Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock

Neuron

Volumn 30, Issue 2, 2001, Pages 525-536

  Bae, Kiho ^a   Jin, Xiaowei ^a   Maywood, Elizabeth S ^b   Hastings, Michael H ^b,c   Reppert, Steven M ^a   Weaver, David R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; GENE PRODUCT; PER1 PROTEIN; PER2 PROTEIN; PERIOD 3 PROTEIN; RNA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; CONTROLLED STUDY; DARKNESS; FEMALE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; LOCOMOTION; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REGULATORY MECHANISM; RNA GENE; SUPRACHIASMATIC NUCLEUS;

EID: 0034989269     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(01)00302-6     Document Type: Article

References (44)

1. Inhibition of light- or glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms
2. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light
3. mPer1 and mPer2 are essential for normal resetting of the circadian clock
4. Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators
5. Mop3 is an essential component of the master circadian pacemaker in mammals
6. Human casein kinase 1δ phosphorylation of human circadian clock proteins Period 1 and 2
7. Molecular bases for circadian clocks
8. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms
9. Role of the CLOCK protein in the mammalian circadian mechanism
10. Interlocked feedback loops within the Drosophila circadian oscillator
11. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock
12. Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: New insights into a core clock mechanism
13. The human and mouse Period1 genes: Five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription
14. The basic helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
15. 1A/7 receptor agonists accompanied by reduced Per1 and Per2 mRNA levels in the suprachiasmatic nuclei
16. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
17. Phosphorylation and destabilization of human period 1 clock protein by human casein kinase Iε
18. Positional cloning of the mouse circadian Clock gene
19. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
20. Interconnected feedback loops in the Neurospora circadian system
21. Positional syntenic cloning and functional characterization of a mammalian circadian mutation tau
22. Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock
23. Photic induction of mPer1 and mPer2 in Cry-deficient mice lacking a biological clock
24. Molecular analysis of mammalian circadian rhythms
25. Mammalian circadian autoregulatory loop: A timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
26. Two period homologs: Circadian expression and photic regulation in the suprachiasmatic nuclei
27. Targeted disruption of the mPer3 gene: Subtle effects on circadian clock function
28. Interacting molecular loops in the mammalian circadian clock
29. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript
30. A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
31. Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses
32. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
33. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
34. Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase 1ε
35. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
36. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2
37. Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift
38. The suprachiasmatic nucleus: A 25-year retrospective
39. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms
40. Dimerization and nuclear entry of mPER proteins in mammalian cells
41. The mPer2 gene encodes a functional component of the mammalian clock
42. Molecular analysis of mammalian Timeless
43. Three period homologs in mammals: Differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain