A Subset of Dorsal Neurons Modulates Circadian Behavior and Light Responses in Drosophila

Neuron

Volumn 53, Issue 5, 2007, Pages 689-701

  Murad, Alejandro ^a   Emery Le, Myai ^a   Emery, Patrick ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

MOLNEURO; SYSNEURO

Indexed keywords

DROSOPHILA PROTEIN; MUTANT PROTEIN; NEUROPEPTIDE; PEPTIDE PDF; PROTEIN CRY; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL SUBPOPULATION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DARK ADAPTATION; DORSAL NEURON; DROSOPHILA; GENE; GENE OVEREXPRESSION; ILLUMINATION; INSECT GENETICS; LIGHT EXPOSURE; MORGUE GENE; NONHUMAN; PACEMAKER NERVE CELL; PER GENE; PHOTOPERIODICITY; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CIRCADIAN RHYTHM; DARKNESS; DROSOPHILA; DROSOPHILA PROTEINS; EYE PROTEINS; LIGHTING; NEURONS; NEUROPEPTIDES; NUCLEAR PROTEINS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 33847128320     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2007.01.034     Document Type: Article

References (42)

1. Busza A., Emery-Le M., Rosbash M., and Emery P. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 304 (2004) 1503-1506
2. Cyran S.A., Buchsbaum A.M., Reddy K.L., Lin M.C., Glossop N.R., Hardin P.E., Young M.W., Storti R.V., and Blau J. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112 (2003) 329-341
3. Dunlap J.C. Molecular bases for circadian clocks. Cell 96 (1999) 271-290
4. Egan E.S., Franklin T.M., Hilderbrand-Chae M.J., McNeil G.P., Roberts M.A., Schroeder A.J., Zhang X., and Jackson F.R. An extraretinally expressed insect cryptochrome with similarity to the bluelight photoreceptors of mammals and plants. J. Neurosci. 19 (1999) 3665-3673
5. Emery P., and Reppert S.M. A rhythmic Ror. Neuron 19 (2004) 443-446
6. Emery P., So W.V., Kaneko M., Hall J.C., and Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell 95 (1998) 669-679
7. Emery P., Stanewsky R., Hall J.C., and Rosbash M. A unique circadian-rhythm photoreceptor. Nature 404 (2000) 456-457
8. Emery P., Stanewsky R., Helfrich-Forster C., Emery-Le M., Hall J.C., and Rosbash M. Drosophila CRY is a deep-brain circadian photoreceptor. Neuron 26 (2000) 493-504
9. Ewer J., Frisch B., Hamblen-Coyle M.J., Rosbash M., and Hall J.C. Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J. Neurosci. 12 (1992) 3321-3349
10. Grima B., Lamouroux A., Chelot E., Papin C., Limbourg-Bouchon B., and Rouyer F. The F-box protein slimb controls the levels of clock proteins period and timeless. Nature 420 (2002) 178-182
11. Grima B., Chelot E., Xia R., and Rouyer F. Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature 431 (2004) 869-873
12. Hardin P.E. The circadian timekeeping system of Drosophila. Curr. Biol. 15 (2005) R714-R722
13. Helfrich-Forster C., Stengl M., and Homberg U. Organization of the circadian system in insects. Chronobiol. Int. 15 (1998) 567-594
14. Helfrich-Forster C., Winter C., Hofbauer A., Hall J.C., and Stanewsky R. The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron 30 (2001) 249-261
15. Hyun S., Lee Y., Hong S.T., Bang S., Paik D., Kang J., Shin J., Lee J., Jeon K., Hwang S., et al. Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Neuron 48 (2005) 267-278
16. Kaneko M., and Hall J.C. Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J. Comp. Neurol. 422 (2000) 66-94
17. Kaneko M., Park J.H., Cheng Y., Hardin P.E., and Hall J.C. Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells of Drosophila cause abnormal behavioral rhythms. J. Neurobiol. 43 (2000) 207-233
18. Klarsfeld A., Malpel S., Michard-Vanhee C., Picot M., Chelot E., and Rouyer F. Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J. Neurosci. 24 (2004) 1468-1477
19. Ko H.W., Jiang J., and Edery I. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 420 (2002) 673-678
20. Koh K., Zheng X., and Sehgal A. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 312 (2006) 1809-1812
21. Konopka R.J., Pittendrigh C., and Orr D. Reciprocal behavior associated with altered homeostasis and photosensitivity of Drosophila clock mutants. J. Neurogenet. 6 (1989) 1-10
22. Lear B.C., Merrill C.E., Lin J.M., Schroeder A., Zhang L., and Allada R. A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior. Neuron 48 (2005) 221-227
23. Levine J.D., Funes P., Dowse H.B., and Hall J.C. Signal analysis of behavioral and molecular cycles. BMC Neurosci. 3 (2002) 1
24. Lin Y., Stormo G.D., and Taghert P.H. The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J. Neurosci. 24 (2004) 7951-7957
25. Mertens I., Vandingenen A., Johnson E.C., Shafer O.T., Li W., Trigg J.S., De Loof A., Schoofs L., and Taghert P.H. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors. Neuron 48 (2005) 213-219
26. Park J.H., Helfrich-Forster C., Lee G., Liu L., Rosbash M., and Hall J.C. Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc. Natl. Acad. Sci. USA 97 (2000) 3608-3613
27. Peng Y., Stoleru D., Levine J.D., Hall J.C., and Rosbash M. Drosophila free-running rhythms require intercellular communication. PLoS Biol. 1 (2003) E13
28. Price J.L., Dembinska M.E., Young M.W., and Rosbash M. Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. EMBO J. 14 (1995) 4044-4049
29. Renn S.C., Park J.H., Rosbash M., Hall J.C., and Taghert P.H. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 99 (1999) 791-802
30. Rieger D., Stanewsky R., and Helfrich-Forster C. Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster. J. Biol. Rhythms 18 (2003) 377-391
31. Rieger D., Shafer O.T., Tomioka K., and Helfrich-Forster C. Functional analysis of circadian pacemaker neurons in Drosophila melanogaster. J. Neurosci. 26 (2006) 2531-2543
32. Rorth P., Szabo K., Bailey A., Laverty T., Rehm J., Rubin G.M., Weigmann K., Milan M., Benes V., Ansorge W., and Cohen S.M. Systematic gain-of-function genetics in Drosophila. Development 125 (1998) 1049-1057
33. Shafer O.T., Rosbash M., and Truman J.W. Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J. Neurosci. 22 (2002) 5946-5954
34. Shafer O.T., Helfrich-Forster C., Renn S.C., and Taghert P.H. Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. J. Comp. Neurol. 498 (2006) 180-193
35. Shearman L.P., Sriram S., Weaver D.R., Maywood E.S., Chaves I., Zheng B., Kume K., Lee C.C., van der horst G.T., Hastings M.H., et al. Interacting molecular loops in the mammalian circadian clock. Science 288 (2000) 1013-1019
36. Stanewsky R., Kaneko M., Emery P., Beretta M., Wager-Smith K., Kay S.A., Rosbash M., and Hall J.C. The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95 (1998) 681-692
37. Stoleru D., Peng Y., Agusto J., and Rosbash M. Coupled oscillators control morning and evening locomotor behaviour of Drosophila. Nature 431 (2004) 862-868
38. Stoleru D., Peng Y., Nawathean P., and Rosbash M. A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Nature 438 (2005) 238-242
39. Stoleru D., Nawathean P., Fernandez M.P., Menet J., Ceriani M.F., and Rosbash M. The Drosophila circadian network is a seasonal timer. Cell (2007) in press
40. Veleri S., Brandes C., Helfrich-Forster C., Hall J.C., and Stanewsky R. A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain. Curr. Biol. 13 (2003) 1758-1767
41. Wing J.P., Schreader B.A., Yokokura T., Wang Y., Andrews P.S., Huseinovic N., Dong C.K., Ogdahl J.L., Schwartz L.M., White K., and Nambu J.R. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat. Cell Biol. 4 (2002) 451-456
42. Yoshii T., Heshiki Y., Ibuki-Ishibashi T., Matsumoto A., Tanimura T., and Tomioka K. Temperature cycles drive Drosophila circadian oscillation in constant light that otherwise induces behavioural arrhythmicity. Eur. J. Neurosci. 22 (2005) 1176-1184