Co-expression of the 5-HT3B subunit with the 5-HT3A receptor reduces alcohol sensitivity

Molecular Brain Research

Volumn 142, Issue 2, 2005, Pages 146-150

  Hayrapetyan, Volodya ^a   Jenschke, Monica ^a   Dillon, Glenn H ^a   Machu, Tina K ^a  

^a UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

5 HT3A B; 5 HT3A; Ethanol; Ligand gated ion channel; Trichloroethanol

Indexed keywords

ALCOHOL; SEROTONIN; SEROTONIN 3 RECEPTOR; TRICHLOROETHANOL;

ARTICLE; CELL STRAIN HEK293; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL LINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ETHANOL; ETHYLENE CHLOROHYDRIN; GENE EXPRESSION; HUMANS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; TRANSFECTION;

EID: 27944482252     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2005.09.011     Document Type: Article

References (15)

1. 3A receptor Mol. Brain Res. 119 2003 207 212
2. 3B subunit is a major determinant of serotonin-receptor function Nature 397 1999 359 363
3. 3 receptors are membrane ion channels Nature 339 1989 706 709
4. 3B receptor subunit J. Biol. Chem. 274 1999 30799 30810
5. A.M. Karnovsky, L.F. Gotow, D.D. McKinley, J.L. Piechan, C.L. Ruble, C.J. Mills, K.A.B. Schellin, J.L. Slightom, L.R. Fitzgerald, C.W. Benjamin, and S.L. Roberds A cluster of novel serotonin receptor 3-like genes on human chromosome 3 Gene 319 2003 137 148
6. 3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons Mol. Pharmacol. 40 1991 263 270
7. 3 receptor mediated ion current in nodose ganglion neurons from the adult rat J. Pharmacol. Exp. Ther. 265 1993 771 776
8. 3 receptors expressed in Xenopus laevis oocytes J. Pharmacol. Exp. Ther. 271 1994 898 905
9. 3 receptor, a serotonin-gated ion channel Science 154 1991 432 434
10. 3 receptors synthesized in the rat CNS and peripheral nervous system J. Neurosci. 22 2002 6732 6741
11. B. Niesler, B. Frank, J. Kapeller, and G.A. Rappold Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E Gene 319 2003 137 148
12. 3A receptor stabilizes channel opening and alters alcohol modulatory actions J. Pharmacol. Exp. Ther. 306 2003 595 604
13. R. Stevens, D. Rusch, K. Solt, D.E. Raines, and P.A. Davies Modulation of human 5-Hydroxytryptamine3AB receptors by volatile anesthetics and n-alcohols J. Pharmacol. Exp. Ther. 314 2005 338 345
14. 3 receptors in rat CA1 hippocampal interneurons: functional and molecular characterization J. Physiol. 544.3 2002 715 726
15. 3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state J. Physiol. 507.2 1998 335 352