Kainate receptor physiology

Current Opinion in Pharmacology

Volumn 6, Issue 1 SPEC. ISS., 2006, Pages 89-97

  Lerma, Juan ^a  

^a INSTITUTO DE NEUROCIENCIAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,4A,5,6,7,8,8A DECAHYDRO 6 (1H TETRAZOL 5 YLMETHOXYMETHYL) 3 ISOQUINOLINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; 6 (4 CARBOXYBENZYL) 1,2,3,4,4A,5,6,7,8,8A DECAHYDRO 3 ISOQUINOLINECARBOXYLIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CALCINEURIN; CALCIUM; CALCIUM CHANNEL N TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DECAHYDRO 6 [2 (1H TETRAZOL 5 YL)ETHYL] 3 ISOQUINOLINECARBOXYLIC ACID; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR 7; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR AGONIST; KAINIC ACID RECEPTOR ANTAGONIST; LY 377770; PHOSPHOLIPASE C; PILOCARPINE; POSTSYNAPTIC DENSITY PROTEIN 95; POSTSYNAPTIC RECEPTOR; PRESYNAPTIC RECEPTOR; PROTEIN INTERACTING WITH PROTEIN KINASE C; PROTEIN KINASE C; UBP 296; UBP 302; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALLODYNIA; BRAIN DEPTH STIMULATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHANNEL GATING; CLINICAL TRIAL; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENANTIOMER; ENZYME ACTIVITY; EPILEPSY; GABAERGIC SYSTEM; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUNTINGTON CHOREA; HYPERALGESIA; LONG TERM POTENTIATION; MIGRAINE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RECEPTOR BLOCKING; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

EID: 30844458571     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2005.08.004     Document Type: Review

References (78)

1. J. Lerma A.V. Paternain A. Rodriguez-Moreno J.C. Lopez-Garcia Molecular physiology of kainate receptors Physiol Rev 81 2001 971-998
2. A.V. Paternain M. Morales J. Lerma Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons Neuron 14 1995 185-189
3. T.J. Wilding J.E. Huettner Antagonist pharmacology of kainate- and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring receptors Mol Pharmacol 49 1996 540-546
4. C. Mulle A. Sailer I. Perez-Otano H. Dickinson-Anson P.E. Castillo I. Bureau C. Maron F.H. Gage J.R. Mann B. Bettler S.F. Heinemann Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice Nature 392 1998 601-605
5. A. Contractor G. Swanson S.F. Heinemann Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus Neuron 29 2001 209-216
6. A. Contractor A.W. Sailer M. Darstein C. Maron J. Xu G.T. Swanson S.F. Heinemann Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice J Neurosci 23 2003 422-429
7. P.E. Castillo R.C. Malenka R.A. Nicoll Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons Nature 388 1997 182-186
8. M. Vignes G.L. Collingridge The synaptic activation of kainate receptors Nature 388 1997 179-182
9. M. Frerking R.C. Malenka R.A. Nicoll Synaptic activation of kainate receptors on hippocampal interneurons Nat Neurosci 1 1998 479-486
10. R. Cossart M. Esclapez J.C. Hirsch C. Bernard Y. Ben-Ari GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells Nat Neurosci 1 1998 470-478
11. A. Rodriguez-Moreno O. Herreras J. Lerma Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus Neuron 19 1997 893-901
12. V.R. Clarke B.A. Ballyk K.H. Hoo A. Mandelzys A. Pellizzari C.P. Bath J. Thomas E.F. Sharpe C.H. Davies P.L. Ornstein et al. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission Nature 389 1997 599-603
13. H. Kamiya S. Ozawa Kainate receptor-mediated presynaptic inhibition at the mouse hippocampal mossy fibre synapse J Physiol 523 2000 653-665
14. A. Rodriguez-Moreno J. Lerma Kainate receptor modulation of GABA release involves a metabotropic function Neuron 20 1998 1211-1218
15. J.L. Rozas A.V. Paternain J. Lerma Noncanonical signaling by ionotropic kainate receptors Neuron 39 2003 543-553
16. Z. Melyan B. Lancaster H.V. Wheal Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors J Neurosci 24 2004 4530-4534
17. A. Fisahn S.F. Heinemann C.J. McBain The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones J Physiol 562 2005 199-203
18. J. Lerma Roles and rules of kainate receptors in synaptic transmission Nat Rev Neurosci 4 2003 481-495
19. J.E. Huettner Kainate receptors and synaptic transmission Prog Neurobiol 70 2003 387-407
20. D. Schmitz J. Mellor R.A. Nicoll Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses Science 291 2001 1972-1976
21. D. Schmitz J. Mellor J. Breustedt R.A. Nicoll Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation Nat Neurosci 6 2003 1058-1063
22. A. Rodriguez-Moreno T.S. Sihra Presynaptic kainate receptor facilitation of glutamate release involves protein kinase A in the rat hippocampus J Physiol 557 2004 733-745
23. S.E. Lauri M. Segerstrale A. Vesikansa F. Maingret C. Mulle G.L. Collingridge J.T. Isaac T. Taira Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus J Neurosci 25 2005 4473-4484
24. R. Cossart R. Tyzio C. Dinocourt M. Esclapez J.C. Hirsch Y. Ben-Ari C. Bernard Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons Neuron 29 2001 497-508
25. C. Mulle A. Sailer G.T. Swanson C. Brana S. O'Gorman B. Bettler S.F. Heinemann Subunit composition of kainate receptors in hippocampal interneurons Neuron 28 2000 475-484
26. F. Maingret S. Lauri T. Taira J. Isaac Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations J Physiol 567 2005 131-142
27. M.Y. Min Z. Melyan D.M. Kullmann Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors Proc Natl Acad Sci USA 96 1999 9932-9937
28. I. Smolders Z.A. Bortolotto V.R. Clarke R. Warre G.M. Khan M.J. O'Neill P.L. Ornstein D. Bleakman A. Ogden B. Weiss et al. Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures Nat Neurosci 5 2002 796-804
29. M. Frerking R.A. Nicoll Synaptic kainate receptors Curr Opin Neurobiol 10 2000 342-351
30. A. Rodriguez-Moreno J.C. Lopez-Garcia J. Lerma Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons Proc Natl Acad Sci USA 97 2000 1293-1298
31. J.K. Christensen A.V. Paternain S. Selak P.K. Ahring J. Lerma A mosaic of functional kainate receptors in hippocampal interneurons J Neurosci 24 2004 8986-8993
32. M. Frerking D. Schmitz Q. Zhou J. Johansen R.A. Nicoll Kainate receptors depress excitatory synaptic transmission at CA3 → CA1 synapses in the hippocampus via a direct presynaptic action J Neurosci 21 2001 2958-2966
33. A. Tashiro A. Dunaevsky R. Blazeski C.A. Mason R. Yuste Bidirectional regulation of hippocampal mossy fiber filopodial motility by kainate receptors: A two-step model of synaptogenesis Neuron 38 2003 773-784
34. A.R. Cunha J.O. Malva J.A. Ribeiro Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [(3)H]GABA release FEBS Lett 469 2000 159-162
35. F. Coussen D. Perrais F. Jaskolski S. Sachidhanandam E. Normand J. Bockaert P. Marin C. Mulle Coassembly of two GluR6 kainate receptor splice variants within a functional protein complex Neuron 47 2005 555-566
36. D.S. Bredt R.A. Nicoll AMPA receptor trafficking at excitatory synapses Neuron 40 2003 361-379
37. I. Perez-Otano M.D. Ehlers Homeostatic plasticity and NMDA receptor trafficking Trends Neurosci 28 2005 229-238
38. G.L. Collingridge J.T. Isaac Y.T. Wang Receptor trafficking and synaptic plasticity Nat Rev Neurosci 5 2004 952-962
39. F. Jaskolski F. Coussen N. Nagarajan E. Normand C. Rosenmund C. Mulle Subunit composition and alternative splicing regulate membrane delivery of kainate receptors J Neurosci 24 2004 2506-2515
40. G. Ayalon Y. Stern-Bach Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions Neuron 31 2001 103-113
41. Z. Ren N.J. Riley L.A. Needleman J.M. Sanders G.T. Swanson J. Marshall Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal J Biol Chem 278 2003 52700-52709
42. S.J. Mah E. Cornell N.A. Mitchell M.W. Fleck Glutamate receptor trafficking: Endoplasmic reticulum quality control involves ligand binding and receptor function J Neurosci 25 2005 2215-2225
43. E.P. Garcia S. Mehta L.A. Blair D.G. Wells J. Shang T. Fukushima J.R. Fallon C.C. Garner J. Marshall SAP90 binds and clusters kainate receptors causing incomplete desensitization Neuron 21 1998 727-739
44. H. Hirbec O. Perestenko A. Nishimune G. Meyer S. Nakanishi J.M. Henley K.K. Dev The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs J Biol Chem 277 2002 15221-15224
45. H. Hirbec J.C. Francis S.E. Lauri S.P. Braithwaite F. Coussen C. Mulle K.K. Dev V. Couthino G. Meyer J.T. Isaac et al. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP Neuron 37 2003 625-638
46. J. Lerma Kainate reveals its targets Neuron 19 1997 1155-1158
47. R. Cossart J. Epsztein R. Tyzio H. Becq J. Hirsch Y. Ben-Ari V. Crepel Quantal release of glutamate generates pure kainate and mixed AMPA/ kainate EPSCs in hippocampal neurons Neuron 35 2002 147-159
48. F.L. Kidd J.T. Isaac Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: Role of glutamate clearance J Neurophysiol 86 2001 1139-1148
49. S. Tomita H. Adesnik M. Sekiguchi W. Zhang K. Wada J.R. Howe R.A. Nicoll D.S. Bredt Stargazin modulates AMPA receptor gating and trafficking by distinct domains Nature 435 2005 1052-1058
50. A. Priel A. Kolleker G. Ayalon M. Gillor P. Osten Y. Stern-Bach Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors J Neurosci 25 2005 2682-2686
51. M. Eder K. Becker G. Rammes A. Schierloh S.C. Azad W. Zieglgansberger H.U. Dodt Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons J Neurosci 23 2003 6660-6670
52. Q.S. Liu Q. Xu G. Arcuino J. Kang M. Nedergaard Astrocyte-mediated activation of neuronal kainate receptors Proc Natl Acad Sci U S A 101 2004 3172-3177
53. F.L. Kidd J.T. Isaac Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses Nature 400 1999 569-573
54. S. Martin J.M. Henley Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways EMBO J 23 2004 4749-4759
55. M. Frerking P. Ohliger-Frerking AMPA receptors and kainate receptors encode different features of afferent activity J Neurosci 22 2002 7434-7443
56. Z.A. Bortolotto V.R. Clarke C.M. Delany M.C. Parry I. Smolders M. Vignes K.H. Ho P. Miu B.T. Brinton R. Fantaske et al. Kainate receptors are involved in synaptic plasticity Nature 402 1999 297-301
57. J.C.A. More H.M. Troop N.P. Dolman D.E. Jane Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists Br J Pharmacol 138 2003 1093-1100
58. J.C. More R. Nistico N.P. Dolman V.R. Clarke A.J. Alt A.M. Ogden F.P. Buelens H.M. Troop E.E. Kelland F. Pilato Characterisation of UBP296: A novel, potent and selective kainate receptor antagonist Neuropharmacology 47 2004 46-64
59. D.H. Youn M. Randic Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit J Physiol 555 2004 683-698
60. A. Sailer G.T. Swanson I. Perez-Otano L. O'Leary S.A. Malkmus R.H. Dyck H. Dickinson-Anson H.H. Schiffer C. Maron T.L. Yaksh et al. Generation and analysis of GluR5(Q636R) kainate receptor mutant mice J Neurosci 19 1999 8757-8764
61. S. Ko M.G. Zhao H. Toyoda C.S. Qiu M. Zhuo Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice J Neurosci 25 2005 977-984
62. J.L. Sutton M.L. Maccecchini K.C. Kajander The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury Neuroscience 91 1999 283-292
63. R.M. Simmons D.L. Li K.H. Hoo M. Deverill P.L. Ornstein S. Iyengar Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat Neuropharmacology 37 1998 25-36
64. C.N. Sang N.M. Ramadan R.G. Wallihan A.S. Chappell F.G. Freitag T.R. Smith S.D. Silberstein K.W. Johnson L.A. Phebus D. Bleakman et al. LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine Cephalalgia 24 2004 596-602
65. J. Palecek V. Neugebauer S.M. Carlton S. Iyengar W.D. Willis The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates Pain 111 2004 151-161
66. J. Epsztein A. Represa I. Jorquera Y. Ben-Ari V. Crepel Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats J Neurosci 25 2005 8229-8239
67. R. Delorme M.O. Krebs N. Chabane I. Roy B. Millet M.C. Mouren-Simeoni W. Maier T. Bourgeron M. Leboyer Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder Neuroreport 15 2004 699-702
68. M.E. MacDonald J.P. Vonsattel J. Shrinidhi N.N. Couropmitree L.A. Cupples E.D. Bird J.F. Gusella R.H. Myers Evidence for the GluR6 gene associated with younger onset age of Huntington's disease Neurology 53 1999 1330-1332
69. D.C. Rubinsztein J. Leggo M. Chiano A. Dodge G. Norbury E. Rosser D. Craufurd Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease Proc Natl Acad Sci USA 94 1997 3872-3876
70. T. Sander T. Hildmann R. Kretz R. Furst U. Sailer G. Bauer B. Schmitz G. Beck-Mannagetta T.F. Wienker D. Janz Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism Am J Med Genet 74 1997 416-421
71. T. Sander D. Janz C. Ramel C.A. Ross W. Paschen T. Hildmann T.F. Wienker A. Bianchi G. Bauer U. Sailer et al. Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies Neurology 45 1995 1713-1720
72. Z. Chettouh M.F. Croquette B. Delobel S. Gilgenkrants C. Leonard C. Maunoury M. Prieur M.O. Rethore P.M. Sinet M. Chery et al. Molecular mapping of 21 features associated with partial monosomy 21: Involvement of the APP-SOD1 region Am J Hum Genet 57 1995 62-71
73. P. Gregor R.H. Reeves E.W. Jabs X. Yang W. Dackowski J.M. Rochelle R.H. Brown Jr. J.L. Haines B.F. O'Hara G.R. Uhl et al. Chromosomal localization of glutamate receptor genes: Relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans Proc Natl Acad Sci USA 90 1993 3053-3057
74. S. Jamain C. Betancur H. Quach A. Philippe M. Fellous B. Giros C. Gillberg M. Leboyer T. Bourgeron Linkage and association of the glutamate receptor 6 gene with autism Mol Psychiatry 7 2002 302-310
75. J. Bah H. Quach R.P. Ebstein R.H. Segman J. Melke S. Jamain M. Rietschel I. Modai K. Kanas O. Karni et al. Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia Neuroreport 15 2004 1987-1991
76. H. Shibata A. Joo Y. Fujii A. Tani C. Makino N. Hirata R. Kikuta H. Ninomiya N. Tashiro Y. Fukumaki Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia Psychiatr Genet 11 2001 139-144
77. M.L. Mayer Crystal structures of the GluR5 and GluR6 ligand binding cores: Molecular mechanisms underlying kainate receptor selectivity Neuron 45 2005 539-552
78. M.J. O'Neill A. Bond P.L. Ornstein M.A. Ward C.A. Hicks K. Hoo D. Bleakman D. Lodge Decahydroisoquinolines: Novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia Neuropharmacology 37 1998 1211-1222