Principles and problems revolving round rhythm-related genetic variants

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 72, Issue , 2007, Pages 215-232

  Hall, J C ^a   Chang, D C ^a   Dolezelova, E ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLK PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; NUCLEAR PROTEIN; PERIOD PROTEIN, INSECT; TRANSCRIPTION FACTOR;

ALLELE; ANIMAL; CIRCADIAN RHYTHM; DROSOPHILA; FEMALE; GENE; GENETIC VARIABILITY; GENETICS; MALE; MUTATION; PHENOTYPE; PHYSIOLOGY; REVIEW; GENE LOCUS; GENETIC BACKGROUND; NONHUMAN;

ALLELES; ANIMALS; CIRCADIAN RHYTHM; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENES, INSECT; MALE; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 46249088875     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2007.72.039     Document Type: Conference Paper

References (123)

1. Akten B., Jauch E., Genova G.K., Kim E.Y., Edery I., Raabe T., and Jackson F.R. 2003. A role for CK2 in the Drosophila circadian oscillator. Nat. Neurosci. 6: 251.
2. Alavizadeh A., Kiernan A.E., Nolan P., Lo C., Steel K.P., and Bucan M. 2001. The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. Dev. Biol. 234: 244.
3. Antoch M.P., Song E.-J., Change A.-M., Vitaterna M.H., Zhao Y., Wilsbacher L.D., Sangoram A.M., King D.P., Pinto L.H., and Takahashi J.S. 1997. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89: 655.
4. Aronson B.D., Johnson K.A., and Dunlap J.C. 1994. Circadian clock locus frequency: Protein encoded by a single open reading frame defines period length and temperature compensation. Proc. Natl. Acad. Sci. 91: 7683.
5. Bacon Y., Ooi A., Kerr S., Shaw-Andrews L., Winchester L., Breeds S., Tymoska-Lalanne Z., Clay J., Greenfield A.G., and Nolan P.M. 2004. Screening for novel ENU-induced rhythm, entrainment and activity mutants. Genes Brain Behav. 3: 196.
6. Bargiello T.A. and Young M.W. 1984. Molecular genetics of a biological clock in Drosophila. Proc. Natl. Acad. Sci. 81: 2142.
7. Barnes J.W., Tischkau S.A., Barnes J.A., Mitchell J.W., Burgoon P.W., Hickok J.R., and Gillette M.U. 2003. Requirement of mammalian Timeless for circadian rhythmicity (erratum in Science 302: 1153). Science 302: 439.
8. Baylies M.K., Bargiello T.A., and Young M.W. 1987. Changes in abundance and structure of the per gene product can alter periodicity of the Drosophila clock. Nature 326: 390.
9. Benna C., Scannapieco P., Piccin A., Sandrelli F., Zordan M., Rosato E., Kyriacou C.P., Valle G., and Costa R. 2000. A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim. Curr. Biol. 10: R512.
10. Bi X. and Rong Y.S. 2003. Genome manipulation by homologous recombination in Drosophila. Brief. Funct. Genomics Proteomics 2: 142.
11. Blau J. 2003. A new role for an old kinase: CK2 and the circadian clock. Nat. Neurosci. 6: 208.
12. Borycz J., Borycz J.A., Loubani M., and Meinertzhagen I.A. 2002. tan and ebony genes regulate a novel pathway for transmitter metabolism at fly photoreceptor terminals. J. Neurosci. 22: 10549.
13. Brandes C., Plautz J.D., Stanewsky R., Jamison C.F., Straume M., Wood K.V., Kay S.A., and Hall J.C. 1996. Novel features of Drosophila period transcription revealed by real-time luciferase reporting. Neuron 16: 687.
14. Bushey D., Huber R., Tononi G., and Cirelli C. 2007. Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. J. Neurosci. 27: 5384.
15. Busza A., Emery-Le M., Rosbash M., and Emery P. 2004. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 304: 1503.
16. Chandrashekaran, M.K. and Loher W. 1969. The effect of light intensity on the circadian rhythm of eclosion in Drosophila pseudoobscura. Z. Vgl. Physiol. 62: 337.
17. Cheng Y. and Hardin P.E. 1998. Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling. J. Neurosci. 18: 741.
18. Cirelli C., Bushey D., Hill S., Huber R., Kreber R., Ganetzky B., and Tononi G. 2005. Reduced sleep in Drosophila Shaker mutants. Nature 434: 1087.
19. Costa R., Peixoto A.A., Barbujani G., and Kyriacou C.P. 1992. A latitudinal cline in a Drosophila clock gene. Proc. R. Soc. Lond. B Biol. Sci. 250: 43.
20. Coté G.G., and Brody S. 1986. Circadian rhythms in Drosophila melanogaster: Analysis of period as a function of gene dosage at the per (period) locus. J. Theor. Biol. 121: 487.
21. Crenshaw E.B., III, Ryan A., Dillon S.R., Kalla K., and Rosenfeld M.G. 1991. Wocko, a neurological mutant generated in a transgenic mouse pedigree. J. Neurosci. 11: 1524.
22. DeBruyne J.P, Weaver D.R., and Reppert S.M. 2007. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 10: 543.
23. DeBruyne J.P., Noton E., Lambert C.M., Maywood E.S., Weaver D.R., and Reppert S.M. 2006. A clock shock: Mouse CLOCK is not required for circadian oscillator function. Neuron 50: 465.
24. DiBartolomeis S.M., Akten B., Genova G., Roberts M.A., and Jackson F.R. 2002. Molecular analysis of the Drosophila miniature-dusky (m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin. Mol. Genet. Genomics 267: 564.
25. Dolezelova E., Dolezel D., and Hall J.C. 2007. Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene. Genetics 177: 329.
26. Dunlap J.C., Loros J.J., and Decoursey P.P. 2004. Chronobiology: Biological timekeeping. Sinauer Associates, Sunderland, Massachusetts.
27. Dushay M.S., Rosbash M., and Hall J.C. 1989. The disconnected visual system mutations in Drosophila drastically disrupt circadian rhythms. J. Biol. Rhythms 4: 1.
28. ---. 1992. Mapping the Clock mutation rhythm mutation to the period locus of Drosophila melanogaster by germline transformation. J. Neurogenet. 8: 173.
29. Dushay M.S., Konopka R.J., Orr D., Greenacre M.L., Kyriacou C.P., Rosbash M., and Hall J.C. 1990. Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster. Genetics 125: 557.
30. Emery P., Stanewsky R., Hall J.C., and Rosbash M. 2000a. Drosophila cryptochrome - A unique circadian-rhythm photoreceptor. Nature 404: 456.
31. Emery P., Stanewsky R., Helfrich-Förster C., Emery-Le M., Hall J.C., and Rosbash M. 2000b. Drosophila CRY is a deep brain circadian photoreceptor. Neuron 26: 493.
32. Ewer J., Frisch B., Hamblen-Coyle M.J., Rosbash M., and Hall J.C. 1992. Expression of the period clock gene within different cells types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J. Neurosci. 12: 3321.
33. Frank K.D. and Zimmerman W.F. 1969. Action spectra for phase shifts of a circadian rhythm in Drosophila. Science 163: 688.
34. Frisch B., Hardin P.E., Hamblen-Coyle M.J., Rosbash M., and Hall J.C. 1994. A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron 12: 555.
35. Gailey D.A., Villella A., and Tully T. 1991. Reassessment of the effects of biological rhythm mutations on learning in Drosophila melanogaster. J. Comp. Physiol. A 169: 685.
36. Gotter A.L. 2006. A Timeless debate: Resolving TIM's noncircadian roles with possible clock function. Neuroreport 17: 1229.
37. Gotter A.L., Manganaro T., Weaver D.R., Kolakowski L.F., Jr., Possidente B., Sriram S., MacLaughlin D.T., and Reppert S.M. 2000. A time-less function for mouse timeless. Nat. Neurosci. 8: 755.
38. Greenspan R.J., Tononi G., Cirelli C., and Shaw P.J. 2001. Sleep and the fruit fly. Trends Neurosci. 24: 142.
39. Hall J.C. 1995. Tripping along the trail to the molecular mechanisms of biological clocks. Trends Neurosci. 18: 230.
40. ---. 2003. Genetics and molecular biology of rhythms in Drosophila and other insects. Adv. Genet. 48: 1.
41. ---. 2005. Systems approaches to biological rhythms in Drosophila. Methods Enzymol. 393: 61.
42. Hamblen-Coyle M., Konopka R.J., Zwiebel L.J., Colot H.V., Dowse H.B., Rosbash M., and Hall J.C. 1989. A new mutation at the period locus of Drosophila melanogaster with some novel effects on circadian rhythms. J. Neurogenet. 5: 229.
43. Hardin P.E., Hall J.C., and Rosbash M. 1992. Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster. EMBO J. 11: 1.
44. Heilig J.S., Freeman M., Laverty T., Lee K.J., Campos A.R., Rubin G.M., and Steller H. 1991. Isolation and characterization of the disconnected gene of Drosophila melanogaster. EMBO J. 10: 809.
45. Helfrich-Förster C. 1995. The period clock gene is expressed in CNS neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc. Natl. Acad. Sci. 92: 612.
46. ---. 1998. Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: A brain-behavioral study of disconnected mutants. J. Comp. Physiol. A 182: 435.
47. ---. 2002. The circadian system of Drosophila melanogaster and its light input pathways. Zoology 105: 297.
48. Hendricks J.C. 2003. Sleeping flies don't lie: The use of Drosophila melanogaster to study sleep and circadian rhythms. J. Appl. Physiol. 94: 1660.
49. Jacob F. 1997. The operon after 25 years (translation). C.R. Acad. Sci. III 320: 199.
50. Jauch E., Melzig J., Brkulj M., and Raabe T. 2002. In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) β-subunit. Gene 298: 29.
51. Kadener S., Stoleru D., McDonald M., Nawathean P., and Rosbash M. 2007. Clockwork orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev. 21: 1675.
52. Kaneko M. and Hall J.C. 2000. Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J. Comp. Neurol. 422: 66.
53. Kernan M.J., Kuroda M.I., Kreber R., Baker B.S., and Ganetzky B. 1991. napts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription. Cell 66: 949
54. King D.P. and Takahashi J.S. 2000. Molecular genetics of circadian rhythms in mammals. Ann. Rev. Neurosci. 23: 713.
55. 19H deletion, distal of Kit. Genetics 146: 1049.
56. King D.P., Zhao Y., Sangoram A.M., Wilsbacher L.D., Tanaka M., Antoch M.P., Steeves T.D.L., Vitaterna M.H., Kornhauser J.M., Lowrey P.L., Turek F.W., and Takahashi J.S. 1997b. Positional cloning of the mouse circadian Clock gene. Cell 89: 641.
57. Klemm E. and Ninnemann H. 1976. Detailed action spectrum for the delay shift in pupae emergence of Drosophila pseudoobscura. Photochem. Photobiol. 24: 369.
58. Kloss B., Price J.L., Saez L., Blau J., Rothenfluh A., Wesley C.S., and Young M.W. 1998. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase lepsilon. Cell 94: 97.
59. Koh K., Zheing H., and Sehgal A. 2006. JETLAG resets the Drosophila circadian clock by promoting light-induced dedgradatin of TIMELESS. Science 312: 1809.
60. Konopka R.J. and Benzer S. 1971. Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. 68: 2112.
61. Konopka R.J., Smith R.F., and Orr D. 1991. Characterization of Andante, a new Drosophila clock mutant, and its interactions with other clock mutants. J. Neurogenet. 7: 103.
62. Krishnan B., Levine J.D., Lynch K.S., Dowse H.B., Funes P., Hall J.C., Hardin P.E., and Dryer S.E. 2001. A novel role for cryptochrome in a Drosophila circadian oscillator. Nature 411: 313.
63. Lakin-Thomas P.L. 2006. Transcriptonal feedback oscillators: Maybe, maybe not... J. Biol. Rhythms 21: 83.
64. Lawrence P.A. 1992. The making of a fly. Blackwell Scientific, Oxford, United Kingdom.
65. Levine J.D., Funes P., Dowse H.B., and Hall J.C. 2002. Signal analysis of behavioral and molecular cycles. BMC Neurosci. 3: 1.
66. Lin J.M., Kilman V.L, Keegan K., Paddock B., Emery-Le M., Rosbash M., and Allada R. 2002. A role for casein kinase 2alpha in the Drosophila circadian clock. Nature 420: 816.
67. Liu X., Lorenz L., Yu Q., Hall J.C., and Rosbash M. 1988. Spatial and temporal expression of the period gene in Drosophila melanogaster. Genes Dev. 2: 228.
68. Low-Zeddies S.S. and Takahashi J.S. 2001. Circadian analysis of the Clock mutation in mice shows that complex cellular intergration determines circadian behavior. Cell 105: 25.
69. Lowrey P.L. and Takahashi J.S. 2000. Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu. Rev. Genet. 34: 533.
70. ---. 2004. Mammalian circadian biology: Elucidating genome-wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 5: 407.
71. Martinek S., Inonog S., Manoukian A.S., and Young M.W. 2001. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105: 769.
72. Matsumoto A., Motoshige T., Murata T., Tomioka K., Tanimura T., and Chiba Y. 1994. Chronobiological analysis of a new clock mutant, Toki, in Drosophila melanogaster. J. Neurogenet. 9: 141.
73. Mealey-Ferrara M.L., Montalvo A.G., and Hall J.C. 2003. Effects of combining a cryptochrome mutation with other visual-system variants on entrainment of locomotor and adult-emergence rhythms in Drosophila. J. Neurogenet. 17: 171.
74. Myers E.M., Yu J., and Sehgal A. 2003. Circadian control of eclosion: Interaction between a central and peripheral clock in Drosophila melanogaster. Curr. Biol. 13: 526.
75. Naylor E., Bergmann B.M., Krauski K., Zee P.C., Takahashi J.S., Vitaterna M.H., and Turek F.W. 2000. The circadian clock mutation alters sleep homeostasis in the mouse. J. Neurosci. 20: 8138.
76. Newby L.M. and Jackson F.R. 1991. Drosophila ebony mutants have altered circadian activity rhythms but normal eclosion rhythms. J. Neurogenet. 7: 85.
77. Newby L.M., White L., DiBartolomeis S.M., Walker B.J., Dowse H.B., Ringo J.M., Khuda N., and Jackson F.R. 1991. Mutational analysis of the Drosophila miniature-dusky (m-dy) locus: Effects on cell size and circadian rhythms. Genetics 128: 571.
78. Ohata K., Nishiyama H., and Tsukahara Y. 1998. Action spectrum of the circadian clock photoreceptor in Drosophila melanogaster. In Biological clocks. Mechanisms and applications (ed. Y. Touitou), p. 167. Elsevier, Amsterdam, The Netherlands.
79. Oishi K., Ohkura N., Wakabayashi M., Shirai H., Sato K., Matsuda J., Atsumi G., and Ishida N. 2006. CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression. J. Thromb. Haemost. 4: 1774.
80. Peifer M., Pai L.-M., and Casey M. 1994. Phosphorylation of the Drosphila adherens junction protein ARMADILLO: Roles for WINGLESS and ZESTE-WHITE 3 kinase. Dev. Biol. 166: 543.
81. Peschel N., Veleri S., and Stanewsky R. 2006. Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc. Nat. Acad. Sci. 103: 17313.
82. Pickard G.E., Sollars P.J., Rincjick E.M., Nolan P.M., and Bucan M. 1995. Mutagenesis and behavioral screening for altered circadian activity identifies the mouse mutant, Wheels. Brain Res. 705: 255.
83. Price J.L. 2005. Genetic screens for clock mutants in Drosophila. Methods Enzymol. 393: 35.
84. Price J.L., Blau J., Rothenfluh A., Abodeely M., Kloss B., and Young M.W. 1998. double-time is a new Drosophila clock gene that regulates PERIOD protein accumulation. Cell 94: 83.
85. Prosser R.A., Edgar D.M., Heller H.C., and Miller J.D. 1994. A possible glial role in the mammalian circadian clock. Brain Res. 643: 296.
86. Richardt A., Rybak J., Stortkuhl K.F., Meinertzhagen I.A., and Hovemann B.T. 2002. Ebony protein in the Drosophila nervous system: Optic neuropile expression in glial cells. J. Comp. Neurol. 452: 93.
87. Roch F., Alonso C.R., and Akam M. 2003. Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis J. Cell Sci. 116: 1199.
88. Rosato E., Trevisan A., Sandrelli F., Zordan M., Kyriacou C.P., and Costa R. 1997. Conceptual translation of timeless reveals alternative initiating methionines in Drosophila. Nucleic Acids Res. 25: 455.
89. Rothenfluh A., Abodeely M., Price J.L., and Young M.W. 2000. Isolation and analysis of six timeless alleles that cause shortor long-period circadian rhythms in Drosophila. Genetics 156: 665.
90. Saez L. and Young M.W. 1988. In situ localization of the per clock protein during development of Drosophila melanogaster. Mol. Cell. Biol. 8: 5378.
91. Sancar A. 2000. Cryptochrome: The second photoactive pigment in the eye and its role in circadian photoreception. Annu. Rev. Biochem. 69: 31.
92. Sandrelli F., Tauber E., Pegoraro M., Mazzotta G., Cisotto P., Landskron J., Stanewsky R., Piccin P., Rosato E., Zordan M., Costa R., and Kyriacou C.P. 2007. A molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science 316: 1898.
93. Sawyer L.A., Sandrelli F., Pasetto C., Peixoto A.A., Rosato E., Costa R., and Kyriacou C.P. 2006. The period gene Thr-Gly polymorphism in Australia and African Drosophila melanogaster population: Implications for selection. Genetics 174: 465.
94. Scheuch G.C., Johnson W., Connor R.L., and Silver J. 1982. Investigation of circadian rhythms in a genetically anophthalmic mouse strain: Correlation of activity patterns with suprachiasmatic nuclei hypogenesis. J. Comp. Physiol. A 149: 333.
95. Sehgal A., Price J.L., Man B., and Young M.W. 1994. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 263: 1603.
96. Shannon M.P., Kaufman T.C., Shen M.W., and Judd B.H. 1972. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Genetics 72: 615.
97. Shimomura K., Low-Zeddies S.S., King D.P., Steeves T.D., Whiteley A., Kushla J., Zemenides P.D., Lin A., Vitaterna M.H., Churchill G.A., and Takahashi J.S. 2001. Genomewide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res. 11: 959.
98. Siepka, S.M., Yoo S.-H., Park J., Song W., Kumar V., Hu Y., Lee C., and Takahashi J.S. 2007. Circadian mutant overtime Reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression. Cell 129: 1011.
99. Simpson P. and Carteret C. 1989. A study of shaggy reveals spatial domains of expression of achaete-scute alleles on the thorax of Drosophila. Development 106: 57.
100. Siwicki K.K., Eastman C., Petersen G., Rosbash M., and Hall J.C. 1988. Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythm changes in the visual system. Neuron 1: 141.
101. Smith R.F. and Konopka R.J. 1981. Circadian clock phenotypes of chromosome aberrations with a breakpoint at the per locus. Mol. Gen. Genet. 183: 243.
102. ---. 1982. Effects of dosage alterations at the per locus on the circadian clock of Drosophila. Mol. Gen. Genet. 185: 30.
103. So W.V. and Rosbash M. 1997. Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J. 16: 7146.
104. Sollars P.J., Ryan A., Oglivie M.D., and Pickard G.E. 1996. Altered circadian rhythmicity in the Wocko mouse, a hyperactive transgenic mutant. Neuroreport 7: 1245.
105. Stanewsky R. 2003. Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54: 111.
106. Stanewsky R., Jamison C.F., Plautz J.D., Kay S.A., and Hall J.C. 1997. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J. 16: 5006.
107. b mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95: 681.
108. Steller H., Fischbach K.-F., and Rubin G.M. 1987. disconnected: A locus required for neuronal pathway formation in the visual system of Drosophila. Cell 50: 1139.
109. Tauber E., Zordan M., Sandrelli F., Pergoraro M., Osterwalder N., Breda C., Daga A., Selmin A., Monger K., Benna C., Rosato E., Kyriacou C.P., and Costa R. 2007. Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316: 1895.
110. Turek F.W., Joshu C., Kohsaka A., Lin E., Ivanova G., McDearmon E., Laposky A., Losee-Olson S., Easton A., Jensen D.R., Eckel R.H., Takahashi J.S., and Bass J. 2005. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308: 1043.
111. Veleri S., Rieger D., Helfrich-Förster C., and Stanewsky R. 2007. Hofbaur-Buchner eyelet affects circadian photosensitivity and coordinates PER and TIM expression in Drosophila clock neurons. J. Biol. Rhythms 22: 29.
112. Venken K.J.T. and Bellen H.J. 2005. Emerging technologies for gene manipulation in Drosophila melanogaster (erratum in Nat. Rev. Genet. 6: 340). Nat. Rev. Genet. 6: 167.
113. Vitaterna M.H., King D.P., Chang A.-M., Kornhauser J.M., Lowrey P.L., McDonald J.D., Dove W.F., Pinto L.H., Turek F.W., and Takahashi J.S. 1994. Mutagenesis and mapping of a mouse gene essential for circadian behavior. Science 264: 719.
114. Vosshall L.B. and Young M.W. 1995. Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. Neuron 15: 345.
115. Weaver D.R. 1998. The suprachiasmatic nucleus: A 25-year retrospective. J. Biol. Rhythms 13: 100.
116. Weiner J. 1999. Time, love, memory: A great biologist and his quest for the origins of behavior. Alfred A. Knopf, New York.
117. Wu C.F., Ganetzky B., Jan L.Y., and Jan Y.N. 1978. A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc. Natl. Acad. Sci. 75: 4047.
118. blind mutation affects behavioral rhythms but not periodic eclosion. Genetics 169: 751.
119. Yang Z. and Sehgal A. 2001. Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron 29: 453.
120. Yu Q., Jacquier A.C., Citri Y., Hamblen M., Hall J.C., and Rosbash M. 1987. Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. Proc. Natl. Acad. Sci. 84: 784.
121. Zerr D.M., Hall J.C., Rosbash M., and Siwicki K.K. 1990. Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J. Neurosci. 10: 2749.
122. Zilian O., Frei E., Burke R., Brentrup D., Gutjahr T., Bryant P.J., and Noll M. 1999. double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Development 126: 5409.
123. Zimmerman W.F. and Goldsmith T.H. 1971. Photosensitivity of the circadian rhythm and of visual receptors in carotenoid-depleted Drosophila. Science 171: 1167.