Elevated postsynaptic [CA2+]i and L-type calcium channel activity in aged hippocampal neurons: Relationship to impaired synaptic plasticity

Journal of Neuroscience

Volumn 21, Issue 24, 2001, Pages 9744-9756

  Thibault, Olivier ^a   Hadley, Robert ^a   Landfield, Philip W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Dendrites; Frequency facilitation; Homeostasis; Imaging; Memory; Repetitive activation

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL L TYPE; CALCIUM ION; CALCIUM; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM CHANNELS, L TYPE; FLUORESCENT DYE;

AFTERHYPERPOLARIZATION; AGE; AGED; AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN NERVE CELL; BRAIN SLICE; CALCIUM CELL LEVEL; COGNITION; COGNITIVE DEFECT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; EXCITATORY POSTSYNAPTIC POTENTIAL; FACILITATION; HIPPOCAMPUS; MALE; NERVE CELL PLASTICITY; NERVE FIBER MEMBRANE STEADY POTENTIAL; NEUROPATHOLOGY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; ACTION POTENTIAL; ANIMAL; CALCIUM CHANNEL L TYPE; CYTOLOGY; DENDRITE; DRUG EFFECT; ELECTROSTIMULATION; IN VITRO STUDY; INTRACELLULAR FLUID; METABOLISM; METHODOLOGY; NERVE CELL; PATCH CLAMP; PHYSIOLOGY; RAT STRAIN; SYNAPSE; ULTRASTRUCTURE;

ACTION POTENTIALS; AGING; ANIMAL; BAY-K-8644; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS, L-TYPE; DENDRITES; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; FLUORESCENT DYES; HIPPOCAMPUS; IN VITRO; INTRACELLULAR FLUID; MALE; MICROSCOPY, CONFOCAL; NEURONAL PLASTICITY; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED F344; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPSES;

EID: 0035892243     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-24-09744.2001     Document Type: Article

References (91)

1. 2+ signals induced in hippocampal CA1 neurons by the synaptic activation of NMDA receptors
2. Potassium and short-term response plasticity in the hippocampal slice
3. Mode of control of hippocampal pyramidal cell discharges
4. Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats
5. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
6. Memory deficits associated with senescence: A behavioral and neurophysiological study in the rat
7. Normal aging: Regionally specific changes in hippocampal synaptic transmission
8. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence
9. Age-related decrease in the N-methyl-D-aspartateR-mediated excitatory postsynaptic potential in hippocampal region CA1
10. Whole cell recording from neurons in slices of reptilian and mammalian cortex
11. Calcium imaging in hippocampal neurons using confocal microscopy
12. Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons
13. Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus
14. B autoreceptors in rat hippocampus
15. Nimodipine facilitates associative learning in aging rabbits
16. Functional aspects of calcium-channel modulation
17. Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus
18. Role of calcium channel subtypes in calcium transients in hippocampal CA3 neurons
19. Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines
20. Properties and distribution of single voltage-gated calcium channels in adult hippocampal neurons
21. 2+-dependent processes: Relationship to hippocampal synaptic plasticity
22. Sequential dependencies regulate sensory evoked responses of single units in the rat hippocampus
23. Kinetics and pharmacological properties distinguishing three types of calcium currents in chick sensory neurons
24. Calcium and the aging nervous system
25. Modification of ion channels and calcium homeostasis of basal forebrain neurons during aging
26. 2+ signaling pathways linked to glutamate receptor activation in the somatic and dendritic regions of cultured cerebellar Purkinje neurons
27. 2+ indicators with greatly improved fluorescence properties
28. Properties of synchronous and asynchronous release during pulse train depression in cultured neurons
29. Differential shunting of EPSPs by action potentials
30. Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel 1 subunits
31. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease
32. Metabotrotopic glutamate receptor activation induces calcium waves within hippocampal dendrites
33. Confocal imaging of dendritic Ca transients in hippocampal brain slices during simultaneous current- and voltage-clamp recording
34. Regulation of back-propagating action potentials in hippocampal neurons
35. Corticosteroid modulation of hippocampal potentials: Increased effect with aging
36. Towards theories of brain aging
37. The role of calcium regulation in brain aging: Reexamination of a hypothesis
38. i recordings from neural cells in acutely isolated cerebellar slices employing differential loading of the membrane-permeant form of calcium indicator fura-2
39. Monitoring presynaptic calcium dynamics in projection fibers by in vivo loading of a novel calcium indicator
40. Hippocampal neurobiological mechanisms of age-related memory dysfunction
41. 2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats
42. A neuroholographic model of memory: Theta rhythms, facilitation, and calcium channels
43. Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats
44. 2+ ratios on frequency potentiation in hippocampal slices of young and aged animals
45. Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease
46. Calcium-induced calcium release in cerebellar Purkinje cells
47. Control of the repetitive discharge of rat CA1 pyramidal neurones in vitro
48. Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons
49. A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons
50. Short-term changes in synaptic efficacy
51. Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels
52. Dihydropyridine modulation of normal hippocampal physiology in young and aged rats
53. Use-dependent depression of IPSPs in rat hippocampal pyramidal cells in vitro
54. 2+ regulation
55. Decreased plasma membrane calcium transport activity in aging brain
56. 2+ channels
57. Behavioral correlates of theta-on and theta-off cells recorded from hippocampal formation of mature young and aged rats
58. Hippocampal plasticity induced by primed burst but not long-term potentiation stimulation is impaired in area CA1 of aged Fischer 344 rats
59. Methods for whole-cell recording from visually preselected neurons of perirhinal cortex in brain slices from young and aging rats
60. Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner
61. Increased calcium buffering in basal forebrain neurons during aging
62. Age-related alterations in caffeine-sensitive calcium stores and mitochondrial buffering in rat basal forebrain
63. 2+ from IP3-sensitive stores evoked by synaptic activation of mGluRs paired with backpropagating action potentials
64. A bicuculline-resistant inhibitory post-synaptic potential in rat hippocampal pyramidal cells in vitro
65. Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging
66. 2+ channels
67. Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: Evidence for altered calcium homeostasis in aging
68. The role of Ca entry via synaptically activated NMDA receptors in the induction of long-term potentiation
69. Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment
70. Postsynaptic membrane shifts during frequency potentiation of the hippocampal EPSP
71. Calcium channel density and hippocampal cell death with age in long-term culture
72. Age-related alterations in the properties of hippocampal pyramidal neurons among rat strains
73. 2+ channel currents in rat cerebellar granule neurons
74. Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal cells
75. Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation
76. Definition of the readily releasable pool of vesicles at hippocampal synapses
77. Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons
78. Role of temporal summation in age-related long-term potentiation-induction deficits
79. Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: Implications for the integration of long-term potentiation
80. Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurons
81. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation
82. 2+-dependent conductances in rat neocortical pyramidal neurons
83. Pharmacological basis for the use of nimodipine in central nervous system disorders
84. Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1
85. Potassium currents in hippocampal pyramidal cells
86. Increase in single L-type calcium channels in hippocampal neurons during aging
87. Calcium dysregulation in neuronal aging and Alzheimer's disease: History and new directions
88. Synaptic desensitization of NMDA receptors by calcineurin
89. Calcium and neuronal ageing
90. Mechanisms of calcium influx into hippocampal spines: Heterogeneity among spines, coincidence detection by NMDA receptors, optical quantal analysis
91. Exocytosis: A molecular and physiological perspective