Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component

Genes and Development

Volumn 21, Issue 13, 2007, Pages 1675-1686

  Kadener, Sebastian ^a   Stoleru, Dan ^a   McDonald, Michael ^b   Nawathean, Pipat ^a   Rosbash, Michael ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Chromatin; Circadian; Clk; Drosophila; Transcriptional oscillations

Indexed keywords

MESSENGER RNA;

ARTICLE; CIRCADIAN RHYTHM; DROSOPHILA; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE TARGETING; GENETIC TRANSCRIPTION; MAMMAL; NONHUMAN; OSCILLATION; PACEMAKER; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL CLOCKS; CELLS, CULTURED; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEURONS; NUCLEAR PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 34347382964     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1552607     Document Type: Article

References (45)

1. Allada, R., White, N.E., So, W.V., Hall, J.C., and Rosbash, M. 1998. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 93: 791-804.
2. Allada, R., Kadener, S., Nandakumar, N., and Rosbash, M. 2003. A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. EMBO J. 22: 3367-3375.
3. Beato, M. and Eisfeld, K. 1997. Transcription factor access to chromatin. Nucleic Acids Res. 25: 3559-3563.
4. Belden, W.J., Loros, J.J., and Dunlap, J.C. 2007. Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCK-SWITCH. Mol. Cell 25: 587-600.
5. Blau, J. and Young, M.W. 1999. Cycling vrille expression is required for a functional Drosophila clock. Cell 99: 661-671.
6. Brand, A.H. and Perrimon, N. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
7. Ceriani, M.F., Hogenesch, J.B., Yanovsky, M., Panda, S., Straume, M., and Kay, S.A. 2002. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J. Neurosci. 22: 9305-9319.
8. Claridge-Chang, A., Wijnen, H., Naef, F., Boothroyd, C., Rajewsky, N., and Young, M.W. 2001. Circadian regulation of gene expression systems in the Drosophila head. Neuron 32: 657-671.
9. Cyran, S., Buchsbaum, A., Reddy, K., Lin, M., Glossop, N., Hardin, P., Young, M., Storti, R., and Blau, J. 2003. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112: 329-341.
10. Davis, R.L. and Turner, D.L. 2001. Vertebrate hairy and Enhancer of split related proteins: Transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20: 8342-8357.
11. Dubruille, R., Laurencon, A., Vandaele, C., Shishido, E., Coulon-Bublex, M., Swoboda, P., Couble, P., Kernan, M., and Durand, B. 2002. Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Development 129: 5487-5498.
12. Dunlap, J.C. 1999. Molecular bases for circadian clocks. Cell 96: 271-290.
13. Glossop, N.R., Houl, J.H., Zheng, H., Ng, F.S., Dudek, S.M., and Hardin, P.E. 2003. VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron 37: 249-261.
14. Grima, B., Chelot, E., Xia, R., and Rouyer, F. 2004. Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature 431: 869-873.
15. Hall, J. 2003. Genetics and molecular biology of rhythms in Drosophila and other insects. Adv. Genet. 48: 1-280.
16. Hardin, P.E., Hall, J.C., and Rosbash, M. 1990. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343: 536-540.
17. Honma, S., Kawamoto, T., Takagi, Y., Fujimoto, K., Sato, F., Noshiro, M., Kato, Y., and Honma, K. 2002. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419: 841-844.
18. Houl, J.H., Yu, W., Dudek, S.M., and Hardin, P.E. 2006. Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J. Biol. Rhythms 21: 93-103.
19. Lee, C., Bae, K., and Edery, I. 1999. PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription. Mol. Cell. Biol. 19: 5316-5325.
20. Levine, J., Funes, P., Dowse, H., and Hall, J. 2002. Signal analysis of behavioral and molecular cycles. BMC Neurosci. doi: 10.1186/1471-2202-3- 1.
21. Lin, Y., Han, M., Shimada, B., Wang, L., Gibler, T.M., Amarakone, A., Awad, T.A., Stormo, G.D., Van Gelder, R.N., and Taghert, P.H. 2002. Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc. Natl. Acad. Sci. 99: 9562-9567.
22. Matsumoto, A., Ukai-Tadenuma, M., Yamada, R.G., Houl, J., Uno, K.D., Kasukawa, T., Dauwalder, B., Ito, T.Q., Takahashi, K., Ueda, R., et al. 2007. A functional genomics strategy reveals clockwork orange as a transcriptional regulator Drosophila circadian clock. Genes & Dev. (this issue), doi: 10.1101/gad.1552207.
23. McDonald, M.J. and Rosbash, M. 2001. Microarray analysis and organization of circadian gene expression in Drosophila. Cell 107: 567-578.
24. McDonald, M.J., Rosbash, M., and Emery, P. 2001. Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter. Mol. Cell. Biol. 21: 1207-1217.
25. Nawathean, P. and Rosbash, M. 2004. The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol. Cell 13: 213-223.
26. Nawathean, P., Menet, J.S., and Rosbash, M. 2005. Assaying the Drosophila negative feedback loop with RNA interference in S2 cells. Methods Enzymol. 393: 610-622.
27. Panda, S., Hogenesch, J., and Kay, S. 2002. Circadian rhythms from flies to human. Nature 417: 329-335.
28. Ripperger, J.A. and Schibler, U. 2006. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat. Genet. 38: 369-374.
29. Roenneberg, T. and Merrow, M. 2005. Timeline: Circadian clocks - The fall and rise of physiology. Nat. Rev. Mol. Cell Biol. 6: 965-971.
30. SL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle. J. Biol. Rhythms 13: 380-392.
31. Rutila, J.E., Suri, V., Le, M., So, W.V., Rosbash, M., and Hall, J.C. 1998b. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell 93: 805-814.
32. Salzberg, A., D'Evelyn, D., Schulze, K.L., Lee, J.K., Strumpf, D., Tsai, L., and Bellen, H.J. 1994. Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-287.
33. Sehgal, A., Price, J., Man, B., and Young, M. 1994. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 263: 1603-1606.
34. Sehgal, A., Rothenfluh-Hilfiker, A., Hunter-Ensor, M., Chen, Y., Myers, M., and Young, M.W. 1995. Circadian oscillations and autoregulation of timeless RNA. Science 270: 808-810.
35. Shafer, O.T., Helfrich-Forster, C., Renn, S.C., and Taghert, P.H. 2006. Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. J. Comp. Neurol. 498: 180-193.
36. Stoleru, D., Peng, Y., Agosto, J., and Rosbash, M. 2004. Coupled oscillators control morning and evening locomotor behaviour of Drosophila. Nature 431: 862-868.
37. Stoleru, D., Peng, Y., Nawathean, P., and Rosbash, M. 2005. A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Nature 438: 238-242.
38. Tomita, J., Nakajima, M., Kondo, T., and Iwasaki, H. 2005. No transcription-translation feedback in circadian rhythm of KaiC phosphorylation. Science 307: 251-254.
39. Ueda, H.R., Matsumoto, A., Kawamura, M., Iino, M., Tanimura, T., and Hashimoto, S. 2002. Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. J. Biol. Chem. 277: 14048-14052.
40. Vitaterna, M.H., Ko, C.H., Chang, A.M., Buhr, E.D., Fruechte, E.M., Schook, A., Antoch, M.P., Turek, F.W., and Takahashi, J.S. 2006. The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc. Natl. Acad. Sci. 103: 9327-9332.
41. Wang, G.K., Ousley, A., Darlington, T.K., Chen, D., Chen, Y., Fu, W., Hickman, L.J., Kay, S.A., and Sehgal, A. 2001. Regulation of the cycling of timeless (tim) RNA. J. Neurobiol. 47: 161-175.
42. Wysocka, J. and Herr, W. 2003. The herpes simplex virus VP16-induced complex: The makings of a regulatory switch. Trends Biochem. Sci. 28: 294-304.
43. Yang, Z. and Sehgal, A. 2001. Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron 29: 453-467.
44. Yu, W., Zheng, H., Houl, J.H., Dauwalder, B., and Hardin, P.E. 2006. PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes & Dev. 20: 723-733.
45. Zhao, J., Kilman, V.L., Keegan, K.P., Peng, Y., Emery, P., Rosbash, M., and Allada, R. 2003. Drosophila clock can generate ectopic circadian clocks. Cell 113: 755-766.