Melanopsin is required for non-image-forming photic responses in blind mice

Science

Volumn 301, Issue 5632, 2003, Pages 525-527

  Panda, Satchidananda ^a,b   Provencio, Ignacio ^c   Tu, Daniel C ^d   Pires, Susana S ^a   Rollag, Mark D ^c   Castrucci, Ana Maria ^c,e   Pletcher, Mathew T ^a,b   Sato, Trey K ^a,b   Wiltshire, Tim ^a   Andahazy, Mary ^a   Kay, Steve A ^b   Van Gelder, Russell N ^d   Hogenesch, John B ^a,b  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; LIGHT; PHOTOSENSITIVITY; PROTEINS;

PHOTORECEPTORS;

BIOCHEMISTRY;

ACYLTRANSFERASE;

LIGHT; VISUAL ANALYSIS;

ARTICLE; BLINDNESS; CIRCADIAN RHYTHM; LOCOMOTION; MAMMAL; NONHUMAN; PHOTORECEPTOR; PHOTOSENSITIVITY; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA GANGLION CELL; VISUAL STIMULATION;

ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; BLINDNESS; CIRCADIAN RHYTHM; LIGHT; MICE; MICE, INBRED C3H; MOTOR ACTIVITY; OPSIN; PHOTORECEPTORS, VERTEBRATE; PHOTOTRANSDUCTION; REFLEX, PUPILLARY; RETINAL DEGENERATION; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS;

MAMMALIA;

EID: 0041843770     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1086179     Document Type: Article

References (25)

1. R. G. Foster, M. W. Hankins, Prog. Retinal Eye Res. 21, 507 (2002).
2. S. Hattar, H. W. Liao, M. Takao, D. M. Berson, K. W. Yau, Science 295, 1065 (2002).
3. D. M. Berson, F. A. Dunn, M. Takao, Science 295, 1070 (2002).
4. R. J. Lucas et al., Science 299, 245 (2003).
5. S. Panda et al., Science 298, 2213 (2002).
6. N. F. Ruby et al., Science 298, 2211 (2002).
7. Materials and methods are available as supporting material on Science Online.
8. R. G. Foster et al., J. Comp. Physiol. A 169, 39 (1991).
9. R. J. Nelson, I. Zucker, Comp. Biochem. Physiol. A 69, 145 (1981).
10. R. Wee, A. M. Castrucci, I. Provencio, L. Gan, R. N. Van Gelder, J. Neurosci. 22, 10427 (2002).
11. H. Faradji, R. Cespuglio, G. Rondot, L. Paut, M. Jouvet, Brain Res. 202, 41 (1980).
12. R. J. Lucas, R. H. Douglas, R. G. Foster, Nature Neurosci. 4, 621 (2001).
13. R. N. Van Gelder, R. Wee, J. A. Lee, D. C. Tu, Science 299, 222 (2003).
14. S. Panda, J. B. Hogenesch, unpublished observation.
15. D. C. Klein, J. L. Weller, Science 177, 532 (1972).
16. R. J. Lucas, M. S. Freedman, M. Munoz, J. M. Garcia-Fernandez, R. G. Foster, Science 284, 505 (1999).
17. P. H. Roseboom et al, Endocrinology 137, 3033 (1996).
18. M. A. Belenky, C. A. Smeraski, I. Provencio, P. J. Sollars, G. E. Pickard, J. Comp. Neurol. 460, 380 (2003).
19. D. E. Somers, P. F. Devlin, S. A. Kay, Science 282, 1488 (1998).
20. P. Emery, W. V. So, M. Kaneko, J. C. Hall, M. Rosbash, Cell 95, 669 (1998).
21. Y. Miyamoto, A. Sancar, Proc. Natl. Acad. Sci. U.S.A. 95, 6097 (1998).
22. R. N. Van Gelder et al.,J. Neurogenet. 16, 181 (2002).
23. P. F. Devlin, S. A. Kay, Annu. Rev. Physiol. 63, 677 (2001).
24. C. Helfrich-Forster, C. Winter, A. Hofbauer, J. C. Hall, R. Stanewsky, Neuron 30, 249 (2001).
25. Supported by the Novartis Research Foundation (to S.P., M.T.P., T.W., M.A., and J.B.H.), the National Institute of Mental Health (MH 62405 to I.P., MH51573 to S.A.K.), grants from Research to Prevent Blindness (to R.N.V.G. and D.C.T.), Becker/Association of University Professors of Ophthalmology/Research to Prevent Blindness Clinician-Scientist Award, the Culpepper Medical Scientist Award (to R.N.V.G.), National Eye Institute (K08-EY00403 and R01-EY14988 to R.N.V.G.), the American Cancer Society (PF-02-108-01-DDC to T.K.S.), the Fundacáo de Amparo à Pesquisa do Estado de São Paulo (01102460-1 to A.M.C.), and Icep, Portugal (to S.S.P.). We thank M. Morrison, J. Watson, and K. Spencer for help with histology and microscopy and R. McDowell and R. M. Allan for animal care.