An isoform-specific mutant reveals a role of PDP1ε in the circadian oscillator

Journal of Neuroscience

Volumn 29, Issue 35, 2009, Pages 10920-10927

  Zheng, Xiangzhong ^a   Koh, Kyunghee ^a   Sowcik, Mallory ^a   Smith, Corinne J ^a   Chen, Dechun ^a   Wu, Mark N ^a   Sehgal, Amita ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MUTANT PROTEIN; PER1 PROTEIN; PROTEIN; PROTEIN CLK; PROTEIN PDP1EPSILON; UNCLASSIFIED DRUG;

ARTICLE; CIRCADIAN RHYTHM; DROSOPHILA; GENE EXPRESSION; HOMOZYGOSITY; LIGHT DARK CYCLE; MOLECULAR CLOCK; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; MALE; MOTOR ACTIVITY; MUTATION; PROTEIN ISOFORMS;

EID: 69749116301     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2133-09.2009     Document Type: Article

References (21)

1. Allada R, Kadener S, Nandakumar N, RosbashM (2003) A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. EMBO J 22:3367-3375.
2. Benito J, Zheng H, Hardin PE (2007) PDP1ε functions downstream of the circadian oscillator to mediate behavioral rhythms. J Neurosci 27:2539-2547. (Pubitemid 46393584)
3. Blau J, Young MW (1999) Cycling vrille expression is required for a functional Drosophila clock. Cell 99:661-671.
4. Blau J, Blanchard F, Collins B, Dahdal D, Knowles A, Mizrak D, Ruben M (2007) What is there left to learn about the Drosophila clock? Cold Spring Harb Symp Quant Biol 72:243-250.
5. Cyran SA, Buchsbaum AM, Reddy KL, Lin M-C, Glossop NRJ, Hardin PE, Young MW, Storti RV, Blau J (2003) vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112:329-341.
6. Glossop NRJ, Houl JH, Zheng H, Ng FS, Dudek SM, Hardin PE (2003) VRILLE feeds back to control circadian transcription of clock in the Drosophila circadian oscillator. Neuron 37:249-261.
7. Hardin PE (2005) The circadian timekeeping system of Drosophila. Curr Biol 15:R714-R722.
8. Houl JH, Yu W, Dudek SM, Hardin PE (2006) Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J Biol Rhythms 21:93-103.
9. Kim EY, Edery I (2006) Balance between DBT/CKIε kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc Natl Acad Sci U S A 103:6178-6183.
10. Koundakjian EJ, Cowan DM, Hardy RW, Becker AH (2004) The Zuker collection: a resource for the analysis of autosomal gene function in Drosophila melanogaster. Genetics 167:203-206.
11. Lee C, Bae K, Edery I (1998) The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron 21:857-867.
12. Lim C, Lee J, Koo E, Choe J (2007) Targeted inhibition of Pdp1 epsilon abolishes the circadian behavior of Drosophila melanogaster. Biochem Biophys Res Commun 364:294-300.
13. Mitsui S, Yamaguchi S, Matsuo T, Ishida Y, Okamura H (2001) Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev 15:995-1006. (Pubitemid 32323549)
14. Park JH, Helfrich-Förster C, Lee G, Liu L, Rosbash M, Hall JC (2000) Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A 97:3608-3613. (Pubitemid 30183350)
15. Peng Y, Stoleru D, Levine JD, Hall JC, Rosbash M (2003) Drosophila free-running rhythms require intercellular communication. PLoS Biol 1:E13.
16. Reddy KL, Wohlwill A, Dzitoeva S, Lin M-H, Holbrook S, Storti RV (2000) The Drosophila PAR Domain Protein 1 (Pdp1) gene encodes multiple differentially expressed mRNAs and proteins through the use of multiple enhancers and promoters. Dev Biol 224:401-414.
17. Reddy KL, Rovani MK, Wohlwill A, Katzen A, Storti RV (2006) The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, mitosis and endoreplication. Dev Biol 289:100-114.
18. Rubin GM, Spradling AC (1982) Genetic transformation of Drosophila with transposable element vectors. Science 218:348-353.
19. Sathyanarayanan S, Zheng X, Xiao R, Sehgal A (2004) Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 116:603-615.
20. Wu MN, Koh K, Yue Z, Joiner WJ, Sehgal A (2008) Agenetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep 31:465-472. (Pubitemid 351694268)
21. Yu W, Zheng H, Houl JH, Dauwalder B, Hardin PE (2006) PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev 20:723-733.