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Volumn 22, Issue 14, 2002, Pages 5946-5954

Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster

Author keywords

Circadian rhythm; Drosophila; Lateral neurons; Nuclear accumulation; Period; Pigment dispersing factor; Timeless

Indexed keywords

PROTEIN;

EID: 0037101628     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-14-05946.2002     Document Type: Article
Times cited : (202)

References (38)
  • 1
    • 17044451254 scopus 로고    scopus 로고
    • A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless
    • Allada R, White NE, So WV, Hall JC, Rosbash M (1998) A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 93:791-804.
    • (1998) Cell , vol.93 , pp. 791-804
    • Allada, R.1    White, N.E.2    So, W.V.3    Hall, J.C.4    Rosbash, M.5
  • 2
    • 0028838141 scopus 로고
    • Temporally regulated nuclear entry of the Drosophila Period protein contributes to the circadian clock
    • Curtin KD, Huang ZJ, Rosbash M (1995) Temporally regulated nuclear entry of the Drosophila Period protein contributes to the circadian clock. Neuron 14:365-372.
    • (1995) Neuron , vol.14 , pp. 365-372
    • Curtin, K.D.1    Huang, Z.J.2    Rosbash, M.3
  • 4
    • 34250106896 scopus 로고
    • The ultrastructure of nerve endings containing the pigment-dispersing hormone (PDH) in crustacean sinus glands: Identification by an antiserum against synthetic PDH
    • Dircksen H, Zahnow CA, Gaus G, Keller R, Rao KR, Riehm JP (1987) The ultrastructure of nerve endings containing the pigment-dispersing hormone (PDH) in crustacean sinus glands: Identification by an antiserum against synthetic PDH. Cell Tissue Res 250:377-387.
    • (1987) Cell Tissue Res , vol.250 , pp. 377-387
    • Dircksen, H.1    Zahnow, C.A.2    Gaus, G.3    Keller, R.4    Rao, K.R.5    Riehm, J.P.6
  • 5
    • 0033593306 scopus 로고    scopus 로고
    • Molecular bases for circadian clocks
    • Dunlap JC (1999) Molecular bases for circadian clocks. Cell 96:271-290.
    • (1999) Cell , vol.96 , pp. 271-290
    • Dunlap, J.C.1
  • 6
    • 0026757788 scopus 로고
    • Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms
    • Ewer J, Frisch B, Hamblen-Coyle MJ, Rosbash M, Hall JC (1992) Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J Neurosci 12:3321-3349.
    • (1992) J Neurosci , vol.12 , pp. 3321-3349
    • Ewer, J.1    Frisch, B.2    Hamblen-Coyle, M.J.3    Rosbash, M.4    Hall, J.C.5
  • 7
    • 0028314111 scopus 로고
    • A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system
    • Frisch B, Hardin PE, Hamblen-Coyle MJ, Rosbash M, Hall JC (1994) A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron 12:555-570.
    • (1994) Neuron , vol.12 , pp. 555-570
    • Frisch, B.1    Hardin, P.E.2    Hamblen-Coyle, M.J.3    Rosbash, M.4    Hall, J.C.5
  • 8
    • 0025044560 scopus 로고
    • Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
    • Hardin PE, Hall JC, Rosbash M (1990) Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343:536-540.
    • (1990) Nature , vol.343 , pp. 536-540
    • Hardin, P.E.1    Hall, J.C.2    Rosbash, M.3
  • 9
    • 0026541402 scopus 로고
    • Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster
    • Hardin PE, Hall JC, Rosbash M (1992) Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster. EMBO J 11:1-6.
    • (1992) EMBO J , vol.11 , pp. 1-6
    • Hardin, P.E.1    Hall, J.C.2    Rosbash, M.3
  • 10
    • 0028873144 scopus 로고
    • The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster
    • Helfrich-Forster C (1995) The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc Natl Acad Sci USA 92:612-616.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 612-616
    • Helfrich-Forster, C.1
  • 11
    • 0001376796 scopus 로고    scopus 로고
    • Drosophila rhythms: From brain to behavior
    • Helfrich-Forster C (1996) Drosophila rhythms: From brain to behavior. Semin Cell Dev Biol 7:791-802.
    • (1996) Semin Cell Dev Biol , vol.7 , pp. 791-802
    • Helfrich-Forster, C.1
  • 12
    • 2642607006 scopus 로고    scopus 로고
    • Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: A brain-behavioral study of disconnected mutants
    • Helfrich-Forster C (1998) Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: A brain-behavioral study of disconnected mutants. J Comp Physiol [A] 182:435-453.
    • (1998) J Comp Physiol [A] , vol.182 , pp. 435-453
    • Helfrich-Forster, C.1
  • 13
    • 0027439330 scopus 로고
    • Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity
    • Helfrich-Forster C, Homberg U (1993) Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity. J Comp Neurol 337:177-190.
    • (1993) J Comp Neurol , vol.337 , pp. 177-190
    • Helfrich-Forster, C.1    Homberg, U.2
  • 14
    • 0029965130 scopus 로고    scopus 로고
    • Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light
    • Hunter-Ensor M, Ousley A, Sehgal A (1996) Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 84:677-685.
    • (1996) Cell , vol.84 , pp. 677-685
    • Hunter-Ensor, M.1    Ousley, A.2    Sehgal, A.3
  • 15
    • 0034686552 scopus 로고    scopus 로고
    • Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections
    • Kaneko M, Hall JC (2000) Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J Comp Neurol 422:66-94.
    • (2000) J Comp Neurol , vol.422 , pp. 66-94
    • Kaneko, M.1    Hall, J.C.2
  • 16
    • 0034964474 scopus 로고    scopus 로고
    • Phosphorylation of PERIOD is influenced by cycling physical associations of DOUBLE- TIME, PERIOD, and TIMELESS in the Drosophila clock
    • Kloss B, Rothenfluh A, Young MW, Saez L (2001) Phosphorylation of PERIOD is influenced by cycling physical associations of DOUBLE- TIME, PERIOD, and TIMELESS in the Drosophila clock. Neuron 30:699-706.
    • (2001) Neuron , vol.30 , pp. 699-706
    • Kloss, B.1    Rothenfluh, A.2    Young, M.W.3    Saez, L.4
  • 17
    • 0015119210 scopus 로고
    • Clock mutants of Drosophila melanogaster
    • Konopka RJ, Benzer S (1971) Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci USA 68:2112-2116.
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 2112-2116
    • Konopka, R.J.1    Benzer, S.2
  • 18
    • 0030012253 scopus 로고    scopus 로고
    • Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex
    • Lee C, Parikh V, Itsukaichi T, Bae K, Edery I (1996) Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science 271:1740-1744.
    • (1996) Science , vol.271 , pp. 1740-1744
    • Lee, C.1    Parikh, V.2    Itsukaichi, T.3    Bae, K.4    Edery, I.5
  • 19
    • 0032778040 scopus 로고    scopus 로고
    • PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription
    • Lee C, Bae K, Edery I (1999) PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription. Mol Cell Biol 19:5316-5325.
    • (1999) Mol Cell Biol , vol.19 , pp. 5316-5325
    • Lee, C.1    Bae, K.2    Edery, I.3
  • 21
    • 0029989521 scopus 로고    scopus 로고
    • Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock
    • Myers MP, Wager-Smith K, Rothenfluh-Hilfiker A, Young MW (1996) Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 271:1736-1740.
    • (1996) Science , vol.271 , pp. 1736-1740
    • Myers, M.P.1    Wager-Smith, K.2    Rothenfluh-Hilfiker, A.3    Young, M.W.4
  • 23
    • 0029161853 scopus 로고
    • Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless
    • Price JL, Dembinska ME, Young MW, Rosbash M (1995) Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. EMBO J 14:4044-4049.
    • (1995) EMBO J , vol.14 , pp. 4044-4049
    • Price, J.L.1    Dembinska, M.E.2    Young, M.W.3    Rosbash, M.4
  • 24
    • 0033599009 scopus 로고    scopus 로고
    • A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    • Renn SC, Park JH, Rosbash M, Hall JC, Taghert PH (1999) A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 99:791-802.
    • (1999) Cell , vol.99 , pp. 791-802
    • Renn, S.C.1    Park, J.H.2    Rosbash, M.3    Hall, J.C.4    Taghert, P.H.5
  • 25
    • 0033711617 scopus 로고    scopus 로고
    • A TIMELESS-independent function for PERIOD proteins in the Drosophila clock
    • Rothenfluh A, Young MW, Saez L (2000) A TIMELESS-independent function for PERIOD proteins in the Drosophila clock. Neuron 26:505-514.
    • (2000) Neuron , vol.26 , pp. 505-514
    • Rothenfluh, A.1    Young, M.W.2    Saez, L.3
  • 26
    • 0032577450 scopus 로고    scopus 로고
    • CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
    • Rutila JE, Suri V, Le M, So WV, Rosbash M, Hall JC (1998) CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell 93:805-814.
    • (1998) Cell , vol.93 , pp. 805-814
    • Rutila, J.E.1    Suri, V.2    Le, M.3    So, W.V.4    Rosbash, M.5    Hall, J.C.6
  • 27
    • 0030293638 scopus 로고    scopus 로고
    • Regulation of nuclear entry of the Drosophila clock proteins period and timeless
    • Saez L, Young MW (1996) Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron 17:911-920.
    • (1996) Neuron , vol.17 , pp. 911-920
    • Saez, L.1    Young, M.W.2
  • 28
    • 0034143237 scopus 로고    scopus 로고
    • Altered entrainment and feedback loop function effected by a mutant period protein
    • Schotland P, Hunter-Ensor M, Lawrence T, Sehgal A (2000) Altered entrainment and feedback loop function effected by a mutant period protein. J Neurosci 20:958-968.
    • (2000) J Neurosci , vol.20 , pp. 958-968
    • Schotland, P.1    Hunter-Ensor, M.2    Lawrence, T.3    Sehgal, A.4
  • 29
    • 0028330442 scopus 로고
    • Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless
    • Sehgal A, Price JL, Man B, Young MW (1994) Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 263:1603-1606.
    • (1994) Science , vol.263 , pp. 1603-1606
    • Sehgal, A.1    Price, J.L.2    Man, B.3    Young, M.W.4
  • 30
    • 0028838668 scopus 로고
    • Rhythmic expression of timeless: A basis for promoting circadian cycles in period gene autoregulation
    • Sehgal A, Rothenfluh-Hilfiker A, Hunter-Ensor M, Chen Y, Myers MP, Young MW (1995) Rhythmic expression of timeless: A basis for promoting circadian cycles in period gene autoregulation. Science 270:808-810.
    • (1995) Science , vol.270 , pp. 808-810
    • Sehgal, A.1    Rothenfluh-Hilfiker, A.2    Hunter-Ensor, M.3    Chen, Y.4    Myers, M.P.5    Young, M.W.6
  • 31
    • 0030698128 scopus 로고    scopus 로고
    • Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling
    • So WV, Rosbash M (1997) Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J 16:7146-7155.
    • (1997) EMBO J , vol.16 , pp. 7146-7155
    • So, W.V.1    Rosbash, M.2
  • 33
    • 0033081054 scopus 로고    scopus 로고
    • TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock
    • Suri V, Lanjuin A, Rosbash M (1999) TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock. EMBO J 18:675-686.
    • (1999) EMBO J , vol.18 , pp. 675-686
    • Suri, V.1    Lanjuin, A.2    Rosbash, M.3
  • 34
    • 0028286849 scopus 로고
    • Block in nuclear localization of period protein by a second clock mutation, timeless
    • Vosshall LB, Price JL, Sehgal A, Saez L, Young MW (1994) Block in nuclear localization of period protein by a second clock mutation, timeless. Science 263:1606-1609.
    • (1994) Science , vol.263 , pp. 1606-1609
    • Vosshall, L.B.1    Price, J.L.2    Sehgal, A.3    Saez, L.4    Young, M.W.5
  • 35
    • 0035052919 scopus 로고    scopus 로고
    • Molecular components of the circadian system in Drosophila
    • Williams JA, Sehgal A (2001) Molecular components of the circadian system in Drosophila. Annu Rev Physiol 63:729-755.
    • (2001) Annu Rev Physiol , vol.63 , pp. 729-755
    • Williams, J.A.1    Sehgal, A.2
  • 36
    • 0035102288 scopus 로고    scopus 로고
    • Role of molecular oscillations in generating behavioral rhythms in Drosophila
    • Yang Z, Sehgal A (2001) Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron 29:453-467.
    • (2001) Neuron , vol.29 , pp. 453-467
    • Yang, Z.1    Sehgal, A.2
  • 37
    • 0029979174 scopus 로고    scopus 로고
    • A light-entrainment mechanism for the Drosophila circadian clock
    • Zeng H, Qian Z, Myers MP, Rosbash M (1996) A light-entrainment mechanism for the Drosophila circadian clock. Nature 380:129-135.
    • (1996) Nature , vol.380 , pp. 129-135
    • Zeng, H.1    Qian, Z.2    Myers, M.P.3    Rosbash, M.4
  • 38
    • 0025468873 scopus 로고
    • Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila
    • Zerr DM, Hall JC, Rosbash M, Siwicki KK (1990) Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J Neurosci 10:2749-2762.
    • (1990) J Neurosci , vol.10 , pp. 2749-2762
    • Zerr, D.M.1    Hall, J.C.2    Rosbash, M.3    Siwicki, K.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.