Posttranslational Regulation of Drosophila PERIOD Protein by Protein Phosphatase 2A

Cell

Volumn 116, Issue 4, 2004, Pages 603-615

  Sathyanarayanan, Sriram ^a   Zheng, Xiangzhong ^a   Xiao, Rui ^a   Sehgal, Amita ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; PERIOD PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BEHAVIOR; BIOACCUMULATION; CATALYSIS; CELL LINE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME ACTIVITY; FLY; HEAD; IN VITRO STUDY; IN VIVO STUDY; MUTANT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TARGETING; REGULATORY MECHANISM; RNA TRANSLATION;

ANIMALIA; ARACHNIDA; DROSOPHILA; HEXAPODA;

EID: 1342285689     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(04)00128-X     Document Type: Article

References (58)

1. Akten B., Jauch E., Genova G.K., Kim E.Y., Edery I., Raabe T., Jackson F.R. A role for CK2 in the Drosophila circadian oscillator. Nat. Neurosci. 6:2003;251-257.
2. Allada R. Circadian clocks. a tale of two feedback loops Cell. 112:2003;284-286.
3. Ashmore L.J., Sathyanarayanan S., Silvestre D.W., Emerson M.M., Schotland P., Sehgal A. Novel insights into the regulation of the timeless protein. J. Neurosci. 23:2003;7810-7819.
4. Bao S., Rihel J., Bjes E., Fan J.Y., Price J.L. The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. J. Neurosci. 21:2001;7117-7126.
5. Blau J., Young M.W. Cycling vrille expression is required for a functional Drosophila clock. Cell. 99:1999;661-671.
6. Cegielska A., Shaffer S., Derua R., Goris J., Virshup D.M. Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. Mol. Cell. Biol. 14:1994;4616-4623.
7. Cegielska A., Gietzen K.F., Rivers A., Virshup D.M. Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis. J. Biol. Chem. 273:1998;1357-1364.
8. Ceriani M.F., Darlington T.K., Staknis D., Mas P., Petti A.A., Weitz C.J., Kay S.A. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science. 285:1999;553-556.
9. Darlington T.K., Wager-Smith K., Ceriani M.F., Staknis D., Gekakis N., Steeves T.D., Weitz C.J., Takahashi J.S., Kay S.A. Closing the circadian loop. CLOCK-induced transcription of its own inhibitors per and tim Science. 280:1998;1599-1603.
10. Edery I., Zwiebel L.J., Dembinska M.E., Rosbash M. Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. USA. 91:1994;2260-2264.
11. Frisch B., Hardin P.E., Hamblen-Coyle M.J., Rosbash M., Hall J.C. A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron. 12:1994;555-570.
12. Glossop N.R., Hardin P.E. Central and peripheral circadian oscillator mechanisms in flies and mammals. J. Cell Sci. 115:2002;3369-3377.
13. Greaves S., Sanson B., White P., Vincent J.P. A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. Genetics. 153:1999;1753-1766.
14. Grima B., Lamouroux A., Chelot E., Papin C., Limbourg-Bouchon B., Rouyer F. The F-box protein slimb controls the levels of clock proteins period and timeless. Nature. 420:2002;178-182.
15. Groves M.R., Hanlon N., Turowski P., Hemmings B.A., Barford D. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell. 96:1999;99-110.
16. Hammond S.M., Bernstein E., Beach D., Hannon G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 404:2000;293-296.
17. Hannus M., Feiguin F., Heisenberg C.P., Eaton S. Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development. 129:2002;3493-3503.
18. Huelsken J., Behrens J. The Wnt signalling pathway. J. Cell Sci. 115:2002;3977-3978.
19. Janssens V., Goris J. Protein phosphatase 2A. a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling Biochem. J. 353:2001;417-439.
20. Jiang J., Struhl G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature. 391:1998;493-496.
21. Kalderon D. Similarities between the Hedgehog and Wnt signaling pathways. Trends Cell Biol. 12:2002;523-531.
22. Kaneko M., Helfrich-Forster C., Hall J.C. Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila. newly identified pacemaker candidates and novel features of clock gene product cycling J. Neurosci. 17:1997;6745-6760.
23. Kaneko M., Park J.H., Cheng Y., Hardin P.E., Hall J.C. Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells of Drosophila cause abnormal behavioral rhythms. J. Neurobiol. 43:2000;207-233.
24. Kins S., Crameri A., Evans D.R., Hemmings B.A., Nitsch R.M., Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J. Biol. Chem. 276:2001;38193-38200.
25. Kloss B., Price J.L., Saez L., Blau J., Rothenfluh A., Wesley C.S., Young M.W. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell. 94:1998;97-107.
26. Kloss B., Rothenfluh A., Young M.W., Saez L. Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron. 30:2001;699-706.
27. Ko H.W., Jiang J., Edery I. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature. 420:2002;673-678.
28. Li X., Yost H.J., Virshup D.M., Seeling J.M. Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J. 20:2001;4122-4131.
29. Li X., Scuderi A., Letsou A., Virshup D.M. B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol. Cell. Biol. 22:2002;3674-3684.
30. Lin J.M., Kilman V.L., Keegan K., Paddock B., Emery-Le M., Rosbash M., Allada R. A role for casein kinase 2alpha in the Drosophila circadian clock. Nature. 420:2002;816-820.
31. Martinek S., Inonog S., Manoukian A.S., Young M.W. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell. 105:2001;769-779.
32. Mayer-Jaekel R.E., Hemmings B.A. Role of protein phosphatase 2A in Drosophila development. Semin. Cancer Biol. 6:1995;249-256.
33. Mayer-Jaekel R.E., Ohkura H., Gomes R., Sunkel C.E., Baumgartner S., Hemmings B.A., Glover D.M. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell. 72:1993;621-633.
34. Mayer-Jaekel R.E., Ohkura H., Ferrigno P., Andjelkovic N., Shiomi K., Uemura T., Glover D.M., Hemmings B.A. Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. J. Cell Sci. 107:1994;2609-2616.
35. Moon R.T., Bowerman B., Boutros M., Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science. 296:2002;1644-1646.
36. Myers E.M., Yu J., Sehgal A. Circadian control of eclosion. Interaction between a central and peripheral clock in Drosophila melanogaster. Curr. Biol. 13:2003;526-533.
37. Naidoo N., Song W., Hunter-Ensor M., Sehgal A. A role for the proteasome in the light response of the timeless clock protein. Science. 285:1999;1737-1741.
38. Nowak S.J., Pai C.Y., Corces V.G. Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster. Mol. Cell. Biol. 23:2003;6129-6138.
39. Perrimon N., Lanjuin A., Arnold C., Noll E. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics. 144:1996;1681-1692.
40. Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., Schibler U. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 110:2002;251-260.
41. Price J.L., Blau J., Rothenfluh A., Abodeely M., Kloss B., Young M.W. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell. 94:1998;83-95.
42. Ratcliffe M.J., Itoh K., Sokol S.Y. A positive role for the PP2A catalytic subunit in Wnt signal transduction. J. Biol. Chem. 275:2000;35680-35683.
43. Renn S.C., Park J.H., Rosbash M., Hall J.C., Taghert P.H. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell. 99:1999;791-802.
44. Rothenfluh A., Abodeely M., Young M.W. Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. Curr. Biol. 10:2000;1399-1402.
45. Saez L., Young M.W. Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron. 17:1996;911-920.
46. Seeling J.M., Miller J.R., Gil R., Moon R.T., White R., Virshup D.M. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science. 283:1999;2089-2091.
47. Shafer O.T., Rosbash M., Truman J.W. Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J. Neurosci. 22:2002;5946-5954.
48. Silverstein A.M., Barrow C.A., Davis A.J., Mumby M.C. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc. Natl. Acad. Sci. USA. 99:2002;4221-4226.
49. Snaith H.A., Armstrong C.G., Guo Y., Kaiser K., Cohen P.T. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos. J. Cell Sci. 109:1996;3001-3012.
50. Stanewsky R. Clock mechanisms in Drosophila. Cell Tissue Res. 309:2002;11-26.
51. Stempfl T., Vogel M., Szabo G., Wulbeck C., Liu J., Hall J.C., Stanewsky R. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Genetics. 160:2002;571-593.
52. Uemura T., Shiomi K., Togashi S., Takeichi M. Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs. Genes Dev. 7:1993;429-440.
53. Vielhaber E., Eide E., Rivers A., Gao Z.H., Virshup D.M. Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol. Cell. Biol. 20:2000;4888-4899.
54. Virshup D.M. Protein phosphatase 2A. a panoply of enzymes Curr. Opin. Cell Biol. 12:2000;180-185.
55. Vosshall L.B., Young M.W. Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. Neuron. 15:1995;345-360.
56. Williams J.A., Su H.S., Bernards A., Field J., Sehgal A. A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science. 293:2001;2251-2256.
57. Yang Z., Sehgal A. Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron. 29:2001;453-467.
58. Zeng H., Qian Z., Myers M.P., Rosbash M. A light-entrainment mechanism for the Drosophila circadian clock. Nature. 380:1996;129-135.