메뉴 건너뛰기




Volumn 277, Issue 18, 2010, Pages 3622-3636

Calcium-dependent mitochondrial function and dysfunction in neurons: Minireview

Author keywords

calcium buffering; calcium deregulation; cell death; electron microscopy; electron probe microanalysis; energy filtering electron microscopy; excitotoxicity; hippocampal neurons; mitochondria; permeability transition

Indexed keywords

CYCLOPHILIN D; CYCLOSPORIN A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; XANTHINE OXIDASE;

EID: 77956319634     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07754.x     Document Type: Short Survey
Times cited : (256)

References (129)
  • 1
    • 37149029370 scopus 로고    scopus 로고
    • Calcium signaling
    • Clapham DE (2007) Calcium signaling. Cell 131, 1047 1058.
    • (2007) Cell , vol.131 , pp. 1047-1058
    • Clapham, D.E.1
  • 2
    • 0034523882 scopus 로고    scopus 로고
    • Mitochondria as regulators of stimulus-evoked calcium signals in neurons
    • Friel DD (2000) Mitochondria as regulators of stimulus-evoked calcium signals in neurons. Cell Calcium 28, 307 316.
    • (2000) Cell Calcium , vol.28 , pp. 307-316
    • Friel, D.D.1
  • 3
    • 12944314765 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons
    • Verkhratsky A (2005) Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev 85, 201 279.
    • (2005) Physiol Rev , vol.85 , pp. 201-279
    • Verkhratsky, A.1
  • 4
    • 33644847375 scopus 로고    scopus 로고
    • 2+: Molecular determinants and functional consequences
    • 2+: molecular determinants and functional consequences. Physiol Rev 86, 369 408.
    • (2006) Physiol Rev , vol.86 , pp. 369-408
    • Rizzuto, R.1    Pozzan, T.2
  • 5
    • 0032127595 scopus 로고    scopus 로고
    • Neuronal calcium signaling
    • Berridge MJ (1998) Neuronal calcium signaling. Neuron 21, 13 26.
    • (1998) Neuron , vol.21 , pp. 13-26
    • Berridge, M.J.1
  • 6
    • 0036479054 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in acute neurodegeneration
    • Friberg H Wieloch T (2002) Mitochondrial permeability transition in acute neurodegeneration. Biochimie 84, 241 250.
    • (2002) Biochimie , vol.84 , pp. 241-250
    • Friberg, H.1    Wieloch, T.2
  • 7
    • 3342910554 scopus 로고    scopus 로고
    • Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury
    • Starkov AA, Chinopoulos C Fiskum G (2004) Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium 36, 257 264.
    • (2004) Cell Calcium , vol.36 , pp. 257-264
    • Starkov, A.A.1    Chinopoulos, C.2    Fiskum, G.3
  • 8
    • 34250705186 scopus 로고    scopus 로고
    • The mitochondrial permeability transition in neurologic disease
    • Norenberg MD Rao KV (2007) The mitochondrial permeability transition in neurologic disease. Neurochem Int 50, 983 997.
    • (2007) Neurochem Int , vol.50 , pp. 983-997
    • Norenberg, M.D.1    Rao, K.V.2
  • 9
    • 61849142791 scopus 로고    scopus 로고
    • Calcium signaling and neurodegenerative diseases
    • Bezprozvanny I (2009) Calcium signaling and neurodegenerative diseases. Trends Mol Med 15, 89 100.
    • (2009) Trends Mol Med , vol.15 , pp. 89-100
    • Bezprozvanny, I.1
  • 10
    • 71849095133 scopus 로고    scopus 로고
    • Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases
    • Gibson GE, Starkov A, Blass JP, Ratan RR Beal MF (2010) Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta 1802, 122 134.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 122-134
    • Gibson, G.E.1    Starkov, A.2    Blass, J.P.3    Ratan, R.R.4    Beal, M.F.5
  • 11
    • 68649127352 scopus 로고    scopus 로고
    • Mitochondrial calcium in health and disease
    • Halestrap AP (2009) Mitochondrial calcium in health and disease. Biochim Biophys Acta 1787, 1289 1290.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1289-1290
    • Halestrap, A.P.1
  • 13
    • 0033785386 scopus 로고    scopus 로고
    • High tide of calcium in mitochondria
    • Pozzan T Rizzuto R (2000) High tide of calcium in mitochondria. Nat Cell Biol 2, E25 E27.
    • (2000) Nat Cell Biol , vol.2
    • Pozzan, T.1    Rizzuto, R.2
  • 16
    • 0033179293 scopus 로고    scopus 로고
    • Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: Spatial and temporal characteristics
    • Pivovarova NB, Hongpaisan J, Andrews SB Friel DD (1999) Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics. J Neurosci 19, 6372 6384.
    • (1999) J Neurosci , vol.19 , pp. 6372-6384
    • Pivovarova, N.B.1    Hongpaisan, J.2    Andrews, S.B.3    Friel, D.D.4
  • 19
    • 0031770844 scopus 로고    scopus 로고
    • Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons
    • Cheng C Reynolds IJ (1998) Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons. J Neurochem 71, 2401 2410.
    • (1998) J Neurochem , vol.71 , pp. 2401-2410
    • Cheng, C.1    Reynolds, I.J.2
  • 20
    • 33749831752 scopus 로고    scopus 로고
    • Intracellular zinc elevation measured with a 'calcium-specific' indicator during ischemia and reperfusion in rat hippocampus: A question on calcium overload
    • Stork CJ Li YV (2006) Intracellular zinc elevation measured with a 'calcium-specific' indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload. J Neurosci 26, 10430 10437.
    • (2006) J Neurosci , vol.26 , pp. 10430-10437
    • Stork, C.J.1    Li, Y.V.2
  • 21
    • 68649087359 scopus 로고    scopus 로고
    • Measurements of mitochondrial calcium in vivo
    • Pozzan T Rudolf R (2009) Measurements of mitochondrial calcium in vivo. Biochim Biophys Acta 1787, 1317 1323.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1317-1323
    • Pozzan, T.1    Rudolf, R.2
  • 22
    • 56249108340 scopus 로고    scopus 로고
    • Measuring calcium dynamics in living cells with genetically encodable calcium indicators
    • McCombs JE Palmer AE (2008) Measuring calcium dynamics in living cells with genetically encodable calcium indicators. Methods 46, 152 159.
    • (2008) Methods , vol.46 , pp. 152-159
    • McCombs, J.E.1    Palmer, A.E.2
  • 23
    • 0029985460 scopus 로고    scopus 로고
    • X-ray microanalysis in cell biology and cell pathology
    • Roomans GM Von Euler A (1996) X-ray microanalysis in cell biology and cell pathology. Cell Biol Int 20, 103 109.
    • (1996) Cell Biol Int , vol.20 , pp. 103-109
    • Roomans, G.M.1    Von Euler, A.2
  • 24
    • 46249124039 scopus 로고    scopus 로고
    • Electron probe X-ray microanalysis for the study of cell physiology
    • Fernandez-Segura E Warley A (2008) Electron probe X-ray microanalysis for the study of cell physiology. Methods Cell Biol 88, 19 43.
    • (2008) Methods Cell Biol , vol.88 , pp. 19-43
    • Fernandez-Segura, E.1    Warley, A.2
  • 25
    • 0141941110 scopus 로고    scopus 로고
    • New techniques in electron energy-loss spectroscopy and energy-filtered imaging
    • Egerton RF (2003) New techniques in electron energy-loss spectroscopy and energy-filtered imaging. Micron 34, 127 139.
    • (2003) Micron , vol.34 , pp. 127-139
    • Egerton, R.F.1
  • 26
    • 59849128805 scopus 로고    scopus 로고
    • Quantitative EFTEM mapping of near physiological calcium concentrations in biological specimens
    • Aronova MA, Kim YC, Pivovarova NB, Andrews SB Leapman RD (2009) Quantitative EFTEM mapping of near physiological calcium concentrations in biological specimens. Ultramicroscopy 109, 201 212.
    • (2009) Ultramicroscopy , vol.109 , pp. 201-212
    • Aronova, M.A.1    Kim, Y.C.2    Pivovarova, N.B.3    Andrews, S.B.4    Leapman, R.D.5
  • 27
    • 0033971898 scopus 로고    scopus 로고
    • Mitochondria and neuronal survival
    • Nicholls DG Budd SL (2000) Mitochondria and neuronal survival. Physiol Rev 80, 315 360.
    • (2000) Physiol Rev , vol.80 , pp. 315-360
    • Nicholls, D.G.1    Budd, S.L.2
  • 29
    • 0017919178 scopus 로고
    • The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues
    • Crompton M, Moser R, Ludi H Carafoli E (1978) The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues. Eur J Biochem 82, 25 31.
    • (1978) Eur J Biochem , vol.82 , pp. 25-31
    • Crompton, M.1    Moser, R.2    Ludi, H.3    Carafoli, E.4
  • 30
    • 24644462789 scopus 로고    scopus 로고
    • Mitochondria and calcium signaling
    • Nicholls DG (2005) Mitochondria and calcium signaling. Cell Calcium 38, 311 317.
    • (2005) Cell Calcium , vol.38 , pp. 311-317
    • Nicholls, D.G.1
  • 31
    • 77956322223 scopus 로고    scopus 로고
    • 2+ sequestration system
    • 2+ sequestration system. FEBS J 277, 3652 3663.
    • (2010) FEBS J , vol.277 , pp. 3652-3663
    • Starkov, A.A.1
  • 32
    • 77956324397 scopus 로고    scopus 로고
    • 2+ sequestration and precipitation revisited
    • 2+ sequestration and precipitation revisited. FEBS J 277, 3637 3651.
    • (2010) FEBS J , vol.277 , pp. 3637-3651
    • Chinopoulos, C.1    Adam-Vizi, V.2
  • 33
    • 4043086952 scopus 로고    scopus 로고
    • Mitochondria in health and disease: Perspectives on a new mitochondrial biology
    • Duchen MR (2004) Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol Aspects Med 25, 365 451.
    • (2004) Mol Aspects Med , vol.25 , pp. 365-451
    • Duchen, M.R.1
  • 34
    • 57049143140 scopus 로고    scopus 로고
    • Mitochondria in neuroplasticity and neurological disorders
    • Mattson MP, Gleichmann M Cheng A (2008) Mitochondria in neuroplasticity and neurological disorders. Neuron 60, 748 766.
    • (2008) Neuron , vol.60 , pp. 748-766
    • Mattson, M.P.1    Gleichmann, M.2    Cheng, A.3
  • 35
    • 0031931879 scopus 로고    scopus 로고
    • Mitochondrial calcium in relaxed and tetanized myocardium
    • Horikawa Y, Goel A, Somlyo AP Somlyo AV (1998) Mitochondrial calcium in relaxed and tetanized myocardium. Biophys J 74, 1579 1590.
    • (1998) Biophys J , vol.74 , pp. 1579-1590
    • Horikawa, Y.1    Goel, A.2    Somlyo, A.P.3    Somlyo, A.V.4
  • 36
    • 0037395951 scopus 로고    scopus 로고
    • Historical review: Mitochondria and calcium: Ups and downs of an unusual relationship
    • Carafoli E (2003) Historical review: mitochondria and calcium: ups and downs of an unusual relationship. Trends Biochem Sci 28, 175 181.
    • (2003) Trends Biochem Sci , vol.28 , pp. 175-181
    • Carafoli, E.1
  • 37
    • 0038143180 scopus 로고    scopus 로고
    • The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria
    • Chalmers S Nicholls DG (2003) The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. J Biol Chem 278, 19062 19070.
    • (2003) J Biol Chem , vol.278 , pp. 19062-19070
    • Chalmers, S.1    Nicholls, D.G.2
  • 38
    • 3042595335 scopus 로고    scopus 로고
    • Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons
    • Pivovarova NB, Nguyen HV, Winters CA, Brantner CA, Smith CL Andrews SB (2004) Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J Neurosci 24, 5611 5622.
    • (2004) J Neurosci , vol.24 , pp. 5611-5622
    • Pivovarova, N.B.1    Nguyen, H.V.2    Winters, C.A.3    Brantner, C.A.4    Smith, C.L.5    Andrews, S.B.6
  • 40
    • 1542268971 scopus 로고    scopus 로고
    • Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: Comparison of rat liver and brain mitochondria
    • Panov AV, Andreeva L Greenamyre JT (2004) Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: comparison of rat liver and brain mitochondria. Arch Biochem Biophys 424, 44 52.
    • (2004) Arch Biochem Biophys , vol.424 , pp. 44-52
    • Panov, A.V.1    Andreeva, L.2    Greenamyre, J.T.3
  • 41
    • 0022333161 scopus 로고
    • A role for the mitochondrion in the protection of cells against calcium overload?
    • Nicholls DG (1985) A role for the mitochondrion in the protection of cells against calcium overload? Prog Brain Res 63, 97 106.
    • (1985) Prog Brain Res , vol.63 , pp. 97-106
    • Nicholls, D.G.1
  • 44
    • 68649116755 scopus 로고    scopus 로고
    • SR/ER-mitochondrial local communication: Calcium and ROS
    • Csordas G Hajnoczky G (2009) SR/ER-mitochondrial local communication: calcium and ROS. Biochim Biophys Acta 1787, 1352 1362.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1352-1362
    • Csordas, G.1    Hajnoczky, G.2
  • 46
    • 0025014719 scopus 로고
    • Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron
    • Hernandez-Cruz A, Sala F Adams PR (1990) Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron. Science 247, 858 862.
    • (1990) Science , vol.247 , pp. 858-862
    • Hernandez-Cruz, A.1    Sala, F.2    Adams, P.R.3
  • 51
    • 0014682523 scopus 로고
    • Brain lesions in an infant rhesus monkey treated with monosodium glutamate
    • Olney JW Sharpe LG (1969) Brain lesions in an infant rhesus monkey treated with monosodium glutamate. Science 166, 386 388.
    • (1969) Science , vol.166 , pp. 386-388
    • Olney, J.W.1    Sharpe, L.G.2
  • 52
    • 0026497926 scopus 로고
    • Excitotoxic cell death
    • Choi DW (1992) Excitotoxic cell death. J Neurobiol 23, 1261 1276.
    • (1992) J Neurobiol , vol.23 , pp. 1261-1276
    • Choi, D.W.1
  • 53
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity
    • Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7, 369 379.
    • (1987) J Neurosci , vol.7 , pp. 369-379
    • Choi, D.W.1
  • 55
    • 68649104009 scopus 로고    scopus 로고
    • Mitochondrial calcium function and dysfunction in the central nervous system
    • Nicholls DG (2009) Mitochondrial calcium function and dysfunction in the central nervous system. Biochim Biophys Acta 1787, 1416 1424.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1416-1424
    • Nicholls, D.G.1
  • 56
    • 0029810095 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
    • Schinder AF, Olson EC, Spitzer NC Montal M (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 16, 6125 6133.
    • (1996) J Neurosci , vol.16 , pp. 6125-6133
    • Schinder, A.F.1    Olson, E.C.2    Spitzer, N.C.3    Montal, M.4
  • 57
    • 0033199019 scopus 로고    scopus 로고
    • Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones
    • Vergun O, Keelan J, Khodorov BI Duchen MR (1999) Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones. J Physiol 519, 451 466.
    • (1999) J Physiol , vol.519 , pp. 451-466
    • Vergun, O.1    Keelan, J.2    Khodorov, B.I.3    Duchen, M.R.4
  • 58
    • 0036313059 scopus 로고    scopus 로고
    • Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane
    • Brustovetsky N, Brustovetsky T, Jemmerson R Dubinsky JM (2002) Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane. J Neurochem 80, 207 218.
    • (2002) J Neurochem , vol.80 , pp. 207-218
    • Brustovetsky, N.1    Brustovetsky, T.2    Jemmerson, R.3    Dubinsky, J.M.4
  • 60
    • 0034705057 scopus 로고    scopus 로고
    • Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons
    • Budd SL, Tenneti L, Lishnak T Lipton SA (2000) Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proc Natl Acad Sci USA 97, 6161 6166.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6161-6166
    • Budd, S.L.1    Tenneti, L.2    Lishnak, T.3    Lipton, S.A.4
  • 61
    • 24144495250 scopus 로고    scopus 로고
    • Cytochrome c release from CNS mitochondria and potential for clinical intervention in apoptosis-mediated CNS diseases
    • Jemmerson R, Dubinsky JM Brustovetsky N (2005) Cytochrome c release from CNS mitochondria and potential for clinical intervention in apoptosis-mediated CNS diseases. Antioxid Redox Signal 7, 1158 1172.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1158-1172
    • Jemmerson, R.1    Dubinsky, J.M.2    Brustovetsky, N.3
  • 62
    • 57649233085 scopus 로고    scopus 로고
    • Mitochondrial and nuclear cross talk in cell death: Parthanatos
    • Andrabi SA, Dawson TM Dawson VL (2008) Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann NY Acad Sci 1147, 233 241.
    • (2008) Ann NY Acad Sci , vol.1147 , pp. 233-241
    • Andrabi, S.A.1    Dawson, T.M.2    Dawson, V.L.3
  • 63
    • 33846565429 scopus 로고    scopus 로고
    • 2+ signals and neuronal death in brain ischemia
    • 2+ signals and neuronal death in brain ischemia. Stroke 38, 674 676.
    • (2007) Stroke , vol.38 , pp. 674-676
    • Bano, D.1    Nicotera, P.2
  • 64
    • 41149174763 scopus 로고    scopus 로고
    • Mechanistic role of calpains in postischemic neurodegeneration
    • Bevers MB Neumar RW (2008) Mechanistic role of calpains in postischemic neurodegeneration. J Cereb Blood Flow Metab 28, 655 673.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 655-673
    • Bevers, M.B.1    Neumar, R.W.2
  • 65
    • 33846818524 scopus 로고    scopus 로고
    • Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
    • Abramov AY, Scorziello A Duchen MR (2007) Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci 27, 1129 1138.
    • (2007) J Neurosci , vol.27 , pp. 1129-1138
    • Abramov, A.Y.1    Scorziello, A.2    Duchen, M.R.3
  • 66
    • 58149460658 scopus 로고    scopus 로고
    • Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules
    • Forder JP Tymianski M (2009) Postsynaptic mechanisms of excitotoxicity: involvement of postsynaptic density proteins, radicals, and oxidant molecules. Neuroscience 158, 293 300.
    • (2009) Neuroscience , vol.158 , pp. 293-300
    • Forder, J.P.1    Tymianski, M.2
  • 67
    • 1842430709 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures
    • Nicholls DG (2004) Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Curr Mol Med 4, 149 177.
    • (2004) Curr Mol Med , vol.4 , pp. 149-177
    • Nicholls, D.G.1
  • 68
    • 67349117275 scopus 로고    scopus 로고
    • What is the mitochondrial permeability transition pore?
    • Halestrap AP (2009) What is the mitochondrial permeability transition pore? J Mol Cell Cardiol 46, 821 831.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 821-831
    • Halestrap, A.P.1
  • 70
    • 68649090703 scopus 로고    scopus 로고
    • The role of the mitochondrial permeability transition pore in heart disease
    • Halestrap AP Pasdois P (2009) The role of the mitochondrial permeability transition pore in heart disease. Biochim Biophys Acta 1787, 1402 1415.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1402-1415
    • Halestrap, A.P.1    Pasdois, P.2
  • 73
    • 33644953299 scopus 로고    scopus 로고
    • Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme
    • Chinopoulos C Adam-Vizi V (2006) Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J 273, 433 450.
    • (2006) FEBS J , vol.273 , pp. 433-450
    • Chinopoulos, C.1    Adam-Vizi, V.2
  • 74
    • 0034668844 scopus 로고    scopus 로고
    • Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria
    • Brustovetsky N Dubinsky JM (2000) Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria. J Neurosci 20, 8229 8237.
    • (2000) J Neurosci , vol.20 , pp. 8229-8237
    • Brustovetsky, N.1    Dubinsky, J.M.2
  • 75
    • 34547457567 scopus 로고    scopus 로고
    • Calcium-induced precipitate formation in brain mitochondria: Composition, calcium capacity, and retention
    • Kristian T, Pivovarova NB, Fiskum G Andrews SB (2007) Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention. J Neurochem 102, 1346 1356.
    • (2007) J Neurochem , vol.102 , pp. 1346-1356
    • Kristian, T.1    Pivovarova, N.B.2    Fiskum, G.3    Andrews, S.B.4
  • 76
    • 67649785237 scopus 로고    scopus 로고
    • Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death
    • Li V, Brustovetsky T Brustovetsky N (2009) Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death. Exp Neurol 218, 171 182.
    • (2009) Exp Neurol , vol.218 , pp. 171-182
    • Li, V.1    Brustovetsky, T.2    Brustovetsky, N.3
  • 78
    • 65549130400 scopus 로고    scopus 로고
    • Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults
    • Lee J, Schriner SE Wallace DC (2009) Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults. Biochim Biophys Acta 1787, 364 370.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 364-370
    • Lee, J.1    Schriner, S.E.2    Wallace, D.C.3
  • 81
    • 0026608995 scopus 로고
    • Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
    • Randall RD Thayer SA (1992) Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci 12, 1882 1895.
    • (1992) J Neurosci , vol.12 , pp. 1882-1895
    • Randall, R.D.1    Thayer, S.A.2
  • 82
    • 0027339920 scopus 로고
    • 2+ overload indicates early neuronal injury which precedes staining with viability indicators
    • 2+ overload indicates early neuronal injury which precedes staining with viability indicators. Brain Res 607, 319 323.
    • (1993) Brain Res , vol.607 , pp. 319-323
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3    Tator, C.H.4
  • 83
    • 0029827804 scopus 로고    scopus 로고
    • Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells
    • Budd SL Nicholls DG (1996) Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 67, 2282 2291.
    • (1996) J Neurochem , vol.67 , pp. 2282-2291
    • Budd, S.L.1    Nicholls, D.G.2
  • 84
    • 39849098739 scopus 로고    scopus 로고
    • Reduced calcium-dependent mitochondrial damage underlies the reduced vulnerability of excitotoxicity-tolerant hippocampal neurons
    • Pivovarova NB, Stanika RI, Watts CA, Brantner CA, Smith CL Andrews SB (2008) Reduced calcium-dependent mitochondrial damage underlies the reduced vulnerability of excitotoxicity-tolerant hippocampal neurons. J Neurochem 104, 1686 1699.
    • (2008) J Neurochem , vol.104 , pp. 1686-1699
    • Pivovarova, N.B.1    Stanika, R.I.2    Watts, C.A.3    Brantner, C.A.4    Smith, C.L.5    Andrews, S.B.6
  • 86
    • 33846022729 scopus 로고    scopus 로고
    • Calcium-dependent spontaneously reversible remodeling of brain mitochondria
    • Shalbuyeva N, Brustovetsky T, Bolshakov A Brustovetsky N (2006) Calcium-dependent spontaneously reversible remodeling of brain mitochondria. J Biol Chem 281, 37547 37558.
    • (2006) J Biol Chem , vol.281 , pp. 37547-37558
    • Shalbuyeva, N.1    Brustovetsky, T.2    Bolshakov, A.3    Brustovetsky, N.4
  • 87
    • 46349104861 scopus 로고    scopus 로고
    • Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity
    • Abramov AY Duchen MR (2008) Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. Biochim Biophys Acta 1777, 953 964.
    • (2008) Biochim Biophys Acta , vol.1777 , pp. 953-964
    • Abramov, A.Y.1    Duchen, M.R.2
  • 88
    • 0037007227 scopus 로고    scopus 로고
    • Mitochondria are morphologically and functionally heterogeneous within cells
    • Collins TJ, Berridge MJ, Lipp P Bootman MD (2002) Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J 21, 1616 1627.
    • (2002) EMBO J , vol.21 , pp. 1616-1627
    • Collins, T.J.1    Berridge, M.J.2    Lipp, P.3    Bootman, M.D.4
  • 89
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82, 47 95.
    • (2002) Physiol Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 90
    • 10044225935 scopus 로고    scopus 로고
    • Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons
    • Hongpaisan J, Winters CA Andrews SB (2004) Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons. J Neurosci 24, 10878 10887.
    • (2004) J Neurosci , vol.24 , pp. 10878-10887
    • Hongpaisan, J.1    Winters, C.A.2    Andrews, S.B.3
  • 91
    • 70349769764 scopus 로고    scopus 로고
    • Reactive oxygen species production by mitochondria
    • Lambert AJ Brand MD (2009) Reactive oxygen species production by mitochondria. Methods Mol Biol 554, 165 181.
    • (2009) Methods Mol Biol , vol.554 , pp. 165-181
    • Lambert, A.J.1    Brand, M.D.2
  • 94
    • 3342941452 scopus 로고    scopus 로고
    • Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate
    • Vesce S, Kirk L Nicholls DG (2004) Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. J Neurochem 90, 683 693.
    • (2004) J Neurochem , vol.90 , pp. 683-693
    • Vesce, S.1    Kirk, L.2    Nicholls, D.G.3
  • 95
    • 34249781383 scopus 로고    scopus 로고
    • 'Mild uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress
    • Johnson-Cadwell LI, Jekabsons MB, Wang A, Polster BM Nicholls DG (2007) 'Mild uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress. J Neurochem 101, 1619 1631.
    • (2007) J Neurochem , vol.101 , pp. 1619-1631
    • Johnson-Cadwell, L.I.1    Jekabsons, M.B.2    Wang, A.3    Polster, B.M.4    Nicholls, D.G.5
  • 100
    • 0028097733 scopus 로고
    • The quantity of calcium that appears to induce neuronal death
    • Eimerl S Schramm M (1994) The quantity of calcium that appears to induce neuronal death. J Neurochem 62, 1223 1226.
    • (1994) J Neurochem , vol.62 , pp. 1223-1226
    • Eimerl, S.1    Schramm, M.2
  • 102
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • Tymianski M, Charlton MP, Carlen PL Tator CH (1993) Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 13, 2085 2104.
    • (1993) J Neurosci , vol.13 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3    Tator, C.H.4
  • 103
    • 0033546347 scopus 로고    scopus 로고
    • Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
    • Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF Tymianski M (1999) Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284, 1845 1848.
    • (1999) Science , vol.284 , pp. 1845-1848
    • Sattler, R.1    Xiong, Z.2    Lu, W.Y.3    Hafner, M.4    MacDonald, J.F.5    Tymianski, M.6
  • 105
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham GE, Fukunaga Y Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5, 405 414.
    • (2002) Nat Neurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 106
    • 33645010267 scopus 로고    scopus 로고
    • Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors
    • Zhou M Baudry M (2006) Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. J Neurosci 26, 2956 2963.
    • (2006) J Neurosci , vol.26 , pp. 2956-2963
    • Zhou, M.1    Baudry, M.2
  • 110
    • 58149476292 scopus 로고    scopus 로고
    • In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    • Martel MA, Wyllie DJ Hardingham GE (2009) In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience 158, 334 343.
    • (2009) Neuroscience , vol.158 , pp. 334-343
    • Martel, M.A.1    Wyllie, D.J.2    Hardingham, G.E.3
  • 114
    • 0034055456 scopus 로고    scopus 로고
    • Ionic selectivity of low-affinity ratiometric calcium indicators: Mag-Fura-2, Fura-2FF and BTC
    • Hyrc KL, Bownik JM Goldberg MP (2000) Ionic selectivity of low-affinity ratiometric calcium indicators: mag-Fura-2, Fura-2FF and BTC. Cell Calcium 27, 75 86.
    • (2000) Cell Calcium , vol.27 , pp. 75-86
    • Hyrc, K.L.1    Bownik, J.M.2    Goldberg, M.P.3
  • 115
    • 0031839233 scopus 로고    scopus 로고
    • Privileged access to mitochondria of calcium influx through N-methyl-d-aspartate receptors
    • Peng TI Greenamyre JT (1998) Privileged access to mitochondria of calcium influx through N-methyl-d-aspartate receptors. Mol Pharmacol 53, 974 980.
    • (1998) Mol Pharmacol , vol.53 , pp. 974-980
    • Peng, T.I.1    Greenamyre, J.T.2
  • 117
    • 0141676771 scopus 로고    scopus 로고
    • Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    • Ikonomidou C Turski L (2002) Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 1, 383 386.
    • (2002) Lancet Neurol , vol.1 , pp. 383-386
    • Ikonomidou, C.1    Turski, L.2
  • 118
    • 0346787871 scopus 로고    scopus 로고
    • Neuroprotection in cerebral ischaemia: Facts and fancies - The need for new approaches
    • Wahlgren NG Ahmed N (2004) Neuroprotection in cerebral ischaemia: facts and fancies - the need for new approaches. Cerebrovasc Dis 17 (Suppl 1 153 166.
    • (2004) Cerebrovasc Dis , vol.17 , Issue.SUPPL. 1 , pp. 153-166
    • Wahlgren, N.G.1    Ahmed, N.2
  • 119
    • 33847125205 scopus 로고    scopus 로고
    • 2+-permeable AMPA receptors in synaptic plasticity and neuronal death
    • 2+-permeable AMPA receptors in synaptic plasticity and neuronal death. Trends Neurosci 30, 126 134.
    • (2007) Trends Neurosci , vol.30 , pp. 126-134
    • Liu, S.J.1    Zukin, R.S.2
  • 120
    • 34249776660 scopus 로고    scopus 로고
    • Acid sensing ion channels - Novel therapeutic targets for ischemic brain injury
    • Xiong ZG, Chu XP Simon RP (2007) Acid sensing ion channels - novel therapeutic targets for ischemic brain injury. Front Biosci 12, 1376 1386.
    • (2007) Front Biosci , vol.12 , pp. 1376-1386
    • Xiong, Z.G.1    Chu, X.P.2    Simon, R.P.3
  • 121
    • 42749094007 scopus 로고    scopus 로고
    • Beyond NMDA and AMPA glutamate receptors: Emerging mechanisms for ionic imbalance and cell death in stroke
    • Besancon E, Guo S, Lok J, Tymianski M Lo EH (2008) Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci 29, 268 275.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 268-275
    • Besancon, E.1    Guo, S.2    Lok, J.3    Tymianski, M.4    Lo, E.H.5
  • 122
    • 24744431841 scopus 로고    scopus 로고
    • Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death
    • Noh KM, Yokota H, Mashiko T, Castillo PE, Zukin RS Bennett MV (2005) Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death. Proc Natl Acad Sci USA 102, 12230 12235.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12230-12235
    • Noh, K.M.1    Yokota, H.2    Mashiko, T.3    Castillo, P.E.4    Zukin, R.S.5    Bennett, M.V.6
  • 125
    • 33344477023 scopus 로고    scopus 로고
    • ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia
    • Peng PL, Zhong X, Tu W, Soundarapandian MM, Molner P, Zhu D, Lau L, Liu S, Liu F Lu Y (2006) ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. Neuron 49, 719 733.
    • (2006) Neuron , vol.49 , pp. 719-733
    • Peng, P.L.1    Zhong, X.2    Tu, W.3    Soundarapandian, M.M.4    Molner, P.5    Zhu, D.6    Lau, L.7    Liu, S.8    Liu, F.9    Lu, Y.10
  • 126
    • 33745460795 scopus 로고    scopus 로고
    • Calcium-permeable AMPA channels in neurodegenerative disease and ischemia
    • Kwak S Weiss JH (2006) Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol 16, 281 287.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 281-287
    • Kwak, S.1    Weiss, J.H.2
  • 127
    • 0035869336 scopus 로고    scopus 로고
    • Mitochondria control AMPA/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells
    • Rego AC, Ward MW Nicholls DG (2001) Mitochondria control AMPA/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells. J Neurosci 21, 1893 1901.
    • (2001) J Neurosci , vol.21 , pp. 1893-1901
    • Rego, A.C.1    Ward, M.W.2    Nicholls, D.G.3
  • 128
    • 44949179393 scopus 로고    scopus 로고
    • 2+ homeostasis in neuronal dendrites is a downstream consequence of metabolic compromise during extended NMDA exposures
    • 2+ homeostasis in neuronal dendrites is a downstream consequence of metabolic compromise during extended NMDA exposures. J Neurosci 28, 5029 5039.
    • (2008) J Neurosci , vol.28 , pp. 5029-5039
    • Vander Jagt, T.A.1    Connor, J.A.2    Shuttleworth, C.W.3
  • 129
    • 70450207200 scopus 로고    scopus 로고
    • Spare respiratory capacity, oxidative stress and excitotoxicity
    • Nicholls DG (2009) Spare respiratory capacity, oxidative stress and excitotoxicity. Biochem Soc Trans 37, 1385 1388.
    • (2009) Biochem Soc Trans , vol.37 , pp. 1385-1388
    • Nicholls, D.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.