PER-TIM interactions in living Drosophila cells: An interval timer for the circadian clock

Science

Volumn 311, Issue 5758, 2006, Pages 226-229

  Meyar, Pablo ^a   Saez, Lino ^a   Young, Michael W ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; DISSOCIATION; ENERGY TRANSFER; FLUORESCENCE; PROTEINS;

DROSOPHILA CELLS; FLUORESCENCE RESONANCE ENERGY TRANSFER; PER-TIM INTERACTIONS; PROTEIN BINDING;

PLANT CELL CULTURE;

DROSOPHILA PROTEIN; PROTEIN PER; PROTEIN TIM; UNCLASSIFIED DRUG;

CIRCADIAN RHYTHM;

ANIMAL CELL; ARTICLE; ASSAY; CELL CULTURE; CELL NUCLEUS; CELL TRANSPORT; CIRCADIAN RHYTHM; COMPLEX FORMATION; CYTOPLASM; DISSOCIATION; DROSOPHILA MELANOGASTER; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE; GENE MUTATION; IMAGING SYSTEM; NONHUMAN; PER GENE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SINGLE CELL IMAGING ASSAY; TIM GENE; TIME;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CELL NUCLEUS; CIRCADIAN RHYTHM; CYTOPLASM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

ANIMALIA; DROSOPHILA MELANOGASTER;

EID: 30844466208     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1118126     Document Type: Article

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26. We thank A. North for her interest and help while using the Delta Vision Microscope at the Rockefeller University Bio-Imaging Resource Center; M. Sigman for help using Matlab; and C. Bargmann, J. Blau, and L. Vosshall for helpful comments on the manuscript. This work was supported by a grant from the NIH (GM54339) to M.W.Y, and a Burroughs Wellcome Fellowship to P.M.