A molecular basis for natural selection at the timeless locus in Drosophila melanogaster

Science

Volumn 316, Issue 5833, 2007, Pages 1898-1900

  Sandrelli, Federica ^a   Tauber, Eran ^b   Pegoraro, Mirko ^a   Mazzotta, Gabriella ^a   Cisotto, Paola ^a   Landskron, Johannes ^c   Stanewsky, Ralf ^c,d   Piccin, Alberto ^a   Rosato, Ezio ^b   Zordan, Mauro ^a   Costa, Rodolfo ^a   Kyriacou, Charalambos P ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME; ISOPROTEIN; VISUAL PIGMENT;

ALLELE; CIRCADIAN RHYTHM; DIAPAUSE; FLY; MUTATION; NATURAL SELECTION; PHOTORECEPTION; PHYSIOLOGICAL RESPONSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIAPAUSE; DROSOPHILA MELANOGASTER; GENE; GENE MUTATION; MOLECULAR BIOLOGY; NATURAL SELECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIMELESS GENE; WESTERN BLOTTING;

ALLELES; ANIMALS; CIRCADIAN RHYTHM; CLIMATE; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EUROPE; FEMALE; FLAVOPROTEINS; LIGHT; MOTOR ACTIVITY; MUTATION; PHOTOPERIOD; PROTEIN ISOFORMS; SEASONS; SELECTION (GENETICS); TEMPERATURE; TRANSGENES; TWO-HYBRID SYSTEM TECHNIQUES;

EURASIA; EUROPE;

DROSOPHILA MELANOGASTER; HEXAPODA;

EID: 34347397042     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1138426     Document Type: Article

References (20)

1. E. Tauber et al., Science 316, 1895 (2007).
2. E. Rosato et al., Nucleic Acids Res. 25, 455 (1997).
3. M. W. Young, K. Wager-Smith, L. Vosshall, L. Saez, M. P. Myers, Cold Spring Harbor Symp. Quant. Biol. 61, 279 (1996).
4. M. F. Ceriani et al., Science 285, 553 (1999).
5. F. J. Lin, W. Song, E. Meyer-Bernstein, N. Naidoo, A. Sehgal, Mol. Cell. Biol. 21, 7287 (2001).
6. R. Stanewsky et al., Cell 95, 681 (1998).
7. Materials and methods are available as supporting material on Science Online.
8. P. Emery, R. Stanewsky, J. C. Hall, M. Rosbash, Nature 404, 456 (2000).
9. H. Zeng, Z. Qian, M. P. Myers, M. Rosbash, Nature 380, 129 (1996).
10. I. Edery, L. J. Zwiebel, M. E. Dembinska, M. Rosbash, Proc. Natl. Acad. Sci. U.S.A. 91, 2260 (1994).
11. S. Martinek, S. Inonog, A. S. Manoukian, M. W. Young, Cell 105, 769 (2001).
12. N. Peschel, S. Veleri, R. Stanewsky, Proc. Natl. Acad. Sci. U.S.A. 103, 17313 (2006).
13. C. Helfrich-Forster, C. Winter, A. Hofbauer, J. C. Hall, R. Stanewsky, Neuron 30, 249 (2001).
14. S. Dissel et al., Nat. Neurosci. 7, 834 (2004).
15. A. Busza, M. Emery-Le, M. Rosbash, P. Emery, Science 304, 1503 (2004).
16. E. Rosato et al., Curr. Biol. 11, 909 (2001).
17. L. J. Ashmore, A. Sehgal, J. Biol. Rhythms 18, 206 (2003).
18. C. S. Pittendrigh, T. Takamura, J. Biol. Rhythms 4, 217 (1989).
19. C. S. Pittendrigh, W. T. Kyner, T. Takamura, J. Biol. Rhythms 6, 299 (1991).
20. Supported by the European Community (EC Biotechnology Program ERB-B104-CT960096 and the 6th Framework Project EUCLOCK no. 018741), Ministero dell'Università e della Ricerca Scientifica e Tecnologica/British Council (C.P.K. and R.C.), the National Environmental Research Council (C.P.K., E.T., and E.R.), the Royal Society Wolfson Research Merit Award (C.P.K.), Ministero dell' Università e della Ricerca (R.C.), Agenzia Spaziale Italiana, DMC grant (R.C.), the Marie Curie Postdoctoral Fellowship (E.T.), and Università di Padova grant 116 g03 (F.S.). R.S. and J.L. were supported by Deutsche Forschungsgemeinschaft grants (STA421/3-3 and STA421/6-1) to R.S. We thank M. Young, M. Rosbash, and M. Gatti for antibodies.