Physiology and pathology of calcium signaling in the brain

Frontiers in Pharmacology

Volumn 3 APR, Issue , 2012, Pages

  Kawamoto, Elisa Mitiko ^a   Vivar, Carmen ^a   Camandola, Simonetta ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Calcium channels; Synaptic plastici

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DYNAMIN I; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MITOFUSIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINIC RECEPTOR; NIMODIPINE; PRESENILIN; PROTEIN KINASE C; PURINERGIC P2X RECEPTOR; RECEPTOR OPERATED CHANNEL; RYANODINE RECEPTOR; SEROTONIN RECEPTOR; SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN 1; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT CALCIUM CHANNEL;

ADDICTION; AGING; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTISM; BASOLATERAL AMYGDALA; BRAIN MITOCHONDRION; BRAIN REGION; BRAIN STEM; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CEREBELLUM CORTEX; CEREBROVASCULAR ACCIDENT; CORPUS STRIATUM; DENTATE GYRUS; ENDOPLASMIC RETICULUM; EPILEPSY; FOREBRAIN; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL MOSSY FIBER; HIV ASSOCIATED DEMENTIA; HUMAN; HUNTINGTON CHOREA; HYPOTHALAMUS; LATERAL AMYGDALA; LEARNING; LONG TERM POTENTIATION; MEMORY; NERVE CELL MEMBRANE; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NEUROPHYSIOLOGY; NEUROTRANSMISSION; NONHUMAN; OLFACTORY BULB; PARKINSON DISEASE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SCHIZOPHRENIA; SPATIAL MEMORY; THALAMUS;

EID: 84864722301     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00061     Document Type: Article

References (366)

1. Abou-Sleiman, P. M., Muqit, M. M., and Wood, N. W. (2006). Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat. Rev. Neurosci. 7, 207-219.
2. Andrews, S. B., Leapman, R. D., Landis, D. M., and Reese, T. S. (1988). Activity-dependent accumulation of calcium in Purkinje cell dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 85, 1682-1685.
3. Annaert, W. G., Levesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D., George-Hyslop, P. S., Cordell, B., Fraser, P., and De Strooper, B. (1999). Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J. Cell Biol. 147, 277-294.
4. Bading, H., and Greenberg, M. E. (1991). Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science 253, 912-914.
5. Bah, J., Quach, H., Ebstein, R. P., Segman, R. H., Melke, J., Jamain, S., Rietschel, M., Modai, I., Kanas, K., Karni, O., Lerer, B., Gourion, D., Krebs, M. O., Etain, B., Schürhoff, F., Szöke, A., Leboyer, M., and Bourgeron, T. (2004). Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. Neuroreport 15, 1987-1991.
6. Bajjalieh, S. M., and Scheller, R. H. (1995). The biochemistry of neurotransmitter secretion. J. Biol. Chem. 270, 1971-1974.
7. Balschun, D., Wolfer, D. P., Bertocchini, F., Barone, V., Conti, A., Zuschratter, W., Missiaen, L., Lipp, H. P., Frey, J. U., and Sorrentino, V. (1999). Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. EMBO J. 18, 5264-5273.
8. Ban, T. A., Morey, L., Aguglia, E., Azzarelli, O., Balsano, F., Marigliano, V., Caglieris, N., Sterlicchio, M., Capurso, A., Tomasi, N. A., Cerepaldi, G., Volpe, D., Palmieri, G., Ambrosi, G., Polli, E., Cortellano, M., Zanussi, C., and Froldi, M. (1990). Nimodipine in the treatment of old age dementias. Prog. Neuropsychopharmacol. Biol. Psychiatry 14, 525-551.
9. Barco, A., Alarcon, J. M., and Kandel, E. R. (2002). Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108, 689-703.
10. Baughman, J. M., Perocchi, F., Girgis, H. S.,Plovanich,M.,Belcher-Timme,C. A., Sancak, Y., Bao, X. R., Strittmatter, L., Goldberger, O., Bogorad, R. L., Koteliansky,V., and Mootha,V. K. (2011). Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476, 342-345.
11. Bean, B. P. (1989). Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340, 153-156.
12. Begni, S., Popoli, S., Moraschi, S., Bignotti, S., Tura, G. B., and Gennarelli, M. (2002). Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. Mol. Psychiatry 7, 416-418.
13. Ben-Ari, Y. (1985). Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14, 375-403.
14. 2+)-storing compartment associated with GABAergic synapses in the axon initial of hippocampal pyramidal neurons. Exp. Brain Res. 101, 216-230.
15. Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., and Meador-Woodruff, J. H. (2007). Abnormal glutamate expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 32, 188801902.
16. Berridge, M. J. (1997). Elementary and global aspects of calcium signaling. J. Physiol. 499, 291-306.
17. Berridge, M. J. (1998). Neuronal calcium signaling. Neuron 21, 13-26.
18. Berridge, M. J. (2002). The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 32, 235-249.
19. Beutner, G., Sharma, V. K.,Giovannucci, D. R., Yule, D. I., and Sheu, S. S. (2001). Identification of a ryanodine receptor in rat heart mitochondria. J. Biol. Chem. 276, 21482-21488.
20. Bezprozvanny, I. (2009). Calcium signaling and neurodegenerative diseases. Trends Mol. Med. 15, 89-100.
21. Bezprozvanny, I., and Mattson, M. P. (2008). Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci. 31, 454-463.
22. Bezprozvanny, I.,Watras, J., and Ehrlich, B. E. (1991). Bell-shaped calciumresponse curves of Ins(1,4,5)P3and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 351, 751-754.
23. Billups, B., and Forsythe, I. D. (2002). Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses. J. Neurosci. 22, 5840-5847.
24. Bolshakov, V. Y., and Siegelbaum, S. A. (1994). Postsynaptic induction and presynaptic expression of hippocampal long-term depression. Science 264, 1148-1152.
25. + signals underlying waves and graded responses in HeLa cells. Curr. Biol. 6, 855-865.
26. Bortolotto, Z. A., Clarke, V. R., Delany, C. M., Parry, M. C., Smolders, I., Vignes, M., Ho, K. H., Miu, P., Brinton, B. T., Fantaske, R., Ogden, A., Gates, M., Ornstein, P. L., Lodge, D., Bleakman, D., and Collingridge, G. L. (1999). Kainate receptors are involved in synaptic plasticity. Nature 402, 297-301.
27. Breuer, A. C., Bond, M., and Atkinson, M. B. (1992). Fast axonal transport is modulated by altering transaxolemmal calcium flux. Cell Calcium 13, 249-262.
28. Browne, L. E., Jiang, L. H., and North, R. A. (2010). New structure enlivens interest in P2X receptors. Trends Pharmacol. Sci. 31, 229-237.
29. Bullock, R., Graham, D. I., Swanson, S., and McCulloch, J. (1994). Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat. J. Cereb. Blood Flow Metab. 14, 466-471.
30. Burnstock, G., and Knight, G. E. (2004). Cellular distribution and functions of P2 receptor subtypes in different systems. Int. Rev. Cytol. 240, 31-304.
31. 2+ homeostasis and accelerates apoptosis. J. Biol. Chem. 281, 16649-16655.
32. Cain, S. M., and Snutch, T. P. (2010). Contribution of T-type calcium channels isoforms to neuronal firing. Channels 4, 475-482.
33. Cain, S. M., and Snutch, T. P. (2011). Voltage-gated calcium channels and disease. Biofactors 37, 197-205.
34. Campbell, L. W., Hao, S. Y., Thibault, O., Blalock, E. M., and Landfield, P. W. (1996). Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons. J. Neurosci. 16, 6286-6295.
35. Campbell, S. L., Mathew, S. S., and Hablitz, J. J. (2007). Preand postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortex. Neuropharmacology 53, 37-47.
36. Carafoli, E. (1987). Intracellular calcium homeostasis. Annu. Rev. Biochem. 56, 395-433.
37. Carafoli, E., Tiozzo, R., Lugli, G., Crovetti, F., and Kratzing, C. (1974). The release of calcium from herat mitochondria by sodiun. J. Mol. Cell. Cardiol. 6, 361-371.
38. Castillo, P. E., Malenka, R. C., and Nicoll, R. A. (1997). Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 388, 182-186.
39. Catterall, W. A. (2011). Voltage-gated calcium channels. Cold. Spring. Harb. Perspect. Biol. 3, a003947.
40. Catterall, W. A., and Few, A. P. (2008). Calcium channel regulation and presynaptic plasticity. Neuron 59, 882-901.
41. Catterall, W. A., Perez-Reyes, E., Snutch, T. P., and Striessnig, J. (2005). Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol. Rev. 57, 411-425.
42. Cavus, I., and Teyler, T. (1996). Two forms of long-term potentiation in area CA1 activate different signal transduction cascades. J. Neurophysiol. 76, 3038-3047.
43. Chan, C. S., Guzman, J. N., Ilijic, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., and Surmeier, D. J. (2007). 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature 447, 1081-1086.
44. Chan, S. L., Mayne, M., Holden, C. P., Geiger, J. D., and Mattson, M. P. (2000). Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J. Biol. Chem. 275, 18195-18200.
45. Chang, C. S., Gertler, T. S., and Sumeier, D. J. (2009). Calcium homeostasis, selective vulnerability and Parkinson's disease. Trends Neurosci. 32, 249-256.
46. Charvin, N., L'Evêque, C., Walker, D., Berton, F., Raymond, C., Kataoka, M., Shoji-Kasai, Y., Takahashi, M., De Waard, M., and Seagar, M. J. (1997). Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Qtype calcium channel. EMBO J. 16, 4591-4596.
47. Chavis, P., Fagni, L., Lansman, J. B., and Bockaert, J. (1996). Functional coupling between ryanodine receptors and L-type calcium channels in neurons. Nature 382, 719-722.
48. Chawla, S., Hardingham, G. E, Quinn, D. R., and Bading, H. (1998). CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281, 1505-1509.
49. 2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58, 871-883.
50. Chittajallu, R., Braithwaite, S. P., Clarke, V. R., and Henley, J. M. (1999). Kainate receptors: subunits, synaptic localization and function. Trends Pharmacol. Sci. 20, 26-35.
51. Chohan, M. O., and Iqbal, K. (2006). From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease. J. Alzheimers Dis. 10, 81-87.
52. Choi, D. W. (1990). Possible mechanisms limiting N-methyl-Daspartate receptor overactivation and the therapeutic efficacy of N-methyl-D-aspartate antagonists. Stroke 21(SUPPL. 11), III20-III22.
53. Christie, B. R., Magee, J. C., and Johnston, D. (1996). Dendritic calcium channels and hippocampal longterm depression. Hippocampus 6, 17-23.
54. Chrivia, J. C., Kwok, R. P., Lamb, N., Hagiwara, M., Montminy, M. R., and Goodman, R. H. (1993). Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
55. Clarke, V. R., Ballyk, B. A., Hoo, K. H., Mandelzys, A., Pellizzari, A., Bath, C. P., Thomas, J., Sharpe, E. F., Davies, C. H., Ornstein, P. L., Schoepp, D. D., Kamboj, R. K., Collingridge, G. L., Lodge, D., and Bleakman, D. (1997). A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389, 599-603.
56. Collingridge, G. L., Olsen, R. W., Peters, J., and Spedding, M. (2009). A nomenclature for ligand-gated ion channels. Neuropharmacology 56, 2-5.
57. Contractor, A., Mulle, C., and Swanson, T. G. (2011). Kainate receptors coming of age: milestones of two decades of research. Trends Neurosci. 34, 154-163.
58. Contractor,A., Swanson, G., and Heinemann, S. F. (2001). Kainate receptors are involved in shortand long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 29, 209-216.
59. Contractor, A., Swanson, G. T., Sailer, A., O'Gorman, S., and Heinemann, S. F. (2000). Identification of the kainite receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J. Neurosci. 20, 8269-8278.
60. Coon, A. L., Wallace, D. R., Mactutus, C. F., and Booze, R. M. (1999). L-type calcium channels in the hippocampus and cerebellum of Alzheimer's disease brain tissue. Neurobiol. Aging 20, 597-603.
61. Cossart, R., Tyzio, R., Dinocourt, C., Esclapez, M., Hirsch, J. C., Ben-Ari, Y., and Bernard, C. (2001). Presynaptic kainite receptors that enhance the release of GABA on CA1 hippocampal interneurons. Neuron 29, 497-508.
62. 2+ channels and NREM sleep. Cell Calcium 40, 175-190.
63. Csordás, G., Renken, C.,Várnai, P., Walter, L., Weaver, D., Buttle, K. F., Balla, T., Mannella, C. A., and Hajnóczky, G. (2006). Structural and functional features and significance of the physical linkage between ER and mitochondria. J. Cell Biol. 174, 915-921.
64. 2+ stores. J. Neurochem. 81, 606-614.
65. Dani, J. A., and Bertrand, D. (2007). Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 47, 699-729.
66. 2+) channel Ca(v)1.2 during aging. Proc. Natl. Acad. Sci. U.S.A. 100, 16018-16023.
67. 2+ channel Cav1.2. Science 293, 98-101.
68. 2+)] in mouse motor nerve terminals are limited by mitochondrial uptake and are temperature-dependent. J. Neurosci. 20, 7290-7296.
69. 2+ uptake prevents desynchronization of quantal release and minimizes depletion during repetitive stimulation of mouse motor nerve terminals. J. Physiol. (Lond.) 548, 425-438.
70. Davies, P. A., Pistis, M., Hanna, M. C., Peters, J. A., Lambert, J. J., Hales, T. G., and Kirkness, E. F. (1999). The 5-HT3B subunit is a major determinant of serotonin receptor function. Nature 397, 359-363.
71. Day, N. C., Shaw, P. J., McCormack, A. L., Craig, P. J., Smith, W., Beattie, R., Williams, T. L., Ellis, S. B., Ince, P. G,, Harpold, M. M., Lodge, D., and Volsen, S. G. (1996). Distribution of alpha 1A, alpha 1B and alpha 1E voltage-dependent calcium channel subunits in the human hippocampus and parahippocampal gyrus. Neuroscience 71, 1013-1024.
72. de Brito, O. M., and Scorrano, L. (2009). Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras. Mitochondrion 9, 222-226.
73. de Brito, O. M., and Scorrano, L. (2010). An intimate liaison: spatial organization of the endoplasmic reticulummitochondria relationship. EMBO J. 29, 2715-2723.
74. De Stefani, D., Raffaello, A., Teardo, E., Szabò, I., Rizzuto, R. (2011). A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476, 336-340.
75. De Strooper,B.,and Annaert,W. (2010). Novel research horizons for presenilins and g-secretases in cell biology and disease. Annu.Rev.CellDev. Biol. 26, 235-260.
76. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998). Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
77. De Waard, M., Liu, H. Y., Walker, D., Scott, V. E. S., Gurnett, C. A., and Campbell, K. P. (1997). Direct binding of G-protein βγ complex to voltage-dependent calcium channels. Nature 385, 446-450.
78. Deisseroth, K., Heist, E. K., and Tsien, R. W. (1998). Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 392, 198-202.
79. Delmas, P., Abogadie, F. C., Buckley, N. J., and Brown, D. A. (2000). Calcium channel gating and modulation by transmitters depend on cellular compartmentalization. Nat. Neurosci. 3, 670-678.
80. Delorme, R., Krebs, M. O., Chabane, N., Roy, I., Millet, B., Mouren-Simeoni, M. C., Maier, W., Bourgeron, T., and Leboyer, M. (2004). Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. Neuroreport 15, 699-702.
81. Deluca, H. F., and Engstrom, G. W. (1961). Calcium uptake by rat kidney mitochondria. Proc. Natl. Acad. Sci. U.S.A. 47, 1744-1750.
82. 2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria. Biochem. J. 190, 107-117.
83. Deyo, R. A., Straube, K. T., and Disterhoft, J. F. (1989). Nimodipine facilitates associative learning in aging rabbits. Science 243, 809-811.
84. 2+ channels. Neuron 39, 483-496.
85. Dingledine, R., Borges, K., Bowie, D., and Traynelis, S. F. (1999). The glutamate receptor ion channels. Pharmacol. Rev. 51, 7-61.
86. Disterhoft, J. F., Moyer, J. R., and Thompson, L. T. (1994). The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging. Ann. N. Y. Acad. Sci. 747, 382-406.
87. Disterhoft, J. F., and Oh, M. M. (2006). Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease. J. Physiol. Paris 99, 180-192.
88. Dolmetsch, R. (2003). Excitationtranscription coupling: signaling by ion channels to the nucleus. Sci. STKE 3, PE4.
89. Dubin, A. E., Huvar, R., D'Andrea, M. R., Pyati, J., Zju, J. Y., Joy, K. C., Wilson, S. J., Galindo, J. E., Glass, C. A., Luo, L., Jackson, M. R., Lovenberg, T. W., and Erlander, M. G. (1999). The pharmacological and functional characteristics of the serotonin 5HT3 receptor are specifically modified by a 5-HT3B receptor subunit. J. Biol. Chem. 274, 30799-30810.
90. 2+ channels in mammalian central neurons. Trends Neurosci. 18, 89-98.
91. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6. Proc. Natl. Acad. Sci. U.S.A. 90, 755-759.
92. 2+ entry, and spontaneous transmitter release. Neuron 29, 197-208.
93. Engleman, E. A., Rodd, Z. A., Bell, R. L., and Murphy, J. M. (2008). The role of 5-HT3 receptors in drug abuse and as a target for pharmacotherapy. CNS Neurol. Disord. Drug Targets 7, 454-467.
94. Fan, M. M., and Raymond, L. A. (2007). N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Prog. Neurobiol. 81, 272-293.
95. Färber, L., Haus, U., Späth, M., and Drechsler, S. (2004). Physiology and pathophysiology of the 5-HT3 receptor. Scand. J. Rheumatol. Suppl. 119, 2-8.
96. Finch, E. A., Turner, T. J., and Goldin, S. M. (1991). Calcium as a coagonist of inositol 1,4,5-trisphospahteinduced calcium release. Science 252, 443-446.
97. 2+-dependent routes to ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron 16, 233-236.
98. Florczyk, A. P., Schurig, J. E., and Bradner, W. T. (1982). Cisplatin-induced emesis in the ferret. A new animal model. Cancer Treat. Rep. 66, 187-189.
99. Floyd, R. A., and Hensley, K. (2002). Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23, 795-807.
100. Forette, F., Seux, M. L., Staessen, J. A., Thijs, L., Babarskiene, M. R., Babeanu, S., Bossini, A., Fagard, R., Gil-Extremera, B., Laks, T., Kobalava, Z., Sarti, C., Tuomilehto, J., Vanhanen, H., Webster, J., Yodfat, Y., and Birkenhager, W. H. (2002). The prevention of dementia with antihypertensive treatment: new evidence from the systolic hypertension in Europe (Syst-Eur) study, Arch. Intern. Med. 162, 2046-2052.
101. 2+ release channels. Physiol. Rev. 87, 593-658.
102. Foster, T. C. (2006). Biological markers of age-related memory deficits: treatment of senescent physiology. CNS Drugs 20, 153-166.
103. 2+ dysregulation with brain aging. J. Neurosci. 21, 4066-4073.
104. Fozard,J. R.,and Mobarok,A. A. (1978). Blockade of neuronal tryptamine receptors by metoclopramide. Eur. J. Pharmacol. 49, 109-112.
105. Frerking, M., and Ohlinger-Frerking, P. (2002). AMPA receptors and kainite receptors encode different features of afferent activity. J. Neurosci. 22, 7434-7443.
106. Frerking, M., Schmitz, D., Zhou, Q., Johansen, J., and Nicoll, R. A. (2001). Kainate receptors depress excitatory synaptic transmission at CA3->CA1 synapses in the hippocampus via a direct presynaptic action. J. Neurosci. 21, 2958-2966.
107. 2+ permeability of nicotinic acetylcholine receptors. Cell Calcium 35, 1-8.
108. Fujii, S., Matsumoto, M., Igarashi, K., Kato, H., and Mikoshiba, K. (2000). Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors. Learn. Mem. 7, 312-320.
109. 2+ release channels are differentially expressed in rabbit brain. J. Neurosci. 14, 4794-4805.
110. Futatsugi, A., Kato, K., Ogura, H., Li, S. T., Nagata, E., Kuwajima, G., Tanaka, K., Itohara, S., and Mikoshiba, K. (1999). Facilitation of NMDARindependent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron 24, 701-173.
111. Gallagher,M.,Landfield,P. W.,McEwen, B., Meaney, M. J., Rapp, P. R., Sapolsky, R., and West, M. J. (1996). Hippocampal neurodegeneration in aging. Science 25, 484-485.
112. 2+ release. J. Neurosci. 26, 3482-3490.
113. Gao, J., Yin, D., Yao, Y., Williams, T. D., and Squier, T. C. (1998). Progressive decline in the ability of calmodulin isolated from aged brain to activate the plasma membrane Ca-ATPase. Biochemistry 37, 9536-9548.
114. Gibson, G. E., and Peterson, C. (1987). Calcium and the aging nervous system. Neurobiol. Aging 8, 329-343.
115. Gill, R., and Lodge, D. (1994). The neuroprotective effects of the decahydroisoquinoline, LY215490; a novel AMPA antagonist in focal ischemia. Neuropharmacology 33, 1529-1536.
116. Green, D. R., and Kroemer, G. (2004). The pathophysiology of mitochondrial cell death. Science 305, 626-629.
117. Green, E. M, Barrett, C. F., Bultynck, G., Shamah, S. M., and Dolmetsch, R. E. (2007). The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2. Neuron 55, 615-632.
118. Green, K. N., Demuro, A., Akbari, Y., Hitt, B. D., Smith, I. F., Parker, I., and LaFerla, F. M. (2008). SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J. CellBiol. 181, 1107-1116.
119. Grover, L. M., and Teyler, T. J. (1990). Two components of longterm potentiation induced by different patterns of afferent activation. Nature 347, 477-479.
120. Gu, J. G.,Albuquerque, C., Lee, C. J., and MacDermott, A. B. (1996). Synaptic strengthening through activation of Ca2+-permeable AMPA receptors. Nature 381, 793-796.
121. Guo, Q., Fu, W., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., and Mattson,M. P. (1999). Increased vulnerability in hippocampal neurons to excitotoxic necrosis in presenilin1 mutant knock-in mice. Nat. Med. 5, 101-106.
122. Guo, Q., Furukawa, K., Sopher, B. L., Pham, D. G., Xie, J., Robinson, N., Martin, G. M., and Mattson, M. P. (1996). Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport 8, 379-383.
123. Hakamata, Y., Nakai, J., Takeshima, H., and Imoto,K. (1992). Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain. FEBS Lett. 312, 229-235.
124. Halestrap, A. P. (2009). What is the mitochondrial permeability transition pore? J. Mol. Cell. Cardiol. 46, 821-831.
125. Hansford, R. G. (1980). Control of mitochondrial substrate oxidation. Curr. Top. Bioenerg. 10, 217-278.
126. Hardingham, G. E., Arnold, F. J., and Bading, H. (2001a). Calcium microdomain near NMDA receptors: on-switch of ERKdependent synapse-to-nucleus communication. Nat. Neurosci. 4, 565-566.
127. Hardingham, G. E., Arnold, F. J., and Bading, H. (2001b). Nuclear calcium signaling controls CREBmediated gene expression triggered by synaptic activity. Nat. Neurosci. 4, 261-267.
128. Hardingham, G. E., and Bading, H. (2010). Synaptic versus extrasynaptic NMDA receptor signaling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696.
129. Hardingham, G. E., Chawla, S., Cruzalegui, F. H., and Bading, H. (1999). Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and Ltype calcium channels. Neuron 22, 789-798.
130. 2+ permeability of cloned and native 5hydroxytryptamine type 3 receptors. Mol. Pharmacol. 46, 1120-1128.
131. 2+ signaling in the heart. J. Cell. Sci. 122, 1005-1013.
132. Hayashi, T., and Su, T. P. (2007). Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival. Cell 131, 596-610.
133. Hayrapetyan, V., Jenschke, M., Dillon, G. H., and Machu, T. K. (2005). Coexpression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res. Mol. Brain Res. 142, 146-150.
134. Hell, J. W., Westenbroek, R. E., Warner, C., Ahlijanian, M. K., Prystay, W., Gilbert, M. M., Snutch, T. P., and Catterall, W. A. (1993). Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits. J. Cell Biol. 123, 949-962.
135. Henkart, M. P., Reese, T. S., and Brinley, F. J. Jr. (1978). Endoplasmic reticulum sequesters calcium in the squid giant axon. Science 202, 1300-1303.
136. Herb, A., Burnashev, N., Werner, P., Sakmann, B., Wisden, W., and Seeburg, P. H. (1992). The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8, 775-785.
137. Herlitze, S., Garcia, D. E., Mackie, K., Hille, B., Scheuer, T., and Catterall, W. A. (1996). Modulation of calcium channels by G protein βγ subunits. Nature 380, 258-262.
138. 2+ channel subunit mRNA expression in the hippocampus of aged F344 rats. Neurobiol. Aging 19, 581-587.
139. Heron, S. E., Phillips, H. A., Mulley, J. C., Mazarib, A., Neufeld, M. Y., Berkovic, S. F., and Scheffer, I. E. (2004). Genetic variation of CACNA1H in idiopatic generalized epilepsy. Ann. Neurol. 55, 595-596.
140. Higo, T., Hattori, M., Nakamura, T., Natsume, T., Michikawa, T., and Mikoshiba, K. (2005). Subtype specific and Er luminal environmentaldependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell 120, 85-98.
141. Hollmann, M., and Heinemann, S. (1994). Cloned glutamate receptors. Annu.Rev.Neurosci.17, 31-108.
142. Hollmann, M., Maron, C., and Heinemann,S. (1994). N-glycosylation site taggin suggest a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13, 1331-1343.
143. Huettner, J. E. (2003). Kainate receptors and synaptic transmission. Prog. Neurobiol. 70, 387-407.
144. Huguenard, J. R. (1996). Low-threshold calcium channels currents in central nervous system neurons. Annu. Rev. Physiol. 58, 329-348.
145. Impey, S., Fong, A. L., Wang, Y., Cardinaux, J. R., Fass, D. M., Obrietan, K., Wayman, G. A., Storm, D. R., Soderling, T. R., and Goodman, R. H. (2002). Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron 34, 235-244.
146. Impey, S., and Goodman, R. H. (2001). CREB signaling-timing is everything. Sci. STKE 82, pe1.
147. Impey, S., Mark, M., Villacres, E. C., Poser, S., Chavkin, C., and Storm, D. R. (1996). Induction of CREmediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. Neuron 16, 973-982.
148. Ingram, D. K., Joseph, J. A., Spangler, E. L., Roberts, D., Hengemihle, J., and Fanelli, R. J. (1994). Chronic nimodipine treatment in aged rats: analysis of motor and cognitive effects and muscarinic-induced striatal dopamine release. Neurobiol. Aging 15, 55-61.
149. Inoue, T., Kato, K., Kohda, K., and Mikoshiba, K. (1998). Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J. Neurosci. 18, 5366-5373.
150. Isaac, J. T., Ashby, M. C., and McBain, C. J. (2007). The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron 54, 859-871.
151. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 91, 534-538.
152. Iwai, M., Tateishi, Y., Hattori, M., Mizutani, A., Nakamura, T., Futatsugi, A., Inoue,T.,Furuichi,T.,Michikawa,T., and Mikoshiba, K. (2005). Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J. Biol. Chem. 280, 10305-10317.
153. Jia, Z., Agopyan, N., Miu, P., Xiong, Z., Henderson, J., Gerlai, R., Taverna, F. A., Velumian, A., MacDonald, J., Carlen, P.,Abramow-Newerly, W., and Roder, J. (1996). Enhanced LTP in mice deficient in the AMPA receptor GluR2. Neuron 17, 945-56.
154. 2+/H+ antiporter. Science 326, 144-147.
155. Jiang, L., Xu, J., Nedergaard, M., and Kang, J. (2001). A kainite receptor increases the efficacy of GABAergic synapses. Neuron 30, 503-513.
156. Jin, X. T., Pare, J. F., Raju, D. V., and Smith, Y. (2006) Localization and function of preand postsynaptic kainite receptors in the rat globus pallidus. Eur. J. Neurosci. 23, 374-386.
157. Jouaville, l. S., Pinton, P., Bastianutto, C., Rutter, G. A., and Rizzuto, R. (1999). Regulation of mitochondrial ATP synthesis by calcium: evidence for long-term metabolic priming. Proc. Natl. Acad. Sci. U.S.A. 96, 13807-13812.
158. Kamiya, H., and Ozawa, S. (1998). Kainate receptor-mediated inhibition of presynaptic Ca2+ influx and EPSP in area CA1 of the rat hippocampus. J. Physiol. (Lond.) 509, 833-845.
159. Kamiya, H., and Ozawa, S. (2000). Kainate receptor-mediated presynaptic inhibition at the mouse hippocampal mossy fibre synapse. J. Physiol. (Lond.) 523, 653-665.
160. Kawai, T., and Watanabe, M. (1989). Effects of ryanodine on the spike after-hyperpolarization in sympathetic neurones of the rat superior cervical ganglion. Pflugers Arch. 413, 470-475.
161. Khachaturian, Z. S. (1989). Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview. Ann. N. Y. Acad. Sci. 568, 1-4.
162. Khachaturian, Z. S. (1994). Calcium hypothesis of Alzheimer's disease and brain aging. Ann. N. Y. Acad. Sci. 747, 1-11.
163. Kilpatrick, G. J., Jones, B. J., and Tyers, M. B. (1987). Identification and distribution of 5-HT3 receptor, a serotonin-gated ion channel. Nature 330, 746-748.
164. Ko, S., Zhao, M. G., Toyoda, H., Qiu, C. S., and Zhuo, M. (2005). Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)or GluR6deficient mice. J. Neurosci. 25, 977-984.
165. 2+ stores, is required for the induction of LTD in cultured cerebellar Purkinje cells. J. Neurophysiol. 74, 2184-2188.
166. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 10, 491-500.
167. Korenkov, A. I., Pahnke, J., Frei, K., Warzok, R., Schroeder, H. W., Frick, R., Muljana, L., Piek, J., Yonekawa, Y., and Gaab, M. R. (2000). Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg. Rev. 23, 145-150.
168. Kouzu, Y., Moriya, T., Takeshima, H., Yoshioka, T., and Shibata, S. (2000). Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulindependent protein kinase II in the hippocampus. Brain Res. Mol. Brain Res. 76, 142-150.
169. Kowalska, M., and Disterhoft, J. F. (1994). Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits. Exp. Neurol. 127, 159-166.
170. Koyama, S., Matsumoto, N., Kubo, C., and Akaike, N. (2000). Presynaptic 5-HT3 receptor-mediated modulation of synaptic GABA release in the mechanically dissociated rat amygdala neurons. J. Physiol. (Lond.) 529, 373-383.
171. Kullmann, D. M., and Lamsa, K. P. (2007). Long-term synaptic plasticity in hippocampal interneurons. Nat. Rev. Neurosci. 8, 687-699.
172. Kumar, A., and Foster, T. C. (2004). Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores. J. Neurophysiol. 91, 2437-2444.
173. Kumar, A., and Foster, T. C. (2005). Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging. Brain Res. 1031, 125-128.
174. Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Masaki, H., Kumanishi, T., Arakawa, M., and Mishina, M. (1992). Molecular diversity of NMDA receptor channel. Nature 358, 36-41.
175. Lancelot,E.,and Beal,M. F. (1998). Glutamate toxicity in chronic neurodegenerative disease. Prog. Brain Res. 116, 331-347.
176. 2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. Science 226, 1089-1092.
177. 2+ stores in kainite receptordependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron 39, 327-341.
178. Lauri, S. E., Segerstrale, M., Vesikansa, A., Maingret, F., Mulle, C., Collingridge, G. L., Isaac, J. T., and Taira, T. (2005). Endogenous activation of kainite receptors regulates glutamate release and network activity in the developing hippocampus. J. Neurosci. 25, 4473-4484.
179. Lauri, S. E., and Taira, T. (2011). Role of kainite receptors in network activity during development. Adv. Exp. Med. Biol. 717, 81-91.
180. Lauri, S. E., Vesikansa, A., Segerstrale, M., Collingridge, G. L., Isaac, J. T., and Taira,T. (2006). Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainite receptor-mediated inhibition of glutamate release. Neuron 50, 415-429.
181. 2+ sites. Clin. Exp. Pharmacol. Physiol. 34, 889-896.
182. Lee, A. C., Xu, X., Blachly-Dyson, E., Forte, M., and Colombini, M. (1998). The role of yeast VDAC genes on the permeability of the mitochondrial outer membrane. J. Membr. Biol. 161, 173-181.
183. Lee, H. K., and Kirkwood, A. (2011). AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex. Semin. Cell Dev. Biol. 22, 514-520.
184. Lee, H. K., Min, S. S., Gallagher, M., and Kirkwood, A. (2005). NMDA receptor-independent longterm depression correlates with successful aging in rats. Nat. Neurosci. 8, 1657-1659.
185. Lee, S. J., Escobedo-Lozoya,Y., Szatmari, E. M., and Yasuda, R. (2009). Activation of CaMKII in single dendritic spines during long-term potentiation. Nature 458, 299-304.
186. Leissring, M. A., Akbari, Y., Fanger, C. M., Cahalan, M. D., Mattson, M. P., and LaFerla, F. M. (2000). Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J. Cell Biol. 149, 793-798.
187. Leissring, M. A., Parker, I., and LaFerla, F. M. (1999a). Presenilin-2 mutations modulate amplitude and kinetics of inositol 1,4,5-trisphosphatemediated calcium signals. J. Biol. Chem. 274, 32535-32538.
188. Leissring, M. A., Paul, B. A., Parker, I., Cotman, C. W., and LaFerla, F. M. (1999b). Alzheimer's presenilin-1 potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J. Neurochem. 72, 1061-1068.
189. Lerma, J. (2006). Kainate receptors physiology. Curr. Opin. Pharmacol. 6, 89-97.
190. Leung, A. W., and Halestrap, A. P. (2008). Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition. Biochim. Biophys. Acta 1777, 946-952.
191. Levere, T. E., and Walker, A. (1992). Old age and cognition: enhancement of recent memory in aged rats by the calcium channel blocker nimodipine. Neurobiol. Aging 13, 63-66.
192. Levin, E. D., and Simon, B. B. (1998). Nicotinic acetylcholine involvement in cognitive function in animals. Psychopharmacology (Berl.) 138, 217-230.
193. Levy-Lahad, E., Wijsman, E. M., Nemens, E., Anderson, L., Goddard, K. A., Weber, J. L., Bird, T. D., and Schellenberg, G. D. (1995). A familial Alzheimer's disease locus on chromosome 1. Science 269, 970-973.
194. Li,B.,Zhong,H.,Scheuer,T.,and Catterall, W. A. (2004). Functional role of a C-terminal Gβγ-binding domain of Cav2.2 channels. Mol. Pharmacol. 66, 761-769.
195. Lin, M. T., and Beal, M. F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795.
196. 2+-permeable AMPA receptors in synaptic plasticity and neuronal death. Trends Neurosci. 30, 126-134.
197. Liu, P., Smith, P. F., and Darlington, C. L. (2008). Glutamate receptor subunits expression in memory-associated brain structures: regional variations and effects of aging. Synapse 62, 834-841.
198. Llinas, R. R. (1988). The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242, 1654-1664.
199. Lohmann, C., and Wong, R. O. (2005). Regulation of dendritic growth and plasticity by local and global calcium dynamics. Cell Calcium 37, 403-409.
200. Ma, H., Cai, Q., Lu, W., Sheng, Z. H., and Mochida, S. (2009). KIF5B motor adaptor syntabulin maintains synaptic transmission in sympathetic neurons.J.Neurosci.41, 13019-13029.
201. 2+ activation. J. Biol. Chem. 274, 22231-22237.
202. Mak, D. O. D., McBride, S., and Foskett, J. K. (2001). ATP regulation of recombinant type 3 inositol 1,4,5-trisphosphate receptor channel gating.J.Gen.Physiol.274, 22231-22237.
203. Malenka, R. C. (2003). Synaptic plasticity and AMPA receptor trafficking. Ann. N. Y. Acad. Sci. 1003, 1-11.
204. Mansvelder, H. D., and McGehee, D. S. (2000). Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 27, 349-57.
205. Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M., and Julius, D. (1991). Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science 254, 432-443.
206. 2+ release channels (Ryanodine Receptors). Science 281, 818-821.
207. Mark, S. O., Reiken, S., Hisamatsu, Y., Jayaraman, T., Burkhoff, D., Rosemblit, N., and Marks, A. R. (2000). PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (Ryanodine Receptor): defective regulation in failing hearts. Cell 101, 365-376.
208. Markram, H., Helm, P. J., and Sakmann, B. (1995). Dendritic calcium transients evoked by single backpropagating action potentials in rat neocortical pyramidal neurons. J. Physiol. 485, 1-20.
209. 2+ channels in hippocampal neurons. Nature 395, 900-905.
210. Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S.,Yamada, M., Yoneshima, H., Miyawaki, A., Fukuuchi, Y., Furuichi, T., Okano, H., Mikoshiba, K., and Noda, T. (1996). Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379, 168-171.
211. Matthews, E. A., Linardakis, J. M., and Disterhoft, J. F. (2009). The fast and slow afterhyperpolarizations are differentially modulated in hippocampal neurons by aging and learning. J. Neurosci. 29, 4750-4755.
212. Mattson, M. P. (2004). Pathways towards and away from Alzheimer's disease. Nature 430, 631-639.
213. Mattson, M. P. (2007). Calcium and neurodegeneration. Aging Cell 6, 337-350.
214. McEnery, M. W., Dawson, T. M., Verma, A., Gurley, D., Colombini, M., and Snyder, S. H. (1993). Mitochondrial voltage-dependent anion channel. Immunochemical and immunohistochemical characterization in rat brain. J. Biol. Chem. 268, 23289-23296.
215. McCobb, D. P., and Beam, K. G. (1991). Action potential waveform voltage - clamp commands reveal striking differences in calcium entry via low and high voltage-activated calcium channels. Neuron 7, 119-127.
216. McGraw, C. F., Somlyo, A. V., and Blaustein, M. P. (1980). Localization of calcium in presynaptic nerve terminals. An ultrastructural and electron microprobe analysis. J. Cell Biol. 85, 228-241.
217. 2+release in sarcoplasmic reticulum. J. Biol. Chem. 259, 2365-2374.
218. Meissner, G. (2002). Regulation of mammalian ryanodine receptors. Front. Biosci. 7, 2072-2080.
219. Melyan, Z., Wheal, H. V., and Lancaster, B. (2002). Metabotropic-mediated kainite receptor regulation of IsAHP and excitability in pyramidal cells. Neuron 34, 107-114.
220. Michaelis, M. L., Bigelow, D. J., Schöneich, C., Williams, T. D., Ramonda, L., Yin, D., Hühmer,A. F.,Yao,Y., Gao, J., and Squier, T. C. (1996). Decreased plasma membrane calcium transport activity in aging brain. Life Sci. 59, 405-412.
221. Michaelsen, K., and Lohmann, C. (2010). Calcium dynamics at the developing synapses: mechanisms and functions. Eur. J. Neurosci. 32, 218-223.
222. 2+ channel: from discovery to new signaling concepts. J. Neurochem. 102, 1426-1446.
223. 2+ homeostasis. Prog. Neurobiol. 37, 255-285.
224. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., and Seeburg, P. H. (1992). Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221.
225. Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Muller, J., Stiess, M., Marais, E., Schulla, V., Lacinova, L., Goebbels, S., Nave, K. A., Storm, D. R., Hofmann, F., and Kleppisch, T. (2005). Role of hippocampal Cav1.2-Ca2 channels in NMDA receptor-independent synaptic plasticity and spatial memory. J. Neurosci. 25, 9883-9892.
226. Mothet, J. P., Fossier, P., Meunier, F. M., Stinnakre, J., Tauc, L., and Baux, G. (1998). Cyclic ADP-ribose and calcium-induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia J. Physiol. 507, 405-414.
227. Moyer, J. R. Jr., and Disterhoft, J. F. (1994). Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentrationdependent manner. Hippocampus 4, 11-17.
228. Mulle, C., Sailer, A., Perez-Otano, I., Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J. R., Bettler, B., and Heinemann, S. F. (1998). Altered synaptic physiology and reduced susceptibility to kainite induced seizures in GluR6-deficient mice. Nature 392, 601-605.
229. Mulle, C., Sailer, A., Swanson, G. T., Brana, C., O'Gorman, S., Bettler, B., and Heinemann, S. F. (2000) Subunit composition of kainite receptors in hippocampal interneurons. Neuron 28, 475-484.
230. Murchison, D., and Griffith, W. H. (1999). Age-related alterations in caffeine-sensitive calcium stores and mitochondrial buffering in rat basal forebrain. Cell Calcium 25, 439-452.
231. Murchison, D., Zawieja, D. C., and Griffith, W. H. (2004). Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons. Cell Calcium 36, 61-75.
232. Navarro, A. (2004). Mitochondrial enzyme activities as biochemical markers of aging. Mol. Aspects Med. 25, 37-48.
233. Nayak, S.V., Ronde, P., Spier, A. D., Lummis, S. C., and Nichols, R. A. (1999). Calcium changes induced by presynaptic 5-hydroxytryptamine-3 serotonin receptors on isolated terminals from various regions of the rat brain. Neuroscience 91, 107-117.
234. 2+ leak function of presenilin 1. J. Clin. Invest. 117, 1230-1239.
235. Nichols, R. A., and Mollard, P. (1996). Direct observation of serotonin 5HT3 receptor-induced increases in calcium levels in individual brain nerve terminals. J. Neurochem. 67, 581-592.
236. 2+ channels in the induction of longterm potentiation in the basolateral amygdala-dentate gyrus pathway of anesthetized rats. Brain Res. 1017, 218-221.
237. Nishiyama, M., Hong, K., Mikoshiba, K., Poo, M. M., and Kato, K. (2000). Calcium stores regulate the polarity and input specificity of synaptic modification. Nature 408, 584-588.
238. Nixon, R. A., Saito, K. I., Grynspan, F., Griffin, W. R., Katayama, S., Honda, T.,Mohan,P. S.,Shea,T. B.,and Beermann,M. (1994). Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Ann. NY Acad. Sci. 747, 77-91.
239. 2+ channel activity in hippocampal neurons: increased effect with age in culture. Neuroscience 110, 213-225.
240. Norris, C. M., Korol, D. L., and Foster, T. C. (1996). Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging. J. Neurosci. 16, 5382-5392.
241. 2+ channel alpha 1C (Cav1.2) to synaptic and extrasynaptic compartments in hippocampal neurons. Eur. J. Neurosci. 19, 2109-2122.
242. Olivera, B. M., Miljanich, G. P., Ramachandran, J., and Adams, M. E. (1994). Calcium channels diversity and neurotransmitter release: The omega-conotoxins and omegaagatoxins. Annu. Rev. Biochem. 63, 823-867.
243. 2+ channel activity and nuclear signaling. Neuron 55, 261-275.
244. O'Neill, M. J., Bogaert, L., Hicks, C. A., Bond, A., Ward, M. A., Ebinger, G., Ornstein, P. L., Michotte, Y., and Lodge, D. (2000). LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischemia. Neuropharmacology 39, 1575-1588.
245. O'Neill, M. J., Bond, A., Ornstein, P. L., Ward, M. A., Hicks, C. A., Hoo, K., Bleakman, D., and Lodge, D. (1998). Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global and focal cerebral ischemia. Neuropharmacology 37, 1211-1222.
246. Page, K. M., Canti, C., Stephens, G. J., Berrow, N. S., and Dolphin, A. C. (1998). Identification of the amino terminus of neuronal Ca2+ channel α1 subunits α1B and a1E as an essential determinant of Gprotein modulation. J. Neurosci. 18, 4815-4824.
247. 2+ exchange. Proc. Natl. Acad. Sci. U. S. A. 107, 436-441.
248. Pankratov, Y., Lalo, U., Krishtal, O. A., and Verkhratsky, A. (2008). P2X receptors and synaptic plasticity. Neuroscience 158, 137-148.
249. Pankratov, Y., Lalo, U, Krishtal, O. A., and Verkhratsky, A. (2003). P2X receptors excitatory synaptic currents in somatosensory cortex. Mol. Cell. Neurosci. 24, 842-849.
250. Paoletti, P. (2011). Molecular basis of NMDA receptors functional diversity. Eur. J. Neurosci. 33, 1351-1365.
251. Park, M. K., Choi, Y. M., Kang, Y. K., and Petersen, O. H. (2008). The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14, 68-77.
252. Patterson, R. L., Boehning, D., and Snyder, S. H. (2004). Inositol 1,4,5trisphosphate receptors as signal integrators. Annu. Rev. Biochem. 73, 437-465.
253. 2+permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol-3-kinasedependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. J. Neurosci. 19, 5861-5874.
254. 2+ uptake. Nature 467, 291-296.
255. Pickard, B. S., Malloy, M. P., Christoforou, A., Thomson, P. A., Evans, K. L., Morris, S. W., Hampson, M., Porteous, D. J., Blackwood, D. H., and Muir, W. J. (2006). Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry 11, 847-857.
256. Pinheiro, P., and Mulle, C. (2006). Kainate receptors. Cell Tissue Res. 326, 457-482.
257. Pitts, K. R., Yoon, Y., Krueger, E. W., and McNiven, M. A. (1999). The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol. Cell. Biol. 10, 4403-4417.
258. Pivovarova, N. B., and Andrews, S. B. (2010). Calcium-dependent mitochondrial function and dysfunction in neurons. FEBS J. 277, 3622-3636.
259. Power, J. M., Wu, W. W., Sametsky, E., Oh, M. M., and Disterhoft, J. F. (2002). Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro. J. Neurosci. 22, 7234-7243.
260. Pratt, K. G., Zimmerman, E. C., Cook, D. G., and Sullivan, J. M. (2011). Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling. Nat. Neurosci. 14, 1112-1114.
261. Prins, D., and Michalak, M. (2011). Organellar calcium buffers. Cold Spring Harb. Perspect. Biol. 3. Pii a004069.
262. Raymond, C. R., and Redman, S. J. (2002). Different calcium sources are narrowly tuned to the induction of different forms of LTP. J. Neurophysiol. 88, 249-255.
263. Raymond, C. R., and Redman, S. J. (2006). Spatial segregation of neuronal calcium signaling encode different forms of LTP in rat hippocampus. J. Physiol. (Lond.) 570, 97-111.
264. Redmond, L., and Ghosh, A. (2005). Regulation of dendritic development by calcium signaling. Cell Calcium 37, 411-416.
265. 2+ channels with the presynaptic proteins syntaxin and SNAP25. Proc. Natl. Acad. Sci. U. S. A. 93, 7363-7368.
266. 2+ from separate presynaptic and postsynaptic intracellular stores. J. Neurosci. 16, 5951-5960.
267. Ris, L., and Godaux, E. (2007). Synapse specificity of long-term potentiation breaks down with aging. Learn. Mem. 14, 185-189.
268. 2+ liaison. Sci. STKE 2004, re1.
269. 2+ transfer from the ER to the mitochondria: when,how,and why. Biochem. Biophys. Acta 1787, 1342-1351.
270. 2+ and calmodulin. Biochemistry 39, 7807-7812.
271. Rodríguez-Moreno, A., Herreras, O., and Lerma, J. (1997). Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19, 893-901.
272. Rodríguez-Moreno, A., and Lerma, J. (1998). Kainate receptor modulation of GABA release involves a metabotropic function. Neuron 20, 1211-1218.
273. Roerig, B., Nelson, D. A., and Katz, L. C. (1997). Fast synaptic signalling by nicotinic acetylcholine and serotonin 5-HT3 receptors in developing visual cortex. J. Neurosci. 17, 8353-8362.
274. Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chiumakov, I., Cohen, D., Lannfelt, L., Fraser, E., Rommens, J. M., and St George-Hyslop, P. H. (1995). Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
275. Rose, J., Jin, S. X., and Craig, A. M. (2009). Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II. Neuron 61, 351-358.
276. Rosenzweig, E. S., and Barnes, C. A. (2003). Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog. Neurobiol. 69, 143-179.
277. Rozas, J. L., Paternain, A. V., and Lerma, J. (2003). Noncanonical signaling by ionotropic kainate receptors. Neuron 39, 543-553.
278. Rubinsztein, D. C., Leggo, J., Chiano, M., Norbury, G., Rosser, E., and Craufurd, D. (1997). Genotype at the GluR6 kainate receptor locus are associated with variations in the age of onset of Huntington disease. Proc. Natl. Acad. Sci. U.S.A. 94, 3872-3876.
279. Ruiz, A., Sachidhanandam, S., Utvik, J. K., Coussen, F., and Mulle, C. (2005). Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses. J. Neurosci. 25, 11710-11718.
280. Sandin, M., Jasmin, S., and Levere, T. E. (1990). Aging and cognition: facilitation of recent memory in aged nonhuman primates by nimodipine. Neurobiol. Aging 11, 573-575.
281. Satoh, T, Ross, C. A., Villa, A, Supattapone, S, Pozzan, T, Snyder, S. H., and Meldolesi, J. (1990). The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J. Cell Biol. 111, 615-624.
282. Saura, C. A., Choi, S. Y., Beglopoulos, V., Malkani, S., Zhang, D., Shankaranarayana Rao, B. S., Chattarji, S., Kelleher, R. J. 3rd, Kandel, E. R., Duff, K., Kirkwood, A., and Shen, J. (2004). Loss of presenilin function causes impairments of memory and synaptic plasticity followed by agedependent neurodegeneration. Neuron 42, 23-36.
283. Schiffer, H. H., and Heinemann, S. F. (2007). Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 20-26.
284. Schmitz, D., Frerking, M., and Nicoll, R. A. (2000). Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses. Neuron 27, 327-338.
285. Schmitz, D., Mellor, J., Breustedt, J., and Nicoll, R. A. (2003). Presynaptic kainite receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat. Neurosci. 6, 1058-1063.
286. Schmitz, D., Mellor, J., and Nicoll, R. A. (2001). Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses. Science 291, 1972-1976.
287. Scotty, F., Danik, M., Manseau, F., Lapnate, F., Quirion, R., and Williams, S. (2003). Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity. J. Physiol. (Lond.) 551, 927-943.
288. Shakiryanova, D., Klose, M. K., Zhou, Y., Gu, T., Deitcher, D. L., Atwood, H. L., Hewes, R. S., Levitan, E. S. (2007). Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release. J. Neurosci. 27, 7799-7806.
289. Shankar, S., Teyler, T. J., and Robbins, N. (1998). Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1. J. Neurophysiol. 79, 334-341.
290. Sharma, G., and Vijayaraghavan, S. (2001), Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores. Proc. Natl. Acad. Sci. U.S.A. 98, 4148-4153.
291. 2+ release channels in rat brain. J. Neurosci. 13, 3051-3063.
292. Shen, J. X., and Yakel, J. L. (2009). Nicotinic acetylcholine receptors - mediate calcium signaling in the nervous system. Acta Pharmacol. Sin. 30, 673-680.
293. Sheng, Z.-H., Rettig, J., Cook, T., and Catterall, W. A. (1996). Calciumdependent interaction of N-type calcium channels with the synaptic core-complex. Nature 379, 451-454.
294. Sheng, Z.-H., Rettig, J., Takahashi, M., and Catterall, W. A. (1994). Identification of a syntaxin-binding site on N-type calcium channels. Neuron 13, 1303-1313.
295. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J. F., Bruni, A. C., Montesi, M. P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R. J., Wasco, W., Da Silva, H. A., Haines, J. L., Perkicak-Vance, M. A., Tanzi, R. E., Roses, A. D., Fraser, P. E., Rommens, J. M., and St George-Hyslop, P. H. (1995). Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
296. 2+. Neuroscience 73, 1061-1067.
297. Simmen, T., Aslan, J. E., Blagoveshchenskaya, A. D, Thomas, L., Wan, L., Xiang, Y., Feliciangeli, S. F., Hung, C. H., Crump, C. M., and Thomas, G. (2005). PACS2 controls endoplasmic reticulummitochondria communication and BID-mediated apoptosis. EMBO J. 24, 717-729.
298. Sitsapesan, R., and Williams, A. J. (1995). The gating of the sheep skeletal sarcoplasmic reticulum Ca2{thorn}-release channel is regulated by luminal Ca2{thorn}. J. Membr. Biol. 146, 133-144.
299. Smolders, I., Bortolotto, Z. A., Clarke,V. R., Warre, R., Khan, G. M., O'Neill, M. J., Ornstein, P. L., Bleakman, D., Ogden, A., Weiss, B., Stables, J. P., Ho, K. H., Ebinger, G., Collingridge, G. L., Lodeg, D., and Michotte, Y. (2002). Antagonists of Glu(K5)containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat. Neurosci. 5, 796-804.
300. 2+ entry. EMBO J. 21, 622-630.
301. Sparagna, G. C., Gunter, K. K., Sheu, S. S., and Gunter, T. E. (1995). Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode. J. Biol. Chem. 270, 27510-27515.
302. Splawski, I., Yoo, D. S., Cherry, A., Clapham, D. E., and Keating, M. T. (2006). CACNA1H mutations in autism spectrum disorders. J. Biol. Chem. 281, 22085-22091.
303. Stanley, E. F. (1997). The calcium channel and the organization of the presynaptic transmitter release face. Trends Neurosci. 20, 404-409.
304. Strutz-Seebohm, N., Korniychuk, G., Schwarz, R., Baltaev, R., Ureche, O. N., Mack, A. F., Ma, Z. L., Hollmann, M., Lang, F., and Seebohm, G. (2006). Functional significance of the kainate receptor GluR6(M836I) mutation that is linked to autism. Cell. Physiol. Biochem. 18, 287-294.
305. 2+ signals and altered membrane excitability. J. Neurosci. 24, 508-513.
306. 2+ disruptions in young, adult, and aged Alzheimer's disease mice. J. Neurosci. 26, 5180-5189.
307. Sudhof, T. C. (2004). The synaptic vesicle cycle. Annu.Rev.Neurosci.27, 509-547.
308. Sugita, S., Shen, K. Z., and North, R. A. (1992). 5-Hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat lateral amygdala. Neuron 8, 199-203.
309. Surprenant, A., and North, R. A. (2009). Signaling at purinergic P2X receptors. Annu. Rev. Physiol. 71,333-359.
310. Sweatt, J. D. (2001). The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J. Neurochem. 76, 1-10.
311. 2+ channels. J. Cell Biol. 175, 901-911.
312. Takei, K., Shin, R. M., Inoue, T., Kato, K., and Mikoshiba, K. (1998). Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science 282, 1705-1708.
313. Talley, E. M., Cribbs, L. L., Lee, J. H., Daud, A., Perez-Reyes, E., and Volsen, S. G. (1999). Differential distribution of the voltage-dependent calcium channels α1G subunit mRNA and protein throughout the mature rat brain. Eur. J. Neurosci. 11, 2949-2964.
314. Tanaka, D., Nakada, K., Takao, K., Ogasawara, E., Kasahara, A., Sato, A., Yonekawa, H., Miyakawa, T., and Hayashi, J. (2008). Normal mitochondrial respiratory function is essential for spatial remote memory in mice. Mol. Brain 16, 1-21.
315. Tang, Y., and Zucker, R. S. (1997). Mitochondrial involvement in posttetanic potentiation of synaptic transmission. Neuron 18, 483-491.
316. Taylor, C. W., da Fonseca, P. C. A., and Morris, E. P. (2004). IP3 receptors: the search for structure. Trends Biochem. Sci. 29, 210-219.
317. 2+ signals. Chaos 19, 037102.
318. Tecott, L. H., Maricq, A. V., and Julius, D. (1993). Nervous system distribution of the 5-HT3 receptor in rat brain using radioligand binding. Proc. Natl. Acad. Sci. U.S.A. 90, 1430-1443.
319. 2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. J. Neurosci. 21, 9744-9756.
320. Thibault, O., and Landfield, P. W. (1996). Increase in single L-type calcium channels in hippocampal neurons during aging. Science 272, 1017-1020.
321. Thompson, A. J., and Lummis, S. C. (2007). The 5-HT3 receptor as a therapeutic target. Expert Opin. Ther. Targets 11, 527-540.
322. Tian, X., and Feig, L. A. (2006). Agedependent participation of RasGRF proteins in coupling calciumpermeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons. J. Biol. Chem. 28, 7578-7582.
323. 2+ regulation and gene expression in normal brain aging. Trends Neurosci. 27, 614-620.
324. Toescu, E. C., and Vreugdenhil, M. (2010). Calcium and normal brain ageing. Cell Calcium 47, 158-164.
325. Tollefson, G. D. (1990). Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia. Biol. Psychiatry 27, 1133-1142.
326. Tonkikh, A., Janus, C., El-Beheiry, H., Pennefather, P. S., Samoilova, M., McDonald, P., Ouanounou, A., and Carlen, P. L. (2006). Calcium chelation improves spatial learning and synaptic plasticity in aged rats. Exp. Neurol. 197, 291-300.
327. Tonkikh, A. A., and Carlen, P. L. (2009). Impaired presynaptic cytosolic and mitochondrial calcium dynamics in aged compared to young adult hippocampal CA1 synapses ameliorated by calcium chelation. Neuroscience 159, 1300-1308.
328. Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, S. F., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, B., Myers, S. J., and Dingledine, R. (2010). Glutamate receptor ion channels: structure, regulation, and function. Pharmacol. Rev. 62, 405-496.
329. 2+ release channel. Biophys. J. 70, 2600-2615.
330. Tripathy, A., Xu, L., Mann, G., and Meissner, G. (1995). Calmodulin activation and inhibition of skeletal muscle Ca2{thorn}release channel (ryanodine receptor). Biophys. J. 69, 106-119.
331. Tsang, C. W., Elrick, D. B., and Charlton, M. P. (2000). alpha-Latrotoxin releases calcium in frog motor nerve terminals. J. Neurosci. 20, 8685-8692.
332. Tsien, R. W., Lipscombe, D. V., Madison, D. V., Bley, K. R., and Fox, A. P. (1988). Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci. 11, 431-438.
333. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126, 981-993.
334. Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., and Worley, P. F. (1998). Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21, 717-726.
335. van Hooft, J. A., and Vijverberg, H. P. M. (2000). 5-HT3 receptors and neurotransmitter release in the CNS: a nerve ending story? Trends Neurosci. 23, 605-610.
336. 2+ pimps of the endoplasmic reticulum and Golgi apparatum. Cold Spring Harb. Perspect. Biol. 3. Pii a004184.
337. 2+ uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation. J. Biol. Chem. 237, 2670-2677.
338. Verkhratsky, A. (2005). Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol. Rev. 85, 201-279.
339. Verstreken, P., Ly, C. V., Venken, K. J., Koh, T. W., Zhou, Y., and Bellen, H. J. (2005). Synaptic mitochondria are critical form mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47, 365-378.
340. Vignes, M., and Collingridge, G. (1997). The synaptic activation of kainate receptors. Nature 388, 179-182.
341. Vissel, B., Royle, G. A., Christie, B. R., Schiffer, H. H., Ghetti, A., Tritto, T., Perez-Otano, I., Radcliffe, R. A., Seamans, J., Sejnoski, T., Wehner, J. M., Collins, A. C., O'Gorman, S., and Heinemann, S. F. (2001). The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29, 217-227.
342. Wallace, T. L., and Porter, R. H. (2011). Targeting the nicotinic alpha7 acetyltcholine receptor to enhance cognition in disease. Biochem. Pharmacol. 82, 891-903.
343. Wang, H. J., Guay, G., Pogan, L., Sauvé, R., and Nabi, I. R. (2000). Calcium regulates the association between mitochondria and smooth subdomain of the endoplasmic reticulum. J. Cell Biol. 150, 1489-1498.
344. Weeber, E. J., Levy, M., Sampson, M. J., Anflous, K., Armstrong, D. L., Brown, S. E., Sweatt, J. D., and Craigen, W. J. (2002). The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. J. Biol. Chem. 277, 18891-18897.
345. Westenbroek, R. E., Hell, J. W., Warner, C., Dubel, S. J., Snutch, T. P., and Cattarell, W. (1992). Biochemical properties and subcellular distribution of an N-type calcium channels α1 subunit. Neuron 6, 1099-1115.
346. Wilson, G. M., Flibotte, S., Chopra, V., Melnyk, B. L., Honer, W. G., and Holt, R. A. (2006). DNA copynumber analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling. Hum. Mol. Genet. 15, 743-749.
347. Wiser, O., Tobi, D., Trus, M., and Atlas, D. (1997) Synaptotagmin restores kinetic properties of a syntaxinassociated N-type voltage sensitive calcium channel. FEBS Lett. 404, 203-207.
348. 2+ channels: differences between chicken sympathetic and parasympathetic neurons suggest different regulatory mechanisms. Proc. Natl. Acad. Sci. U.S.A. 91, 2858-2862.
349. Wo, Z. G., and Oswald, R. E. (1994). Transmembrane topology of two kainite receptor subunits revealed by N-glycosylation. Proc. Natl. Acad. Sci. U.S.A. 91, 7154-7158.
350. Wu, G. Y., Deisseroth, K., and Tsien, R. W. (2001). Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. U.S.A. 98, 2808-2813.
351. Wu, L. G., Westenbroek, R. E., Borst, J. G., Catterall, W. A., and Sakmann, B. (1999). Calcium channels types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J. Neurosci. 19, 726-736.
352. 2+ currents evoke transmitter release at a rat central synapses. Proc. Natl. Acad. Sci. U.S.A. 95, 4720-4725.
353. 2+ homeostasis in aged cerebellar granule neurons in brain slices. J. Neurosci. 22, 10761-10771.
354. Yakel, J. L. (2000). " The 5-HT3 receptor channel: function, activation and regulation," in Pharmacology of Ionic Channel Function: Activators and Inhibitors, ed. M. Endo (Berlin: Springer-Verlag), 541-560.
355. Yakel, J. L., Shao, X. M., and Jackson, M. B. (1990). The selectivity of the channel coupled to the 5-HT3 receptor. Brain Res. 533, 46-52.
356. Yamaguchi, N., Xu, L., Pasek, D. A., Evans, K. E., Chen, S. R. W., and Meissner, G. (2005). Calmodulin regulation and identification of calmodulin binding region of Type-3 ryanodine receptor calcium release channel. Biochemistry 44, 15074-15081.
357. 2+ exchanger and protein kinase C. J. Cell Biol. 163, 511-523.
358. Yang, J. (1990). Ion permeation through 5-hydroxytryptaminegated channels in neuroblastoma [18N] cells. J. Gen. Physiol. 96, 1177- 1198.
359. Yokoyama, C. T., Myers, S. J., Fu, J., Mockus, S. M, Scheuer, T., and Catterall, W. A. (2005). Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site. Mol. Cell. Neurosci. 28, 1-17.
360. Yokoyama, C. T., Westenbroek, R. E., Hell, J. W., Soong, T. W., Snutch, T. P., and Catterall, W. A. (1995). Biochemical properties and subcellular distribution of the neuronal class E calcium channel alpha 1 subunit. J. Neurosci. 15, 6419- 6432.
361. Yu, D. F., Wu, P. F., Fu, H., Cheng, J., Yang, Y. J., Chen, T., Long, L. H., Chen, J. G., and Wang, F. (2011). Aging-related alterations in the expression and distribution of GluR2 and PICK1 in the rat hippocampus. Neurosci. Lett. 497, 42-45.
362. 2+-ATPase by hydrogen peroxide and protection by calmodulin. Biochemistry 42, 12001-12010.
363. Zamponi, G. W., Bourinet, E., Nelson, D., Nargeot, J., and Snutch, T. P. (1997). Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit. Nature 385, 442-446.
364. Zamponi, G. W., Lory, P., and Perez-Reyes, E. (2010). Role of voltage-gated calcium channels in epilepsy. Eur. J. Physiol. 460, 395-403.
365. Zhang, C., Wu, B., Beglopoulos, V., Wines-Samuelson, M., Zhang, D., Dragatsi, I., Sudhof, T. C., and Shen, J. (2009). Presenilins are essential for regulating neurotransmitter release. Nature 460, 632-636.
366. Zhang, D., Zhang, C., Ho, A., Kirkwood, A., Sudhof, T. C., and Shen, J. (2010). Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. J. Neurochem. 115, 1215-1221.