700.
173. Mazzoni E.O., Desplan C., Blau J. Circadian pacemaker neurons transmit and modulate visual information to control a rapid behavioral response. Neuron 2005, 45:293-300.
174. McDonald M.J., Rosbash M. Microarray analysis and organization of circadian gene expression in Drosophila. Cell 2001, 107:567-578.
175. McDonald M.J., Rosbash M., Emery P. Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter. Mol. Cell Biol. 2001, 21:1207-1217.
176. McFarlane R.J., Mian S., Dalgaard J.Z. The many facets of the Tim-Tipin protein families' roles in chromosome biology. Cell Cycle 2010, 9:700-705.
177. Meissner R.A., Kilman V.L., Lin J.M., Allada R. TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo. J. Neurosci. 2008, 28:9732-9740.
178. Menet J.S., Abruzzi K.C., Desrochers J., Rodriguez J., Rosbash M. Dynamic PER repression mechanisms in the Drosophila circadian clock: From on-DNA to off-DNA. Genes Dev. 2010, 24:358-367.
179. Merlin C., Lucas P., Rochat D., Francois M.C., Maibeche-Coisne M., Jacquin-Joly E. An antennal circadian clock and circadian rhythms in peripheral pheromone reception in the moth Spodoptera littoralis. J. Biol. Rhythms 2007, 22:502-514.
180. Merlin C., Gegear R.J., Reppert S.M. Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies. Science 2009, 325:1700-1704.
181. Mertens I., Vandingenen A., Johnson E.C., Shafer O.T., Li W., et al. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors. Neuron 2005, 48:213-219.
182. Meyer P., Saez L., Young M.W. PER-TIM interactions in living Drosophila cells: An interval timer for the circadian clock. Science 2006, 311:226-229.
183. Minis D.H., Pittendrigh C.S. Circadian oscillation controlling hatching: Its ontogeny during embryogenesis of a moth. Science 1968, 159:534-536.
184. Miyasako Y., Umezaki Y., Tomioka K. Separate sets of cerebral clock neurons are responsible for light and temperature entrainment of Drosophila circadian locomotor rhythms. J. Biol. Rhythms 2007, 22:115-126.
185. Moore D., Siegfried D., Wilson R., Rankin M.A. The influence of time of day on the foraging behavior of the honeybee, Apis mellifera. J. Biol. Rhythms 1989, 4:305-325.
186. Moriyama Y., Sakamoto T., Karpova S.G., Matsumoto A., Noji S., Tomioka K. RNA interference of the clock gene period disrupts circadian rhythms in the cricket Gryllus bimaculatus. J. Biol. Rhythms 2008, 23:308-318.
187. Moriyama Y., Sakamoto T., Matsumoto A., Noji S., Tomioka K. Functional analysis of the circadian clock gene period by RNA interference in nymphal crickets Gryllus bimaculatus. J. Insect Physiol. 2009, 55:183-187.
188. Mouritsen H., Frost B.J. Virtual migration in tethered flying monarch butterflies reveals their orientation mechanisms. Proc. Natl. Acad. Sci. USA 2002, 99:10162-10166.
189. Murad A., Emery-Le M., Emery P. A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila. Neuron 2007, 53:689-701.
190. Myers M.P., Wager-Smith K., Wesley C.S., Young M.W., Sehgal A. Positional cloning and sequence analysis of the Drosophila clock gene timeless. Science 1995, 270:805-808.
191. Myers M.P., Wager-Smith K., Rothenfluh-Hilfiker A., Young M.W. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 1996, 271:1736-1740.
192. Myers E.M., Yu J., Sehgal A. Circadian control of eclosion: Interaction between a central and peripheral clock in Drosophila melanogaster. Curr. Biol. 2003, 13:526-533.
193. Nagoshi E., Saini C., Bauer C., Laroche T., Naef F., Schibler U. Circadian gene expression in individual fibroblasts: Cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 2004, 119:693-705.
194. Nagoshi E., Sugino K., Kula E., Okazaki E., Tachibana T., et al. Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nat. Neurosci. 2009, 13:60-68.
195. Naidoo N., Song W., Hunter-Ensor M., Sehgal A. A role for the proteasome in the light response of the timeless clock protein. Science 1999, 285:1737-1741.
196. Nakajima M., Imai K., Ito H., Nishiwaki T., Murayama Y., et al. Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science 2005, 308:414-415.
197. Nawathean P., Rosbash M. The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol. Cell 2004, 13:213-223.
198. Nawathean P., Stoleru D., Rosbash M. A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity. Mol. Cell Biol. 2007, 27:5002-5013.
199. Newby L.M., Jackson F.R. Drosophila ebony mutants have altered circadian activity rhythms but normal eclosion rhythms. J. Neurogenet 1991, 7:85-101.
200. Nitabach M.N., Taghert P.H. Organization of the Drosophila circadian control circuit. Curr. Biol. 2008, 18:R84-93.
201. Oishi K., Shiota M., Sakamoto K., Kasamatsu M., Ishida N. Feeding is not a more potent Zeitgeber than the light-dark cycle in Drosophila. Neuroreport 2004, 15:739-743.
202. Ousley A., Zafarullah K., Chen Y., Emerson M., Hickman L., Sehgal A. Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies. Genetics 1998, 148:815-825.
203. Ozturk N., Song S.H., Ozgur S., Selby C.P., Morrison L., et al. Structure and function of animal cryptochromes. Cold Spring Harb. Symp. Quant. Biol. 2007, 72:119-131.
204. Ozturk N., Song S.H., Selby C.P., Sancar A. Animal type 1 cryptochromes. Analysis of the redox state of the flavin cofactor by site-directed mutagenesis. J. Biol. Chem. 2008, 283:3256-3263.
205. Page T.L. Transplantation of the cockroach circadian pacemaker. Science 1982, 216:73-75.
206. Panda S., Provencio I., Tu D.C., Pires S.S., Rollag M.D., et al. Melanopsin is required for non-image-forming photic responses in blind mice. Science 2003, 301:525-527.
207. Pandian R.S. Circadian rhythm in the biting behaviour of a mosquito Armigeres subalbatus (Coquillett). Indian J. Exp. Biol. 1994, 32:256-260.
208. Parisky K.M., Agosto J., Pulver S.R., Shang Y., Kuklin E., et al. PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron 2008, 60:672-682.
209. Park J.H., Helfrich-Forster C., Lee G., Liu L., Rosbash M., Hall J.C. Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc. Natl. Acad. Sci. USA 2000, 97:3608-3613.
210. Pelc D., Steel C.G. Rhythmic steroidogenesis by the prothoracic glands of the insect Rhodnius prolixus in the absence of rhythmic neuropeptide input: Implications for the role of prothoracicotropic hormone. Gen. Comp. Endocrinol. 1997, 108:358-365.
211. Peng Y., Stoleru D., Levine J.D., Hall J.C., Rosbash M. Drosophila free-running rhythms require intercellular communication. PLOS Biol. 2003, 1:E13.
212. Peschel N., Veleri S., Stanewsky R. Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc. Natl. Acad. Sci. USA 2006, 103:17313-17318.
213. Peschel N., Chen K.F., Szabo G., Stanewsky R. Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless. Curr. Biol 2009, 19:241-247.
214. Petri B., Stengl M. Pigment-dispersing hormone shifts the phase of the circadian pacemaker of the cockroach Leucophaea maderae. J. Neurosci 1997, 17:4087-4093.
215. Phillips J.B., Sayeed O. Wavelength-dependent effects of light on magnetic compass orientation in Drosophila melanogaster. J. Comp. Physiol. A 1993, 172:303-308.
216. Picot M., Cusumano P., Klarsfeld A., Ueda R., Rouyer F. Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol. 2007, 5:e315.
217. Picot M., Klarsfeld A., Chelot E., Malpel S., Rouyer F. A role for blind DN2 clock neurons in temperature entrainment of the Drosophila larval brain. J. Neurosci. 2009, 29:8312-8320.
218. Pittendrigh C.S. On temperature independence in the clock-system controlling emergence time in Drosophila. Proc. Natl. Acad. Sci. USA 1954, 40:1018-1029.
219. Pittendrigh C.S. Circadian rhythms and the circadian organization of living systems. Cold Spring Harbor Symp.Quant. Biol. 1960, 25:159-182.
220. Pittendrigh C.S. Circadian systems. I. The driving oscillation and its assay in Drosophila pseudoobscura. Proc. Natl. Acad. Sci. USA 1967, 58:1762-1767.
221. Pittendrigh C.S. Temporal organization: Reflections of a Darwinian clock-watcher. Annu. Rev. Physiol. 1993, 55:17-54.
222. Pittendrigh C.S., Kyner W.T., Takamura T. The amplitude of circadian oscillations: Temperature-dependence, latitudinal clines, and the photoperiodic time measurement. J. Biol. Rhythms 1991, 6:299-313.
223. Plautz J.D., Kaneko M., Hall J.C., Kay S.A. Independent photoreceptive circadian clocks throughout Drosophila. Science 1997, 278:1632-1635.
224. Preuss F., Fan J.Y., Kalive M., Bao S., Schuenemann E., et al. Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I. Mol. Cell Biol. 2004, 24:886-898.
225. Price J.L., Blau J., Rothenfluh-Hilfiker A., Abodeely M., Kloss B., Young M.W. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 1998, 94:83-95.
226. Pszczolkowski M.A., Dobrowolski M. Circadian dynamics of locomotor activity and deltamethrin susceptibility in the pine weevil, Hylobius abietis. Phytoparasitica 1999, 27:19-25.
227. Reddy P., Zehring W.A., Wheeler D.A., Pirrotta V., Hadfield C., et al. Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell 1984, 38:701-710.
228. Reischig T., Stengl M. Ectopic transplantation of the accessory medulla restores circadian locomotor rhythms in arrhythmic cockroaches (Leucophaea maderae). J. Exp. Biol. 2003, 206:1877-1886.
229. Reischl S., Vanselow K., Westermark P.O., Thierfelder N., Maier B., et al. Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics. J. Biol. Rhythms 2007, 22:375-386.
230. Remy S., Tesson L., Menoret S., Usal C., Scharenberg A.M., Anegon I. Zinc-finger nucleases: A powerful tool for genetic engineering of animals. Transgenic Res 2010, 19:363-371.
231. Renn S.C.P., Park J.H., Rosbash M., Hall J.C., Taghert P.H. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 1999, 99:791-802.
232. Reppert S.M., Gegear R.J., Merlin C. Navigational mechanisms of migrating monarch butterflies. Trends Neurosci. 2010, 33:399-406.
233. Richier B., Michard-Vanhee C., Lamouroux A., Papin C., Rouyer F. The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression. J. Biol. Rhythms 2008, 23:103-116.
234. Richter K. Daily changes in neuroendocrine control of moulting hormone secretion in the prothoracic gland of the cockroach Periplaneta americana (L.). J. Insect Physiol. 2001, 47:333-338.
235. Rieger D., Stanewsky R., Helfrich-Forster C. Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster. J. Biol. Rhythms 2003, 18:377-391.
236. Rieger D., Wulbeck C., Rouyer F., Helfrich-Forster C. Period gene expression in four neurons is sufficient for rhythmic activity of Drosophila melanogaster under dim light conditions. J. Biol. Rhythms 2009, 24:271-282.
237. Ritz T., Dommer D.H., Phillips J.B. Shedding light on vertebrate magnetoreception. Neuron 2002, 34:503-506.
238. Rorth P., Szabo K., Bailey A., Laverty T., Rehm J., et al. Systematic gain-of-function genetics in Drosophila. Development 1998, 125:1049-1057.
239. Rosato E., Trevisan A., Sandrelli F., Zordan M., Kyriacou C.P., Costa R. Conceptual translation of timeless reveals alternative initiating methionines in Drosophila. Nucleic Acids Res. 1997, 25:455-458.
240. Rosato E., Codd V., Mazzotta G., Piccin A., Zordan M., et al. Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY. Curr. Biol. 2001, 11:909-917.
241. Rosbash M. The implications of multiple circadian clock origins. PLoS Biol. 2009, 7:e62.
242. Rothenfluh A., Young M.W., Saez L. A TIMELESS-independent function for PERIOD proteins in the Drosophila clock. Neuron 2000, 26:505-515.
243. Rubin E.B., Shemesh Y., Cohen M., Elgavish S., Robertson H.M., Bloch G. Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the circadian clock. Genome Res. 2006, 16:1352-1365.
244. Rutila J.E., Suri V., Le M., So W.V., Rosbash M., Hall J.C. CYCLE is a second bHLH-PAS protein essential for circadian transcription of Drosophila period and timeless. Cell 1998, 93:805-814.
245. Rymer J., Bauernfeind A.L., Brown S., Page T.L. Circadian rhythms in the mating behavior of the cockroach, Leucophaea maderae. J. Biol. Rhythms 2007, 22:43-57.
246. Saez L., Young M.W. Regulation of nuclear entry of the Drosophila clock proteins PERIOD and TIMELESS. Neuron 1996, 17:911-920.
247. Sakai T., Ishida N. Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc. Natl. Acad. Sci. USA 2001, 98:9221-9225.
248. Sakai T., Ishida N. Time, love and species. Neuro. Endocrinol. Lett. 2001, 22:222-228.
249. Sakamoto T., Uryu O., Tomioka K. The clock gene period plays an essential role in photoperiodic control of nymphal development in the cricket Modicogryllus siamensis. J. Biol. Rhythms 2009, 24:379-390.
250. Sancar A. Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors. Chem. Rev. 2003, 103:2203-2237.
251. Sancar A. Structure and function of photolyase and in vivo enzymology: 50th anniversary. J. Biol. Chem. 2008, 283:32153-32157.
252. Sandrelli F., Tauber E., Pegoraro M., Mazzotta G., Cisotto P., et al. A molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science 2007, 316:1898-1900.
253. Sandrelli F., Costa R., Kyriacou C.P., Rosato E. Comparative analysis of circadian clock genes in insects. Insect Mol. Biol. 2008, 17:447-463.
254. Sathyanarayanan S., Zheng X., Xiao R., Sehgal A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 2004, 116:603-615.
255. Sathyanarayanan S., Zheng X., Kumar S., Chen C.H., Chen D., et al. Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes. Dev. 2008, 22:1522-1533.
256. Sauman I., Reppert S.M. Period protein is necessary for circadian control of egg hatching behavior in the silmoth Antheraea pernyi. Neuron 1996, 17:901-909.
257. Saunders D.S. The circadian basis of ovarian diapause regulation in Drosophila melanogaster: Is the period gene causally involved in photoperiodic time measurement?. J. Biol. Rhythms 1990, 5:315-331.
258. Saunders D.S., Thomson E.J. "Strong" phase response curve for the circadian rhythm of locomotor activity in a cockroach (Nauphoeta cinerea). Nature 1977, 270:241-243.
259. Saunders D.S., Henrich V.C., Gilbert L.I. Induction of diapause in Drosophila melanogaster: Photoperiodic regulation and the impact of arrhythmic clock mutations on time measurement. Proc. Natl. Acad. Sci. USA 1989, 86:3748-3752.
260. Sehadova H., Glaser F.T., Gentile C., Simoni A., Giesecke A., et al. Temperature entrainment of Drosophila's circadian clock involves the gene nocte and signaling from peripheral sensory tissues to the brain. Neuron 2009, 64:251-266.
261. Sehgal A., Price J.L., Man B., Young M.W. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 1994, 263:1603-1606.
262. Sehgal A., Rothenfluh-Hilfiker A., Hunter-Ensor M., Chen Y., Myers M., Young M.W. Circadian oscillations and autoregulation of timeless RNA. Science 1995, 270:808-810.
263. Shafer O.T., Rosbash M., Truman J.W. Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J. Neurosci. 2002, 22:5946-5954.
264. Shafer O.T., Helfrich-Forster C., Renn S.C., Taghert P.H. Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. J. Comp. Neurol. 2006, 498:180-193.
265. Shafer O.T., Kim D.J., Dunbar-Yaffe R., Nikolaev V.O., Lohse M.J., Taghert P.H. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron 2008, 58:223-237.
266. Shang Y., Griffith L.C., Rosbash M. Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc. Natl. Acad. Sci. USA 2008, 105:19587-19594.
267. Sheeba V., Sharma V.K., Gu H., Chou Y.T., O'Dowd D.K., Holmes T.C. Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J. Neurosci. 2008, 28:217-227.
268. Sheeba V., Fogle K.J., Kaneko M., Rashid S., Chou Y.T., et al. Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr. Biol. 2008, 18:1537-1545.
269. Sheeba V., Kaneko M., Sharma V.K., Holmes T.C. The Drosophila circadian pacemaker circuit: Pas de deux or tarantella?. Crit. Rev. Biochem. Mol. Biol. 2008, 43:37-61.
270. Sheeba V., Fogle K.J., Holmes T.C. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS One 2010, 5:e11628.
271. Shirasu-Hiza M.M., Dionne M.S., Pham L.N., Ayres J.S., Schneider D.S. Interactions between circadian rhythm and immunity in Drosophila melanogaster. Curr. Biol. 2007, 17:R353-355.
272. Silvegren G., Lofstedt C., Qi Rosen W. Circadian mating activity and effect of pheromone pre-exposure on pheromone response rhythms in the moth Spodoptera littoralis. J. Insect Physiol. 2005, 51:277-286.
273. Siwicki K.K., Eastman C., Petersen G., Rosbash M., Hall J.C. Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron 1988, 1:141-150.
274. Smith E.M., Lin J.M., Meissner R.A., Allada R. Dominant-negative CK2alpha induces potent effects on circadian rhythmicity. PLoS Genet 2008, 4:e12.
275. So W.V., Rosbash M. Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J. 1997, 16:7146-7155.
276. Sogawa K., Nakano R., Kobayashi A., Kikuchi Y., Ohe N., et al. Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation. Proc. Natl. Acad. Sci. USA 1995, 92:1936-1940.
277. Sothern R.B., Hermida R.C., Nelson R., Mojon A., Koukkari W.L. Reanalysis of filter-feeding behavior of caddis fly (Brachycentrus) larvae reveals masking and circadian rhythmicity. Chronobiol. Intl. 1998, 15:595-606.
278. Standfast H.A. Biting times of nine speccies of New Guinea Cullicidae (Diptera). J. Med. Entomol. 1967, 4:192-196.
279. Stanewsky R., Jamison C.F., Plautz J.D., Kay S.A., Hall J.C. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J. 1997, 16:5006-5018.
280. Stanewsky R., Kaneko M., Emery P., Beretta M., Wager-Smith K., et al. The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 1998, 95:681-692.
281. Stanewsky R., Lynch K.S., Brandes C., Hall J.C. Mapping of elements involved in regulating normal temporal period and timeless RNA expression patterns in Drosophila melanogaster. J. Biol. Rhythms 2002, 17:293-306.
282. Steel C.G., Vafopoulou X. Circadian orchestration of developmental hormones in the insect, Rhodnius prolixus. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2006, 144:351-364.
283. Stelzer J.R., Stanewsky R., Chittka L. Circadian foraging rhythms of bumblebees monitored by radio-frequency identification. J. Biol. Rhythms 2010, 25:257-267.
284. Stengl M., Homberg U. Pigment-dispersing hormone-immunoreactive neurons in the cockroach Leucophaea maderae share properties with circadian pacemaker neurons. J. Comp. Physiol. A 1994, 175:203-213.
285. Stoleru D., Peng Y., Agusto J., Rosbash M. Coupled oscillators control morning and evening locomotor behaviour of Drosophila. Nature 2004, 431:862-868.
286. Stoleru D., Peng Y., Nawathean P., Rosbash M. A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Nature 2005, 438:238-242.
287. Stoleru D., Nawathean P., Fernandez Mde L., Menet J.S., Ceriani M.F., Rosbash M. The Drosophila circadian network is a seasonal timer. Cell 2007, 129:207-219.
288. Suh J., Jackson F.R. Drosophila ebony activity is required in glia for the circadian regulation of locomotor activity. Neuron 2007, 55:435-447.
289. Sullivan W.N., Cawley B., Hayes D.K., Rosenthal J., Halberg F. Circadian rhythm in susceptibility of house flies and Madeira cockroaches to pyrethrum. J. Econ. Entomol. 1970, 63:159-163.
290. Sun W.C., Jeong E.H., Jeong H.J., Ko H.W., Edery I., Kim E.Y. Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription. J. Neurosci. 2010, 30:14458-14469.
291. Suri V., Qian Z., Hall J.C., Rosbash M. Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron 1998, 21:225-234.
292. Suri V., Lanjuin A., Rosbash M. TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock. EMBO J. 1999, 18:675-686.
293. Suri V., Hall J.C., Rosbash M. Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. J. Neurosci. 2000, 20:7547-7555.
294. Swanson H.I., Chan W.K., Bradfield C.A. DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J. Biol. Chem. 1995, 270:26292-26302.
295. Takasu Y., Kobayashi I., Beumer K., Uchino K., Sezutsu H., et al. Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection. Insect Biochem. Mol. Biol. 2010, 40:759-765.
296. Tang C.H., Hinteregger E., Shang Y., Rosbash M. Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. Neuron 2010, 66:378-385.
297. Tanoue S., Krishnan P., Chatterjee A., Hardin P.E. G-protein Receptor Kinase 2 is required for rhythmic olfactory responses in Drosophila. Curr. Biol. 2008, 787-794.
298. Tauber E., Zordan M., Sandrelli F., Pegoraro M., Osterwalder N., et al. Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 2007, 316:1895-1898.
299. Tischkau S.A., Gillette M.U. Oligodeoxynucleotide methods for analyzing the circadian clock in the suprachiasmatic nucleus. Methods Enzymol. 2005, 393:593-610.
300. Tomioka K., Matsumoto A. A comparative view of insect circadian clock systems. Cell Mol. Life Sci. 2010, 67:1397-1406.
301. Truman J.W. Physiology of insect rhythms: II. The silkmoth brain as the location of the biological clock controlling eclosion. J. Comp. Physiol. 1972, 99:99-114.
302. Truman J.W. Physiology of insect rhythms: IV. Role of the brain in the regulation of the flight rhythm of the giant silkmoths. J. Comp. Physiol. 1974, 95:281-296.
303. Tu D.C., Batten M.L., Palczewski K., Van Gelder R.N. Nonvisual photoreception in the chick iris. Science 2004, 306:129-131.
304. Ueda H.R., Matsumoto A., Kawamura M., Iino M., Tanimura T., Hashimoto S. Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. J. Biol. Chem. 2002, 277:14048-14052.
305. Unsal-Kacmaz K., Mullen T.E., Kaufmann W.K., Sancar A. Coupling of human circadian and cell cycles by the timeless protein. Mol. Cell Biol. 2005, 25:3109-3116.
306. Uryu O., Tomioka K. Circadian oscillations outside the optic lobe in the cricket Gryllus bimaculatus. J. Insect Physiol. 2010, 56:1284-1290.
307. Vafopoulou X., Steel C.G. Circadian regulation of synthesis of ecdysteroids by prothoracic glands of the insect Rhodnius prolixus: Evidence of a dual oscillator system. Gen. Comp. Endocrinol. 1991, 83:27-34.
308. Vafopoulou X., Steel C.G. Circadian regulation of a daily rhythm of release of prothoracicotropic hormone from the brain retrocerebral complex of Rhodnius prolixus (hemiptera) during larval-adult development. Gen. Comp. Endocrinol. 1996, 102:123-129.
309. van der Horst G.T., Muijtjens M., Kobayashi K., Takano R., Kanno S., et al. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 1999, 398:627-630.
310. VanVickle-Chavez S.J., Van Gelder R.N. Action spectrum of Drosophila cryptochrome. J. Biol. Chem. 2007, 282:10561-10566.
311. Veleri S., Brandes C., Helfrich-Forster C., Hall J.C., Stanewsky R. A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain. Curr. Biol. 2003, 13:1758-1767.
312. Veleri S., Rieger D., Helfrich-Forster C., Stanewsky R. Hofbauer-Buchner eyelet affects circadian photosensitivity and coordinates TIM and PER expression in Drosophila clock neurons. J. Biol. Rhythms 2007, 22:29-42.
313. Vosshall L.B., Price J.L., Sehgal A., Saez L., Young M.W. Specific block in nuclear localization of period protein by a second clock mutation, timeless. Science 1994, 263:1606-1609.
314. Wehner R., Labhart T. Perception of the geomagnetic field in the fly Drosophila melanogaster. Experientia 1970, 26:967-968.
315. Wheeler D.A., Hamblen-Coyle M.J., Dushay M.S., Hall J.C. Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J. Biol. Rhythms 1993, 8:67-94.
316. Wijnen H., Young M.W. Interplay of circadian clocks and metabolic rhythms. Annu. Rev. Genet 2006, 40:409-448.
317. Xu K., Zheng X., Sehgal A. Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. 2008, 8:289-300.
318. Xu Y., Padiath Q.S., Shapiro R.E., Jones C.R., Wu S.C., et al. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 2005, 434:640-644.
319. Yang H.Q., Wu Y., Tang R.H., Liu D., Liu Y., Cashmore A.R. The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell 2000, 103:815-827.
320. Yang M., Lee J.E., Padgett R.W., Edery I. Circadian regulation of a limited set of conserved microRNAs in Drosophila. BMC Genomics 2008, 9:83.
321. Yang Z., Sehgal A. Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron 2001, 29:453-467.
322. Yang Z., Emerson M., Su H.S., Sehgal A. Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception. Neuron 1998, 21:215-223.
323. Yildiz O., Doi M., Yujnovsky I., Cardone L., Berndt A., et al. Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD. Mol. Cell 2005, 17:69-82.
324. Yoshii T., Heshiki Y., Ibuki-Ishibashi T., Matsumoto A., Tanimura T., Tomioka K. Temperature cycles drive Drosophila circadian oscillation in constant light that otherwise induces behavioural arrhythmicity. Eur. J. Neurosci. 2005, 22:1176-1184.
325. Yoshii T., Todo T., Wulbeck C., Stanewsky R., Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J. Comp. Neurol. 2008, 508:952-966.
326. Yoshii T., Ahmad M., Helfrich-Forster C. Cryptochrome mediates light-dependent magnetosensitivity of Drosophila's circadian clock. PLoS Biol. 2009, 7:e1000086.
327. Yoshii T., Vanin S., Costa R., Helfrich-Forster C. Synergic entrainment of Drosophila's circadian clock by light and temperature. J. Biol. Rhythms 2009, 24:452-464.
328. Yoshii T., Wulbeck C., Sehadova H., Veleri S., Bichler D., et al. The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock. J. Neurosci. 2009, 29:2597-2610.
329. Yu W., Zheng H., Houl J.H., Dauwalder B., Hardin P.E. PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes. Dev. 2006, 20:723-733.
330. Yu W., Zheng H., Price J.L., Hardin P.E. DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock. Mol. Cell Biol. 2009, 29:1452-1458.
331. Yuan Q., Lin F., Zheng X., Sehgal A. Serotonin modulates circadian entrainment in Drosophila. Neuron 2005, 47:115-127.
332. Yuan Q., Metterville D., Briscoe A.D., Reppert S.M. Insect cryptochromes: Gene duplication and loss define diverse ways to construct insect circadian clocks. Mol. Biol. Evol. 2007, 24:948-955.
333. Zehring W.A., Wheeler D.A., Reddy P., Konopka R.J., Kyriacou, et al. P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster. Cell 1984, 39:369-376.
334. Zeng H., Hardin P.E., Rosbash M. Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J. 1994, 13:3590-3598.
335. Zeng H., Qian Z., Myers M.P., Rosbash M. A light-entrainment mechanism for the Drosophila circadian clock. Nature 1996, 380:129-135.
336. Zerr D.M., Hall J.C., Rosbash M., Siwicki K.K. Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J. Neurosci. 1990, 10:2749-2762.
337. Zhang L., Lear B.C., Seluzicki A., Allada R. The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in Drosophila. Curr. Biol. 2009, 19:2050-2055.
338. Zhang L., Chung B.Y., Lear B.C., Kilman V.L., Liu Y., et al. DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila. Curr. Biol. 2010, 20:591-599.
339. Zhang Y., Liu Y., Bilodeau-Wentworth D., Hardin P.E., Emery P. Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behavior. Curr. Biol. 2010, 20:600-605.
340. Zheng X., Koh K., Sowcik M., Smith C.J., Chen D., et al. An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator. J. Neurosci. 2009, 29:10920-10927.
341. Zhu H., Yuan Q., Briscoe A.D., Froy O., Casselman A., Reppert S.M. The two CRYs of the butterfly. Curr. Biol. 2005, 15:R953-954.
342. Zhu H., Sauman I., Yuan Q., Casselman A., Emery-Le M., et al. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008, 6:e4.
343. Zimmerman W.F., Goldsmith T.H. Photosensitivity of the circadian rhythm and of visual receptors in carotenoid-depleted Drosophila. Science 1971, 171:1167-1168.
344. Zwiebel L.J., Hardin P.E., Liu X., Hall J.C., Rosbash M. A post-transcriptional mechanism contributes to circadian cycling of per B-galactosidase fusion protein. Proc. Natl. Acad. Sci. USA 1991, 88:3882-3886.