Coupling of human circadian and cell cycles by the timeless protein

Molecular and Cellular Biology

Volumn 25, Issue 8, 2005, Pages 3109-3116

  Ünsal Kaçmaz, Keziban ^a   Mullen, Thomas E ^a   Kaufmann, William K ^a   Sancar, Aziz ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE; TIMELESS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DOWN REGULATION; EMBRYO; EMBRYO CELL; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN INTERACTION;

CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CIRCADIAN RHYTHM; DNA DAMAGE; DNA REPLICATION; DOWN-REGULATION; EXODEOXYRIBONUCLEASES; FLAVOPROTEINS; HUMANS; HYDROXYUREA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

EID: 16244408025     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.8.3109-3116.2005     Document Type: Article

References (43)

1. Barnes, J. W., S. A. Tischkau, J. A. Barnes, J. W. Mitchell, P. W. Burgoon, J. R. Hickok, and M. U. Gillette. 2003. Requirement of mammalian Timeless for circadian rhythmicity. Science 302:439-442.
2. Benna, C., P. Scannapieco, A. Piccin, F. Sandrelli, M. Zordan, E. Rosato, C. P. Kyriacou, G. Valle, and R. Costa. 2000. A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim. Curr. Biol. 10:R512-R513.
3. Bjarnason, G. A., and R. Jordan. 2000. Circadian variation of cell proliferation and cell cycle protein expression in man: clinical implications. Prog. Cell Cycle Res. 4:193-206.
4. Canaple, L., T. Kakizawa, and V. Laudet. 2003. The days and nights of cancer cells. Cancer Res. 63:7545-7552.
5. Chan, R. C., A. Chan, M. Jeon, T. F. Wu, D. Pasqualone, A. E. Rougvie, and B. J. Meyer. 2003. Chromosome cohesion is regulated by a clock gene paralogue TIM-1. Nature 423:1002-1009.
6. Cortez, D., S. Guntuku, J. Qin, and S. J. Elledge. 2001. ATR and ATRIP: partners in checkpoint signaling. Science 294:1713-1716.
7. Dekens, M. P., C. Santoriello, D. Vallone, G. Grassi, D. Whitmore, and N. S. Foulkes. 2003. Light regulates the cell cycle in zebrafish. Curr. Biol. 13:2051-2057.
8. Field, M. D., E. S. Maywood, J. A. O'Brien, D. R. Weaver, S. M. Reppert, and M. H. Hastings. 2000. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms. Neuron 25:437-447.
9. Foss, E. J. 2001. Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae. Genetics 157:567-577.
10. Fu, L., H. Pelicano, J. Liu, P. Huang, and C. Lee. 2002. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111:41-50.
11. Gotter, A. L. 2003. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J. Mol. Biol. 331:167-176.
12. Gotter, A. L., T. Manganaro, D. R. Weaver, L. F. Kolakowski, Jr., B. Possidente, S. Sriram, D. T. MacLaughlin, and S. M. Reppert. 2000. A time-less function for mouse timeless. Nat. Neurosci. 3:755-756.
13. Griffin, E. A., Jr., D. Staknis, and C. J. Weitz. 1999. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 286:768-771.
14. Guo, Z., A. Kumagai, S. X. Wang, and W. G. Dunphy. 2000. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev. 14:2745-2756.
15. Hastings, M. H., M. D. Field, E. S. Maywood, D. R. Weaver, and S. M. Reppert. 1999. Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism. J. Neurosci. 19:RC11.
16. Heffernan, T. P., D. A. Simpson, A. R. Frank, A. N. Heinloth, R. S. Paules, M. Cordeiro-Stone, and W. K. Kaufmann. 2002. An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol. Cell. Biol. 22:8552-8561.
17. King, D. P., and J. S. Takahashi. 2000. Molecular genetics of circadian rhythms in mammals. Annu. Rev. Neurosci. 23:713-742.
18. Koike, N., A. Hida, R. Numano, M. Hirose, Y. Sakaki, and H. Tei. 1998. Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1. FEBS Lett. 441:427-431.
19. Krings, G., and D. Bastia. 2004. swil- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 101:14085-14090.
20. Kume, K., M. J. Zylka, S. Sriram, L. P. Shearman, D. R. Weaver, X. Jin, E. S. Maywood, M. H. Hastings, and S. M. Reppert. 1999. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193-205.
21. 20a. Lee, C., J. P. Etchegaray, F. R. A. Cagampang, A. S. I. Loudon, and S. M. Reppert. 2001. Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107:855-867.
22. Li, Z., R. O. Stuart, J. Qiao, A. Pavlova, K. T. Bush, M. Pohl, H. Sakurai, and S. K. Nigam. 2000. A role for Timeless in epithelial morphogenesis during kidney development. Proc. Natl. Acad. Sci. USA 97:10038-10043.
23. Liu, Q., S. Guntuku, X. S. Cui, S. Matsuoka, D. Cortez, K. Tamai, G. Luo, S. Carattini-Rivera, F. DeMayo, A. Bradley, L. A. Donehower, and S. J. Elledge. 2000. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14:1448-1459.
24. Matsuo, T., S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, and H. Okamura. 2003. Control mechanism of the circadian clock for timing of cell division in vivo. Science 302:255-259.
25. Merrow, M., and T. Roenneberg. 2004. Cellular clocks: coupled circadian and cell division cycles. Curr. Biol. 14:R25-R26.
26. Nagoshi, E., C. Saini, C. Bauer, T. Laroche, F. Naef, and U. Schibier. 2004. Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119:693-705.
27. Nasmyth, K. 1996. Viewpoint: putting the cell cycle in order. Science 274:1643-1645.
28. Nghiem, P., P. K. Park, Y. Kim, C. Vaziri, and S. L. Schreiber. 2001. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl. Acad. Sci. USA 98:9092-9097.
29. Nikaido, S. S., and C. H. Johnson. 2000. Daily and circadian variation in survival from ultraviolet radiation in Chlamydomonas reinhardtii. Photochem. Photobiol. 71:758-765.
30. Noguchi, E., C. Noguchi, L. L. Du, and P. Russell. 2003. Swil prevents replication fork collapse and controls checkpoint kinase Cds1. Mol. Cell. Biol. 23:7861-7874.
31. Nyberg, K. A., R. J. Michelson, C. W. Putnam, and T. A. Weinert. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36:617-656.
32. Oishi, K., K. Miyazaki, K. Kadota, R. Kikuno, T. Nagase, G. Atsumi, N. Ohkura, T. Azama, M. Mesaki, S. Yukiraasa, H. Kobayashi, C. Iitaka, T. Umehara, M. Horikoshi, T. Kudo, Y. Shimizu, M. Yano, M. Monden, K. Machida, J. Matsuda, S. Horie, T. Todo, and N. Ishida. 2003. Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J. Biol. Chem. 278:41519-41527.
33. Park, H., and R. Sternglanz. 1999. Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae. Yeast 15:35-41.
34. Reppert, S. M., and D. R. Weaver. 2002. Coordination of circadian timing in mammals. Nature 418:935-941.
35. Sancar, A. 2004. Regulation of the mammalian circadian clock by cryptochrome. J. Biol. Chem. 279:34079-34082.
36. Sancar, A., L. A. Lindsey-Boltz, K. Unsal-Kacmaz, and S. Linn. 2004. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73:39-85.
37. Sangoram, A. M., L. Saez, M. P. Antoch, N. Gekakis, D. Staknis, A. Whiteley, E. M. Fruechte, M. H. Vitaterna, K. Shimomura, D. P. King, M. W. Young, C. J. Weitz, and J. S. Takahashi. 1998. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron 21:1101-1113.
38. Unsal-Kacmaz, K., and A. Sancar. 2004. Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol. Cell. Biol. 24:1292-1300.
39. Welsh, D. K., S. H. Yoo, A. C. Liu, J. S. Takahashi, and S. A. Kay. 2004. Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr. Biol. 14:2289-2295.
40. Xiao, J., C. Li, N. L. Zhu, Z. Borok, and P. Minoo. 2003. Timeless in lung morphogenesis. Dev. Dyn. 228:82-94.
41. Young, M. W., and S. A. Kay. 2001. Time zones: a comparative genetics of circadian clocks. Nat. Rev. Genet. 2:702-715.
42. Zhou, B. B., and S. J. Elledge. 2000. The DNA damage response: putting checkpoints in perspective. Nature 408:433-439.
43. Zylka, M. J., L. P. Shearman, J. D. Levine, X. Jin, D. R. Weaver, and S. M. Reppert. 1998. Molecular analysis of mammalian timeless. Neuron 21:1115-1122.